The Wu lab highlights the growing impact of computational methods, combined imaging techniques, and animal models in advancing neuroscience research and identifying new imaging biomarkers for neurodegenerative diseases (NDDs). The overview provided encompasses innovative imaging techniques sensitive to emerging biological concepts and utilizes animal models to facilitate translational research for diagnosing and monitoring patients with these conditions. Overall, this collection underscores the increasing integration of artificial and biological models to enhance translational and therapeutic strategies within the realm of neurodegenerative diseases.