The Wu lab investigates the longitudinal relationship between blood-based neural biomarkers and white matter neuroimaging biomarkers in collegiate athletes with sport-related concussions (SRC) from 24 hours post-injury to one week after return to play. Analysis of clinical and imaging data revealed significant associations between total tau and diffusion tensor imaging (DTI) metrics across the three time points, indicating a strong link between blood-based biomarkers and white matter microstructural changes. Notably, total tau exhibited consistent associations with elevated radial diffusivity (RD) in specific white matter tracts, emphasizing its potential as a robust indicator of SRC-related neurobiological alterations.
