The Gaston lab does basic and translational research focused on improving the management of childhood respiratory disease. The experimental methods involve cell and molecular biology, imaging, single cell analyses, biochemistry, human translational protocols and informatic analyses. Diseases studied include apnea, asthma, viral pneumonia and bronchiolitis, primary ciliary dyskinesia, bronchopulmonary dysplasia and septic shock.

Gaston Lab

Dr. Benjamin Gaston working in his lab

The laboratory of Benjamin Gaston, MD, leads basic and translational research focused on improving the management of childhood respiratory disease.

The experimental methods involve cell and molecular biology, imaging, single cell analyses, biochemistry, human translational protocols and informatic analyses. Diseases studied include apnea, asthma, viral pneumonia and bronchiolitis, primary ciliary dyskinesia, bronchopulmonary dysplasia and septic shock.

Meet the Gaston lab team

Research

PrecISE

PrecISE Network logo

Riley Hospital for Children is a major site for the Precision Interventions for Severe and Exacerbation-Prone Asthma (PrecISE) Network, a novel study aimed at personalized, biomarker-driven therapies for severe asthma. There are five interventions focused primarily on non-T2 asthma. The study uses an adaptive trial design, similar to many studies in oncology, in which different novel therapies can be evaluated to identify the one(s) best suited to the patient. One of the five interventions makes use of discoveries that have been central to Project 1 of the Gaston lab's P01.

Visit the PrecISE website for more information

Research Funding

  • P01 HL158507 - Scientific innovation for personalized severe asthma management

    The goal is to characterize the cell biology and physiology of recently identified asthma mechanisms.

    Principal Investigator, Overall:
    Benjamin Gaston
    Principal Investigator, Project 2: Benjamin Gaston
    Principal Investigator, Admin Core: Benjamin Gaston
    Funding agency: NIH/NHLBI
    Period: 08/01/21 - 07/30/26               
    Amount: $1,575,000 per year direct

  • R03 HL155246 - (Raffay; Gaston CoI) Pilot Study of an Inhaled Treatment for BPD      

    The goal is to develop a new therapy for BPD using novel biochemical data.

    Principal Investigator: Thomas Raffay
    Dr. Gaston's Role: Co-I
    Funding agency: NIH/NHLBI
    Period: 08/01/21 – 07/30/23 (In NCE)
    Amount: $50,000 direct per year     

  • R44, NHLBI - Atelerix Life Sciences Phase II SBIR

    The goal of this grant is to complete preclinical studies for ATLX-0199

    Principal Investigator: James Bates, MD, PhD
    Dr. Gaston's Role: Company founder and consultant
    Funding agency: NIH/NHLBI
    Period: 9/2022 - 8/2024
    Amount: Consultant fees, $15,000/year.  Overall, $1.8 Million

  • T32 GM148383 - Indiana Physician-Scientist and Physician-Engineer Training Program
    The goal of this program is to support the training of physician-scientists and physician-engineers at Indiana University School of Medicine and Purdue University School of Biomedical Engineering.

    Dr. Gaston's Role: Co-PI with Dr. Herbert
    Period: 06/01/23 - 05/31/28
    Amount: $1,358,000 direct/year
  • UG1 HL139126 - Clinical Centers for the NHLBI's Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE) Network (UG1)

    The goal of this network is to develop targeted therapies for severe asthma patients with specific biological endotypes.  It is the first-of-its-kind adaptive trial design in asthma; and it is a Phase 2 trial of Cavosonstat and other novel therapies in severe asthma.
     

    Principal Investigator/PD: Benjamin Gaston
    Funding agency:
    NIH/NHLBI
    Period:
    09/23/2017 - 06/30/2023 (in NCE) 
    Amount:
    $280,000 direct/year

  • BARDA agreement with Atelerix Life Sciences

    The goal of this project is to advance from the pre-IND meeting with FDA into Phase 1 clinical trials for ATLX-0199.

    PI: Jim Bates, MD, PhD
    Dr. Gaston's Role: Consultant
    Period: 2023-2024
    Amount: $749,000 total

  • U01 HL146002 - SARP 4
    The goal of this project is to continue to follow the natural history of the SARP cohort.

    Principal Investigator:
    Bruce Levy
    Dr. Gaston's Role:
    Consultant
    Funding agency:
    NIH/NHLBI
    Funding period:
    2019-2024
  • R25 HL163860 - The Medical Physician Engineers, Scientists and Clinicians Preparatory Program

    The purpose of this grant is to enhance predoctoral recruitment of under-represented minorities in STEM training.

    Principal Investigator: Wade Clapp
    Dr. Gaston's Role: Co-PI and trainer
    Funding agency: NIH/NHLBI
    Period: 06/01.2022 - 05/31/2027

  • IU School of Medicine-Purdue Biomedical Engineering Research Initiative
    The goal of this pilot grant is to develop a membrane-embedded, genetically corrected airway epithelium that can be used for personalized treatment of primary ciliary dyskinesia patients.

    Dr. Gaston's Role: Co-PI with Dr. Harbin (Purdue)
    Funding:
    IU School of Medicine and Purdue Weldon School of Biomedical Engineering
    Period: 06/01/2023 - 05/31/2025
    Amount:
    $50,000 per year
  • 2023

    Gaffin JM, Petty CR, Sorkness RL, Denlinger LC, Phillips BR, Ly NP, Gaston B, Ross K, Fitzpatrick A, Bacharier LB, DeBoer MD, Teague WG, Wenzel SE, Ramratnam S, Israel E, Mauger DT, Phipatanakul W; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3. J Allergy Clin Immunol. 2023;151:138-46. PMID 3604165.

    Zein JG, Bazeley P, Meyers D, Bleecker E, Gaston B, Hu B, Attaway A, Ortega VA Between-Sex Comparison of the Genomic Architecture of Asthma. Am J Respir Cell Mol Biol. 2023;68:456-458. doi: 10.1165/rcmb.2022-0430LE. PMID 37000440.

    Adaikalam S, Gaston B, Mucus Plugging in Primary Ciliary Dyskinesia. Ann Am Thorac Soc. 2023; 20:514-515. doi: 10.1513/AnnalsATS.202301-021ED. PMID 37000147.

    Li X, Li H, Christenson SA, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Bleecker ER, Meyers DA; NHLBI Severe Asthma Research Program (SARP). Genetic analyses of chr11p15.5 region identify MUC5AC-MUC5B associated with asthma-related phenotypes. J Asthma. 2023;21:1-12. doi: 10.1080/02770903.2023.2193631. PMID 36946148.

    Li H, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Wenzel SE, Zein J, Bleecker ER, Meyers DA, Chen Y, Li X; NHLBI Severe Asthma Research Program (SARP). J Asthma. 2023 Apr 21:1-10. doi: 10.1080/02770903.2023.2193634. Online ahead of print. PMID 36940238.


    Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A. Investigations of a combination of atopic status and age of asthma onset identify asthma subphenotypes. J Allergy Clin Immunol. 2023; S0091-6749(23)00289-0. doi: 10.1016/j.jaci.2023.02.028. PMID 36940238.

    Gaston B, Gardner DD, Mahan K, Akuthota P, Mendonca EA, Durrington H, Marozkina N, Martinez-Nunez RT, Newcomb D, Ainsworth B, Owora AH, Chung KF, Walker S,  Fowler SJ, Siddiqui S, Winders T, Zein J, Jarjour N, Huang YJ, Cahill, KN Djukanovic R. Asthma Innovations from the First International Collaborative Asthma Network (ICAN) Forum ERJ Open Research Jan 2023; 00090-2023; DOI: 10.1183/23120541.00090-2023. PMID 37260461.

    Saunders JL, Daniels IA, Edwards TL, Relich RF, Zhao Y, Smith LA, Gaston B, Davis MD. Effects of pH alteration on respiratory syncytial virus in human airway epithelial cells ERJ Open Research 2023; 004042022;  DOI: 10.1183/23120541.00404-2022. PMID 37465558.


    Gauthier M, Kale SL, Oriss TB, Gorry M, Ramonell RP, Dalton K, Ray P, Fahy JV, Seibold MA, Castro M, Jarjour N, Gaston B, Bleecker ER, Meyers DA, Moore W, Hastie AT, Israel E, Levy BD, Mauger D, Erzurum S, Comhair SA, Wenzel SE, Ray A. CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma. J Allergy Clin Immunol. 2023;152(1):94-106.e12. doi: 10.1016/j.jaci.2023.02.028. PMID 36893862.

    Davis MD, Zein JG, Carraro S, Gaston B. Defining and Promoting Pediatric Pulmonary Health: Developing Biomarkers for Pulmonary Health. Pediatrics. 2023;152(Suppl 2):e2023062292C. doi: 10.1542/peds.2023-062292C. PMID 37656025.

  • 2022

    Hannah WB, Seifert BA, Truty R, Zariwala MA, Ameel K, Zhao Y, Nykamp K, Gaston B. The global prevalence and ethnic heterogeneity of primary ciliary dyskinesia gene variants: a genetic database analysis. Lancet Respir Med. 2022 Jan 17:S2213-2600(21)00453-7. doi: 10.1016/S2213-2600(21)00453-7. PMID 35051411.

    Neidigh N, Alexander, van Emmerik P, Higgs A, Plack L, Clem C, Cater D, Marozkina N, Gaston B. Photolytic Measurement of Tissue S-Nitrosothiols in Rats and Humans In Vivo. Molecules 2022; 15;27:1294. PMID 3520989.

    McManus JM, Gaston B, Zein J, Sharifi N. Association between asthma and reduced androgen receptor expression in airways. Journal of the Endocrine Society.  2022; 21;6(5):bvac047. doi: 10.1210/jendso/bvac047. eCollection 2022 May 1. PMID 35402761.

    Gaston B, Bearer CF Thirty-two steps for getting your R01: advice to early career investigators. Pediatr Res. 2022 Mar 12. doi: 10.1038/s41390-022-02017-8; PMID 35279695.

    Getsy PM, Young AP, Grossfield A, Seckler JM, Wilson CG, Gaston B, Bates JN, Lewis SJ D-Cysteine ethylester and D-cystine dimethylester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats. Respir Physiol Neurobiol. 2022; 103912. doi: 10.1016/j.resp.2022.103912.  PMID 35447347.

    Getsy PM, Baby SM, Gruber RB, Gaston B, Lewis THJ, Grossfield A, Seckler JM, Hsieh YH, Bates JN, Lewis SJ. S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats. Front Pharmacol. 2022 May 26;13:892307. PMID 35721204.

    Getsy PM, Baby SM, May WJ, Lewis THJ, Bates JN, Hsieh YH, Gaston B, Lewis SJ. L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry. Biomed Pharmacother. 2022 Jun 17;153:113277. doi: 10.1016/j.biopha.2022.113277. Online ahead of print.Biomed Pharmacother. 2022. PMID 35724513.

    Hubbard D, Turtow K, Gaston B. S-Nitroso-L-cysteine and ventilatory drive: A pediatric perspective.  Pediatric pulmonology 2022;  202257(10):2291-2297. doi: 10.1002/ppul.26036. PMID 35785452.

    Fonseca FV, Raffay TM, Xiao K, McLaughlin PJ, Qian Z, Grimmett ZW, Adachi N, Wang B, Hausladen A, Cobb BA, Zhang R, Hess DT, Gaston B, Lambert NA, Reynolds JD, Premont RT, Stamler JS. S-nitrosylation is required for β2AR desensitization and experimental asthma. Mol Cell. 2022 Aug 4:S1097-2765(22)00651-7. PMID 35931084.

    Getsy PM, Baby SM, May WJ, Young AP, Gaston B, Hodges MR, Forster HV, Bates JN, Wilson CG, Lewis THJ, Hsieh YH, Lewis SJ. D-Cysteine Ethyl Ester Reverses the Deleterious Effects of Morphine on Breathing and Arterial Blood-Gas Chemistry in Freely-Moving Rats. Front Pharmacol. 2022 Jun 23;13:883329. PMID 35814208.

    Wang Z, Xu W, Comhair SAA, Fu X, Shao Z, Bearden R, Zein JG, Bleecker ER, Castro M, Denlinger LC, Fahy JV, Israel E, Levy BD, Jarjour NN, Moore WC, Wenzel SE, Mauger DT, Gaston B, Hazen SL, Erzurum SC Urinary total conjugated 3-bromotyrosine, asthma severity and exacerbation risk. Am J Physiol Lung Cell Mol Physiol. 2022; 323:L548-L557. PMID 36126269.

    Getsy PM, Young AP, Bates JN, Baby SM, Seckler JM, Grossfield A, Hsieh YH, Lewis THJ, Jenkins MW, Gaston B, Lewis SJ S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia. Biomed Pharmacother. 2022; 153:113436. PMID 36076552.
     
    Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER; Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. NHLBI Severe Asthma Research Program (SARP). Am J Respir Crit Care Med. 2022; 207:438-451. PMID 36066606.


    Getsy PM, Baby SM, May WJ, Bates JN, Ellis CR, Feasel MG, Wilson CG, Lewis THJ, Gaston B, Hsieh YH, Lewis SJ. L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats. Front Pharmacol. 2022; 13:968378. doi: 10.3389/fphar.2022.968378. eCollection PMID 36249760.

  • 2021
    Wheeler JA, Tutrow KD, Ebenroth ES, Gaston B, Bandyopadhyay A Heart failure is not a determinant of central sleep apnea in the pediatric population. Pediatr Pulmonol. 2021 Jan 12. doi: 10.1002/ppul.25242. PMID 33434409.

    Machogu E, Gaston B.  Respiratory Distress in the Newborn with Primary Ciliary Dyskinesia. Children (Basel). 2021 Feb 18;8(2):153. doi: 10.3390/children8020153.Children (Basel). PMID 33670529.

    Israel E, Denlinger LC, Bacharier LB, LaVange LM, Moore WC, Peters MC, Georas SN, Wright RJ, Mauger DT, Noel P, Akuthota P, Bach J, Bleecker ER, Cardet JC, Carr TF, Castro M, Cinelli A, Comhair SAA, Covar RA, Alexander LC, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Hoffman EA, Holguin F, Jackson DJ, Jain S, Jarjour NN, Ji Y, Kenyon NJ, Kosorok MR, Kraft M, Krishnan JA, Kumar R, Liu AH, Liu MC, Ly NP, Marquis MA, Martinez FD, Moy JN, O'Neal WK, Ortega VE, Peden DB, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Tulchinsky AF, Vijayanand P, Wechsler ME, Wenzel SE, White SR, Zeki AA, Ivanova A..PrecISE: Precision Medicine in Severe Asthma An Adaptive Platform Trial with Biomarker Ascertainment.  J Allergy Clin Immunol. 2021 Mar 2:S0091-6749(21)00352-3. doi: 10.1016/j.jaci.2021.01.037.  PMID 33667479.

    Zein JG, McManus JM, Sharifi N, Erzurum SC, Marozkina N, Lahm T, Giddings O, Davis MD, DeBoer MD, Comhair SA, Bazeley P, Kim HJ, Busse W, Calhoun W, Castro M, Chung KF, Fahy JV, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Ortega VE, Peters M, Bleecker ER, Meyers DA, Zhao Y, Wenzel SE, Gaston B; NHLBI Severe Asthma Research Program (SARP). Benefits of Airway Androgen Receptor Expression in Human Asthma. Am J Respir Crit Care Med. 2021; 204:285-293.  PMID 33779531.

    Raffay TM, Bonilla-Fernandez K, Jafri A, Sopi RB, Smith LA, Cui F, O'Reilly M, Zhang R, Hodges CA, MacFarlane PM, Deutsch G, Martin RJ, Gaston B.  Bronchopulmonary Dysplasia and Pulmonary Hypertension: The Role of Smooth Muscle adh5. Am J Respir Cell Mol Biol. 2021; 65:70-80.  PMID 33780653.

    Gaston B, Marozkina N, Newcomb DC, Sharifi N, Zein J. Asthma Risk Among Individuals With Androgen Receptor Deficiency.  JAMA Pediatr. 2021 Apr 12. doi: 10.1001/jamapediatrics.2021.0281. PMID: 33844005.

    Gaston B, Baby SM, May WJ, Young AP, Grossfield A, Bates JN, Seckler JM, Wilson CG, Lewis SJ. D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception. Sci Rep. 2021 \;;11(1):10038. doi: 10.1038/s41598-021-89455-2. PMID 33976311.

    Baratchian M, McManus JM, Berk MP, Nakamura F, Mukhopadhyay S, Xu W, Erzurum S, Drazba J, Peterson J, Klein EA, Gaston B, Sharifi N. Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes. Sci Rep. 2021; 11(1):11130. doi: 10.1038/s41598-021-90491-1. PMID 34045511.

    Marozkina N, Smith L, Zhao Y, Zein J, Chmiel JF, Kim J, Kiselar J, Davis MD, Cunningham RS, Randell SH, Gaston B. Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium. Sci Rep. 2021; 11(1):15498. doi: 10.1038/s41598-021-94782-5. PMID 34326365.

    Pophal M, Grimmett ZW, Chu C, Margevicius S, Raffay T, Ross K, Jafri A, Giddings O, Stamler JS, Gaston B, Reynolds JD  Airway Thiol-NO Adducts as Determinants of Exhaled NO. Antioxidants (Basel). 2021;10(10):1527. doi: 10.3390/antiox10101527. PMID 34679661.

    Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Alexander LC, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P. The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: an overview of Network organization, procedures and interventions.  J Allergy Clin Immunol. 2021 Nov 27:S0091-6749(21)01819-4. doi: 10.1016/j.jaci.2021.10.035. PMID 34848210.
  • 2020

    Ross KR, Gupta R, DeBoer MD, Zein J,  Phillips BR, Li C, Myers RE, Phipatanakul W, Fitzpatrick AM,, Ly NP, Bacharier LB, Jackson DJ, Celedon JC, Larkin A, Israel E, Fahy JV, Castro M, Bleecker ER, Meyers D, Moore WC,. Wenzel SE, Jarjour NN, Erzurum SC, Teague WG, Gaston B. Severe asthma during childhood and adolescence: A longitudinal study. J Allergy Clin Immunol, 2020; 145(1):140-146.  PMID 31622688.

    Ash SY, Vegas Sanchez-Ferrero G, Schiebler ML, Rahaghi FN, Rai A, Come CE, Ross JC, Colon AG, Cardet JC, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston B, Hoffman EA, Jarjour NN, Lempel JK, Mauger DT, Tattersall MC, Wenzel SE, Levy BD, Washko GR, Israel E, San Jose Estepar R; SARP Investigators. Estimated Ventricular Size, Asthma Severity and Exacerbations: The SARP III Cohort. Chest. 2020i: S0012-3692(19)33744 -4. PMID 31521672.

    Li X, Hastie AT, Peters MC, Hawkins GA, Phipatanakul W, Li H, Moore WC, Busse WW, Castro M, Erzurum SC, Gaston B, Israel E, Jarjour NN, Levy BD, Wenzel SE, Meyers DA, Fahy JV, Bleecker ER; NHLBI Severe Asthma Research Program (SARP) Networks. Investigation of the relationship between IL-6 and type 2 biomarkers in severe asthma. 2020 J Allergy Clin Immunol. 145:430-433. PMID 31513878.

    Fitzpatrick AM, Szefler SJ, Mauger DT, Phillips BR, Denlinger LC, Moore WC, Sorkness RL, Wenzel SE, Gergen PJ, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston B, Israel E, Levy BD, Meyers DA, Teague WG, Bacharier LB, Ly NP, Phipatanakul W, Ross KR, Zein J, Jarjour NN. Development and Initial Validation of the Asthma Severity Scoring System (ASSESS).J Allergy Clin Immunol. 2020: 145:127-139.  PMID 31604088

    Marozkina M, Zein J, DeBoer MD, Logan L, Veri L, Ross K,  Gaston B. Dehydroepiandrosterone supplementation may benefit women with asthma who have low androgen levels: A pilot study.  Pulm Therap 2019; 5:213-220. PMID 32026412.

    Hannah WB,Truty R, Gonzales V, Kithcart GP, Ouyang K, Zeman MK, Li C,  Mitchell Drumm M, Nykamp K, Gaston B. Frequency of CFTR variants in individuals evaluated for primary ciliary dyskinesia. J Pediatr 2019; 215:172-177. PMID 31610925.

    Shapiro AJ, Dell SD, Gaston B, O'Connor M, Marozkina N, Manion M, Hazucha MJ, Leigh MW. Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia: A Technical Paper on Standardized Testing Protocols. Ann Am Thorac Soc, 2020; 17 e1-e12. PMID 31770003.

    Zein J, Gaston B, Bazeley P, DeBoer MD, Igo RP, Bleecker ER, Meyers D, Comhair S, Marozkina NV, Cotton C, Patel M, Noel P, Mauger DT, Levy B, Israel E, Castro M, Moore WC, Peters SP, Jarjour NN, Busse WW, Teague WG, Wenzel SE, Fitzpatrick AM, Fahy JV, Calhoun WJ, Chung KF, Erzurum SC, Sharifi N. Androgen metabolism and severe asthma: HSD3B1 genotype identifies glucocorticoid responsiveness.  Proc Natl Acad Sci USA, 2020; 117: 2187-2193., PMID 31932420.

    Gaston B, Laguna TA, Noah TL, Hagood J, Voynow J, Ferkol T, Hershenson M, Boyne K,  Angela AO, Ross K, Gozal D, Celedón JC, Abman SH, Moore P, Davis S, Cornfield, Murphy T. A proposal for the addressing the needs of the pediatric pulmonary work force. Pediatr Pulmonol 2020; 55:1859-1867. PMID 32531116.

    Marozkina N, Gaston B. An Update on Thiol Signaling: S-Nitrosothiols, Hydrogen Sulfide and a Putative Role for Thionitrous Acid. Antioxidants (Basel). 2020 Mar 10;9(3):225-30. PMID 32164188.

    Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC; National Heart Lung and Blood Institute Severe Asthma Research Program. Evidence for Exacerbation-Prone Asthma and Predictive Biomarkers of Exacerbation Frequency.2020;  Am J Respir Crit Care Med. 2020:973-82. PMID 32479111.  

    Gaston B, Smith L, Bosch J, Seckler J, Kunze D, Kiselar J, Marozkina N, Hodges CA,  Wintrobe P,  McGee K, Morozkina TS, Burton ST, Lewis T, Strassmaier T, Getsy P,  Bates JN, Lewis SJ.  Voltage-gated potassium channel proteins and stereoselective S-nitroso-L-cysteine signaling.  Journal of Clinical Investigation – Insight 2020; 5(18):e134174. doi: 10.1172/jci.insight.134174. PMID 32790645

    Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA; NHLBI Severe Asthma Research Program (SARP) Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. J Allergy Clin Immunol. 2021; 147:894-909.  PMID 32795586.

    Davis MD Clemente TM, Giddings OK, Ross K, Cunningham RS, Smith L, Simpson E, Liu Y, Kloepfer K, Ramsey IS, Zhao Y,Robinson CM, Gilk SD, Gaston B. A safe inhalational treatment eliminates SARS-CoV-2 replication in human airway epithelial cells. Respiratory Care 2021; 66:113-119. PMID 32962996.

    Ivanova A, Israel E, LaVange LM, Peters MC, Denlinger LC, Moore WC, Bacharier LB, Marquis MA, Gotman NM, Kosorok MR, Tomlinson C, Mauger DT, Georas SN, Wright RJ, Noel P, Rosner GL, Akuthota P, Billheimer D, Bleecker ER, Cardet JC, Castro M, DiMango EA, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Holguin F, Jain S, Kenyon NJ, Krishnan JA, Kraft M, Kumar R, Liu MC, Ly NP, Moy JN, Phipatanakul W, Ross K, Smith LJ, Szefler SJ, Teague WG, Wechsler ME, Wenzel SE, White SR . The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations.  J Biopharm Stat. 2020; 30:1026-37. PMID 32941098.

    Baratchian M, McManus JM, Berk M, Nakamura F, Mukhopadhyay S, Xu W, Erzurum S, Drazba J, Peterson J, Klein EA, Gaston B, Sharifi N. Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2.  bioRxiv. 2020 Oct 14:2020.04.21.051201. doi: 10.1101/2020.04.21.051201. PMID 33083800.

    Denlinger LC, Phillips BR, Sorkness RL, Bleecker ER, Castro M, DeBoer MD, Fitzpatrick AM, Hastie AT, Gaffin JM, Moore WC, Peters MC, Peters SP, Phipatanakul W, Cardet JC, Erzurum SC, Fahy JV, Fajt ML, Gaston B, Levy BD, Meyers DA, Ross K, Teague WG, Wenzel SE, Woodruff PG, Zein J, Jarjour NN, Mauger DT, Israel E; National Heart, Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma. Am J Respir Crit Care Med. 2020 Dec 8. doi: 10.1164/rccm.202002-0454OC. PMID 33290668.

  • 2019
    Altawallbeh G, Smith L, Lewis SJ, Authier S, Bujold K, Gaston B, Bederman I. Pharmacokinetic study of Sudaxine in dog plasma using novel LC-MS/MS method.. Drug Test Anal. 2019;11:403-410 2018 . doi: 10.1002/dta.2507. PMID 30242972.

     

    Khalid F, Hannah WB, Gaston B.  Rapid Advances in PCD Research: A Brief Update for Pulmonologists.  Am J Respir Crit Care Med. 2019; 199(2):136-138. PMID 3011018

     

    Mendelsohn L, Wijers C, Gupta R, Marozkina N, Li C, Gaston B. A novel, noninvasive assay shows that distal airway oxygen tension is low in cystic fibrosis, but not in primary ciliary dyskinesia. Pediatr Pulmonol. 54:2019; 27-32. PMID 30485726

     

    O'Connell P, Gaston B, Bonfield T, Grabski T, Fletcher D, Shein SL Periostin levels in children without respiratory disease. Pediatr Pulmonol. 2019;54:200-204. PMID 30548226.

     

    Ross KR, Teague WG, Gaston B. Life Cycle of Childhood Asthma: Prenatal, Infancy and Preschool, Childhood, and Adolescence. Clin Chest Med. 2019; 40(1):125-147. PMID 30691707.

     

    Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. Multiview Cluster Analysis Identifies Variable Corticosteroid Response Phenotypes in Severe Asthma. Am J Respir Crit Care Med. 2019; 199(11):1358-1367. PMID 30682261.

     

    Zaman K,  Knight J, Hussain F, Cao R,  Estabrook SK, Altawallbeh G, Holloway K, Jafri A, Sawczak V, Li Y, Getsy P, Sun F, Raffay T, Cotton C,  Brodsky JL,  Periasamy P, Lewis SJ,  Gaston B. S-Nitrosylation of CHIP Enhances F508Del CFTR Maturation. Am J Respir Cell Molec Biol. 2019; 61(6):765-775. PMID 31596601.

     

    McEvoy CT, Marozkina N, Gaston B, Spindel ER. In utero smoke and gene interactions: long term consequences on respiratory health. Am J Respir Crit Care Med. 2019; 200(4):409-410. PMID 30811946.

     

    Fitzpatrick AM, Gillespie SE, Mauger DT, Phillips BR, Bleecker ER, Israel E, Meyers DA, Moore WC, Sorkness RL, Wenzel SE, Bacharier LB, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Jarjour NN, Larkin A, Levy BD, Ly NP, Ortega VE, Peters SP, Phipatanakul W, Ramratnam S, Teague WG.  Racial disparities in asthma-related health care use in the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2019; 143:2025-61. PMID 30635198.

     

    Weathington N, O'Brien ME, Radder JE, Whisenant TC, Bleecker ER, Busse WW, Erzurum SC, Gaston B, Jarjour NN, Meyers DA, Milosevic J, Tedrow JR, Trudeau JB, Wong HP, Wu W, Kaminski N, Wenzel SE, Modena BD.  Bronchoalveolar Lavage Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications. Am J Respir Crit Care Med. 2019; 200(7):837-856. PMID 31161938.

     

    Marozkina N, Bosch J, Cotton CU, Smith L, Seckler JV, Zaman K, Rehman S, Periasamy A, Gaston H, Altawallbeh G, Davis M, Jones DR, Schilz R, Randell SH, Gaston B. Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2019; 317(2):L247-L258 PMID 31116581. 

     

    Gupta R, Gaston B.  From Genetics to Precision Therapy: Finding a Path through the Scientific Valley of Death. Am J Respir Cell Mol Biol. 2019; 61(6):671-672 PMID 31233696.

     

    Einisman HJ, Gaston B, Wijers C, Smith LA, Lewis TH, Lewis SJ, Raffay TM Tracheomalacia in bronchopulmonary dysplasia: Trachealis hyper-relaxant responses to S-nitrosoglutathione in a hyperoxic murine model. Pediatr Pulmonol. 2019; 54(12):1989-1996. PMID 31486289.

     

    Tonelli AR, Aulak KS, Ahmed MK, Hausladen A, Abuhalimeh B, Casa CJ, Rogers SC, Timm D, Doctor A, Gaston B, Dweik RA. A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers. PLoS One. 2019 Aug 30;14(8):e0221777. PMID 31469867. 

     

    Coverstone AM, Bacharier LB, Wilson BS, Fitzpatrick AM, Teague WG, Phipatanakul W, Wenzel SE, Gaston B, Bleecker ER, Moore WC, Ramratnam S, Jarjour NN, Ly NP, Fahy JV, Mauger DT, Schechtman KB, Yin-DeClue H, Boomer JS, Castro M. Clinical significance of the bronchodilator response in children with severe asthma. Pediatr Pulmonol. 2019.  54(11):1694-1703. PMID 31424170

  • 2018

    Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston B, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018; S2213-2198(17)30526-3. PMID 28866107.

    Stsiapura VI, Bederman I, Stepuro II, Morozkina TS, Lewis SJ, Smith L, Gaston B, Marozkina N. S-Nitrosoglutathione formation at gastric pH is augmented by ascorbic acid and by the antioxidant vitamin complex, Resiston. Pharmaceut. Biol. 2018;56(1):86-93. PMID 29298528.

     

    Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston B, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR; SARP Investigators. Pruning of the Pulmonary Vasculature in Asthma: The SARP Cohort. Am J Respir Crit Care Med. 2018; 198:39-50. PMID 29672122.

    DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston B, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018; 18:570. PMID 29631584.

    Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J. Female Sex and Gender in Lung/Sleep Health and Disease: Increased Understanding of Basic Biological, Pathophysiological and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease. 2018; Am J Respir Crit Care Med. 198(7):850-858. PMID 29746147.

    Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston B, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators.2018; Sci Immunol. 3:eaao4747. PMID 30076281

  • 2017
    Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston B, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017; 10:eaam5466.  PMID 28783702.

    Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston B, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight 2017; 2:14 e93534. PMID 29563345.

    Shein SL, Rotta AT, Speicher R, Slain KN, Gaston B. Corticosteroid Therapy During Acute Bronchiolitis in Patients Who Later Develop Asthma. Hosp Pediatr. 2017; 7:403-409 PMID 28619722.

    Modena BD, Bleecker ER, Busse WW, Erzurum SC, Gaston B, Jarjour NN, Meyers DA, Milosevic J, Tedrow JR, Wu W, Kaminski N, Wenzel SE. Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. Am J Respir Crit Care Med. 2017; 195:1449-1463. PMID 27984699.

    Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston B, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E; Severe Asthma Research Program. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.  Am J Respir Crit Care Med. 2017;195:1439-1448.  PMID 27967215.

    Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017; 195:302-313. PMID 27556234.

    Wong-McGrath K, Denlinger LC, Bleecker ER, Castro M, Gaston B, Israel E, Jarjour NN, Mauger DT, Peters S, Phillips BR, Wenzel SE, Fahy JV, Peters MC; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. Internet-Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control. Chest. 2017; 153(2):378-386. PMID 29080709.

    Seckler JM, Meyer NM, Burton ST, Bates JN, Gaston B, Lewis SJ. Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor. PLoS One. 2017; 26;12:e0187149. PMID 29073241.

    Rodriguez K, Gaston B, Wasman J, Marozkina N. Lessons from unilateral loss of cilia: early nasal nitric oxide gas mixing,  and the role of sinus patency in determining nasal nitric oxide. Clinical Medicine Insights: Ear, Nose and Throat. 2017; 13;10:1179550617746361. PMID 29276419.

    Thomas RG., Rivera Reyes BM, Gaston B, Rivera Acosta NB, Bederman I, Wang B, Hunt J, Bonfield T. Acetaminophen nitration amplifies the immune response to Der p1. PLOS One. 2017; 12:e0188614. PMID 29228007.

    Wijers CD, Chmiel JF, Gaston B. Bacterial infections in patients with primary ciliary dyskinesia: Comparison with cystic fibrosis. Chron Respir Dis. 2017;14:392-406, 2017. PMID 29081265.