Investigators at the IU School of Medicine Center for Computational Biology and Bioinformatics study broad areas of medical science using large scale datasets and unbiased computational approaches.
Bioinformatics research on gene and protein sequences, structures and functions facilitate biomarker discovery and validation for drug response prediction. System biology research on gene/protein networks further extends the understanding of drug response mechanisms at the molecular level. Literature and medical record text mining on genes, drugs, diseases, and their associations reveals new drug targets and new predictors for drug responses.