The research lab of Lynda Bonewald, PhD, focuses on the biology and function of the osteocyte.
Investigators in this lab have two major focus areas: the crosstalk between osteocyte and muscle and the role of the osteocyte in calcium homeostasis under calcium demanding conditions.
Osteocyte Regulation of Bone Muscle with Age- Core A: Administrative Core and Subproject I: Muscle Regulation of Osteoblast/Osteocyte Function in Young compared with Aged Animals. Extracellular Vesicle Mediated Cell-Cell Communication in Bone.
-Sego TJ, Prideaux M, Sterner J, McCarthy BP, Li P, Bonewald LF, Ekser B, Tovar A, Smith JL. Computational fluid Dynamic Analysis of Bioprinted Self-Supporting Perfused (SSuPer) Tissue Models. Biotechnol Bioeng. 2019 PMID 31788785.
-Essex AL, Pin F, Huot JR, Bonewald LF, Plotkin LI, Bonetto A. Bishosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice. Front Endocrinol (Lausanne) 2019 PMID 31803146.
-Mo C, Wang Z, Bonewald L, Brotto M. Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways. Int J Mol Sci, 2019 PMID 31579816.
-Wang Z, Bian L, Mo C, Shen H, Zhao LF, Su KJ, Kukula M, Lee JT, Armstrong DW, Recker R, Lappe J, Bonewald LF, Deng HW, Brotto M Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis. Commun Bio 2020 PMID 31969651.
-Wang H, Li T, Wang X, Yin X, Zhao N, Zou S, Duan P, Bonewald LF. The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction. Biochem BIophys Res Commun 2020 PMID 31941604.
-Prideaux M, Kitase Y, Kimble M, O’Connell TM, Bonewald LF Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/b-catenin signaling pathway Bone 2020 PMIC 32330695.
-Ito N, Prideaux M, Wijenayaka AB, Yang D, Ormsby RT, Bonewald LF, Atkins GJ Sclerostin directly stimulates osteocyte synthesis of Fibroblast Growth Factor 23 Cal Tiss Int. 2021 PMID33616712.
-Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF Non-bone metastatic cancers promote osteocyte-induced bone destruction Cancer Lett 2021 PMIC 32233150. DOI:10.1016/j.canlet.2021.06.030
-Nakamura MT, Zhang H, Guo D, Ueharu H, Pan H, Scott G, Harris M, Ray M, Feng JQ, Harris SE, Bonewald LF, Mishina Y Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background. genesis The Journal of Genetics and Development. 2021, https://doi.org/10.1002/dvg.23450
For a full list of Dr. Bonewald’s publication history, please find her on Google Scholar (https://scholar.google.com/citations?user=FNdjsE0AAAAJ&hl=en) or PubMed (https://www.ncbi.nlm.nih.gov/pubmed/?term=bonewald%2C+l)
