26932-Kitase, Yukiko

Yukiko Kitase, PhD

Assistant Research Professor of Anatomy, Cell Biology & Physiology

MS 5055
Indianapolis, IN

Titles & Appointments

  • Assistant Research Professor of Anatomy, Cell Biology & Physiology
  • Education
    2000 PhD University of Tokushima
    1996 DDS University of Tokushima
  • Research

    The overall goal of my research is to understand molecular mechanisms to mediate beneficial effects of exercise to maintain the homeostasis of musculoskeletal system and to develop new or improved therapies for treating osteoporosis induced by disuse and aging. Recent studies revealed endocrine crosstalk between skeletal muscle and bone in addition to physical and mechanical interaction. In my current project, I am investigating how contracted muscle-derived factors such as b-aminoisobutyric acid (BAIBA) and irisin, affect bone metabolism as well as osteocyte viability/functions by using in vitroosteocyte cell models, conditional knockout mouse models and an in vivo disuse model. BAIBA and irisin alter energy metabolism by regulating the AMPK signaling pathway, which is involved in the regulation of autophagy and mitochondrial function. I am interested in identifying the underlying molecular mechanisms of protective effects of BAIBA and irisin on osteocyte viability and elucidating the role of AMPK signaling in osteocyte energy metabolism in physiological and pathological conditions.

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