26803-Bonewald, Lynda

Lynda F. Bonewald, PhD

Director, Indiana Center for Musculoskeletal Health


Indianapolis, IN 46202


Indiana Center for Musculoskeletal Health

Dr. Bonewald is the Founding Director of the Indiana Center for Musculoskeletal Health, ICMH, a center with over 100 members from 36 departments and four campuses. Her primary faculty appointment is in the Department of Anatomy, Cell Biology & Physiology and her secondary is in the Department of Orthopaedic Surgery. She received her Ph.D. in Immunology/Microbiology from the Medical University of South Carolina, was promoted from Assistant to Full Professor at the Univ. of Texas Health Science Center at San Antonio and served as director of the Bone Biology Research Program and as Vice Chancellor for Research at the University of Missouri-Kansas City. She is a Past-President of the American Society for Bone and Mineral Research, ASBMR, and of the Association of Biomolecular Resource Facilities. She has served as Chair of the Board of Scientific Councilors for the NIDCR and served on Council for NIAMS NIH. She received the "Basic Research in Biological Mineralization Award" from the IADR, the "RIB Award" from Sun Valley, and the prestigious William F. Neuman award from the ASBMR. She has been continually funded by NIH for over thirty years and is best known for her work in the study of osteocytes and is responsible for tools used by researchers globally to determine osteocyte biology and function. She is currently studying bone to muscle crosstalk with aging.


Key Publications

1. Montesi M, Jahn K, Bonewald L, Stea S, Bordini B, Beraudi A., Hypoxia mediates osteocyte ORP150 expression and cell death in vitro Mol Med Rep 2016. PMID: 27748851

2. Vemula H, Kitase Y, Ayon NJ, Bonewald L, Gutheil WG. Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers. Anal Biochem 516:75-85, 2017. PMID: 27771391

3. C. Medina Gomez, J.P. Kemp, N. L. Dimou, E. Kreiner-Møller, A. Chesi, B. S. Zemel, K. Bønnelykke, C. G. Boer, T.S. Ahluwalia, H. Bisggard, E. Evangelou, D. H. M. Heppe, L. F. Bonewald, J. P. Gorski, M. Ghanbari, S. Demissie, D. G. Duque, M. T. Maurano, D.P. Kiel, B.C.J. van der Eerden, C. Ackert-Bicknell, S. Reppe, K. M. Gautvik, T. Raastad, D. Karasik, J. van de Peppel, V. W. V. Jaddoe, A. G. Uitterlinden, J. H. Tobias, S.F.A Grant, P.G. Bagos, D.M. Evans, F. Rivadeneira “Bivariate genome-wide association analysis implicates pleiotropic effects at the 1 SREBF1/TOM1L2 locus on bone mineral density and lean mass in children” Nature Communications: 2017. PMID: 2874360.

4. Yiwen Qin, Yuanzhen Peng, Wei Zhao, Jianping Pan, Christopher P Cardozo, Hanna Ksiezak-Reding, Yingjie Wu, Paola Divieti Pajevic, Lynda F. Bonewald, William A Bauman, Weiping Qin “Myostatin Inhibits Osteoblastic Differentiation by Suppressing Osteocyte-derived Exosomal microRNA-218: A Novel Mechanism in Muscle-Bone Communication”. Journal of Biological Chemistry: 2017. PMID: 28465350

5. Katharina Jähn, Shilpa Kelkar, Hong Zhao, Yixia Xie, LeAnn M. Tiede-Lewis, Vladimir Dusevich, Sarah L. Dallas, Lynda F. Bonewald “Osteocytes Acidify their Microenvironment in response to PTHrP in vitro and in Lactating Mice in vivo”, Journal of Bone and Mineral Research: 2017. PMID: 28470757

6. Jian Huang, Sandra Romero-Suarez, Nuria Lara, Chenglin Mo, Simon Kaja, Leticia Brotto, Sarah L. Dallas, Mark L. Johnson, Katharina Jähn, Lynda F. Bonewald, Marco Brotto. “Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway”. JBMR plus 2017 PMID 29104955.

7. Barreto R, Kitase Y, Matsumoto T, Pin F, Colston KC, Couch KE, O'Connell TM, Couch ME, BonewaldLF, Bonetto A. “ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass”. Sci Rep 2017 PMID 29089584.

8. Tiede-Lewis LM, Xie Y, Hulbert MA, Campos R, Dallas MR, Dusevich V, Bonewald LF, Dallas SL “Degeneration of the osteocyte network in the C57BL/6 mouse model of aging”. Aging 2017 PMID 29074822.

9. Bonewald LF. The Role of the Osteocyte in Bone and Non-Bone Disease. Endocrinol Metab Clin North Am. 2017 Mar; 46(1):1-18.PMID:28131126

10. 40.Ward LM, Kinnett K, Bonewald L, on behalf of Parent Project Muscular Dystrophy Bone Health Workshop Collaborators (Adachi J, Bachrach L, Bellido T, Brotto M, Donovan J, Hoffman E, McMillan H, Novotny S, Rafael-Fortney J, Rauch F, Warden SJ). Morbidity due to osteoporosis in Duchenne muscular dystrophy: the path forward. Neuromuscular Disorders 2017 PMID 28756052

11. Andrea Morrell, Genevieve Brown, Samuel Robinson, Rachel Sattler, Andrew Baik, Gehua Zhen, Xu Cao, Lynda Bonewald, Weiyang Jin, and Lance Kam “Mechanically-induced Ca2+ Oscillations in Osteocytes Release Extracellular Vesicles and Enhance Bone Formation”. Bone Research 2018 Mar 19 PMID 29581909.

12. Kitase Y, Vallejo JA, Gutheil W, Vemula H, Jähn K, Yi J, Zhou J, Brotto M, Bonewald LF. β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. Cell Rep. 2018 Feb 6;22(6):1531-1544. PMID: 29425508

13. Yajima A, Tsuchiya K, Bonewald LF, Inaba M, Tominaga Y, Tanizawa T, Ito A, Nitta K. Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism. Osteoporos Int. 2018 PMID 29492624.

14. Lu Y, Sayed SAK, Wang K, Tiede-Lewis LM, Grillo MA, Veno PA, Dusevich V, Phillips CL, Bonewald LF, Dallas SL. Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-tagged Collagen Constructs. J Bone Miner Res. 2018 PMID 29461659

15. Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC, Rauner M. Postnatal Skeletal deletion of Dickkopt-1 increases bone formation and bone volume in male and female mice despite increased sclerostin expression. J Bone Min Res 2018 PMID 29834465.

16. Morrell AE, Brown GN, Robinson ST, Sattler RL, Baik AD, Zhen G, Cao X, Bonewald LF, Jin W, Kam LC, Guo XE. Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation. Bone Res 2018 PMID 29581909.

17. Pin F, Barreto R, Kitase Y, Mitra S, Eme CD, Novinger LF, Zimmers TA, Couch MR, Bonewald LF, Bonetto A Growth of Ovarian Cancer Xenografts causes loss of Muscle and Bone Mass: A New Model for the Study of Cancer Cachexia J. Cachexia Sarcopenia Muscle 2018 PMIC 30009406

18. Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Richard O. Hynes, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, and Bruce M. Spiegelman. Irisin Mediates Effects on Bone and Fat via alphaV Integrin Receptors Cell 175: 1756-1768 2018 PMID 30550785

19. Tsourdi E, Jahn K, Rauner M, Busse B, Bonewald LF “Physiological and Pathological Osteocytic Osteolysis” J Musculoskelet Neuronal Interact 2018: 18:292-303.

20. Bonewald L, “Use it or lose it to age: A review of bone and muscle communication” Bone 2018 PMID 30408611.

21. DB Maurel, T Matsumoto, J Vallejo, ML Johnson, SL Dallas, Y. Kitase, M Brotto, MJ. Wacker, MA Harris, SE Harris, LF Bonewald. Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes Bone Research 2019 PMID 30820362

22. Wang K, Le L, Chun BM, Tiede-Lewis LM, Shiflett LA, Prideaxu M, Campos RS, Veno PA, Xie Y, Dusevich V., Bonewald LF, Dallas SL. A Novel Osteogenic Cell Line that Differentiates into GFP-Tagged Osteocytes and forms Mineral with a Bone-like Lacunocanalicular Structure J Bone Min Res 2019 PMID 30882939

23. Pin F, Bonetto A, Bonewald L, Klein GL, Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients Front Endocrinol 2019 PMID 31447786

24. Mo C, Wang Z, Bonewald L, Brotto M., Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways Int J Mol Scie 2019 PMIC 31487817

25. Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-kB activity. Sci Adv 2019 PMID: 31579816.

26. Huang J, Wang K, Shiflett LA, Brotto L, Bonewald LF, Wacker MJ, Dallas SL, Brotto M. Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells. Cell Cycle 2019 PMID: 3173519.

27. Pacicca DM, Brown T, Watkins D, Kover K, Yan Y, Prideaux M, Bonewald L Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes. Sci Rep 2019 PMID: 31757981.

Titles & Appointments

  • Director, Indiana Center for Musculoskeletal Health
  • Distinguished Professor
  • Professor of Anatomy, Cell Biology & Physiology
  • Professor of Orthopaedic Surgery

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