26803-Bonewald, Lynda

Lynda F. Bonewald, PhD

Director, Indiana Center for Musculoskeletal Health


Indianapolis, IN 46202


Indiana Center for Musculoskeletal Health

Dr. Bonewald is the Founding Director of the Indiana Center for Musculoskeletal Health, ICMH, a center with over 100 members from 36 departments and four campuses. Her primary faculty appointment is in the Department of Anatomy, Cell Biology & Physiology and her secondary is in the Department of Orthopaedic Surgery. She received her Ph.D. in Immunology/Microbiology from the Medical University of South Carolina, was promoted from Assistant to Full Professor at the Univ. of Texas Health Science Center at San Antonio and served as director of the Bone Biology Research Program and as Vice Chancellor for Research at the University of Missouri-Kansas City. She is a Past-President of the American Society for Bone and Mineral Research, ASBMR, and of the Association of Biomolecular Resource Facilities. She has served as Chair of the Board of Scientific Councilors for the NIDCR and served on Council for NIAMS NIH. She received the "Basic Research in Biological Mineralization Award" from the IADR, the "RIB Award" from Sun Valley, and the prestigious William F. Neuman award from the ASBMR. She has been continually funded by NIH for over thirty years and is best known for her work in the study of osteocytes and is responsible for tools used by researchers globally to determine osteocyte biology and function. She is currently studying bone to muscle crosstalk with aging.


Key Publications

  1. Montesi M, Jahn K, Bonewald L, Stea S, Bordini B, Beraudi A., Hypoxia mediates osteocyte ORP150 expression and cell death in vitro Mol Med Rep PMID: 27748851.
  2. Vemula H, Kitase Y, Ayon NJ, Bonewald L, Gutheil WG. Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers. Anal Biochem 516:75-85, 2017. PMID: 27771391.
  3. Medina Gomez, J.P. Kemp, N. L. Dimou, E. Kreiner-Møller, A. Chesi, B. S. Zemel, K. Bønnelykke, C. G. Boer, T.S. Ahluwalia, H. Bisggard, E. Evangelou, D. H. M. Heppe, L. F. Bonewald, J. P. Gorski, M. Ghanbari, S. Demissie, D. G. Duque, M. T. Maurano, D.P. Kiel, B.C.J. van der Eerden, C. Ackert-Bicknell, S. Reppe, K. M. Gautvik, T. Raastad, D. Karasik, J. van de Peppel, V. W. V. Jaddoe, A. G. Uitterlinden, J. H. Tobias, S.F.A Grant, P.G. Bagos, D.M. Evans, F. Rivadeneira “Bivariate genome-wide association analysis implicates pleiotropic effects at the 1 SREBF1/TOM1L2 locus on bone mineral density and lean mass in children” Nature Communications: 2017. PMID: 2874360
  4. Yiwen Qin, Yuanzhen Peng, Wei Zhao, Jianping Pan, Christopher P Cardozo, Hanna Ksiezak-Reding, Yingjie Wu, Paola Divieti Pajevic, Lynda F. Bonewald, William A Bauman, Weiping Qin “Myostatin Inhibits Osteoblastic Differentiation by Suppressing Osteocyte-derived Exosomal microRNA-218: A Novel Mechanism in Muscle-Bone Communication”. Journal of Biological Chemistry: 2017. PMID: 28465350
  5. Katharina Jähn, Shilpa Kelkar, Hong Zhao, Yixia Xie, LeAnn M. Tiede-Lewis, Vladimir Dusevich, Sarah L. Dallas, Lynda F. Bonewald “Osteocytes Acidify their Microenvironment in response to PTHrP in vitro and in Lactating Mice in vivo”, Journal of Bone and Mineral Research: 2017. PMID: 28470757
  6. Jian Huang, Sandra Romero-Suarez, Nuria Lara, Chenglin Mo, Simon Kaja, Leticia Brotto, Sarah L. Dallas, Mark L. Johnson, Katharina Jähn, Lynda F. Bonewald, Marco Brotto. “Crosstalk between MLO-Y4 osteocytes and C2C12 muscle cells is mediated by the Wnt/β-catenin pathway”. JBMR plus 2017 PMID 29104955.
  7. Barreto R, Kitase Y, Matsumoto T, Pin F, Colston KC, Couch KE, O'Connell TM, Couch ME, BonewaldLF, Bonetto A. “ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass”. Sci Rep 2017 PMID 29089584.
  8. Tiede-Lewis LM, Xie Y, Hulbert MA, Campos R, Dallas MR, Dusevich V, Bonewald LF, Dallas SL “Degeneration of the osteocyte network in the C57BL/6 mouse model of aging”. Aging 2017 PMID 29074822.
  9. Andrea Morrell, Genevieve Brown, Samuel Robinson, Rachel Sattler, Andrew Baik, Gehua Zhen, Xu Cao, Lynda Bonewald, Weiyang Jin, and Lance Kam “Mechanically-induced Ca2+ Oscillations in Osteocytes Release Extracellular Vesicles and Enhance Bone Formation”. Bone Research 2018 Mar 19 PMID 29581909.
  10. Kitase Y, Vallejo JA, Gutheil W, Vemula H, Jähn K, Yi J, Zhou J, Brotto M, Bonewald β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. Cell Rep. 2018 Feb 6;22(6):1531-1544. PMID: 29425508
  11. Yajima A, Tsuchiya K, Bonewald LF, Inaba M, Tominaga Y, Tanizawa T, Ito A, Nitta K. Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism. Osteoporos Int. 2018 PMID 29492624.
  12. Lu Y, Sayed SAK, Wang K, Tiede-Lewis LM, Grillo MA, Veno PA, Dusevich V, Phillips CL, Bonewald LF, Dallas SL. Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-tagged Collagen Constructs. J Bone Miner Res. 2018 PMID 29461659
  13. Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC, Rauner M. Postnatal Skeletal deletion of Dickkopt-1 increases bone formation and bone volume in male and female mice despite increased sclerostin expression. J Bone Min Res 2018 PMID 29834465.
  14. Morrell AE, Brown GN, Robinson ST, Sattler RL, Baik AD, Zhen G, Cao X, Bonewald LF, Jin W, Kam LC, Guo XE. Mechanically induced Ca2+ oscillations in osteocytes release extracellular vesicles and enhance bone formation. Bone Res 2018 PMID 29581909.
  15. Pin F, Barreto R, Kitase Y, Mitra S, Eme CD, Novinger LF, Zimmers TA, Couch MR, Bonewald LF, Bonetto A Growth of Ovarian Cancer Xenografts causes loss of Muscle and Bone Mass: A New Model for the Study of Cancer Cachexia Cachexia Sarcopenia Muscle 2018 PMIC 30009406
  16. Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Richard O. Hynes, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, and Bruce M. Spiegelman. Irisin Mediates Effects on Bone and Fat via alphaV Integrin Receptors Cell 175: 1756-1768 2018 PMID 30550785
  17. DB Maurel, T Matsumoto, J Vallejo, ML Johnson, SL Dallas, Y. Kitase, M Brotto, MJ. Wacker, MA Harris, SE Harris, LF Bonewald. Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes Bone Research 2019 PMID 30820362
  18. Wang K, Le L, Chun BM, Tiede-Lewis LM, Shiflett LA, Prideaxu M, Campos RS, Veno PA, Xie Y, Dusevich V., Bonewald LF, Dallas SL. A Novel Osteogenic Cell Line that Differentiates into GFP-Tagged Osteocytes and forms Mineral with a Bone-like Lacunocanalicular Structure J Bone Min Res 2019 PMID 30882939
  19. Pin F, Bonetto A, Bonewald L, Klein GL, Molecular Mechanisms Responsible for the Rescue Effects of Pamidronate on Muscle Atrophy in Pediatric Burn Patients Front Endocrinol 2019 PMID 31447786
  20. Mo C, Wang Z, Bonewald L, Brotto M., Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways Int J Mol Scie 2019 PMIC 31487817
  21. Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-kB activity. Sci Adv 2019 PMID: 31579816.
  22. Huang J, Wang K, Shiflett LA, Brotto L, Bonewald LF, Wacker MJ, Dallas SL, Brotto M. Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells. Cell Cycle 2019 PMID: 3173519.
  23. Pacicca DM, Brown T, Watkins D, Kover K, Yan Y, Prideaux M, Bonewald L Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes. Sci Rep 2019 PMID: 31757981.
  24. Sego TJ, Prideaux M, Sterner J, McCarthy BP, Li P, Bonewald LF, Ekser B, Tovar A, Smith JL. Computational fluid Dynamic Analysis of Bioprinted Self-Supporting Perfused (SSuPer) Tissue Models. Biotechnol Bioeng. 2019 PMID 31788785.
  25. Essex AL, Pin F, Huot JR, Bonewald LF, Plotkin LI, Bonetto A. Bishosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice. Front Endocrinol (Lausanne) 2019 PMID 31803146.
  26. Mo C, Wang Z, Bonewald L, Brotto M. Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways. Int J Mol Sci, 2019 PMID 31579816.
  27. Wang Z, Bian L, Mo C, Shen H, Zhao LF, Su KJ, Kukula M, Lee JT, Armstrong DW, Recker R, Lappe J, Bonewald LF, Deng HW, Brotto M Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis. Commun Bio 2020 PMID 31969651.
  28. Wang H, Li T, Wang X, Yin X, Zhao N, Zou S, Duan P, Bonewald LF. The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction. Biochem BIophys Res Commun 2020 PMID 31941604.
  29. Prideaux M, Kitase Y, Kimble M, O’Connell TM, Bonewald LF Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/b-catenin signaling pathway Bone 2020 PMIC 32330695.
  30. Ito N, Prideaux M, Wijenayaka AB, Yang D, Ormsby RT, Bonewald LF, Atkins GJ Sclerostin directly stimulates osteocyte synthesis of Fibroblast Growth Factor 23 Cal Tiss Int. 2021 PMID33616712.
  31. Pin F, Prideaux M, Huot JR, Essex AL, Plotkin LI, Bonetto A, Bonewald LF Non-bone metastatic cancers promote osteocyte-induced bone destruction Cancer Lett 2021 PMIC 32233150. DOI:10.1016/j.canlet.2021.06.030
  32. Nakamura MT, Zhang H, Guo D, Ueharu H, Pan H, Scott G, Harris M, Ray M, Feng JQ, Harris SE, Bonewald LF, Mishina Y Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background. genesis The Journal of Genetics and Development. 2021, https://doi.org/10.1002/dvg.23450

Titles & Appointments

  • Director, Indiana Center for Musculoskeletal Health
  • Distinguished Professor
  • Professor of Anatomy, Cell Biology & Physiology
  • Professor of Orthopaedic Surgery

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