Ryan White Center for Infectious Disease and Global Health

The Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine is improving the health of children in Indiana and worldwide through the reduction and prevention of infection. With a research focus on malaria and HIV, infections that represent the leading causes of death and disability in children worldwide, faculty physicians at this center are recognized nationally for their work in global health.

Physicians in the Center provide specialized care in pediatric travel medicine, HIV, infection in the immunocompromised host, infection prevention and antimicrobial stewardship at Riley Hospital for Children at IU Health. These clinical programs ensure that the thousands of children seen at Riley Hospital for Children receive the best infectious disease care and prevention available.

Areas of Expertise


Malaria research at the Ryan White Center for Pediatric Infectious Disease and Global Health focuses on why children develop severe malaria and the neurodevelopment consequences of severe malaria. Investigators are exploring the risks of malaria in children with sickle cell disease and the effects of changing transmission on malaria immunity. Malaria researchers in the Center include Chandy John, MD; Andrea Conroy, PhD; Dibyadyuti Datta, PhD; and Tuan Tran, MD, PhD.


HIV research at the Center (conducted by Rachel Vreeman, MDLeslie Enane, MD, and colleagues) focuses on adherence to HIV medications, stigma in HIV, disclosure of HIV status to children, evaluation and treatment of HIV in adolescents, and neurodevelopmental impairment in infants exposed to HIV.

Clinical Care

The Ryan White Center for Pediatric Infectious Disease and Global Health is the primary clinical referral center for children with pediatric infectious diseases in the state of Indiana as well as other states and countries. As a major referral facility, the center provides the evaluation and care of children with complex infectious diseases. Physicians in this center see more than 600 inpatients each year at Riley Hospital for Children at IU Health and provide more than 1800 follow-up visits. In addition, physicians see more than 1000 outpatients a year at the Riley Outpatient Center.

Chandy John, MD, Lab

Chandy John, MD, Lab

The John Lab focuses on malaria pathogenesis, immunology and epidemiology; the relationships between infection, nutrition and neurodevelopment; and infections in children with sickle cell anemia.
Rachel Vreeman, MD

Rachel Vreeman, MD

Dr. Vreeman's research program focuses on chronic disease management for HIV-infected children in resource-limited settings, with a focus on adherence to antiretroviral therapy (ART).