12491-Schmidt, Nathan

Nathan W. Schmidt, PhD

Associate Professor of Pediatrics

Adjunct Associate Professor of Microbiology & Immunology

(317) 278-5701
Department of Pediatrics Division of Infectious Diseases
1044 W Walnut Street, R4-470
Indianapolis, IN 46202


Nathan Schmidt, PhD, received a BS in Biology from Olivet Nazarene University in 2001 and a PhD in Microbiology and Immunology from Indiana University in 2005.  He did postdoctoral work at the University of Iowa. Dr. Schmidt joined the faculty in the University of Tennessee in 2011 and then the faculty in the University of Louisville in 2014. In 2019, Dr. Schmidt was recruited to the faculty in Indiana University School of Medicine as an Associate Professor in the Department of Pediatrics and a member of Ryan White Center for Pediatric Infectious Diseases and Global Health.  


Dr. Schmidt’s research is focused on malaria, which is a parasitic disease caused by infection with Plasmodium species. Dr. Schmidt is interested in defining the factors that impact the pathogenesis of this disease and identifying novel approaches to prevent children from dying from malaria. One of the observations made by Dr. Schmidt’s research program was that the composition of bacteria residing within the intestinal tract can profoundly impact the severity of malaria. The influence of gut microbiota on malaria remains a central focus of his research interests.

Key Publications

White CE, Villarino NF, Sloan SS, Ganusov VV, and Schmidt NW.  Plasmodium suppresses expansion of T cell responses to heterologous infections.  The Journal of Immunology, 2015, 194:697-708.

Villarino NF, LeCleir GR, Denny JE, Dearth SP, Harding CL, Sloan SS, Gribble JL, Campagna SR, Wilhelm SW and Schmidt NW.  Composition of the gut microbiota modulates the severity of malaria.  Proceedings of the National Academy of Sciences, 2016, 113:2235-2240.

Ippolito MM, Denny JE, Langelier C, Sears CL, and Schmidt NW. Malaria and the microbiome: a systematic review. Clinical Infectious Diseases, 2018, 67:1831.

Denny JE, Powers JB, Castro HF, Zhang J, Joshi-Barve S, Campagna SR, and Schmidt NW. Severity of Plasmodium infection in mice differentially affects gut-liver axis homeostasis. Scientific Reports, 2019, 9:3472.

Mandal RK, Crane RJ, Berkley JA, Gumbi W, Wambua J, Ngoi JM, Ndungu FM, and Schmidt NW. Longitudinal analysis of infant stool bacteria communities before and after acute febrile malaria and artemether/lumefantrine treatment. The Journal of Infectious Diseases, 2018, doi: 10.1093/infdis/jiy740.

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