5188-Tran, Tuan

Tuan M. Tran, MD, PhD

Associate Professor of Medicine

Van Nuys Medical Science Building
635 Barnhill Dr. Suite 224D

Indianapolis, IN 46202
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Dr. Tran is a physician-scientist who began studying malaria as a graduate student in the laboratory of Dr. Mary Galinski at Emory University. After completing his Internal Medicine residency at the Johns Hopkins Hospital and a clinical fellowship in Infectious Diseases at the National Institute of Allergy and Infectious Diseases (NIAID), he trained as a post-doctoral fellow with Dr. Peter Crompton in the Laboratory of Immunogenetics at NIAID, where he studied naturally acquired immunity to falciparum malaria in a prospective cohort study conducted in Mali. He is currently an Assistant Professor of Medicine in the Division of Infectious Diseases within the Department of Medicine at the Indiana University School of Medicine, where he studies both naturally acquired and vaccine-induced immunity to malaria using systems biology approaches. More specifically, Dr. Tran’s lab interrogates the immune system by applying multi-omic technologies to samples obtained from well-defined cohort studies of malaria-exposed individuals. By performing integrative analyses of high dimensional data generated from these multi-omic platforms, his research group aims to elucidate the mechanisms of protective immunity to malaria. Dr. Tran also attends on the Infectious Diseases consult service at the Indianapolis VA Medical Center and holds secondary appointments in the Section of Infectious Diseases & Global Health in the Department of Pediatrics and in the Department of Microbiology and Immunology.

Key Publications

Bhardwaj J, Upadhye A, Gaskin EL, Doumbo S, Kayentao K, Ongoiba A, Traore B, Crompton PD, Tran TM. Neither the African-centric S47 nor P72 variant of TP53 is associated with reduced risk of febrile malaria in a Malian cohort study. J Infect Dis. 2023. Epub 20230324. doi: 10.1093/infdis/jiad066. PubMed PMID: 36961831.

Tashi T, Upadhye A, Kundu P, Wu C, Menant S, Soares RR, Ferreira MU, Longley RJ, Mueller I, Hoang QQ, Tham WH, Rayner JC, Scopel KK, Lima-Junior JC, Tran TM. Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon. PLoS Negl Trop Dis. 2022; 16(11):e0010773. Epub 2022/11/24. doi: 10.1371/journal.pntd.0010773. PubMed PMID: 36417454.

Salgado C, Ayodo G, Macklin MD, Gould MP, Nallandhighal S, Odhiambo EO, Obala A, O'Meara WP, John CC, Tran TM. The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya. Malar J. 2021;20(1):371. Epub 2021/09/19. doi: 10.1186/s12936-021-03905-w. PubMed PMID: 34535134.

Andrade CM, Fleckenstein H, Thomson-Luque R, Doumbo S, Lima NF, Anderson C, Hibbert J, Hopp CS, Tran TM, Li S, Niangaly M, Cisse H, Doumtabe D, Skinner J, Sturdevant D, Ricklefs S, Virtaneva K, Asghar M, Homann MV, Turner L, Martins J, Allman EL, N'Dri ME, Winkler V, Llinas M, Lavazec C, Martens C, Farnert A, Kayentao K, Ongoiba A, Lavstsen T, Osorio NS, Otto TD, Recker M, Traore B, Crompton PD, Portugal S. Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nat Med. 2020. Epub 2020/10/28. doi: 10.1038/s41591-020-1084-0. PubMed PMID: 33106664

Obeng-Adjei N, Larremore DB, Turner L, Ongoiba A, Li S, Doumbo S, Yazew TB, Kayentao K, Miller LH, Traore B, Pierce SK, Buckee CO, Lavstsen T, Crompton PD, Tran TM. Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection. JCI Insight. 2020;5(12). Epub 2020/05/20. doi: 10.1172/jci.insight.137262. PubMed PMID: 32427581; PMCID: PMC7406271.

Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, O'Connell EM, Doumbo OK, Kaushansky A, Alter G, Felgner PL, Lorenzi H, Kayentao K, Traore B, Kirkness EF, Crompton PD. A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity. 2019;51(4):750-65 e10. Epub 2019/09/08. doi: 10.1016/j.immuni.2019.08.009. PubMed PMID: 31492649.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO. Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria. J Exp Med. 2019;216(6):1280-90. Epub 2019/04/14. doi: 10.1084/jem.20181681. PubMed PMID: 30979790; PMCID: PMC6547858.

Tran TM, Bijker EM, Haks MC, Ottenhoff THM, Visser L, Schats R, Venepally P, Lorenzi H, Crompton PD, Sauerwein RW. Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites. Sci Rep. 2019;9(1):8386. Epub 2019/06/12. doi: 10.1038/s41598-019-44924-7. PubMed PMID: 31182757; PMCID: PMC6557840.

Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM. Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia. J Infect Dis. 2019;219(1):154-64. Epub 2018/07/31. doi: 10.1093/infdis/jiy468. PubMed PMID: 30060095; PMCID: PMC6284545.


Titles & Appointments

  • Associate Professor of Medicine
  • Associate Professor of Microbiology & Immunology
  • Associate Professor of Pediatrics

Research Labs

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Faculty Labs