5188-Tran, Tuan
Faculty

Tuan M. Tran, MD, PhD

Assistant Professor of Medicine

Address
Van Nuys Medical Science Building
635 Barnhill Dr. Suite 224D

Indianapolis, IN 46202

Bio

Dr. Tran is a physician-scientist who began studying malaria as a graduate student in the laboratory of Dr. Mary Galinski at Emory University. After completing his Internal Medicine residency at the Johns Hopkins Hospital and a clinical fellowship in Infectious Diseases at the National Institute of Allergy and Infectious Diseases (NIAID), he trained as a post-doctoral fellow with Dr. Peter Crompton in the Laboratory of Immunogenetics at NIAID, where he studied naturally acquired immunity to falciparum malaria in a prospective cohort study conducted in Mali. He is currently an Assistant Professor of Medicine in the Division of Infectious Diseases within the Department of Medicine at the Indiana University School of Medicine, where he studies both naturally acquired and vaccine-induced immunity to malaria using systems biology approaches. More specifically, Dr. Tran’s lab interrogates the immune system by applying multi-omic technologies to samples obtained from well-defined cohort studies of malaria-exposed individuals. By performing integrative analyses of high dimensional data generated from these multi-omic platforms, his research group aims to elucidate the mechanisms of protective immunity to malaria. Dr. Tran also attends on the Infectious Diseases consult service at the Indianapolis VA Medical Center and holds secondary appointments in the Section of Infectious Diseases & Global Health in the Department of Pediatrics and in the Department of Microbiology and Immunology.

Key Publications

Tran TM, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, Jones M, Moebius J, Venepally P, Doumbo S, DeRiso EA, Li S, Vijayan K, Anzick SL, Hart GT, O'Connell EM, Doumbo OK, Kaushansky A, Alter G, Felgner PL, Lorenzi H, Kayentao K, Traore B, Kirkness EF, Crompton PD. A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity. 2019;51(4):750-65 e10. Epub 2019/09/08. doi: 10.1016/j.immuni.2019.08.009. PubMed PMID: 31492649.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO. Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria. J Exp Med. 2019;216(6):1280-90. Epub 2019/04/14. doi: 10.1084/jem.20181681. PubMed PMID: 30979790; PMCID: PMC6547858.

Tran TM, Bijker EM, Haks MC, Ottenhoff THM, Visser L, Schats R, Venepally P, Lorenzi H, Crompton PD, Sauerwein RW. Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites. Sci Rep. 2019;9(1):8386. Epub 2019/06/12. doi: 10.1038/s41598-019-44924-7. PubMed PMID: 31182757; PMCID: PMC6557840.

Nallandhighal S, Park GS, Ho YY, Opoka RO, John CC, Tran TM. Whole-Blood Transcriptional Signatures Composed of Erythropoietic and NRF2-Regulated Genes Differ Between Cerebral Malaria and Severe Malarial Anemia. J Infect Dis. 2019;219(1):154-64. Epub 2018/07/31. doi: 10.1093/infdis/jiy468. PubMed PMID: 30060095; PMCID: PMC6284545.

Portugal S, Tran TM, Ongoiba A, Bathily A, Li S, Doumbo S, Skinner J, Doumtabe D, Kone Y, Sangala J, Jain A, Davies DH, Hung C, Liang L, Ricklefs S, Homann MV, Felgner PL, Porcella SF, Farnert A, Doumbo OK, Kayentao K, Greenwood BM, Traore B, Crompton PD. Treatment of Chronic Asymptomatic Plasmodium falciparum Infection Does Not Increase the Risk of Clinical Malaria Upon Reinfection. Clin Infect Dis. 2017;64(5):645-53. doi: 10.1093/cid/ciw849. PubMed PMID: 28362910.

Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A. Public antibodies to malaria antigens generated by two LAIR1 insertion modalities. Nature. 2017;548(7669):597-601. doi: 10.1038/nature23670. PubMed PMID: 28847005; PMCID: PMC5635981.

Bustamante LY, Powell GT, Lin YC, Macklin MD, Cross N, Kemp A, Cawkill P, Sanderson T, Crosnier C, Muller-Sienerth N, Doumbo OK, Traore B, Crompton PD, Cicuta P, Tran TM, Wright GJ, Rayner JC. Synergistic malaria vaccine combinations identified by systematic antigen screening. Proc Natl Acad Sci U S A. 2017. doi: 10.1073/pnas.1702944114. PubMed PMID: 29078270.

Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD. Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria. Sci Rep. 2016;6:31291. doi: 10.1038/srep31291. PubMed PMID: 27506615; PMCID: PMC4978957.

Titles & Appointments

  • Assistant Professor of Medicine
  • Assistant Professor of Microbiology & Immunology
  • Assistant Professor of Pediatrics

Research Labs

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Faculty Labs