23230-Datta, Dibyadyuti
Faculty

Dibyadyuti Datta, PhD

Assistant Research Professor of Pediatrics

Address
1044 W. Walnut Street
R4 451C

Indianapolis, IN 46202

Bio

Dr. Datta’s research interests and experience have been geared towards a better understanding of parasites biology at a molecular and biochemical level, with a specific focus on developing tools to fight the infection within communities. As a research technician in Dr. Nirbhay Kumar’s malaria vaccine research lab at Johns Hopkins University, she trained in specialized malaria lab techniques such as in-vitro parasite culture, mosquito rearing as well as conducting infection assays. As a PhD student in parasitology, her dissertation was focused on enhancing the immunogenicity of malaria transmission blocking DNA vaccines. Her graduate school training included murine and non-human primate immunization studies.

Dr. Datta joined Dr. Chandy John’s translational research lab at IUSM Department of Pediatrics as a postdoctoral fellow and lab manager and was responsible for establishing the laboratory component at IU, which included training and supervising students and scholars in the lab. As an Assistant Research Professor working with Dr. John, her focus is on assessment of how specific immunologic and parasitic factors influence risk of developing malaria, including severe malaria.

Key Publications

Full List [hyperlink to: https://www.ncbi.nlm.nih.gov/pubmed/?term=Dibyadyuti+Datta]

1. Datta D, Bansal GP, Gerloff DL, Ellefsen B, Hannaman D, Kumar N. Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation. Vaccine. 2017 Jan 5;35(2):264-272. doi: 10.1016/j.vaccine.2016.11.072. PubMed PMID: 27912985; PubMed Central PMCID: PMC5192010.

2. Kumar R, Ray PC, Datta D, Bansal GP, Angov E, Kumar N. Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25 attached gold nanoparticles. Vaccine. 2015 Sep 22;33(39):5064-71. doi: 10.1016/j.vaccine.2015.08.025. PubMed PMID: 26299750; PubMed Central PMCID: PMC4577455.

3. Datta D, Bansal GP, Kumar R, Ellefsen B, Hannaman D, Kumar N. Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice. Clin Vaccine Immunol. 2015 Sep;22(9):1013-9. doi: 10.1128/CVI.00185-15. PubMed PMID: 26135972; PubMed Central PMCID: PMC4550670.

4. Kumar R, Ledet G, Graves R, Datta D, Robinson S, Bansal GP, Mandal T, Kumar N. Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles. Pharm Res. 2015 Dec;32(12):3827-36. doi: 10.1007/s11095-015-1743-x. PubMed PMID: 26113235; PubMed Central PMCID: PMC4628851.

 

Titles & Appointments

  • Assistant Research Professor of Pediatrics
  • Education
    2015 PhD Tulane University
    2009 MS Georgetown University
    2008 BTECH D.Y. Patil University
  • Research

    Parasitology. Malaria immunology, biochemistry, and molecular biology.

  • Professional Organizations
    American Society of Tropical Medicine and Hygiene

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