23230-Datta, Dibyadyuti

Dibyadyuti Datta, PhD

Assistant Professor of Pediatrics

Adjunct Assistant Professor of Microbiology & Immunology

Phone
(317) 274-4103
Address
1044 W. Walnut Street
R4 402D
Indianapolis, IN 46202
PubMed:

Bio

I am interested in establishing reliable, non-invasive prognostic biomarkers of acute brain injury in order to prevent long-term neurodisability in children in low- and middle-income countries because of what I see as a critical gap in research priorities in these settings. I hope that my work will lead to increased neuropsychological referrals for early cognitive screening of childhood survivors of acute brain injury, and the development of therapeutic interventions to prevent or reduce problems that can persist into adulthood and impact the health-related quality of life of children.

I have supervised clinical research labs focused on immuno-epidemiology, pathogenesis and long-term outcomes in pediatric severe malaria in the United States, Kenya, and Uganda, and managed clinical trials of hydroxyurea therapy and zinc for infection prevention in sickle cell anemia in Uganda.

Since the beginning of the COVID-19 pandemic, I have volunteered my experience in global infectious diseases and clinical research management to understand the transmission potential of and immune-protective correlates against SARS-CoV-2 infections, locally in Indianapolis.

Key Publications

For a full list of Dr. Datta's publications, view her PubMed page.

Elevated Cerebrospinal Fluid Tau Protein Concentrations on Admission Are Associated With Long-term Neurologic and Cognitive Impairment in Ugandan Children With Cerebral Malaria.  Datta D, Conroy AL, Castelluccio PF, Ssenkusu JM, Park GS, Opoka RO, Bangirana P, Idro R, Saykin AJ, John CC. Clin Infect Dis. 2020 Mar 3;70(6):1161-1168.

What causes severe malaria and its complications in children? Lessons learned over the past 15 years. Conroy AL, Datta D, John CC. BMC medicine. 2019; 17(1):52.

Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo-controlled trial in Ugandan children with sickle cell anemia. Datta D, Namazzi R, Conroy AL, Cusick SE, Hume HA, Tagoola A, Ware RE, Opoka RO, John CC. Trials. 2019; 20(1):460.

HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya. Odhiambo EO, Datta D, Guyah B, Ayodo G, Ondigo BN, Abong'o BO, John CC, Frosch AEPMalar J. 2019 Aug 30;18(1):297. 

Prevalence of Asymptomatic SARS-CoV-2 Infection in Children and Adults in Marion County, Indiana. Wood J, Datta D, Hudson BL, Co K, Tepner S, Hardwick E, John CC.  Cureus. 2020 Aug 16;12(8):e9794. 

Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques. Datta D, Bansal GP, Grasperge B, Martin DS, Philipp M, Gerloff D, Ellefsen B, Hannaman D, Kumar N. Vaccine. 2017 Nov 10.

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