Faculty Research Labs

Kim Lab

The research laboratory led by Jungsu Kim, PhD, is interested in understanding the molecular and cellular basis of neuronal and glial dysfunction in Alzheimer’s disease, other aging-associated neurodegenerative diseases, and normal brain aging.

Research in Kim lab is aimed at developing therapeutic strategies for Alzheimer’s disease by targeting brain lipid-regulating proteins, such as apolipoprotein E (ApoE), low density lipoprotein receptor (LDLR), and ATP-binding cassette transporter A1 (ABCA1). The Kim lab is also interested in the role of epigenetics and non-coding RNAs in the pathogenesis of Alzheimer’s disease and other aging-associated neurodegenerative diseases. Emerging transcriptomics technologies recently revealed that many non-coding regions actually encode functional RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Using cell culture, animal models, and systems biology approaches, the Kim lab investigates non-coding RNAs that may play critical roles in neurodegenerative diseases, brain aging, and cardiovascular diseases.

Active Research

Research interests are centered on understanding the critical role of ApoE-associated proteins, microRNAs and long non-coding RNAs, leading aging-associated neurodegenerative disease. The lab has been interested in the function of microglia-mediated immune responses to Alzheimer’s disease progression. The research goal is to develop therapeutic targets to delay progression of Alzheimer’s disease by targeting brain lipid-regulating proteins such as apolipoprotein E, low density lipoprotein receptor, and ATP-binding cassette transporter A1. The approaches used in the Kim lab include human and mouse genetics for candidate gene discovery, cell biology and animal modeling for functional study, small-scale drug screening, and long-term in vivo drug efficacy testing.

PI: Jungsu Kim

Agency: NIH

Period: 9/1/2016 – 5/31/2021

The goals of this project are to determine the role of aging-associated microRNA cluster in brain insulin signaling during aging and memory loss using animal models.

PI: Jungsu Kim

Agency: NIH

Period: 9/1/2016 – 4/30/2021

The goals of this project are to study how miR-33 regulates neuroinflammation, ABCA1, and lipid metabolism and to determine the therapeutic effect of anti-miR-33 ASO using animal models.

PI: Jungsu Kim

Agency: NIH

Period: 9/15/2016 – 4/30/2021

PI: Jungsu Kim

Agency: NIH

Period: 9/1/2016 – 5/31/2019

The goal of this project is to study how microRNA-758-3p affects synaptic spine density and cognition by regulating CREB, ABCA1, ApoE lipidation and its implication to Alzheimer’s disease.

PI: Andrew Yoo (Washington University)

Agency: NIH

Period: 9/15/2017 – 6/30/2022

The major goal of this project is to use our established miRNA-TF- based conversion protocol to generate human cortical neurons, a neuronal type largely affected in AD, from fibroblast donors across the age spectrum, and obtain cortical neurons that represent donors’ ages as a cellular model of aging.

Recent Publications

Yoon H, Belmonte KC, Kasten T, Bateman R, Kim J. (2017) Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery. Sci Rep. 7(1):12720. [PMID: 28983117]

Liao F, Yoon H, Kim J. (2017) Apolipoprotein E metabolism and functions in brain and its role in Alzheimer’s disease. Curr Opin Lipidol. 28(1):60-67. [PMID: 27922847]

Kim J, Yoon H, Chung DE, Brown JL, Belmonte KC, Kim J. (2016) miR-186 is decreased in aged brain and suppresses BACE1 expression. J Neurochem. 137(3):436-45. [PMID: 26710318]

Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P. (2015) The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis. Sci Transl Med. 7(314):314ra184. [PMID: 26582899]

Kim J, Yoon H, Horie T, Burchett JM, Restivo JL, Rotllan N, Ramírez CM, Verghese PB, Ihara M, Hoe HS, Esau C, Fernández-Hernando C, Holtzman DM, Cirrito JR, Ono K, Kim J. (2015) microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain. J Neurosci. 35(44):14717-26. [PMID: 26538644]

http://www.ncbi.nlm.nih.gov/sites/myncbi/jungsu.kim.1/bibliography/47851846/public/?sort=date&direction=ascending

Research Team

Jungsu Kim, PhD

Jungsu Kim, PhD

P. Michael Conneally Professor of Medical and Molecular Genetics
Younghye Moon, PhD

Younghye Moon, PhD

Assistant Research Professor of Medical & Molecular Genetics

Additional Research Team Members

Byungwook Kim (Postdoctoral Fellow), Karahan Hande (Postdoctoral Fellow), and Stephanie Philtjens (Postdoctoral Fellow).