The Hashino Lab leverages expertise in CRISPR/Cas9 genome-editing technology to generate inner ear/brain organoids harboring disease-associated mutations and also various reporter stem cell lines for prompt identification of specific cell types. Dr. Hashino and colleague Rick Nelson, MD, PhD [link to PAGE], are modeling diseases of the ear in several ways including through CHARGE syndrome and Tmprss3-mediated hair cell degeneration.
Leading investigators within the group discovered a three-dimensional (3D) culture method for deriving mini inner ear organs, called inner ear organoids, which contain the sensory cells to the inner ear and function similarly to native inner ear organs.
The Hashino Lab is comprised of post-doctoral researchers, research associates, graduate and undergraduate students. The 2,200-square-foot laboratory is located at Walther Hall on the IU School of Medicine—Indianapolis campus.