Newly Published Research


Canela, V. H., C. Dzien, S. B. Bledsoe, M. S. Borofsky, R. S. Boris, J. E. Lingeman, T. M. El-Achkar, and J. C. Williams, Jr. "Human Jackstone Arms Show a Protein-Rich, X-Ray Lucent Core, Suggesting That Proteins Drive Their Rapid and Linear Growth." [In eng]. Urolithiasis 50, no. 1 (Feb 2022): 21-28.

Eadon, M. T., P. C. Dagher, and T. M. El-Achkar. "Cellular and Molecular Interrogation of Kidney Biopsy Specimens." [In eng]. Curr Opin Nephrol Hypertens 31, no. 2 (Mar 1 2022): 160-67.

Micanovic, R., K. A. LaFavers, K. R. Patidar, M. S. Ghabril, E. H. Doud, A. L. Mosley, A. R. Sabo, S. Khan, and T. M. El-Achkar. "The Kidney Releases a Non-Polymerizing Form of Uromodulin in the Urine and Circulation That Retains the External Hydrophobic Patch Domain." [In eng]. Am J Physiol Renal Physiol  (Jan 31 2022).


Ahmed, I. A., M. A. Jaffa, M. Moussa, D. Hatem, G. A. El-Achkar, R. Al Sayegh, M. Karam, et al. "Plasma Kallikrein as a Modulator of Liver Injury/Remodeling." [In eng]. Front Pharmacol 12 (2021): 715111.

Avin, K. G., M. C. Hughes, N. X. Chen, S. Srinivasan, K. D. O'Neill, A. P. Evan, R. L. Bacallao, et al. "Skeletal Muscle Metabolic Responses to Physical Activity Are Muscle Type Specific in a Rat Model of Chronic Kidney Disease." [In eng]. Sci Rep 11, no. 1 (May 7 2021): 9788.

Barwinska, D., T. M. El-Achkar, R. Melo Ferreira, F. Syed, Y. H. Cheng, S. Winfree, M. J. Ferkowicz, et al. "Molecular Characterization of the Human Kidney Interstitium in Health and Disease." [In eng]. Sci Adv 7, no. 7 (Feb 2021).

Black, L. M., E. R. Farrell, D. Barwinska, G. Osis, A. A. Zmijewska, A. M. Traylor, S. K. Esman, et al. "Vegfr3 Tyrosine Kinase Inhibition Aggravates Cisplatin Nephrotoxicity." [In eng]. Am J Physiol Renal Physiol 321, no. 6 (Dec 1 2021): F675-f88.

Black, L. M., S. Winfree, S. D. Khochare, M. M. Kamocka, A. M. Traylor, S. K. Esman, S. Khan, et al. "Quantitative 3-Dimensional Imaging and Tissue Cytometry Reveals Lymphatic Expansion in Acute Kidney Injury." [In eng]. Lab Invest 101, no. 9 (Sep 2021): 1186-96.

Blazer-Yost, B. L., R. L. Bacallao, B. J. Erickson, M. L. LaPradd, M. E. Edwards, N. Sheth, K. Swinney, et al. "A Randomized Phase 1b Cross-over Study of the Safety of Low-Dose Pioglitazone for Treatment of Autosomal Dominant Polycystic Kidney Disease." [In eng]. Clin Kidney J 14, no. 7 (Jul 2021): 1738-46.

Canela, V. H., S. B. Bledsoe, J. E. Lingeman, G. Gerber, E. M. Worcester, T. M. El-Achkar, and J. C. Williams, Jr. "Demineralization and Sectioning of Human Kidney Stones: A Molecular Investigation Revealing the Spatial Heterogeneity of the Stone Matrix." [In eng]. Physiol Rep 9, no. 1 (Jan 2021): e14658.

Canela, V. H., S. B. Bledsoe, E. M. Worcester, J. E. Lingeman, T. M. El-Achkar, and J. C. Williams, Jr. "Collagen Fibrils and Cell Nuclei Are Entrapped within Randall's Plaques but Not in Caox Matrix Overgrowth: A Microscopic Inquiry into Randall's Plaque Stone Pathogenesis." [In eng]. Anat Rec (Hoboken)  (Nov 25 2021).

de Boer, I. H., C. E. Alpers, E. U. Azeloglu, U. G. J. Balis, J. M. Barasch, L. Barisoni, K. N. Blank, et al. "Rationale and Design of the Kidney Precision Medicine Project." [In eng]. Kidney Int 99, no. 3 (Mar 2021): 498-510.

Dunn, K. W. "Digital Image Analysis Tools Developed by the Indiana O'brien Center." [In eng]. Front Physiol 12 (2021): 812170.

Dunn, K. W., B. A. Molitoris, and P. C. Dagher. "The Indiana O'brien Center for Advanced Renal Microscopic Analysis." [In eng]. Am J Physiol Renal Physiol 320, no. 5 (May 1 2021): F671-f82.

Eadon, M. T., S. Lampe, M. M. Baig, K. S. Collins, R. Melo Ferreira, H. Mang, Y. H. Cheng, et al. "Clinical, Histopathologic and Molecular Features of Idiopathic and Diabetic Nodular Mesangial Sclerosis in Humans." [In eng]. Nephrol Dial Transplant 37, no. 1 (Dec 31 2021): 72-84.

El-Achkar, T. M., M. T. Eadon, R. Menon, B. B. Lake, T. K. Sigdel, T. Alexandrov, S. Parikh, et al. "A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project." [In eng]. Physiol Genomics 53, no. 1 (Jan 1 2021): 1-11.

El Achkar, C. M., M. Harrer, L. Smith, M. Kelly, S. Iqbal, S. Maljevic, C. E. Niturad, et al. "Characterization of the Gabrb2-Associated Neurodevelopmental Disorders." [In eng]. Ann Neurol 89, no. 3 (Mar 2021): 573-86.

Ferkowicz, M. J., S. Winfree, A. R. Sabo, M. M. Kamocka, S. Khochare, D. Barwinska, M. T. Eadon, et al. "Large-Scale, Three-Dimensional Tissue Cytometry of the Human Kidney: A Complete and Accessible Pipeline." [In eng]. Lab Invest 101, no. 5 (May 2021): 661-76.

Gallier, S., G. Price, H. Pandya, G. McCarmack, C. James, B. Ruane, L. Forty, et al. "Infrastructure and Operating Processes of Pioneer, the Hdr-Uk Data Hub in Acute Care and the Workings of the Data Trust Committee: A Protocol Paper." [In eng]. BMJ Health Care Inform 28, no. 1 (Apr 2021).

Janosevic, D., J. Myslinski, T. W. McCarthy, A. Zollman, F. Syed, X. Xuei, H. Gao, et al. "The Orchestrated Cellular and Molecular Responses of the Kidney to Endotoxin Define a Precise Sepsis Timeline." [In eng]. Elife 10 (Jan 15 2021).

Mansour, S. G., C. Liu, Y. Jia, P. P. Reese, I. E. Hall, T. M. El-Achkar, K. A. LaFavers, et al. "Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated with Kidney Graft Outcomes." [In eng]. Transplantation 105, no. 4 (Apr 1 2021): 876-85.

Melo Ferreira, R., A. R. Sabo, S. Winfree, K. S. Collins, D. Janosevic, C. J. Gulbronson, Y. H. Cheng, et al. "Integration of Spatial and Single-Cell Transcriptomics Localizes Epithelial Cell-Immune Cross-Talk in Kidney Injury." [In eng]. JCI Insight 6, no. 12 (Jun 22 2021).

Ni, P., E. L. Clinkenbeard, M. L. Noonan, J. M. Richardville, J. McClintick, T. Hato, D. Janosevic, et al. "Targeting Fibroblast Growth Factor 23-Responsive Pathways Uncovers Controlling Genes in Kidney Mineral Metabolism." [In eng]. Kidney Int 99, no. 3 (Mar 2021): 598-608.

Schmidt, I. M., M. R. Colona, B. R. Kestenbaum, L. G. Alexopoulos, R. Palsson, A. Srivastava, J. Liu, et al. "Cadherin-11, Sparc-Related Modular Calcium Binding Protein-2, and Pigment Epithelium-Derived Factor Are Promising Non-Invasive Biomarkers of Kidney Fibrosis." [In eng]. Kidney Int 100, no. 3 (Sep 2021): 672-83.

Thielmann, M., D. Corteville, G. Szabo, M. Swaminathan, A. Lamy, L. J. Lehner, C. D. Brown, et al. "Teprasiran, a Small Interfering Rna, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study." [In eng]. Circulation 144, no. 14 (Oct 5 2021): 1133-44.

Williams, J. C., H. Al-Awadi, M. Muthenini, S. B. Bledsoe, T. El-Achkar, A. P. Evan, F. Coe, J. E. Lingeman, and E. M. Worcester. "Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis." [In eng]. J Endourol  (Dec 17 2021).

Winfree, S., C. Weiler, S. B. Bledsoe, T. Gardner, A. J. Sommer, A. P. Evan, J. E. Lingeman, et al. "Multimodal Imaging Reveals a Unique Autofluorescence Signature of Randall's Plaque." [In eng]. Urolithiasis 49, no. 2 (Apr 2021): 123-35.

Woloshuk, A., S. Khochare, A. F. Almulhim, A. T. McNutt, D. Dean, D. Barwinska, M. J. Ferkowicz, et al. "In Situ Classification of Cell Types in Human Kidney Tissue Using 3d Nuclear Staining." [In eng]. Cytometry A 99, no. 7 (Jul 2021): 707-21.

Yadav, S. P. S., R. M. Sandoval, J. Zhao, Y. Huang, E. Wang, S. Kumar, S. B. Campos-Bilderback, et al. "Mechanism of How Carbamylation Reduces Albumin Binding to Fcrn Contributing to Increased Vascular Clearance." [In eng]. Am J Physiol Renal Physiol 320, no. 1 (Jan 1 2021): F114-f29.

Yu, A., J. Zhao, S. P. S. Yadav, B. A. Molitoris, M. C. Wagner, and Y. Mechref. "Changes in the Expression of Renal Brush Border Membrane N-Glycome in Model Rats with Chronic Kidney Diseases." [In eng]. Biomolecules 11, no. 11 (Nov 11 2021).

Yu, A., J. Zhao, J. Zhong, J. Wang, S. P. S. Yadav, B. A. Molitoris, M. C. Wagner, and Y. Mechref. "Altered O-Glycomes of Renal Brush-Border Membrane in Model Rats with Chronic Kidney Diseases." [In eng]. Biomolecules 11, no. 11 (Oct 21 2021).