Newly Published Research

2022

Canela, V. H., C. Dzien, S. B. Bledsoe, M. S. Borofsky, R. S. Boris, J. E. Lingeman, T. M. El-Achkar, and J. C. Williams, Jr. "Human Jackstone Arms Show a Protein-Rich, X-Ray Lucent Core, Suggesting That Proteins Drive Their Rapid and Linear Growth." [In eng]. Urolithiasis 50, no. 1 (Feb 2022): 21-28. https://doi.org/10.1007/s00240-021-01275-1.

Eadon, M. T., P. C. Dagher, and T. M. El-Achkar. "Cellular and Molecular Interrogation of Kidney Biopsy Specimens." [In eng]. Curr Opin Nephrol Hypertens 31, no. 2 (Mar 1 2022): 160-67. https://doi.org/10.1097/mnh.0000000000000770.

Micanovic, R., K. A. LaFavers, K. R. Patidar, M. S. Ghabril, E. H. Doud, A. L. Mosley, A. R. Sabo, S. Khan, and T. M. El-Achkar. "The Kidney Releases a Non-Polymerizing Form of Uromodulin in the Urine and Circulation That Retains the External Hydrophobic Patch Domain." [In eng]. Am J Physiol Renal Physiol  (Jan 31 2022). https://doi.org/10.1152/ajprenal.00322.2021.

2021

Ahmed, I. A., M. A. Jaffa, M. Moussa, D. Hatem, G. A. El-Achkar, R. Al Sayegh, M. Karam, et al. "Plasma Kallikrein as a Modulator of Liver Injury/Remodeling." [In eng]. Front Pharmacol 12 (2021): 715111. https://doi.org/10.3389/fphar.2021.715111.

Avin, K. G., M. C. Hughes, N. X. Chen, S. Srinivasan, K. D. O'Neill, A. P. Evan, R. L. Bacallao, et al. "Skeletal Muscle Metabolic Responses to Physical Activity Are Muscle Type Specific in a Rat Model of Chronic Kidney Disease." [In eng]. Sci Rep 11, no. 1 (May 7 2021): 9788. https://doi.org/10.1038/s41598-021-89120-8.

Barwinska, D., T. M. El-Achkar, R. Melo Ferreira, F. Syed, Y. H. Cheng, S. Winfree, M. J. Ferkowicz, et al. "Molecular Characterization of the Human Kidney Interstitium in Health and Disease." [In eng]. Sci Adv 7, no. 7 (Feb 2021). https://doi.org/10.1126/sciadv.abd3359.

Black, L. M., E. R. Farrell, D. Barwinska, G. Osis, A. A. Zmijewska, A. M. Traylor, S. K. Esman, et al. "Vegfr3 Tyrosine Kinase Inhibition Aggravates Cisplatin Nephrotoxicity." [In eng]. Am J Physiol Renal Physiol 321, no. 6 (Dec 1 2021): F675-f88. https://doi.org/10.1152/ajprenal.00186.2021.

Black, L. M., S. Winfree, S. D. Khochare, M. M. Kamocka, A. M. Traylor, S. K. Esman, S. Khan, et al. "Quantitative 3-Dimensional Imaging and Tissue Cytometry Reveals Lymphatic Expansion in Acute Kidney Injury." [In eng]. Lab Invest 101, no. 9 (Sep 2021): 1186-96. https://doi.org/10.1038/s41374-021-00609-2.

Blazer-Yost, B. L., R. L. Bacallao, B. J. Erickson, M. L. LaPradd, M. E. Edwards, N. Sheth, K. Swinney, et al. "A Randomized Phase 1b Cross-over Study of the Safety of Low-Dose Pioglitazone for Treatment of Autosomal Dominant Polycystic Kidney Disease." [In eng]. Clin Kidney J 14, no. 7 (Jul 2021): 1738-46. https://doi.org/10.1093/ckj/sfaa232.

Canela, V. H., S. B. Bledsoe, J. E. Lingeman, G. Gerber, E. M. Worcester, T. M. El-Achkar, and J. C. Williams, Jr. "Demineralization and Sectioning of Human Kidney Stones: A Molecular Investigation Revealing the Spatial Heterogeneity of the Stone Matrix." [In eng]. Physiol Rep 9, no. 1 (Jan 2021): e14658. https://doi.org/10.14814/phy2.14658.

Canela, V. H., S. B. Bledsoe, E. M. Worcester, J. E. Lingeman, T. M. El-Achkar, and J. C. Williams, Jr. "Collagen Fibrils and Cell Nuclei Are Entrapped within Randall's Plaques but Not in Caox Matrix Overgrowth: A Microscopic Inquiry into Randall's Plaque Stone Pathogenesis." [In eng]. Anat Rec (Hoboken)  (Nov 25 2021). https://doi.org/10.1002/ar.24837.

de Boer, I. H., C. E. Alpers, E. U. Azeloglu, U. G. J. Balis, J. M. Barasch, L. Barisoni, K. N. Blank, et al. "Rationale and Design of the Kidney Precision Medicine Project." [In eng]. Kidney Int 99, no. 3 (Mar 2021): 498-510. https://doi.org/10.1016/j.kint.2020.08.039.

Dunn, K. W. "Digital Image Analysis Tools Developed by the Indiana O'brien Center." [In eng]. Front Physiol 12 (2021): 812170. https://doi.org/10.3389/fphys.2021.812170.

Dunn, K. W., B. A. Molitoris, and P. C. Dagher. "The Indiana O'brien Center for Advanced Renal Microscopic Analysis." [In eng]. Am J Physiol Renal Physiol 320, no. 5 (May 1 2021): F671-f82. https://doi.org/10.1152/ajprenal.00007.2021.

Eadon, M. T., S. Lampe, M. M. Baig, K. S. Collins, R. Melo Ferreira, H. Mang, Y. H. Cheng, et al. "Clinical, Histopathologic and Molecular Features of Idiopathic and Diabetic Nodular Mesangial Sclerosis in Humans." [In eng]. Nephrol Dial Transplant 37, no. 1 (Dec 31 2021): 72-84. https://doi.org/10.1093/ndt/gfaa331.

El-Achkar, T. M., M. T. Eadon, R. Menon, B. B. Lake, T. K. Sigdel, T. Alexandrov, S. Parikh, et al. "A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project." [In eng]. Physiol Genomics 53, no. 1 (Jan 1 2021): 1-11. https://doi.org/10.1152/physiolgenomics.00104.2020.

El Achkar, C. M., M. Harrer, L. Smith, M. Kelly, S. Iqbal, S. Maljevic, C. E. Niturad, et al. "Characterization of the Gabrb2-Associated Neurodevelopmental Disorders." [In eng]. Ann Neurol 89, no. 3 (Mar 2021): 573-86. https://doi.org/10.1002/ana.25985.

Ferkowicz, M. J., S. Winfree, A. R. Sabo, M. M. Kamocka, S. Khochare, D. Barwinska, M. T. Eadon, et al. "Large-Scale, Three-Dimensional Tissue Cytometry of the Human Kidney: A Complete and Accessible Pipeline." [In eng]. Lab Invest 101, no. 5 (May 2021): 661-76. https://doi.org/10.1038/s41374-020-00518-w.

Gallier, S., G. Price, H. Pandya, G. McCarmack, C. James, B. Ruane, L. Forty, et al. "Infrastructure and Operating Processes of Pioneer, the Hdr-Uk Data Hub in Acute Care and the Workings of the Data Trust Committee: A Protocol Paper." [In eng]. BMJ Health Care Inform 28, no. 1 (Apr 2021). https://doi.org/10.1136/bmjhci-2020-100294.

Janosevic, D., J. Myslinski, T. W. McCarthy, A. Zollman, F. Syed, X. Xuei, H. Gao, et al. "The Orchestrated Cellular and Molecular Responses of the Kidney to Endotoxin Define a Precise Sepsis Timeline." [In eng]. Elife 10 (Jan 15 2021). https://doi.org/10.7554/eLife.62270.

Mansour, S. G., C. Liu, Y. Jia, P. P. Reese, I. E. Hall, T. M. El-Achkar, K. A. LaFavers, et al. "Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated with Kidney Graft Outcomes." [In eng]. Transplantation 105, no. 4 (Apr 1 2021): 876-85. https://doi.org/10.1097/tp.0000000000003299.

Melo Ferreira, R., A. R. Sabo, S. Winfree, K. S. Collins, D. Janosevic, C. J. Gulbronson, Y. H. Cheng, et al. "Integration of Spatial and Single-Cell Transcriptomics Localizes Epithelial Cell-Immune Cross-Talk in Kidney Injury." [In eng]. JCI Insight 6, no. 12 (Jun 22 2021). https://doi.org/10.1172/jci.insight.147703.

Ni, P., E. L. Clinkenbeard, M. L. Noonan, J. M. Richardville, J. McClintick, T. Hato, D. Janosevic, et al. "Targeting Fibroblast Growth Factor 23-Responsive Pathways Uncovers Controlling Genes in Kidney Mineral Metabolism." [In eng]. Kidney Int 99, no. 3 (Mar 2021): 598-608. https://doi.org/10.1016/j.kint.2020.10.024.

Schmidt, I. M., M. R. Colona, B. R. Kestenbaum, L. G. Alexopoulos, R. Palsson, A. Srivastava, J. Liu, et al. "Cadherin-11, Sparc-Related Modular Calcium Binding Protein-2, and Pigment Epithelium-Derived Factor Are Promising Non-Invasive Biomarkers of Kidney Fibrosis." [In eng]. Kidney Int 100, no. 3 (Sep 2021): 672-83. https://doi.org/10.1016/j.kint.2021.04.037.

Thielmann, M., D. Corteville, G. Szabo, M. Swaminathan, A. Lamy, L. J. Lehner, C. D. Brown, et al. "Teprasiran, a Small Interfering Rna, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study." [In eng]. Circulation 144, no. 14 (Oct 5 2021): 1133-44. https://doi.org/10.1161/circulationaha.120.053029.

Williams, J. C., H. Al-Awadi, M. Muthenini, S. B. Bledsoe, T. El-Achkar, A. P. Evan, F. Coe, J. E. Lingeman, and E. M. Worcester. "Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis." [In eng]. J Endourol  (Dec 17 2021). https://doi.org/10.1089/end.2021.0685.

Winfree, S., C. Weiler, S. B. Bledsoe, T. Gardner, A. J. Sommer, A. P. Evan, J. E. Lingeman, et al. "Multimodal Imaging Reveals a Unique Autofluorescence Signature of Randall's Plaque." [In eng]. Urolithiasis 49, no. 2 (Apr 2021): 123-35. https://doi.org/10.1007/s00240-020-01216-4.

Woloshuk, A., S. Khochare, A. F. Almulhim, A. T. McNutt, D. Dean, D. Barwinska, M. J. Ferkowicz, et al. "In Situ Classification of Cell Types in Human Kidney Tissue Using 3d Nuclear Staining." [In eng]. Cytometry A 99, no. 7 (Jul 2021): 707-21. https://doi.org/10.1002/cyto.a.24274.

Yadav, S. P. S., R. M. Sandoval, J. Zhao, Y. Huang, E. Wang, S. Kumar, S. B. Campos-Bilderback, et al. "Mechanism of How Carbamylation Reduces Albumin Binding to Fcrn Contributing to Increased Vascular Clearance." [In eng]. Am J Physiol Renal Physiol 320, no. 1 (Jan 1 2021): F114-f29. https://doi.org/10.1152/ajprenal.00428.2020.

Yu, A., J. Zhao, S. P. S. Yadav, B. A. Molitoris, M. C. Wagner, and Y. Mechref. "Changes in the Expression of Renal Brush Border Membrane N-Glycome in Model Rats with Chronic Kidney Diseases." [In eng]. Biomolecules 11, no. 11 (Nov 11 2021). https://doi.org/10.3390/biom11111677.

Yu, A., J. Zhao, J. Zhong, J. Wang, S. P. S. Yadav, B. A. Molitoris, M. C. Wagner, and Y. Mechref. "Altered O-Glycomes of Renal Brush-Border Membrane in Model Rats with Chronic Kidney Diseases." [In eng]. Biomolecules 11, no. 11 (Oct 21 2021). https://doi.org/10.3390/biom11111560.