Several of our pre-clinical studies have also translated into clinical observational and interventional studies. These projects include biomarkers of (i) subjects with mild traumatic brain injury who develop chronic headache; (ii) subjects with polytrauma alone or in combination with mild to moderate traumatic brain injury and (iii) subjects with spinal cord injury suffering with neuropathic pain. Additionally, an FDA-approved drug identified from one of the preclinical studies is now in a NIH RO1-sponsored phase I clinical trial for a novel use in patients suffering from pain due to chronic pancreatitis. These outcomes, achieved through extensive collaboration with clinical and basic scientists, demonstrate the translational nature of our research.
Current Research Funding
NIH/NINDS R01NS102415 (White, PI)
The Role of Cell-Specific TLR-4 Signaling in Oxaliplatin-induced Peripheral Neuropath
NIH/NIDDK R01DK132709 (Fogel and White, MPI)
Safety, tolerability, and dose limiting toxicity of lacosamide in patients with painful chronic pancreatitis
Department of Veterans Affairs I01BX12983911 (Kacena, PI; White Co-I)
Novel therapeutic approaches to improve fracture healing while reducing pain behavior
Department of Defense W81XWH-18-1-0433 (White and Naugle, MPI)
Chronic headache due to mild traumatic brain injury in adults: Alterations of brain function, central sensitization and inflammatory processes.
Naugle KM, Corrona S, Smith JA, Nguyen T, Saxe J, White FA. Physical activity behavior in the first month following mild traumatic brain injury is associated with physiological and psychological risk factors for chronic pain. Pain Reports, Oct 29;6(4):e969. 2021 PMID: 34765852
Ping X, Chai Z, Wang WM, Cungen M, White FA, Jin X. Blocking receptor for advanced glycation end-products (RAGE) or toll like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice. Epilepsia, Sep 18. doi: 10.1111/epi.17069, 2021 PMID: 34535891
Niculescu AB, Le-Niculescu H, Levey DF, Soe KC, Roseberry K, Khan F, Jones TJ, Judd S, McCormick MA, Williams A, Kurian S, White FA. Towards Precision Medicine for Pain: Diagnostic Biomarkers, Pharmacogenomics, and Repurposed Drugs. Molecular Psychiatry Apr;24(4):501-522, 2019. PMID:30755720
Chen X, Liu D, Zhou D, Si Y, Xu D, Stamatkin CW, Ghozayel M, Ripsch MS, Obukhov AG*, Meroueh SO* and White FA*. A Small-Molecule CaVα1•CaVβ Protein-Protein Interaction Antagonist Suppresses Neuronal Voltage-Gated Calcium Channel Trafficking. Proceedings of the National Academy of Science, USA Nov 6;115(45), E10566-E10575. 2018. PMID: 30355767
Allette YM, Kim Y, Smith JA, Randolph AL, Ripsch MS, White FA. Decoy peptide targeted to Toll-IL-1R domain inhibits LPS and TLR4-active metabolite morphine-3 glucuronide sensitization of sensory neurons. Scientific Reports, Jun 16;7(1):3741, 2017. PMID: 28623271