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Jun Wan’s research interests are in the area of bioinformatics and computational systems biology. Dr. Wan’s lab uses diverse approaches to investigate gene regulation, associated biological pathways and functional networks from transcriptional level to translational level.

Wan Lab

The lab of Jun Wan, PhD, focuses on bioinformatics and computational systems biology. Dr. Wan’s lab uses diverse approaches to investigate gene regulation, associated biological pathways and functional networks from transcriptional level to translational level. In particular, they focus on deciphering epigenetic codes to understand effects of genetic mutations on dynamic gene regulatory networks.

Research Updates

Stay up-to-date on research at IU School of Medicine on our blog.

Current Research Funding

Recent Publications

  1. JL Owens, E Beketova, S Liu, C Li, J Wan†, CD Hu† (2020) PRMT5 cooperates with pICln to function as a master epigenetic activator of DNA double-strand break repair genes. iScience 23 (1): 100750. (PMID: 31884170).
  2. MM Xie, S Fang, Q Chen, H Liu, J Wan†, AL Dent† (2019) Follicular Regulatory T Cells Inhibit the Development of Granzyme B-Expressing Follicular Helper T Cells. JCI Insight 4 (16): 128076. (PMID: 31434804).
  3. Xu J, Liu Y, Li Y, Wang H, Stewart S, Van der Jeught K, Agarwal P, Zhang Y, Liu S, Zhao G, Wan J, Lu X†, He X† (2019) Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. Nature Nanotechnology 14 (4), 388-397. (PMID: 30804480)
  4. X. Huang, B. Guo, S. Liu, J. Wan, H. Broxmeyer (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nature Communications 9 (1), 2741. (PMID: 30013077)
  5. J Wan, Y Su, Q Song, B Tung, O Oyinlade, S Liu, M Ying, G Ming, H Song, J Qian, H Zhu, S Xia (2017) Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration. eLife 6, e20068. (PMID: 28553926)

Bibliography

Research Team

27465-Wan, Jun

Jun Wan, PhD

Associate Professor of Medical & Molecular Genetics

Read Bio

Sheng Liu, PhD
Jilong Bian, PhD
Shuyi Fang
Kailing Li