The research program of Fanyin Meng, PhD focuses on the pathogenesis of non-coding RNAs and extracellular vesicles regulated human cholestatic and alcoholic liver injuries, hepatocellular carcinoma and cholangiocarcinoma and identifying new therapeutic avenues to treat these diseases.
His work during the past 15 years has characterized non-coding RNA mediated pathogenetic pathways in vitro as well as in animal models that closely recapitulate the human cholestatic and alcoholic liver diseases, aging and related malignancies.
This work has been instrumental in the development of novel concepts about hepatobiliary regeneration/repair and the role of ncRNA in the initiation and perpetuation of chronic liver injury, aging and liver cancer.
His expertise in the field of cholestatic and alcoholic liver injuries, aging and hepatobiliary cancer in vitro as well as in animal models, coupled with a very dynamic research team and environment, enables him to be uniquely capable of shedding light on the role of ncRNA manipulation in the phenotypes of liver tissues and cells and their derived extracellular vesicles and non-coding RNAs as the novel therapeutic strategy in cholestatic and alcoholic liver diseases, aging and malignancies.
Dr. Meng is currently funded by US Department of Veterans Affairs (VA Merit Review Award) and the National Institutes of Health (R01 & R21 grants).