The laboratory led by Il-man Kim, PhD, investigates genetic regulation and signaling pathways in cardiac disease using state-of-the-art cell approaches and mouse model systems. The laboratory is particularly interested in transcriptional regulation and noncoding RNA regulatory network by seven-transmembrane receptor (also known as G protein-coupled receptor)-mediated signaling pathways in heart failure.
The goal of his research is to understand the molecular mechanisms in downstream processes by which β-arrestin (β-arr)-mediated β-adrenergic receptor (βAR) signaling confers cardiac protection. Specifically, his laboratory investigates the roles of noncoding RNAs (ncRNAs), a new class of gene regulators, in heart failure. His laboratory also tries to define the importance of βAR/β-arr-regulatable microRNAs (miRs; small ncRNAs) as well as their upstream regulators, long ncRNAs and their functional target genes in the βAR/β-arr-mediated cardioprotection.
Active Research Funding
Identifying novel pathways targeting endothelial-to-mesenchymal transition during heart failure
NIH, R01HL146481
PI: Il-man Kim
The novel role of microRNA-532-5p/prss23 axis in regulating cardiac vascularization during acute myocardial infarction
American Heart Association, 18TPA34170104
PI: Il-man Kim
The novel role of microRNA-125a-5p/bak1 axis in regulating cardiomyocyte survival during acute myocardial infarction
American Heart Association, 20POST34990024
PI: Bruno Moukette
Sponsor/Mentor: Il-man Kim
