The primary focus areas of Dr. Michael Eadon’s laboratory include the translation and implementation of pharmacogenomics into clinical practice as well as the identification of novel predictors of renal injury from large genomic, transcriptomic, and proteomic datasets.
A cellular and molecular atlas of the kidney
The major focus of Dr. Eadon’s research lab is the creation of a cellular and molecular atlas of the kidney in health and disease. Major focus areas include the evaluation of renal disease expression patterns with spatial transcriptomics and understanding genetic variants that affect this expression (expression quantitative trait loci) and identification of novel predictors of renal injury from large genomic, transcriptomic, and proteomic datasets. He is an active member of NIDDK’s Kidney Precision Medicine, integrating diverse orthogonal datasets to characterize molecular patterns of kidney disease in subjects who have underwent a kidney biopsy.
CYP3A5 Drug-gene interactions
Another area of focus of Dr. Eadon’s laboratory is the study of CYP3A5 drug metabolism, specifically with respect to tacrolimus and cannabidiol. The lab is conducting a clinical trial studying the pharmacokinetic and pharmacodynamic interactions of these drugs in individuals with and without chronic kidney disease.
Genetic predictors of blood pressure response and kidney disease progression
Additionally, Dr. Eadon’s laboratory focuses on the translation and implementation of pharmacogenomics into clinical practice. This work includes translating genetic determinants of anti-hypertensive drug response and progression of kidney disease into clinical practice. He is an active contributor to NHGRI’s IGNITE consortium.
Current Research Funding
R01AT011463 Eadon, Michael (PI)
Title: Drug-gene-nutraceutical interactions of cannabidiol.
U01HG010245 NIH/NHGRI PI: Skaar, Eadon, Site PI
Title: Implementing genomic medicine through pragmatic trials in diverse and underserved populations across Indiana
U01 DK114923 NIH/NIDDK Dagher, Ashkar, Eadon (MPI)
Title: Integrated spatial interrogation of cellular and molecular signatures of human kidney disease
U54 DK134301 NIH PI: Jain
Kidney single cell and spatial molecular atlas project – KIDSSMAP
- Melo Ferreira R, Sabo AR, Winfree S, Collins KS, Janosevic D, Gulbronson CJ, Cheng YH, Casbon L, Barwinska D, Ferkowicz MJ, Xuei X, Zhang C, Dunn KW, Kelly KJ, Sutton TA, Hato T, Dagher PC, El-Achkar TM, Eadon MT. Integration of spatial and single cell transcriptomics localizes epithelial-immune cross-talk in kidney injury. JCI Insight. 2021 May 18:147703. PMID: 34003797.
- Collins KS, Cheng YH, Ferreira RM, Gao H, Dollins MD, Janosevic D, Khan NA, White C, Dagher PC, Eadon MT. Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers. Clin Transl Sci. 2020 May 16. PMID: 32415749.
- Barwinska D, El-Achkar TM, Ferreira RM, Syed F, Cheng YH, Winfree S, Ferkowicz MJ, Hato T, Collins KS, Dunn KW, Kelly KJ, Sutton TA, Rovin BH, Parikh SV, Phillips CL, Dagher PC, Eadon MT; Kidney Precision Medicine Project. Molecular characterization of the human kidney interstitium in health and disease. Sci Adv. 2021 Feb 10;7(7). PMID: 33568476.
- Eadon MT, Lampe,S, Baig M, Collins KS, Melo Ferreira R, Mang HE, Cheng YH, Barwinska D, Schwantes-An TH, Winfree S, Temm CJ, Ferkowicz, MJ, Dunn KW, Kelly KJ, Sutton TA, Moe SM, Moorthi RN, Phillips CL, Dagher PC. Clinical, histopathologic, and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans. Nephrol Dial Transplant. 2021 Feb 4. PMID: 33537765.
- Hansen J, Sealfon R, Menon R, Eadon MT, Lake BB, et. al. Quantitative A reference tissue atlas for the human kidney. Sci Adv. 2022 Jun 10;8(23):eabn4965. PMID: 35675394.