Dr. Eadon’s primary research efforts focus on the translation and implementation of pharmacogenomics into clinical practice as well as the identification of novel predictors of renal injury from large genomic, transcriptomic, and proteomic datasets.  Major focus areas include the evaluation of renal disease expression patterns with spatial transcriptomics and understanding genetic variants that affect this expression (expression quantitative trait loci). He is an active member of NIDDK’s Kidney Precision Medicine, integrating diverse orthogonal datasets to characterize molecular patterns of kidney disease in subjects who have underwent a kidney biopsy. A second focus of his research is translating genetic determinants of anti-hypertensive drug response and progression of kidney disease into clinical practice and he is an active contributor to NHGRI’s IGNITE consortium.

My clinical interests include the dosing of medications in renal failure and management of a wide array of renal diseases including chronic kidney disease, acute kidney injury, lupus nephritis, and glomerulonephritis. To this end, I attend in the Eskenazi Health special medicine renal clinic and renal biopsy service. I rotate on the inpatient clinical nephrology services for IU Health and Eskenazi Health. Additionally, I attend on the division of clinical pharmacology’s pharmacogenomics consult service which provides clinical support for the interpretation of genetic testing in clinical practice.