The research lab of Charlie Dong, PhD, is studying the mechanisms regulating nutrient homeostasis, energy expenditure, cell signaling, gene transcription, epigenetic control of chromatin remodeling in normal physiology, aging, cancer, diabetes, obesity, and alcoholic and non-alcoholic fatty liver diseases.
The Dong Laboratory focuses on the pathogenesis of aging, cancer, diabetes, obesity, and fatty liver disease. Specifically, the laboratory team investigates the pathophysiological functions of forkhead box O transcription factors (Foxos) and NAD+-dependent deacetylases (Sirtuins) using cellular and animal model systems. This group is among the first to discover the link from the insulin signaling pathway to the NAD biogenesis and regulation. The Dong Lab also made significant contributions to the molecular mechanisms of triglyceride and cholesterol homeostasis, especially with regard to the role of Foxo3 and Sirt6 genes. Recently, this research team has demonstrated a novel role of Sesn3 in the regulation of mTOR signaling and insulin sensitivity. In addition, this lab has uncovered a novel function of Sirt6 in the regulation of glucose-stimulated insulin secretion from pancreatic beta cells.