Spinophilin is the major synaptic protein phosphatase 1 (PP1) targeting protein with postsynaptic densities. PP1 is a highly promiscuous phosphatase that obtains substrate specificity, at least in part, by employing a host (>200) of targeting proteins, such as spinophilin. The Baucum Lab has created multiple transgenic mouse lines that allow us to temporally and spatially knockout spinophilin and evaluate the role that spinophilin plays in normal and pathophysiological states such as drug abuse/substance use disorder, Parkinson disease, obsessive-compulsive spectrum disorders, motor output and learning, and obesity and diabetes.
Morris CW, Watkins DS, Pennington T, Doud EH, Qi G, Mosley AL, Atwood BK, Baucum AJ (2022). Spinophilin limits metabotropic glutamate receptor 5 scaffolding to the postsynaptic density and cell type-specifically mediates excessive grooming. bioRxiv. 2022:2022.05.24.493240. doi: 10.1101/2022.05.24.493240. In Revision.
Salek AB, Edler MC, McBride JP, Baucum AJ 2nd. (2019). Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N-methyl-D-asparate receptor. J Neurochem. Oct; 151(2): 185-203.
Watkins DS, True JD, Mosley AL, Baucum AJ 2nd. (2018). Proteomic analysis of the spinophilin interactome in rodent striatum following psychostimulant sensitization. Proteomes. Dec 17;6(4). Pii: E53.
Morris CW, Watkins DS, Salek AB, Edler MC, Baucum AJ 2nd. The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5. Molecular and Cellular Neuroscience. 2018 Jun 14;90:60-69
Edler MC, Salek AB, Watkins DS, Kaur H, Morris CW, Yamamoto BK, Baucum II AJ. (2018). Mechanisms regulating the association of protein phosphatase 1 with spinophilin and neurabin. ACS Chemical Neuroscience 2018 Jun 1.
Hiday AC, Edler MC, Salek AB, Morris CW, Thang M, Rentz TJ, Rose KL, Jones LM, and Baucum 2nd AJ. (2017) Mechanisms and consequences of dopamine depletion-induced attenuation of the spinophilin/neurofilament medium interaction. Neural Plasticity 2017, 4153076
PhD Graduate Student, Biology
PhD Graduate Student, Pharmacology & Toxicology
MD/PhD Graduate Student, Medical Neurosciences