Spinophilin is the major synaptic protein phosphatase 1 (PP1) targeting protein with postsynaptic densities. PP1 is a highly promiscuous phosphatase that obtains substrate specificity, at least in part, by employing a host (>200) of targeting proteins, such as spinophilin. The Baucum Lab has created multiple transgenic mouse lines that allow us to temporally and spatially knockout spinophilin and evaluate the role that spinophilin plays in normal and pathophysiological states such as drug abuse/substance use disorder, Parkinson disease, obsessive-compulsive spectrum disorders, motor output and learning, and obesity and diabetes.
PhD Graduate Student, Biology
PhD Graduate Student, Pharmacology & Toxicology
MD/PhD Graduate Student, Medical Neurosciences