41988-Baucum, AJ

AJ Baucum, PhD

Associate Professor of Pharmacology & Toxicology

Associate Professor of Biology

Adjunct Associate Professor of Pharmacology and Toxicology

Primary Faculty Stark Neurosciences Research Institute

(317) 274-0540
MS A420
Indianapolis, IN
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Vanderbilt University School of Medicine - Postdoctoral Fellow 06/2006 - 07/2011

University of Utah - Postdoctoral Training 06/2004 - 05/2006


Indiana University School of Medicine - Associate Professor Pharmacology and Toxicology - 07/2021 - Present

Indiana University School of Medicine - Primary Faculty Stark Neurociences Research Institute - 08/2013-Present

Vanderbilt University School of Medicine - Research Instructor 08/2011 - 07/2013

Indiana University-Purdue University Indianapolis - Associate Professor of Biology - 08/2019-06/2021

Indiana University-Purdue University Indianapolis - Assistant Professor of Biology - 08/2013-07/2019





Key Publications

Stickel KC, Mosley AL, Doud EH, Belecky-Adams TL, Baucum AJ. Mechanisms of spinophilin-dependent pancreas dysregulation underlying diabesity. bioRxiv. 2023:2023.02.07.527495. doi: 10.1101/2023.02.07.527495.

Salek AB, Claeboe ET, Bansal R, Berbari NF, Baucum AJ, 2nd. Spinophilin dependent regulation of GluN2B-containing NMDAR-dependent calcium influx, GluN2B surface expression, and cleaved caspase expression. Synapse. 2023. Epub 2023/02/05. doi: 10.1002/syn.22264. PubMed PMID: 36738175.

Morris CW, Watkins DS, Shah NR, Pennington T, Hens B, Qi G, Doud EH, Mosley AL, Atwood BK, Baucum AJ, 2nd. Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming. Biological psychiatry. 2022. Epub 2023/02/24. doi: 10.1016/j.biopsych.2022.12.008. PubMed PMID: 36822932.

Salek AB, Edler MC, McBride JP, Baucum AJ 2nd. (2019). Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N-methyl-D-asparate receptor. J Neurochem. Oct; 151(2): 185-203.

Watkins DS, True JD, Mosley AL, Baucum AJ 2nd. (2018). Proteomic analysis of the spinophilin interactome in rodent striatum following psychostimulant sensitization. Proteomes. Dec 17;6(4). Pii: E53.

Morris CW, Watkins DS, Salek AB, Edler MC, Baucum AJ 2nd. The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5. Molecular and Cellular Neuroscience. 2018 Jun 14;90:60-69

Edler MC, Salek AB, Watkins DS, Kaur H, Morris CW, Yamamoto BK, Baucum II AJ. (2018). Mechanisms regulating the association of protein phosphatase 1 with spinophilin and neurabin. ACS Chemical Neuroscience 2018 Jun 1. 

Hiday AC, Edler MC, Salek AB, Morris CW, Thang M, Rentz TJ, Rose KL, Jones LM, and Baucum 2nd AJ. (2017) Mechanisms and consequences of dopamine depletion-induced attenuation of the spinophilin/neurofilament medium interaction. Neural Plasticity 2017, 4153076

Baucum 2nd AJ, Brown AM, Colbran RJ (2013). Differential association of postsynaptic signaling protein complexes in striatum and hippocampus. Journal of Neurochemistry. 124(4):490-501. PMCID: PMC3557548

Baucum 2nd AJ, Strack S, and Colbran RJ (2012). Age-Dependent Targeting of Protein Phosphatase 1 to Ca2+/Calmodulin-Dependent Protein Kinase II by Spinophilin in Mouse Striatum. PLoS One. 7(2):e31554. PMCID: PMC3278457


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