The research laboratory led by Jungsu Kim, PhD, is interested in understanding the molecular and cellular basis of neuronal and glial dysfunction in Alzheimer’s disease, other aging-associated neurodegenerative diseases, and normal brain aging.
Research in Kim lab is aimed at developing therapeutic strategies for Alzheimer’s disease by targeting brain lipid-regulating proteins, such as apolipoprotein E (ApoE), low density lipoprotein receptor (LDLR), and ATP-binding cassette transporter A1 (ABCA1). The Kim lab is also interested in the role of epigenetics and non-coding RNAs in the pathogenesis of Alzheimer’s disease and other aging-associated neurodegenerative diseases. Emerging transcriptomics technologies recently revealed that many non-coding regions actually encode functional RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Using cell culture, animal models, and systems biology approaches, the Kim lab investigates non-coding RNAs that may play critical roles in neurodegenerative diseases, brain aging, and cardiovascular diseases.