Amot130 adapts atrophin-1 interacting protein 4 to inhibit yes-associated protein signaling and cell growth. Adler JJ, Heller BL, Bringman LR, Ranahan WP, Cocklin RR, Goebl MG, Oh M, Lim HS, Ingham RJ, Wells CD.J Biol Chem. 2013 May 24;288(21):15181-93.
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases. Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD. Proc Natl Acad Sci U S A. 2013 Oct 7. PMID: 24101513
The Adaptor Protein AMOT Promotes the Proliferation of Mammary Epithelial Cells via the Prolonged Activation of the Extracellular Signal-regulated Kinases. Ranahan WP, Han Z, Smith-Kinnaman W, Nabinger SC, Heller BD, Herbert BS, Chan RJ, Wells CD. Cancer Res. 2011 Feb 1.
Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain. Heller B, Adu-Gyamfi E, Smith-Kinnaman W, Babbey C, Vora M, Xue Y, Bittman R, Stahelin RV, Wells CD. J Biol Chem. 2010 Apr 16;285(16):12308-20.
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells. Wells etal. Cell May 2006
The Wells Lab team includes Kevin Lange, Graduate Student.