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Andrew Tilston-Lunel, PhD

Assistant Research Professor of Pediatrics

Address
Wells R4
PTRS
IN
Indianapolis, IN
PubMed:

Key Publications

Berical AC, Kiyokawa H, Beermann ML, Wallman D, Cherfane G, Dunphy V, Pan J, Tilston-Lunel A, Varelas X, Horani A, Brody SL, Kotton DN, Hawkins FJ. Airway Disease Modeling with Gene-edited Human Basal Cell Transplantation. Am J Respir Crit Care Med. 2024 Nov 8;211(1):131-4. doi: 10.1164/rccm.202406-1110RL. [Epub ahead of print] PubMed PMID: 39514838; PubMed Central PMCID: PMC11755362.
 
Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Wang F, Bawa PS, Varelas X, Hawkins FJ, Kotton DN. Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells. Nat Protoc. 2024 Nov 5;. doi: 10.1038/s41596-024-01067-y. [Epub ahead of print] Review. PubMed PMID: 39501108.
 
Crossey E, Carty S, Shao F, Henao-Vasquez J, Ysasi AB, Zeng M, Hinds A, Lo M, Tilston-Lunel A, Varelas X, Jones MR, Fine A. Influenza induces lung lymphangiogenesis independent of YAP/TAZ activity in lymphatic endothelial cells. Sci Rep. 2024 Sep 12;14(1):21324. doi: 10.1038/s41598-024-72115-6. PubMed PMID: 39266641; PubMed Central PMCID: PMC11393066.
 
Raslan AA, Pham TX, Lee J, Kontodimas K, Tilston-Lunel A, Schmottlach J, Hong J, Dinc T, Bujor AM, Caporarello N, Thiriot A, von Andrian UH, Huang SK, Nicosia RF, Trojanowska M, Varelas X, Ligresti G. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nat Commun. 2024 Jun 27;15(1):5449. doi: 10.1038/s41467-024-49545-x. PubMed PMID: 38937456; PubMed Central PMCID: PMC11211333.
 
Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 7;30(9):1199-1216.e7. doi: 10.1016/j.stem.2023.07.014. Epub 2023 Aug 24. PubMed PMID: 37625411; PubMed Central PMCID: PMC10528754.
 
Ning B, Tilston-Lunel AM, Simonetti J, Hicks-Berthet J, Matschulat A, Pfefferkorn R, Spira A, Edwards M, Mazzilli S, Lenburg ME, Beane JE, Varelas X. Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. J Exp Clin Cancer Res. 2023 May 8;42(1):116. doi: 10.1186/s13046-023-02674-5. PubMed PMID: 37150829; PubMed Central PMCID: PMC10165825.
 
Tilston-Lunel AM, Varelas X. Polarity in respiratory development, homeostasis and disease. Curr Top Dev Biol. 2023;154:285-315. doi: 10.1016/bs.ctdb.2023.02.004. Epub 2023 Mar 15. PubMed PMID: 37100521.
 
Kern JG, Tilston-Lunel AM, Federico A, Ning B, Mueller A, Peppler GB, Stampouloglou E, Cheng N, Johnson RL, Lenburg ME, Beane JE, Monti S, Varelas X. Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas. Nat Commun. 2022 Nov 28;13(1):7198. doi: 10.1038/s41467-022-34864-8. PubMed PMID: 36443313; PubMed Central PMCID: PMC9705439.
 
Shirai T, Sekai M, Kozawa K, Sato N, Tanimura N, Kon S, Matsumoto T, Murakami T, Ito S, Tilston-Lunel A, Varelas X, Fujita Y. Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments. Cancer Sci. 2022 Nov;113(11):3710-3721. doi: 10.1111/cas.15483. Epub 2022 Aug 30. PubMed PMID: 35816400; PubMed Central PMCID: PMC9633292.
 
Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022 Jun 29;13(1):3732. doi: 10.1038/s41467-022-31399-w. PubMed PMID: 35768444; PubMed Central PMCID: PMC9243107.
 
Rabhi N, Desevin K, Belkina AC, Tilston-Lunel A, Varelas X, Layne MD, Farmer SR. Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors. Life Sci Alliance. 2022 May;5(5). doi: 10.26508/lsa.202101286. Print 2022 May. PubMed PMID: 35181634; PubMed Central PMCID: PMC8860101.
 
Alysandratos KD, Russo SJ, Petcherski A, Taddeo EP, Acín-Pérez R, Villacorta-Martin C, Jean JC, Mulugeta S, Rodriguez LR, Blum BC, Hekman RM, Hix OT, Minakin K, Vedaie M, Kook S, Tilston-Lunel AM, Varelas X, Wambach JA, Cole FS, Hamvas A, Young LR, Liesa M, Emili A, Guttentag SH, Shirihai OS, Beers MF, Kotton DN. Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell Rep. 2021 Aug 31;36(9):109636. doi: 10.1016/j.celrep.2021.109636. PubMed PMID: 34469722; PubMed Central PMCID: PMC8432578.
 
Hicks-Berthet J, Ning B, Federico A, Tilston-Lunel A, Matschulat A, Ai X, Lenburg ME, Beane J, Monti S, Varelas X. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021 Jul 13;36(2):109347. doi: 10.1016/j.celrep.2021.109347. PubMed PMID: 34260916; PubMed Central PMCID: PMC8346236.
 
Dela Cruz A, Kartha V, Tilston-Lunel A, Mi R, Reynolds TL, Mingueneau M, Monti S, Jensen JL, Skarstein K, Varelas X, Kukuruzinska MA. Gene expression alterations in salivary gland epithelia of Sjögren's syndrome patients are associated with clinical and histopathological manifestations. Sci Rep. 2021 May 27;11(1):11154. doi: 10.1038/s41598-021-90569-w. PubMed PMID: 34045583; PubMed Central PMCID: PMC8159963.
 
Tilston-Lunel A, Mazzilli S, Kingston NM, Szymaniak AD, Hicks-Berthet J, Kern JG, Abo K, Reid ME, Perdomo C, Wilson AA, Spira A, Beane J, Varelas X. Aberrant epithelial polarity cues drive the development of precancerous airway lesions. Proc Natl Acad Sci U S A. 2021 May 4;118(18). doi: 10.1073/pnas.2019282118. PubMed PMID: 33903236; PubMed Central PMCID: PMC8106308.
 
Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020;8:608044. doi: 10.3389/fcell.2020.608044. eCollection 2020. PubMed PMID: 33490071; PubMed Central PMCID: PMC7817781.
 
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 7;81(1):212. doi: 10.1016/j.molcel.2020.12.028. PubMed PMID: 33417854; PubMed Central PMCID: PMC7831449.
 
Kronenberg NM, Tilston-Lunel A, Thompson FE, Chen D, Yu W, Dholakia K, Gather MC, Gunn-Moore FJ. Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity. Front Cell Neurosci. 2020;14:552213. doi: 10.3389/fncel.2020.552213. eCollection 2020. PubMed PMID: 33088261; PubMed Central PMCID: PMC7498650.
 
Kingston NM, Tilston-Lunel AM, Hicks-Berthet J, Varelas X. Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells. Methods Mol Biol. 2019;1893:107-113. doi: 10.1007/978-1-4939-8910-2_9. PubMed PMID: 30565129; PubMed Central PMCID: PMC7781096.
 
Tilston-Lünel AM, Haley KE, Schlecht NF, Wang Y, Chatterton ALD, Moleirinho S, Watson A, Hundal HS, Prystowsky MB, Gunn-Moore FJ, Reynolds PA. Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells. J Mol Cell Biol. 2016 Oct 1;8(5):439-455. doi: 10.1093/jmcb/mjw020. PubMed PMID: 27190314; PubMed Central PMCID: PMC5055084.
 
Gunn-Moore FJ, Tilston-Lünel AM, Reynolds PA. Willing to Be Involved in Cancer. Genes (Basel). 2016 Jul 18;7(7). doi: 10.3390/genes7070037. Review. PubMed PMID: 27438856; PubMed Central PMCID: PMC4962007.
 
Moleirinho S, Tilston-Lunel A, Angus L, Gunn-Moore F, Reynolds PA. The expanding family of FERM proteins. Biochem J. 2013 Jun 1;452(2):183-93. doi: 10.1042/BJ20121642. Review. PubMed PMID: 23662806.
 
Moleirinho S, Patrick C, Tilston-Lünel AM, Higginson JR, Angus L, Antkowiak M, Barnett SC, Prystowsky MB, Reynolds PA, Gunn-Moore FJ. Willin, an upstream component of the hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts. PLoS One. 2013;8(4):e60028. doi: 10.1371/journal.pone.0060028. Print 2013. PubMed PMID: 23593160; PubMed Central PMCID: PMC3620498.
 
Moleirinho S, Chang N, Sims AH, Tilston-Lünel AM, Angus L, Steele A, Boswell V, Barnett SC, Ormandy C, Faratian D, Gunn-Moore FJ, Reynolds PA. KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals. Oncogene. 2013 Apr 4;32(14):1821-30. doi: 10.1038/onc.2012.196. Epub 2012 May 21. PubMed PMID: 22614006.

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