My research interests are centered on the discovery of targeted therapies for acute kidney injury in sepsis. Sepsis-induced kidney injury is associated with high mortality and there is no specific therapy that can be offered at the bedside beyond supportive care. The lack of therapeutic options is due in part to incomplete understanding of the temporal evolution of sepsis pathology. Our ongoing research focuses on defining the timeline of sepsis-induced kidney injury using a combination of imaging and sequencing tools. In particular, our laboratory is interested in understanding the molecular links between the early phase inflammation and late phase organ shutdown. In parallel, our laboratory also seeks to develop novel therapeutic approaches. For example, we have recently reported the first example of protein cage nanoparticle that can be targeted to renal proximal tubules through glomerular filtration. Our research is funded by the NIH.
Complete List of Published Work in Pubmed: