
Mark W. Geraci, MD, BA
Adjunct Professor of Medicine
Bio
Mark Geraci was born and raised in Cincinnati, OH. He completed his undergraduate training at the University of Colorado, Boulder. Following graduation from the Johns Hopkins University School of Medicine, he completed training in Internal Medicine at the Massachusetts General Hospital. After training in Pulmonary Diseases and Critical Care Medicine at the University of Colorado he remained as faculty, eventually to Head the Pulmonary Division. He is currently the John B. Hickam Professor and Chair of Medicine at Indiana University.
He is a tremendous contributor to medical education, and has served as President of the Association of Specialty Professors for the Alliance of Academic Internal Medicine, and a member of their Education Committee.
Titles & Appointments
- Adjunct Professor of Medicine
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Education1990 FEL University of Colorado1987 RES Massachusetts General Hospital1987 MD Johns Hopkins University1983 BA University of Colorado
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Research
His research interests center on the role of eicosanoids in the biology of pulmonary vascular disease and lung cancer. These endeavors include the use of animal models of lung cancer, and the application of genomics. He is the recipient of the NHLBI R24 for Genomics in Pulmonary Hypertension Consortium Award. He is an awardee of the jointly (NHLBI and NCI) funded “Common Pathogenetic Mechanisms of Lung Cancer and COPD”, which establishes a new National Consortium investigating early carcinogenesis.
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PublicationsTranscriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome.
Glidewell SC; Miyamoto SD; Grossfeld PD; Clouthier DE; Coldren CD; Stearman RS; Geraci MW; Clinical and translational science 2015 Nov 4Signatures of accelerated somatic evolution in gene promoters in multiple cancer types.
Smith KS; Yadav VK; Pedersen BS; Shaknovich R; Geraci MW; Pollard KS; De S; Nucleic acids research 2015 May 1Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis.
Walter ND; Dolganov GM; Garcia BJ; Worodria W; Andama A; Musisi E; Ayakaka I; Van TT; Voskuil MI; de Jong BC; Davidson RM; Fingerlin TE; Kechris K; Palmer C; Nahid P; Daley CL; Geraci M; Huang L; Cattamanchi A; Strong M; Schoolnik GK; Davis JL; The Journal of infectious diseases 2015 Mar 11Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.
Stearman RS; Cornelius AR; Lu X; Conklin DS; Del Rosario MJ; Lowe AM; Elos MT; Fettig LM; Wong RE; Hara N; Cogan JD; Phillips JA 3rd; Taylor MR; Graham BB; Tuder RM; Loyd JE; Geraci MW; American journal of respiratory and critical care medicine 2014 May 1Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.
Campbell JD; Liu G; Luo L; Xiao J; Gerrein J; Juan-Guardela B; Tedrow J; Alekseyev YO; Yang IV; Correll M; Geraci M; Quackenbush J; Sciurba F; Schwartz DA; Kaminski N; Johnson WE; Monti S; Spira A; Beane J; Lenburg ME; RNA (New York, N.Y.) 2014 Dec 17Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis.
Yang IV; Pedersen BS; Rabinovich E; Hennessy CE; Davidson EJ; Murphy E; Guardela BJ; Tedrow JR; Zhang Y; Singh MK; Correll M; Schwarz MI; Geraci M; Sciurba FC; Quackenbush J; Spira A; Kaminski N; Schwartz DA; American journal of respiratory and critical care medicine 2014 Dec 1MODMatcher: multi-omics data matcher for integrative genomic analysis.
Yoo S; Huang T; Campbell JD; Lee E; Tu Z; Geraci MW; Powell CA; Schadt EE; Spira A; Zhu J; PLoS computational biology 2014 Aug 14Giants in chest medicine: Marvin I. Schwarz, MD, FCCP.
Geraci M; Chest 2014 AprIntegrating molecular genetics and systems approaches to pulmonary vascular diseases.
Geraci MW; Pulmonary circulation 2013 JanHands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.
Reisdorph N; Stearman R; Kechris K; Phang TL; Reisdorph R; Prenni J; Erle DJ; Coldren C; Schey K; Nesvizhskii A; Geraci M; Genomics, proteomics & bioinformatics 2013 Dec 6Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.
Nakachi I; Rice JL; Coldren CD; Edwards MG; Stearman RS; Glidewell SC; Varella-Garcia M; Franklin WA; Keith RL; Lewis MT; Gao B; Merrick DT; Miller YE; Geraci MW; Cancer prevention research (Philadelphia, Pa.) 2013 Dec 17Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
Graham BB; Chabon J; Kumar R; Kolosionek E; Gebreab L; Debella E; Edwards M; Diener K; Shade T; Bifeng G; Bandeira A; Butrous G; Jones K; Geraci M; Tuder RM; American journal of respiratory cell and molecular biology 2013 DecPromoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.
Clark DW; Phang T; Edwards MG; Geraci MW; Gillespie MN; Free radical biology & medicine 2012 May 1The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.
Schmidt EP; Yang Y; Janssen WJ; Gandjeva A; Perez MJ; Barthel L; Zemans RL; Bowman JC; Koyanagi DE; Yunt ZX; Smith LP; Cheng SS; Overdier KH; Thompson KR; Geraci MW; Douglas IS; Pearse DB; Tuder RM; Nature medicine 2012 Jul 22Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia.
Lara AR; Cosgrove GP; Janssen WJ; Huie TJ; Burnham EL; Heinz DE; Curran-Everett D; Sahin H; Schwarz MI; Cool CD; Groshong SD; Geraci MW; Tuder RM; Hyde DM; Henson PM; Chest 2012 DecOral iloprost improves endobronchial dysplasia in former smokers.
Keith RL; Blatchford PJ; Kittelson J; Minna JD; Kelly K; Massion PP; Franklin WA; Mao J; Wilson DO; Merrick DT; Hirsch FR; Kennedy TC; Bunn PA Jr; Geraci MW; Miller YE; Cancer prevention research (Philadelphia, Pa.) 2011 JunPGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.
Zhou W; Dowell DR; Geraci MW; Blackwell TS; Collins RD; Polosukhin VV; Lawson WE; Wu P; Sussan T; Biswal S; Goleniewska K; O'Neal J; Newcomb DC; Toki S; Morrow JD; Peebles RS Jr; American journal of physiology. Lung cellular and molecular physiology 2011 Jul 15Con: the case for expanded lung cancer research support.
Geraci MW; Keith RL; American journal of respiratory and critical care medicine 2011 Dec 1Identification of growth arrest and DNA-damage-inducible gene beta (GADD45beta) as a novel tumor suppressor in pituitary gonadotrope tumors.
Michaelis KA; Knox AJ; Xu M; Kiseljak-Vassiliades K; Edwards MG; Geraci M; Kleinschmidt-DeMasters BK; Lillehei KO; Wierman ME; Endocrinology 2011 Aug 2Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension.
Meadows CA; Risbano MG; Zhang L; Geraci MW; Tuder RM; Collier DH; Bull TM; Chest 2010 Sep 9Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
Erzurum S; Rounds SI; Stevens T; Aldred M; Aliotta J; Archer SL; Asosingh K; Balaban R; Bauer N; Bhattacharya J; Bogaard H; Choudhary G; Dorn GW 2nd; Dweik R; Fagan K; Fallon M; Finkel T; Geraci M; Gladwin MT; Hassoun PM; Humbert M; Kaminski N; Kawut SM; Loscalzo J; McDonald D; McMurtry IF; Newman J; Nicolls M; Rabinovitch M; Shizuru J; Oka M; Polgar P; Rodman D; Schumacker P; Stenmark K; Tuder R; Voelkel N; Sullivan E; Weinshilboum R; Yoder MC; Zhao Y; Gail D; Moore TM; American journal of respiratory and critical care medicine 2010 Sep 10Significant downregulation of platelet gene expression in metastatic lung cancer.
Calverley DC; Phang TL; Choudhury QG; Gao B; Oton AB; Weyant MJ; Geraci MW; Clinical and translational science 2010 OctAltered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension.
Risbano MG; Meadows CA; Coldren CD; Jenkins TJ; Edwards MG; Collier D; Huber W; Mack DG; Fontenot AP; Geraci MW; Bull TM; Clinical and translational science 2010 OctSomatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.
Aldred MA; Comhair SA; Varella-Garcia M; Asosingh K; Xu W; Noon GP; Thistlethwaite PA; Tuder RM; Erzurum SC; Geraci MW; Coldren CD; American journal of respiratory and critical care medicine 2010 Jun 25The case for 24/7 in-house intensivist coverage.
Burnham EL; Moss M; Geraci MW; American journal of respiratory and critical care medicine 2010 Jun 1Genomics of pulmonary arterial hypertension: implications for therapy.
Geraci MW; Bull TM; Tuder RM; Heart failure clinics 2010 JanCompetency-based education and training in internal medicine.
Weinberger SE; Pereira AG; Iobst WF; Mechaber AJ; Bronze MS; Alliance for Academic Internal Medicine Education Redesign Task Force II; Annals of internal medicine 2010 Dec 7Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.
Strassheim D; Riddle SR; Burke DL; Geraci MW; Stenmark KR; Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 13Genetics and genomics of pulmonary arterial hypertension.
Machado RD; Eickelberg O; Elliott CG; Geraci MW; Hanaoka M; Loyd JE; Newman JH; Phillips JA 3rd; Soubrier F; Trembath RC; Chung WK; Journal of the American College of Cardiology 2009 Jun 30Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.
Weiser-Evans MC; Wang XQ; Amin J; Van Putten V; Choudhary R; Winn RA; Scheinman R; Simpson P; Geraci MW; Nemenoff RA; Cancer research 2009 Feb 10Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences.
Feng W; Leach SM; Tipney H; Phang T; Geraci M; Spritz RA; Hunter LE; Williams T; PloS one 2009 Dec 16Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance.
West J; Cogan J; Geraci M; Robinson L; Newman J; Phillips JA; Lane K; Meyrick B; Loyd J; BMC medical genomics 2008 Sep 29Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
Arcaroli JJ; Hokanson JE; Abraham E; Geraci M; Murphy JR; Bowler RP; Dinarello CA; Silveira L; Sankoff J; Heyland D; Wischmeyer P; Crapo JD; American journal of respiratory and critical care medicine 2008 Oct 23Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Nemenoff R; Meyer AM; Hudish TM; Mozer AB; Snee A; Narumiya S; Stearman RS; Winn RA; Weiser-Evans M; Geraci MW; Keith RL; Cancer prevention research (Philadelphia, Pa.) 2008 OctHuman herpesvirus-8 infection of primary pulmonary microvascular endothelial cells.
Bull TM; Meadows CA; Coldren CD; Moore M; Sotto-Santiago SM; Nana-Sinkam SP; Campbell TB; Geraci MW; American journal of respiratory cell and molecular biology 2008 Jun 27A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.
Stearman RS; Dwyer-Nield L; Grady MC; Malkinson AM; Geraci MW; Cancer research 2008 Jan 1Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease.
Saavedra MT; Hughes GJ; Sanders LA; Carr M; Rodman DM; Coldren CD; Geraci MW; Sagel SD; Accurso FJ; West J; Nick JA; American journal of respiratory and critical care medicine 2008 Aug 21Assist devices fail to reverse patterns of fetal gene expression despite beta-blockers.
Lowes BD; Zolty R; Shakar SF; Brieke A; Gray N; Reed M; Calalb M; Minobe W; Lindenfeld J; Wolfel EE; Geraci M; Bristow MR; Cleveland J Jr; The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 NovGenetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.
Stearman RS; Grady MC; Nana-Sinkam P; Varella-Garcia M; Geraci MW; Molecular cancer research : MCR 2007 MarProstacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
Wang W; Zolty E; Falk S; Summer S; Stearman R; Geraci M; Schrier R; American journal of physiology. Renal physiology 2007 Jul 25Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke.
Nana-Sinkam SP; Lee JD; Sotto-Santiago S; Stearman RS; Keith RL; Choudhury Q; Cool C; Parr J; Moore MD; Bull TM; Voelkel NF; Geraci MW; American journal of respiratory and critical care medicine 2007 Jan 25Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.
Zhou W; Hashimoto K; Goleniewska K; O'Neal JF; Ji S; Blackwell TS; Fitzgerald GA; Egan KM; Geraci MW; Peebles RS Jr; Journal of immunology (Baltimore, Md. : 1950) 2007 Jan 15Gene expression profiling in pulmonary hypertension.
Bull TM; Coldren CD; Geraci MW; Voelkel NF; Proceedings of the American Thoracic Society 2007 JanMicroRNA in lung cancer.
Nana-Sinkam SP; Geraci MW; Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006 NovFunctional and genomic changes induced by alveolar transmigration in human neutrophils.
Coldren CD; Nick JA; Poch KR; Woolum MD; Fouty BW; O'Brien JM; Gruber MP; Zamora MR; Svetkauskaite D; Richter DA; He Q; Park JS; Overdier KH; Abraham E; Geraci MW; American journal of physiology. Lung cellular and molecular physiology 2006 Jul 21Prostacyclin in lung cancer.
Keith RL; Geraci MW; Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006 JulProstaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.
Keith RL; Geraci MW; Nana-Sinkam SP; Breyer RM; Hudish TM; Meyer AM; Malkinson AM; Dwyer-Nield LD; Anticancer research 2006 JulAttenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.
Meyer AM; Dwyer-Nield LD; Hurteau G; Keith RL; Ouyang Y; Freed BM; Kisley LR; Geraci MW; Bonventre JV; Nemenoff RA; Malkinson AM; American journal of physiology. Lung cellular and molecular physiology 2006 Jan 27Human lung project: evaluating variance of gene expression in the human lung.
Gruber MP; Coldren CD; Woolum MD; Cosgrove GP; Zeng C; Barón AE; Moore MD; Cool CD; Worthen GS; Brown KK; Geraci MW; American journal of respiratory cell and molecular biology 2006 Feb 23Prostacyclin synthase in smoking-related lung disease.
Nana-Sinkam SP; Lee JD; Stearman R; Sakao S; Sotto-Santiago S; Voelkel NF; Geraci MW; Proceedings of the American Thoracic Society 2006 AugBaseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.
Coldren CD; Helfrich BA; Witta SE; Sugita M; Lapadat R; Zeng C; Barón A; Franklin WA; Hirsch FR; Geraci MW; Bunn PA Jr; Molecular cancer research : MCR 2006 AugPeroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC).
Bren-Mattison Y; Van Putten V; Chan D; Winn R; Geraci MW; Nemenoff RA; Oncogene 2005 Feb 17Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension.
Nana-Sinkam P; Oyer RJ; Stearman RS; Sotto-Santiago S; Moore MD; Bull TM; Grady MC; Choudhery Q; Nemenoff RA; Lane K; Loyd JE; Geraci MW; Chest 2005 DecMicroarray analysis of peripheral blood cells in pulmonary arterial hypertension, surrogate to biopsy.
Bull TM; Coldren CD; Nana-Sinkam P; Sotto-Santiago SM; Moore M; Voelkel NF; Geraci MW; Chest 2005 DecThe expression of prostacyclin synthase is decreased in the small pulmonary arteries from patients with emphysema.
Lee JD; Taraseviciene-Stewart L; Keith R; Geraci MW; Voelkel NF; Chest 2005 DecAnalysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.
Stearman RS; Dwyer-Nield L; Zerbe L; Blaine SA; Chan Z; Bunn PA Jr; Johnson GL; Hirsch FR; Merrick DT; Franklin WA; Baron AE; Keith RL; Nemenoff RA; Malkinson AM; Geraci MW; The American journal of pathology 2005 DecPractical cancer genetics, genomics and proteomics.
Gruber MP; Geraci MW; Journal of insurance medicine (New York, N.Y.) 2005Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice.
Blaine SA; Meyer AM; Hurteau G; Wick M; Hankin JA; Murphy RC; Dannenberg AJ; Geraci MW; Subbaramaiah K; Nemenoff RA; Carcinogenesis 2004 Oct 7Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness.
Hashimoto K; Graham BS; Geraci MW; FitzGerald GA; Egan K; Zhou W; Goleniewska K; O'Neal JF; Morrow JD; Durbin RK; Wright PF; Collins RD; Suzutani T; Peebles RS Jr; Journal of virology 2004 OctProstacyclin in human non-small cell lung cancers.
Nana-Sinkam P; Golpon H; Keith RL; Oyer RJ; Sotto-Santiago S; Moore MD; Franklin W; Nemenoff RA; Geraci MW; Chest 2004 MayGene microarray analysis of peripheral blood cells in pulmonary arterial hypertension.
Bull TM; Coldren CD; Moore M; Sotto-Santiago SM; Pham DV; Nana-Sinkam SP; Voelkel NF; Geraci MW; American journal of respiratory and critical care medicine 2004 Jun 23Emphysema lung tissue gene expression profiling.
Golpon HA; Coldren CD; Zamora MR; Cosgrove GP; Moore MD; Tuder RM; Geraci MW; Voelkel NF; American journal of respiratory cell and molecular biology 2004 Jul 29Comparative analysis of algorithms for signal quantitation from oligonucleotide microarrays.
Barash Y; Dehan E; Krupsky M; Franklin W; Geraci M; Friedman N; Kaminski N; Bioinformatics (Oxford, England) 2004 Jan 29Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis.
Nick JA; Coldren CD; Geraci MW; Poch KR; Fouty BW; O'Brien J; Gruber M; Zarini S; Murphy RC; Kuhn K; Richter D; Kast KR; Abraham E; Blood 2004 Aug 31Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.
Keith RL; Miller YE; Hudish TM; Girod CE; Sotto-Santiago S; Franklin WA; Nemenoff RA; March TH; Nana-Sinkam SP; Geraci MW; Cancer research 2004 Aug 15Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis.
Cosgrove GP; Brown KK; Schiemann WP; Serls AE; Parr JE; Geraci MW; Schwarz MI; Cool CD; Worthen GS; American journal of respiratory and critical care medicine 2004 Apr 29Lung tissue banks for gene expression studies.
Cool CD; Geraci MW; COPD 2004Oxygen-dependent regulation of pulmonary circulation.
Tuder RM; McGrath S; Voelkel NF; Geraci MW; Methods in enzymology 2004Expression of human herpesvirus 8 in primary pulmonary hypertension.
Cool CD; Rai PR; Yeager ME; Hernandez-Saavedra D; Serls AE; Bull TM; Geraci MW; Brown KK; Routes JM; Tuder RM; Voelkel NF; The New England journal of medicine 2003 Sep 18Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8.
Bull TM; Cool CD; Serls AE; Rai PR; Parr J; Neid JM; Geraci MW; Campbell TB; Voelkel NF; Badesch DB; The European respiratory journal 2003 SepCirculating endothelial cells in pulmonary hypertension.
Bull TM; Golpon H; Hebbel RP; Solovey A; Cool CD; Tuder RM; Geraci MW; Voelkel NF; Thrombosis and haemostasis 2003 OctHypoxia induces different genes in the lungs of rats compared with mice.
Hoshikawa Y; Nana-Sinkam P; Moore MD; Sotto-Santiago S; Phang T; Keith RL; Morris KG; Kondo T; Tuder RM; Voelkel NF; Geraci MW; Physiological genomics 2003 Feb 6Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth.
Ameshima S; Golpon H; Cool CD; Chan D; Vandivier RW; Gardai SJ; Wick M; Nemenoff RA; Geraci MW; Voelkel NF; Circulation research 2003 Apr 24Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth.
Wick M; Hurteau G; Dessev C; Chan D; Geraci MW; Winn RA; Heasley LE; Nemenoff RA; Molecular pharmacology 2002 NovJanus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension.
Voelkel NF; Cool C; Taraceviene-Stewart L; Geraci MW; Yeager M; Bull T; Kasper M; Tuder RM; Critical care medicine 2002 MayGene expression profiles in pulmonary hypertension.
Geraci MW; Hoshikawa Y; Yeager M; Golpon H; Gesell T; Tuder RM; Voelkel NF; Chest 2002 MarOverexpression of matrix metalloproteinase-7 in pulmonary fibrosis.
Cosgrove GP; Schwarz MI; Geraci MW; Brown KK; Worthen GS; Chest 2002 MarCombined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.
Sugita M; Geraci M; Gao B; Powell RL; Hirsch FR; Johnson G; Lapadat R; Gabrielson E; Bremnes R; Bunn PA; Franklin WA; Cancer research 2002 Jul 15TRAIL and inhibitors of apoptosis are opposing determinants for NF-kappaB-dependent, genotoxin-induced apoptosis of cancer cells.
Spalding AC; Jotte RM; Scheinman RI; Geraci MW; Clarke P; Tyler KL; Johnson GL; Oncogene 2002 Jan 10Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer.
Keith RL; Miller YE; Hoshikawa Y; Moore MD; Gesell TL; Gao B; Malkinson AM; Golpon HA; Nemenoff RA; Geraci MW; Cancer research 2002 Feb 1Effects of chronic estrogen-receptor blockade on ovine perinatal pulmonary circulation.
Parker TA; Afshar S; Kinsella JP; Grover TR; Gebb S; Geraci M; Shaul PW; Cryer CM; Abman SH; American journal of physiology. Heart and circulatory physiology 2001 SepExpression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis.
Tuder RM; Chacon M; Alger L; Wang J; Taraseviciene-Stewart L; Kasahara Y; Cool CD; Bishop AE; Geraci M; Semenza GL; Yacoub M; Polak JM; Voelkel NF; The Journal of pathology 2001 OctGenomic approaches to research in pulmonary hypertension.
Geraci MW; Gao B; Hoshikawa Y; Yeager ME; Tuder RM; Voelkel NF; Respiratory research 2001 May 1Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis.
Geraci MW; Moore M; Gesell T; Yeager ME; Alger L; Golpon H; Gao B; Loyd JE; Tuder RM; Voelkel NF; Circulation research 2001 Mar 30HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema.
Golpon HA; Geraci MW; Moore MD; Miller HL; Miller GJ; Tuder RM; Voelkel NF; The American journal of pathology 2001 MarSevere pulmonary hypertension after the discovery of the familial primary pulmonary hypertension gene.
Tuder RM; Yeager ME; Geraci M; Golpon HA; Voelkel NF; The European respiratory journal 2001 JunProstacyclin receptor-dependent modulation of pulmonary vascular remodeling.
Hoshikawa Y; Voelkel NF; Gesell TL; Moore MD; Morris KG; Alger LA; Narumiya S; Geraci MW; American journal of respiratory and critical care medicine 2001 Jul 15Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer.
Gupta RA; Tan J; Krause WF; Geraci MW; Willson TM; Dey SK; DuBois RN; Proceedings of the National Academy of Sciences of the United States of America 2000 Nov 21Experimental evidence from an animal model of adenocarcinoma that chronic inflammation enhances lung cancer risk
Malkinson AM; Bauer A; Meyer A; Dwyer-Nield L; Koski K; Keith R; Geraci M; Miller Y; Chest 2000 MayPulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension.
Geraci MW; Gao B; Shepherd DC; Moore MD; Westcott JY; Fagan KA; Alger LA; Tuder RM; Voelkel NF; The Journal of clinical investigation 1999 JunProstacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension.
Tuder RM; Cool CD; Geraci MW; Wang J; Abman SH; Wright L; Badesch D; Voelkel NF; American journal of respiratory and critical care medicine 1999 JunSurfactant protein C promoter-driven expression of T1-alpha induces lung inflammation.
Girod CE; Shin DH; Geraci MW; Warren HB; Dobbs LG; Gao B; Rainer JS; Bauer AK; Ikegami M; Shannon JM; Miller YE; Chest 1999 JulPrimary pulmonary hypertension between inflammation and cancer.
Voelkel NF; Cool C; Lee SD; Wright L; Geraci MW; Tuder RM; Chest 1998 SepPulmonary prostacyclin synthase overexpression by adenovirus transfection and in transgenic mice.
Geraci M; Gao B; Shepherd D; Allard J; Curiel D; Westcott J; Voelkel N; Chest 1998 JulAnti-growth factor therapy for lung cancer.
Chan DC; Geraci M; Bunn PA Jr; Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 1998Rat prostacyclin synthase. Cloning and regulation of gene expression in the lung.
Geraci M; Shepherd D; Moore M; Vernon J; Allard J; Shannon J; Voelkel NF; Chest 1997 JunNovel bombesin-like peptide binding proteins from lung.
Geraci MW; Miller YE; Escobedo-Morse A; Kane MA; American journal of respiratory cell and molecular biology 1994 Mar -
Professional OrganizationsAlpha Omega Alpha National Medical Honor SocietyAmerican College of PhysiciansAmerican College of PhysiciansAmerican Medical AssociationAmerican Thoracic SocietyAssociation of Specialty ProfessorsATS Assembly on Respiratory Cell and Molecular BiologyJohns Hopkins Medical and Surgical SocietyMassachusetts Medical SocietyPhi Beta Kappa
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Board CertificationsAmerican Board of Internal Medicine - Pulmonary DiseaseAmerican Board of Internal Medicine - Critical Care MedicineAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
His clinical interests are lung cancer, pulmonary vascular diseases, and critical care.