G. David D. Roodman, MD, PhD

Faculty

G. David D. Roodman, MD, PhD

Distinguished Professor

Phone (317) 274-3589

Address

Joseph E. Walther Hall, Room C312
980 W. Walnut St.

Indianapolis , IN 46202

Titles & Appointments

Distinguished Professor
Professor of Medicine
Professor of Biochemistry & Molecular Biology
Co-Leader of the Hematopoiesis, Hematological Malignancies and Immunology Research Program – IU Simon Cancer Center

Education

1975 PhD University of Kentucky

1973 MD University of Kentucky

1969 AB Johns Hopkins University

1 FEL University of Minnesota

1 RES University of Minnesota
Research

Research focuses on osteoclasts and osteoblast activity in both normal and pathological states including Paget’s disease and Multiple Myeloma.
Publications

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis.
Petrusca DN; Toscani D; Wang FM; Park C; Crean CD; Anderson JL; Marino S; Mohammad KS; Zhou D; Silbermann R; Sun Q; Kurihara N; Galson DL; Giuliani N; Roodman GD; Journal of hematology & oncology 2018 Oct 4

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America.
Raje N; Roodman GD; Willenbacher W; Shimizu K; García-Sanz R; Terpos E; Kennedy L; Sabatelli L; Intorcia M; Hechmati G; 2018 Mar 5

Role of Bone-Modifying Agents in Multiple Myeloma: American Society of Clinical Oncology Clinical Practice Guideline Update.
Anderson K; Ismaila N; Flynn PJ; Halabi S; Jagannath S; Ogaily MS; Omel J; Raje N; Roodman GD; Yee GC; Kyle RA; 2018 Jan 17

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study.
Raje N; Terpos E; Willenbacher W; Shimizu K; García-Sanz R; Durie B; Legiec W; Krejcí M; Laribi K; Zhu L; Cheng P; Warner D; Roodman GD; 2018 Feb 9

Multiple Myeloma and Bone: The Fatal Interaction.
Marino S; Roodman GD; 2018 Aug 1

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth.
Delgado-Calle J; Anderson J; Cregor MD; Condon KW; Kuhstoss SA; Plotkin LI; Bellido T; Roodman GD; 2017 May 22

Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG.
Hadji P; Aapro MS; Body JJ; Gnant M; Brandi ML; Reginster JY; Zillikens MC; Glüer CC; de Villiers T; Baber R; Roodman GD; Cooper C; Langdahl B; Palacios S; Kanis J; Al-Daghri N; Nogues X; Eriksen EF; Kurth A; Rizzoli R; Coleman RE; 2017 Mar 23

Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3.
Hiasa M; Okui T; Allette YM; Ripsch MS; Sun-Wada GH; Wakabayashi H; Roodman GD; White FA; Yoneda T; 2017 Mar 2

EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation.
Adamik J; Jin S; Sun Q; Zhang P; Weiss KR; Anderson JL; Silbermann R; Roodman GD; Galson DL; 2017 Jan 23

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma.
Hao M; Franqui-Machin R; Xu H; Shaughnessy J Jr; Barlogie B; Roodman D; Quelle DE; Janz S; Tomasson MH; Sanderson RD; Qiu L; Frech I; Tricot G; Zhan F; 2017 Apr 12

The Role of Percutaneous Vertebroplasty and Balloon Kyphoplasty for the Treatment of Vertebral Compression Fractures in Multiple Myleoma: New Consensus Statement from the International Myeloma Working Group
Roodman GD Leukemia 2017

Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statement.
Dimopoulos MA; Hillengass J; Usmani S; Zamagni E; Lentzsch S; Davies FE; Raje N; Sezer O; Zweegman S; Shah J; Badros A; Shimizu K; Moreau P; Chim CS; Lahuerta JJ; Hou J; Jurczyszyn A; Goldschmidt H; Sonneveld P; Palumbo A; Ludwig H; Cavo M; Barlogie B; Anderson K; Roodman GD; Rajkumar SV; Durie BG; Terpos E; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Jan 20

CCN1: a sticky issue in myeloma.
Roodman GD; Blood 2014 Sep 25

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers.
Bon J; Kahloon R; Zhang Y; Xue J; Fuhrman CR; Tan J; Burger M; Kass DJ; Csizmadia E; Otterbein L; Chandra D; Bhargava A; Pilewski JM; Roodman GD; Sciurba FC; Duncan SR; PloS one 2014 Sep 12

Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease.
Pianko MJ; Terpos E; Roodman GD; Divgi CR; Zweegman S; Hillengass J; Lentzsch S; Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 7

Pathobiology of Paget's Disease of Bone.
Galson DL; Roodman GD; Journal of bone metabolism 2014 May 31

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.
Teramachi J; Zhou H; Subler MA; Kitagawa Y; Galson DL; Dempster DW; Windle JJ; Kurihara N; Roodman GD; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Jun

Role of osteocytes in multiple myeloma bone disease.
Delgado-Calle J; Bellido T; Roodman GD; Current opinion in supportive and palliative care 2014 Dec

Advances in supportive care for multiple myeloma.
Raje NS; Yee AJ; Roodman GD; Journal of the National Comprehensive Cancer Network : JNCCN 2014 Apr

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Teramachi J; Hiruma Y; Ishizuka S; Ishizuka H; Brown JP; Michou L; Cao H; Galson DL; Subler MA; Zhou H; Dempster DW; Windle JJ; Roodman GD; Kurihara N; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jun

Genes associate with abnormal bone cell activity in bone metastasis.
Roodman GD; Cancer metastasis reviews 2012 Dec
Board Certifications

American Board of Internal Medicine - Hematology

American Board of Internal Medicine - Internal Medicine
Clinical Interests

Paget’s disease and Multiple Myeloma

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