G. David D. Roodman, MD, PhD

Faculty

G. David D. Roodman, MD, PhD

Distinguished Professor

Phone (317) 274-0843

Address

Joseph E. Walther Hall, Room C312
980 W. Walnut St.

Indianapolis , IN 46202

Titles & Appointments

Distinguished Professor
Professor of Medicine
Professor of Biochemistry & Molecular Biology
Co-Leader of the Hematopoiesis, Hematological Malignancies and Immunology Research Program – IU Simon Cancer Center

Education

1975 PhD University of Kentucky

1973 MD University of Kentucky

1969 AB Johns Hopkins University

1 FEL University of Minnesota

1 RES University of Minnesota
Research

Research focuses on osteoclasts and osteoblast activity in both normal and pathological states including Paget’s disease and Multiple Myeloma.
Publications

Increased S1P expression in osteoclasts enhances bone formation in an animal model of Paget's disease.
Nagata Y; Miyagawa K; Ohata Y; Petrusca DN; Pagnotti GM; Mohammad KS; Guise TA; Windle JJ; David Roodman G; Kurihara N; Journal of cellular biochemistry 2020 Oct 27

Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23.
Mulcrone PL; Edwards SKE; Petrusca DN; Haneline LS; Delgado-Calle J; Roodman GD; Scientific reports 2020 Oct 14

Growth factor independence 1 expression in myeloma cells enhances their growth, survival, and osteoclastogenesis.
Petrusca DN; Toscani D; Wang FM; Park C; Crean CD; Anderson JL; Marino S; Mohammad KS; Zhou D; Silbermann R; Sun Q; Kurihara N; Galson DL; Giuliani N; Roodman GD; Journal of hematology & oncology 2018 Oct 4

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in the United States of America.
Raje N; Roodman GD; Willenbacher W; Shimizu K; García-Sanz R; Terpos E; Kennedy L; Sabatelli L; Intorcia M; Hechmati G; 2018 Mar 5

Role of Bone-Modifying Agents in Multiple Myeloma: American Society of Clinical Oncology Clinical Practice Guideline Update.
Anderson K; Ismaila N; Flynn PJ; Halabi S; Jagannath S; Ogaily MS; Omel J; Raje N; Roodman GD; Yee GC; Kyle RA; 2018 Jan 17

Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study.
Raje N; Terpos E; Willenbacher W; Shimizu K; García-Sanz R; Durie B; Legiec W; Krejcí M; Laribi K; Zhu L; Cheng P; Warner D; Roodman GD; 2018 Feb 9

Multiple Myeloma and Bone: The Fatal Interaction.
Marino S; Roodman GD; 2018 Aug 1

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth.
Delgado-Calle J; Anderson J; Cregor MD; Condon KW; Kuhstoss SA; Plotkin LI; Bellido T; Roodman GD; 2017 May 22

Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG.
Hadji P; Aapro MS; Body JJ; Gnant M; Brandi ML; Reginster JY; Zillikens MC; Glüer CC; de Villiers T; Baber R; Roodman GD; Cooper C; Langdahl B; Palacios S; Kanis J; Al-Daghri N; Nogues X; Eriksen EF; Kurth A; Rizzoli R; Coleman RE; 2017 Mar 23

Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3.
Hiasa M; Okui T; Allette YM; Ripsch MS; Sun-Wada GH; Wakabayashi H; Roodman GD; White FA; Yoneda T; 2017 Mar 2

EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation.
Adamik J; Jin S; Sun Q; Zhang P; Weiss KR; Anderson JL; Silbermann R; Roodman GD; Galson DL; 2017 Jan 23

NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma.
Hao M; Franqui-Machin R; Xu H; Shaughnessy J Jr; Barlogie B; Roodman D; Quelle DE; Janz S; Tomasson MH; Sanderson RD; Qiu L; Frech I; Tricot G; Zhan F; 2017 Apr 12

The Role of Percutaneous Vertebroplasty and Balloon Kyphoplasty for the Treatment of Vertebral Compression Fractures in Multiple Myleoma: New Consensus Statement from the International Myeloma Working Group
Roodman GD Leukemia 2017

Role of magnetic resonance imaging in the management of patients with multiple myeloma: a consensus statement.
Dimopoulos MA; Hillengass J; Usmani S; Zamagni E; Lentzsch S; Davies FE; Raje N; Sezer O; Zweegman S; Shah J; Badros A; Shimizu K; Moreau P; Chim CS; Lahuerta JJ; Hou J; Jurczyszyn A; Goldschmidt H; Sonneveld P; Palumbo A; Ludwig H; Cavo M; Barlogie B; Anderson K; Roodman GD; Rajkumar SV; Durie BG; Terpos E; Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Jan 20

CCN1: a sticky issue in myeloma.
Roodman GD; Blood 2014 Sep 25

Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers.
Bon J; Kahloon R; Zhang Y; Xue J; Fuhrman CR; Tan J; Burger M; Kass DJ; Csizmadia E; Otterbein L; Chandra D; Bhargava A; Pilewski JM; Roodman GD; Sciurba FC; Duncan SR; PloS one 2014 Sep 12

Whole-body low-dose computed tomography and advanced imaging techniques for multiple myeloma bone disease.
Pianko MJ; Terpos E; Roodman GD; Divgi CR; Zweegman S; Hillengass J; Lentzsch S; Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Oct 7

Pathobiology of Paget's Disease of Bone.
Galson DL; Roodman GD; Journal of bone metabolism 2014 May 31

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.
Teramachi J; Zhou H; Subler MA; Kitagawa Y; Galson DL; Dempster DW; Windle JJ; Kurihara N; Roodman GD; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 Jun

Role of osteocytes in multiple myeloma bone disease.
Delgado-Calle J; Bellido T; Roodman GD; Current opinion in supportive and palliative care 2014 Dec

Advances in supportive care for multiple myeloma.
Raje NS; Yee AJ; Roodman GD; Journal of the National Comprehensive Cancer Network : JNCCN 2014 Apr

Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Teramachi J; Hiruma Y; Ishizuka S; Ishizuka H; Brown JP; Michou L; Cao H; Galson DL; Subler MA; Zhou H; Dempster DW; Windle JJ; Roodman GD; Kurihara N; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jun

Genes associate with abnormal bone cell activity in bone metastasis.
Roodman GD; Cancer metastasis reviews 2012 Dec

Auditory stimulation alters the pattern of 2-deoxyglucose uptake in the inner ear.
Ryan AF; Goodwin P; Woolf NK; Sharp F; Brain research 1982 Feb 25

[Electrophysiologic study of limbic-hypothalamic interrelationships].
Grachev II; Petrov IuA; Chernysheva MP; Nervnaia sistema 1980
Board Certifications

American Board of Internal Medicine - Hematology

American Board of Internal Medicine - Internal Medicine
Clinical Interests

Paget’s disease and Multiple Myeloma

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