
Bruce A. Molitoris, MD, MS
Distinguished Professor Emeritus
950 W Walnut St
R2 E202
Indianapolis, IN 46202-5188
Titles & Appointments
- Distinguished Professor Emeritus
- Professor Emeritus of Medicine
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Education1979 MD Washington University1975 MS University of Illinois1973 BS University of Illinois
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Research
For the past thirty years I have dedicated my laboratory toward the study of acute kidney injury (AKI) from both ischemic and nephrotoxic compounds, primarily secondary to aminoglycosides. We have helped to understand mechanistically, and developed therapeutically, many potential approaches for acute kidney injury. We have also spent the last ten years developing non-linear microscopy to quantify dynamic cellular and subcellular processes in vivo. This has led to an NIH-P30 Imaging Core O’Brien Center of Excellence beginning in 2002 and recently renewed thru 2017. The center involves MD’s, MD-PhD’s and PhD’s in a synergistic fashion. Of particular importance is our advancement of fluorescent technologies from the bench to now the bedside. Quantitative, mechanistic, therapeutic and toxicologic insights into disease processes have been produced. We are now advancing our techniques and approaches to answer complex and novel therapeutic questions in humans with regard to GFR and plasma volume determinations, areas that have hindered the assessment, analysis and therapeutics in AKI and CKD. We have also developed several unique rodent models allowing novel studies and mechanistic insights.
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PublicationsImmunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine.
Liu XF; Wei J; Zhou Q; Molitoris BA; Sandoval R; Kobayashi H; Okada R; Nagaya T; Karim B; Butcher D; Pastan I; Proceedings of the National Academy of Sciences of the United States of America 2020 Mar 2The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration.
Uchida M; Maier B; Waghwani HK; Selivanovitch E; Pay SL; Avera J; Yun E; Sandoval RM; Molitoris BA; Zollman A; Douglas T; Hato T; The Journal of clinical investigation 2019 Sep 3Protective vascular coagulation in response to bacterial infection of the kidney is regulated by bacterial lipid A and host CD147.
Schulz A; Chuquimia OD; Antypas H; Steiner SE; Sandoval RM; Tanner GA; Molitoris BA; Richter-Dahlfors A; Melican K; Pathogens and disease 2018 Nov 26Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.
Pickkers P; Mehta RL; Murray PT; Joannidis M; Molitoris BA; Kellum JA; Bachler M; Hoste EAJ; Hoiting O; Krell K; Ostermann M; Rozendaal W; Valkonen M; Brealey D; Beishuizen A; Meziani F; Murugan R; de Geus H; Payen D; van den Berg E; Arend J; STOP-AKI Investigators.; 2018 Nov 20A Novel Method for Rapid Bedside Measurement of GFR.
Rizk DV; Meier D; Sandoval RM; Chacana T; Reilly ES; Seegmiller JC; DeNoia E; Strickland JS; Muldoon J; Molitoris BA; 2018 May 10Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.
Kolb AL; Corridon PR; Zhang S; Xu W; Witzmann FA; Collett JA; Rhodes GJ; Winfree S; Bready D; Pfeffenberger ZJ; Pomerantz JM; Hato T; Nagami GT; Molitoris BA; Basile DP; Atkinson SJ; Bacallao RL; 2018 Jan 25Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.
Hato T; Winfree S; Day R; Sandoval RM; Molitoris BA; Yoder MC; Wiggins RC; Zheng Y; Dunn KW; Dagher PC; Journal of the American Society of Nephrology : JASN 2017 Mar 1Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology.
Sandoval RM; Molitoris BA; Methods (San Diego, Calif.) 2017 Jul 19Inhibition of <i>a</i>v<i>ß</i>5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury.
McCurley A; Alimperti S; Campos-Bilderback SB; Sandoval RM; Calvino JE; Reynolds TL; Quigley C; Mugford JW; Polacheck WJ; Gomez IG; Dovey J; Marsh G; Huang A; Qian F; Weinreb PH; Dolinski BM; Moore S; Duffield JS; Chen CS; Molitoris BA; Violette SM; Crackower MA; Journal of the American Society of Nephrology : JASN 2017 Jan 6Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys.
Collett JA; Corridon PR; Mehrotra P; Kolb AL; Rhodes GJ; Miller CA; Molitoris BA; Pennington JG; Sandoval RM; Atkinson SJ; Campos-Bilderback SB; Basile DP; Bacallao RL; Journal of the American Society of Nephrology : JASN 2017 Jan 25Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?
Molitoris BA; American journal of kidney diseases : the official journal of the National Kidney Foundation 2017 Feb 20Intravital imaging of the kidney in a rat model of salt-sensitive hypertension.
Endres BT; Sandoval RM; Rhodes GJ; Campos-Bilderback SB; Kamocka MM; McDermott-Roe C; Staruschenko A; Molitoris BA; Geurts AM; Palygin O; American journal of physiology. Renal physiology 2017 Apr 12Quantifying Glomerular Filtration Rates in Acute Kidney Injury: A Requirement for Translational Success.
Molitoris BA; Reilly ES; Seminars in nephrology 2016 JanMechanism of increased clearance of glycated albumin by proximal tubule cells.
Wagner MC; Myslinski J; Pratap S; Flores B; Rhodes G; Campos-Bilderback SB; Sandoval RM; Kumar S; Patel M; Ashish; Molitoris BA; American journal of physiology. Renal physiology 2016 Feb 17ABT-719 for the Prevention of Acute Kidney Injury in Patients Undergoing High-Risk Cardiac Surgery: A Randomized Phase 2b Clinical Trial.
McCullough PA; Bennett-Guerrero E; Chawla LS; Beaver T; Mehta RL; Molitoris BA; Eldred A; Ball G; Lee HJ; Houser MT; Khan S; Journal of the American Heart Association 2016 Aug 20Shear stress is normalized in glomerular capillaries following 5/6 nephrectomy.
Ferrell N; Sandoval RM; Bian A; Campos-Bilderback SB; Molitoris BA; Fissell WH; American journal of physiology. Renal physiology 2015 Jan 13Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury.
Verma SK; Molitoris BA; Seminars in nephrology 2015 JanRenal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial.
de Zeeuw D; Anzalone DA; Cain VA; Cressman MD; Heerspink HJ; Molitoris BA; Monyak JT; Parving HH; Remuzzi G; Sowers JR; Vidt DG; The lancet. Diabetes & endocrinology 2015 Feb 4Dynamic multiphoton microscopy: focusing light on acute kidney injury.
Hall AM; Molitoris BA; Physiology (Bethesda, Md.) 2014 SepLetter to the editor: "Quantifying albumin permeability with multiphoton microscopy: why the difference?".
Sandoval RM; Molitoris BA; American journal of physiology. Renal physiology 2014 May 1ASN Presidential Address 2013: innovation and individualization--the path forward for nephrology.
Molitoris BA; Journal of the American Society of Nephrology : JASN 2014 Mar 27Finding the bottom and using it: Offsets and sensitivity in the detection of low intensity values in vivo with 2-photon microscopy.
Sandoval RM; Wang E; Molitoris BA; Intravital 2014 Mar 1The proximal tubule and albuminuria: really!
Dickson LE; Wagner MC; Sandoval RM; Molitoris BA; Journal of the American Society of Nephrology : JASN 2014 Jan 9Urinary Biomarkers: Alone Are They Enough?
Molitoris BA; Journal of the American Society of Nephrology : JASN 2014 Dec 22Using 2-photon microscopy to understand albuminuria.
Molitoris BA; Transactions of the American Clinical and Climatological Association 2014Screening: Screening for kidney disease--a lost opportunity.
Molitoris BA; Nature reviews. Nephrology 2013 Dec 3Quantifying glomerular permeability of fluorescent macromolecules using 2-photon microscopy in Munich Wistar rats.
Sandoval RM; Molitoris BA; Journal of visualized experiments : JoVE 2013 Apr 17Designing clinical trials in acute kidney injury.
Molitoris BA; Okusa MD; Palevsky PM; Kimmel PL; Star RA; Clinical journal of the American Society of Nephrology : CJASN 2012 Mar 22Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings.
Molitoris BA; Okusa MD; Palevsky PM; Chawla LS; Kaufman JS; Devarajan P; Toto RM; Hsu CY; Greene TH; Faubel SG; Kellum JA; Wald R; Chertow GM; Levin A; Waikar SS; Murray PT; Parikh CR; Shaw AD; Go AS; Chinchilli VM; Liu KD; Cheung AK; Weisbord SD; Mehta RL; Stokes JB; Thompson AM; Thompson BT; Westenfelder CS; Tumlin JA; Warnock DG; Shah SV; Xie Y; Duggan EG; Kimmel PL; Star RA; Clinical journal of the American Society of Nephrology : CJASN 2012 Mar 22Multiple factors influence glomerular albumin permeability in rats.
Sandoval RM; Wagner MC; Patel M; Campos-Bilderback SB; Rhodes GJ; Wang E; Wean SE; Clendenon SS; Molitoris BA; Journal of the American Society of Nephrology : JASN 2012 Jan 5Kidney endothelial dysfunction: ischemia, localized infections and sepsis.
Molitoris BA; Sandoval RM; Contributions to nephrology 2011 Sep 9Two-photon imaging within the murine thorax without respiratory and cardiac motion artifact.
Presson RG Jr; Brown MB; Fisher AJ; Sandoval RM; Dunn KW; Lorenz KS; Delp EJ; Salama P; Molitoris BA; Petrache I; The American journal of pathology 2011 May 7Pathophysiology of ischemic acute kidney injury.
Sharfuddin AA; Molitoris BA; Nature reviews. Nephrology 2011 Mar 1A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals.
Wang E; Meier DJ; Sandoval RM; Von Hendy-Willson VE; Pressler BM; Bunch RM; Alloosh M; Sturek MS; Schwartz GJ; Molitoris BA; Kidney international 2011 Aug 31The antibiotic gentamicin inhibits specific protein trafficking functions of the Arf1/2 family of GTPases.
Lin L; Wagner MC; Cocklin R; Kuzma A; Harrington M; Molitoris BA; Goebl MG; Antimicrobial agents and chemotherapy 2010 Oct 18Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.
Basile DP; Friedrich JL; Spahic J; Knipe N; Mang H; Leonard EC; Changizi-Ashtiyani S; Bacallao RL; Molitoris BA; Sutton TA; American journal of physiology. Renal physiology 2010 Dec 1Rapid diagnosis and quantification of acute kidney injury using fluorescent ratio-metric determination of glomerular filtration rate in the rat.
Wang E; Sandoval RM; Campos SB; Molitoris BA; American journal of physiology. Renal physiology 2010 Aug 4Multiphoton imaging techniques in acute kidney injury.
Molitoris BA; Sandoval RM; Contributions to nephrology 2010 Apr 20Early monitoring of acute tubular necrosis in the rat kidney by 23Na-MRI.
Atthe BK; Babsky AM; Hopewell PN; Phillips CL; Molitoris BA; Bansal N; American journal of physiology. Renal physiology 2009 Sep 2siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury.
Molitoris BA; Dagher PC; Sandoval RM; Campos SB; Ashush H; Fridman E; Brafman A; Faerman A; Atkinson SJ; Thompson JD; Kalinski H; Skaliter R; Erlich S; Feinstein E; Journal of the American Society of Nephrology : JASN 2009 May 21Soluble thrombomodulin protects ischemic kidneys.
Sharfuddin AA; Sandoval RM; Berg DT; McDougal GE; Campos SB; Phillips CL; Jones BE; Gupta A; Grinnell BW; Molitoris BA; Journal of the American Society of Nephrology : JASN 2009 Jan 28Techniques to study nephron function: microscopy and imaging.
Molitoris BA; Sandoval RM; Pflügers Archiv : European journal of physiology 2009 Jan 15Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation.
Campos SB; Ashworth SL; Wean S; Hosford M; Sandoval RM; Hallett MA; Atkinson SJ; Molitoris BA; American journal of physiology. Renal physiology 2009 Jan 14Contrast nephropathy: are short-term outcome measures adequate for quantification of long-term renal risk?
Molitoris BA; Nature clinical practice. Nephrology 2008 Sep 9Imaging techniques in acute kidney injury.
Sharfuddin AA; Sandoval RM; Molitoris BA; Nephron. Clinical practice 2008 Sep 18Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1.
Wagner MC; Rhodes G; Wang E; Pruthi V; Arif E; Saleem MA; Wean SE; Garg P; Verma R; Holzman LB; Gattone V; Molitoris BA; Nihalani D; The Journal of biological chemistry 2008 Oct 14Technology Insight: biomarker development in acute kidney injury--what can we anticipate?
Molitoris BA; Melnikov VY; Okusa MD; Himmelfarb J; Nature clinical practice. Nephrology 2008 Jan 29Quantifying endocytosis in vivo using intravital two-photon microscopy.
Sandoval RM; Molitoris BA; Methods in molecular biology (Clifton, N.J.) 2008Two-photon microscopy: visualization of kidney dynamics.
Ashworth SL; Sandoval RM; Tanner GA; Molitoris BA; Kidney international 2007 May 30Rapid determination of renal filtration function using an optical ratiometric imaging approach.
Yu W; Sandoval RM; Molitoris BA; American journal of physiology. Renal physiology 2007 Feb 20Improving outcomes of acute kidney injury: report of an initiative.
Molitoris BA; Levin A; Warnock DG; Joannidis M; Mehta RL; Kellum JA; Ronco C; Shah SV; Acute Kidney Injury Network working group; Nature clinical practice. Nephrology 2007 AugQuantifying dynamic kidney processes utilizing multi-photon microscopy.
Molitoris BA; Sandoval RM; Contributions to nephrology 2007A non-nephrotoxic gentamicin congener that retains antimicrobial efficacy.
Sandoval RM; Reilly JP; Running W; Campos SB; Santos JR; Phillips CL; Molitoris BA; Journal of the American Society of Nephrology : JASN 2006 Sep 13Cofilin mediates ATP depletion-induced endothelial cell actin alterations.
Suurna MV; Ashworth SL; Hosford M; Sandoval RM; Wean SE; Shah BM; Bamburg JR; Molitoris BA; American journal of physiology. Renal physiology 2006 Jan 24Loss of the homotypic fusion and vacuole protein sorting or golgi-associated retrograde protein vesicle tethering complexes results in gentamicin sensitivity in the yeast Saccharomyces cerevisiae.
Wagner MC; Molnar EE; Molitoris BA; Goebl MG; Antimicrobial agents and chemotherapy 2006 FebPharmacophotonics: utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney.
Molitoris BA; Sandoval RM; Advanced drug delivery reviews 2006 Aug 15Adenoviral vectors expressing human endostatin-angiostatin and soluble Tie2: enhanced suppression of tumor growth and antiangiogenic effects in a prostate tumor model.
Raikwar SP; Temm CJ; Raikwar NS; Kao C; Molitoris BA; Gardner TA; Molecular therapy : the journal of the American Society of Gene Therapy 2005 Oct 5Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney.
Tanner GA; Sandoval RM; Molitoris BA; Bamburg JR; Ashworth SL; American journal of physiology. Renal physiology 2005 May 10Renal blood flow in sepsis: a complex issue.
Molitoris BA; Critical care (London, England) 2005 Jun 2Intravital multiphoton microscopy of dynamic renal processes.
Molitoris BA; Sandoval RM; American journal of physiology. Renal physiology 2005 JunQuantitative intravital microscopy using a Generalized Polarity concept for kidney studies.
Yu W; Sandoval RM; Molitoris BA; American journal of physiology. Cell physiology 2005 Jul 20 -
Professional OrganizationsAlpha Omega Alpha Honor Medical SocietyAmerican Society for Clinical InvestigationAssociation of American Physicians
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Board CertificationsAmerican Board of Internal Medicine - NephrologyAmerican Board of Internal Medicine - Internal Medicine
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AwardsOrg: Indiana University
Desc: Bicentennial Medal
Scope: University
Date: 1905-07-14
Org: Indiana University
Desc: Distinguished Professor
Scope: University
Date: 1905-07-10
Org: The American Society for Clinical Investigation
Desc: Elected Member
Scope: National
Date: 1905-06-14