4969-Zheng, Qi-Huang
Faculty

Qi-Huang Zheng, PhD

Associate Professor of Radiology & Imaging Sciences

Address
BRTC L3-208
RADI
IN
Indianapolis, IN

Bio

Qi-Huang Zheng, Ph.D. is an Associate Professor with tenure of Radiology and Imaging Sciences and Director of PET Radiochemistry in the Department of Radiology and Imaging Sciences at Indiana University School of Medicine. His expertise ranges from synthetic organic chemistry/natural product chemistry to radiopharmaceutical chemistry/molecular imaging science with a focus on positron emission tomography (PET) radiochemistry. His current research interests are design, synthesis and biological evaluation of new radiopharmaceuticals (tumor, brain and heart imaging agents) for use in the biomedical imaging technique PET to study cancer, neuroscience and cardiovascular diseases. His research activities focus on the development of novel and potent enzyme-, receptor- and transporter-based PET carbon-11 and fluorine-18 radiotracers for the qualitative and quantitative assessment of physiologic changes in vivo, from initial evaluation in cell and animal models to evaluation in clinical trials. His research activities also include development, automation and production of PET radiotracers for preclinical and clinical imaging applications. He has received various honors and awards such as China Young Chemist Prize in 1991; China Guangdong Province Outstanding Teacher Award in 1992, China Guangdong Province Science and Technology Progress Achievement Award in 1995; One of the Top Ten Authors for Radiology Publications at Indiana University School of Medicine in 2008, 2009, 2010; Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2006-2009 Award in 2009; and Bioorganic & Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry, European Journal of Medicinal Chemistry, and Journal of Neuroimmunology Outstanding Reviewer Award in 2015, 2016, 2017, 2018. He is serving as a Senior Editorial/Editorial Board Member in numerous scientific journals, an abstract reviewer for the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting, a manuscript reviewer for more than 80 scientific journals and a grant reviewer for more than 15 grant agencies/foundations. He has authored/co-authored over 150 research and review articles, and book chapters.

Key Publications

Radioligands targeting purinergic P2X7 receptor. Zheng QH. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127169. doi: 10.1016/j.bmcl.2020.127169. Epub 2020 Apr 3. Review. PMID: 32273217

Fully automated radiosynthesis and quality control of estrogen receptor targeting radiopharmaceutical 16α-[18F]fluoroestradiol ([18F]FES) for human breast cancer imaging. Wang M, Glick-Wilson BE, Zheng QH. Appl Radiat Isot. 2020 Jun;160:109109. doi: 10.1016/j.apradiso.2020.109109. Epub 2020 Mar 3. PMID: 32174461

Facile fully automated radiosynthesis and quality control of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) for human brain tumor imaging. Wang M, Glick-Wilson BE, Zheng QH. Appl Radiat Isot. 2019 Dec;154:108852. doi: 10.1016/j.apradiso.2019.108852. Epub 2019 Aug 12. PMID: 31442794

Synthesis and in vitro biological evaluation of new P2X7R radioligands [11C]halo-GSK1482160 analogs. Gao M, Wang M, Meyer JA, Territo PR, Hutchins GD, Zarrinmayeh H, Zheng QH. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1476-1480. doi: 10.1016/j.bmcl.2019.04.018. Epub 2019 Apr 10. PMID: 31005444

Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602. Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH. Appl Radiat Isot. 2019 Feb;144:10-18. doi: 10.1016/j.apradiso.2018.11.006. Epub 2018 Nov 16. PMID: 30476885

Synthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer's disease. Gao M, Wang M, Zheng QH. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2234-2238. doi: 10.1016/j.bmcl.2018.05.053. Epub 2018 May 29. PMID: 29859907

Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F]IUR-1601. Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH. Bioorg Med Chem Lett. 2018 May 15;28(9):1603-1609. doi: 10.1016/j.bmcl.2018.03.044. Epub 2018 Mar 17. PMID: 29628324

Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor. Wang M, Gao M, Meyer JA, Peters JS, Zarrinmayeh H, Territo PR, Hutchins GD, Zheng QH. Bioorg Med Chem. 2017 Jul 15;25(14):3835-3844. doi: 10.1016/j.bmc.2017.05.031. Epub 2017 May 18. PMID: 28554730

 

 

Titles & Appointments

  • Associate Professor of Radiology & Imaging Sciences

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