4969-Zheng, Qi-Huang

Qi-Huang Zheng, PhD

Associate Professor of Radiology & Imaging Sciences

Phone
(317) 278-4671
Address
BRTC L3-112
RADY
IN
Indianapolis, IN
PubMed:

Bio

Qi-Huang Zheng, Ph.D. is an Associate Professor of Radiology and Imaging Sciences with tenure in the Department of Radiology and Imaging Sciences at Indiana University School of Medicine. His expertise ranges from synthetic organic chemistry/natural product chemistry to radiopharmaceutical chemistry/molecular imaging science with a focus on positron emission tomography (PET) radiochemistry. His current research interests are design, synthesis and biological evaluation of new radiopharmaceuticals (tumor, brain and heart imaging agents) for use in the biomedical imaging technique PET to study cancer, neuroscience and cardiovascular diseases. His research activities focus on the development of novel and potent enzyme-, receptor- and transporter-based PET carbon-11 and fluorine-18 radiotracers for the qualitative and quantitative assessment of physiologic changes in vivo, from initial evaluation in cell and animal models to evaluation in clinical trials. His research activities also include development, automation and production of PET radiotracers for preclinical and clinical imaging applications. He has received various honors and awards such as China Young Chemist Prize in 1991; China Guangdong Province Outstanding Teacher Award in 1992, China Guangdong Province Science and Technology Progress Achievement Award in 1995; One of the Top Ten Authors for Radiology Publications at Indiana University School of Medicine in 2008, 2009, 2010; Bioorganic & Medicinal Chemistry Letters Most Cited Paper 2006-2009 Award in 2009; and Bioorganic & Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry, European Journal of Medicinal Chemistry, and Journal of Neuroimmunology Outstanding Reviewer Award in 2015, 2016, 2017, 2018. He is serving as a Senior Editorial/Editorial Board Member in numerous scientific journals, an abstract reviewer for the Society of Nuclear Medicine and Molecular Imaging (SNMMI) Annual Meeting, a manuscript reviewer for more than 80 scientific journals and a grant reviewer for more than 15 grant agencies/foundations. He has authored/co-authored over 150 research and review articles, and book chapters.

Key Publications

PET imaging with [68Ga]-labeled TGFβ-targeting peptide in a mouse PANC-1 tumor model. Li Y, Zhao H, Hu S, Zhang X, Chen H, Zheng QH. Front Oncol. 2023 Sep 15;13:1228281. doi: 10.3389/fonc.2023.1228281. eCollection 2023. PMID: 37781175

A carbon-11 labeled imidazo[1,2- a]pyridine derivative as a new potential PET probe targeting PI3K/mTOR in cancer. Li W, Ma W, Wang M, Wang Z, Grega SD, Zheng QH, Xu Z. Am J Nucl Med Mol Imaging. 2023 Jun 25;13(3):95-106. eCollection 2023. PMID: 37457324 

Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2-null rat model of glioblastoma. Jackson LR, Masi MR, Selman BM, Sandusky GE, Zarrinmayeh H, Das SK, Maharjan S, Wang N, Zheng QH, Pollok KE, Snyder SE, Sun PZ, Hutchins GD, Butch ER, Veronesi MC. Front Oncol. 2022 Nov 22;12:939260. doi: 10.3389/fonc.2022.939260. eCollection 2022. PMID: 36483050

Imaging ligands targeting glypican-3 receptor expression in hepatocellular carcinoma. Grega SD, Zheng DX, Zheng QH. Am J Nucl Med Mol Imaging. 2022 Aug 20;12(4):113-121. eCollection 2022. PMID: 36072763

Design, synthesis, and preclinical evaluation of a novel bifunctional macrocyclic chelator for theranostics of cancers. Xu JF, Cai F, Luo ZG, Fan WB, Dai J, Cui JJ, Li SH, Geng CR, Zheng QH, Wang Z, Tang XB. Eur J Nucl Med Mol Imaging. 2022 Jul;49(8):2618-2633. doi: 10.1007/s00259-022-05750-8. Epub 2022 Mar 26. PMID: 35347438

HRD1 attenuates the high uptake of [18F]FDG in hepatocellular carcinoma PET imaging. Li A, Lin X, Shen J, Li M, Zheng QH, Zhou Z, Shi M. Nucl Med Biol. 2021 May-Jun;96-97:27-34. doi: 10.1016/j.nucmedbio.2021.02.006. Epub 2021 Mar 11. PMID: 33725499

Radioligands targeting purinergic P2X7 receptor. Zheng QH. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127169. doi: 10.1016/j.bmcl.2020.127169. Epub 2020 Apr 3. Review. PMID: 32273217

Fully automated radiosynthesis and quality control of estrogen receptor targeting radiopharmaceutical 16α-[18F]fluoroestradiol ([18F]FES) for human breast cancer imaging. Wang M, Glick-Wilson BE, Zheng QH. Appl Radiat Isot. 2020 Jun;160:109109. doi: 10.1016/j.apradiso.2020.109109. Epub 2020 Mar 3. PMID: 32174461

Facile fully automated radiosynthesis and quality control of O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) for human brain tumor imaging. Wang M, Glick-Wilson BE, Zheng QH. Appl Radiat Isot. 2019 Dec;154:108852. doi: 10.1016/j.apradiso.2019.108852. Epub 2019 Aug 12. PMID: 31442794

Synthesis and in vitro biological evaluation of new P2X7R radioligands [11C]halo-GSK1482160 analogs. Gao M, Wang M, Meyer JA, Territo PR, Hutchins GD, Zarrinmayeh H, Zheng QH. Bioorg Med Chem Lett. 2019 Jun 15;29(12):1476-1480. doi: 10.1016/j.bmcl.2019.04.018. Epub 2019 Apr 10. PMID: 31005444

Synthesis and initial in vitro characterization of a new P2X7R radioligand [18F]IUR-1602. Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH. Appl Radiat Isot. 2019 Feb;144:10-18. doi: 10.1016/j.apradiso.2018.11.006. Epub 2018 Nov 16. PMID: 30476885

Synthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer's disease. Gao M, Wang M, Zheng QH. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2234-2238. doi: 10.1016/j.bmcl.2018.05.053. Epub 2018 May 29. PMID: 29859907

Synthesis and preliminary biological evaluation of a novel P2X7R radioligand [18F]IUR-1601. Gao M, Wang M, Glick-Wilson BE, Meyer JA, Peters JS, Territo PR, Green MA, Hutchins GD, Zarrinmayeh H, Zheng QH. Bioorg Med Chem Lett. 2018 May 15;28(9):1603-1609. doi: 10.1016/j.bmcl.2018.03.044. Epub 2018 Mar 17. PMID: 29628324

Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor. Wang M, Gao M, Meyer JA, Peters JS, Zarrinmayeh H, Territo PR, Hutchins GD, Zheng QH. Bioorg Med Chem. 2017 Jul 15;25(14):3835-3844. doi: 10.1016/j.bmc.2017.05.031. Epub 2017 May 18. PMID: 28554730

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