Kieren J. Mather, MD
Adjunct Professor of Medicine
Bio
Kieren Mather, MD, is a Professor of Medicine in the Department of Internal Medicine at IU School of Medicine. His expertise is in diabetes mellitus and prediabetes, with research efforts ranging from diabetes prevention to metabolic physiology to diabetes treatment. His overarching focus is on the prevention of diabetes-related complications, particularly cardiovascular disease.
Key Publications
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Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults. RISE Consortium. Pediatr Diabetes. 2019 Nov;20(7):849-860. doi: 10.1111/pedi.12883. Epub 2019 Jul 29. PMID: 31301210
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Does diabetes prevention translate into reduced long-term vascular complications of diabetes? Nathan DM, Bennett PH, Crandall JP, Edelstein SL, Goldberg RB, Kahn SE, Knowler WC, Mather KJ, Mudaliar S, Orchard TJ, Temprosa M, White NH; and the DPP Research Group. Diabetologia. 2019 Aug;62(8):1319-1328. doi: 10.1007/s00125-019-4928-8. Epub 2019 Jul 4. Review. PMID:31270584
Lack of Durable Improvements in β-Cell Function Following Withdrawal of Pharmacological Interventions in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes. RISE Consortium. Diabetes Care. 2019 Sep;42(9):1742-1751. doi: 10.2337/dc19-0556. Epub 2019 Jun 9. PMID:31178434
Effects of Treatment of Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes With Metformin Alone or in Combination With Insulin Glargine on β-Cell Function: Comparison of Responses In Youth And Adults. RISE Consortium; RISE Consortium Investigators. Diabetes. 2019 Aug;68(8):1670-1680. doi: 10.2337/db19-0299. Epub 2019 Jun 9. PMID: 31178433
Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization. Baker HE, Kiel AM, Luebbe ST, Simon BR, Earl CC, Regmi A, Roell WC, Mather KJ, Tune JD, Goodwill AG. Basic Res Cardiol. 2019 Apr 19;114(3):25. doi: 10.1007/s00395-019-0733-2. PMID: 31004234
Titles & Appointments
- Adjunct Professor of Medicine
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Education1992 MD University of Calgary1989 BSC University of Calgary
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Research
Dr Mather is interested in prevention of diabetes-related complications, particularly diabetes-associated cardiovascular disease.
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PublicationsMetabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.
Chen ZZ; Liu J; Morningstar J; Heckman-Stoddard BM; Lee CG; Dagogo-Jack S; Ferguson JF; Hamman RF; Knowler WC; Mather KJ; Perreault L; Florez JC; Wang TJ; Clish C; Temprosa M; Gerszten RE; Diabetes Prevention Program Research Group.; Diabetes 2019 Oct 3Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors.
Merino J; Jablonski KA; Mercader JM; Kahn SE; Chen L; Harden M; Delahanty LM; Araneta MRG; Walford GA; Jacobs SBR; Ibebuogu UN; Franks PW; Knowler WC; Florez JC; Diabetes Prevention Program Research Group.; Diabetes 2019 Oct 21Recruitment effort and costs from a multi-center randomized controlled trial for treating depression in type 2 diabetes.
Myers BA; Pillay Y; Guyton Hornsby W Jr; Shubrook J; Saha C; Mather KJ; Fitzpatrick K; de Groot M; Trials 2019 Nov 6Baseline Characteristics of Randomized Participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Wexler DJ; Krause-Steinrauf H; Crandall JP; Florez HJ; Hox SH; Kuhn A; Sood A; Underkofler C; Aroda VR; GRADE Research Group.; Diabetes care 2019 Aug 7Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS).
Perreault L; Pan Q; Aroda VR; Barrett-Connor E; Dabelea D; Dagogo-Jack S; Hamman RF; Kahn SE; Mather KJ; Knowler WC; Diabetes Prevention Program Research Group.; Diabetic medicine : a journal of the British Diabetic Association 2017 Sep 19Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation.
Herman WH; Pan Q; Edelstein SL; Mather KJ; Perreault L; Barrett-Connor E; Dabelea DM; Horton E; Kahn SE; Knowler WC; Lorenzo C; Pi-Sunyer X; Venditti E; Ye W; Diabetes Prevention Program Research Group.; Diabetes care 2017 Oct 11Depressive Symptoms, Antidepressant Medication Use, and Inflammatory Markers in the Diabetes Prevention Program.
de Groot M; Marrero D; Mele L; Doyle T; Schwartz F; Mather KJ; Goldberg R; Price DW; Ma Y; Knowler WC; Diabetes Prevention Program Research Group.; Psychosomatic medicine 2017 Oct 10Comparison of ß-Cell Function Between Overweight/Obese Adults and Adolescents Across the Spectrum of Glycemia.
Chen ME; Chandramouli AG; Considine RV; Hannon TS; Mather KJ; Diabetes care 2017 Nov 28Glucagon-Like Peptide 1 Receptor Activation Augments Cardiac Output and Improves Cardiac Efficiency in Obese Swine After Myocardial Infarction.
Sassoon DJ; Tune JD; Mather KJ; Noblet JN; Eagleson MA; Conteh AM; Sturek JT; Goodwill AG; Diabetes 2017 May 8Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium.
Goldberg RB; Aroda VR; Bluemke DA; Barrett-Connor E; Budoff M; Crandall JP; Dabelea D; Horton ES; Mather KJ; Orchard TJ; Schade D; Watson K; Temprosa M; Diabetes Prevention Program Research Group.; Circulation 2017 May 5The Confusion Assessment Method for the ICU-7 Delirium Severity Scale: A Novel Delirium Severity Instrument for Use in the ICU.
Khan BA; Perkins AJ; Gao S; Hui SL; Campbell NL; Farber MO; Chlan LL; Boustani MA; Critical care medicine 2017 MayFinding the Distribution Channels for Effective Transitional Care Services.
Khan BA; Alder CA; Boustani MA; Journal of the American Geriatrics Society 2017 Mar 29Review of methods for measuring ß-cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium.
Hannon TS; Kahn SE; Utzschneider KM; Buchanan TA; Nadeau KJ; Zeitler PS; Ehrmann DA; Arslanian SA; Caprio S; Edelstein SL; Savage PJ; Mather KJ; RISE Consortium.; Diabetes, obesity & metabolism 2017 Jun 22Cardiovascular consequences of metabolic syndrome.
Tune JD; Goodwill AG; Sassoon DJ; Mather KJ; Translational research : the journal of laboratory and clinical medicine 2017 Jan 9Erratum to: "Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the diabetes prevention program" [Metabolism (2016) 65; 764-775].
Goldberg RB; Temprosa M; Mele L; Orchard T; Mather K; Bray G; Horton E; Kitabchi A; Krakoff J; Marcovina S; Perreault L; White N; Diabetes Prevention Program Research Group.; Metabolism: clinical and experimental 2017 Jan 5Retinopathy predicts progression of fasting plasma glucose: An Early Diabetes Intervention Program (EDIP) analysis.
Patel YR; Kirkman MS; Considine RV; Hannon TS; Mather KJ; Journal of diabetes and its complications 2016 Nov 12Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism.
Sassoon DJ; Goodwill AG; Noblet JN; Conteh AM; Herring BP; McClintick JN; Tune JD; Mather KJ; Basic research in cardiology 2016 May 27Testosterone and depressive symptoms among men in the Diabetes Prevention Program.
Kim C; Barrett-Connor E; Aroda VR; Mather KJ; Christophi CA; Horton ES; Pi-Sunyer X; Bray GA; Labrie F; Golden SH; Diabetes Prevention Program Research Group.; Psychoneuroendocrinology 2016 Jun 15Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-[18F]fluoro-4-thiapalmitate, a novel PET fatty acid tracer.
Mather KJ; Hutchins GD; Perry K; Territo W; Chisholm R; Acton A; Glick-Wilson B; Considine RV; Moberly S; DeGrado TR; American journal of physiology. Endocrinology and metabolism 2016 Jan 5Imaging of myocardial fatty acid oxidation.
Mather KJ; DeGrado TR; Biochimica et biophysica acta 2016 Feb 27Changes in Weight and Glucose Can Protect Against Progression in Early Diabetes Independent of Improvements in ß-Cell Function.
Patel YR; Kirkman MS; Considine RV; Hannon TS; Mather KJ; The Journal of clinical endocrinology and metabolism 2016 Aug 17Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study.
Diabetes Prevention Program Research Group.; The lancet. Diabetes & endocrinology 2015 Sep 13Response.
Thosar SS; Wallace JP; Mather KJ; Medicine and science in sports and exercise 2015 SepLifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Hivert MF; Christophi CA; Franks PW; Jablonski KA; Ehrmann DA; Kahn SE; Horton ES; Pollin TI; Mather KJ; Perreault L; Barrett-Connor E; Knowler WC; Florez JC; Diabetes Prevention Program Research Group; Diabetes 2015 Nov 2Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.
Fisher MM; Watkins RA; Blum J; Evans-Molina C; Chalasani N; DiMeglio LA; Mather KJ; Tersey SA; Mirmira RG; Diabetes 2015 Jul 27Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.
Mather KJ; Kim C; Christophi CA; Aroda VR; Knowler WC; Edelstein SE; Florez JC; Labrie F; Kahn SE; Goldberg RB; Barrett-Connor E; Diabetes Prevention Program; The Journal of clinical endocrinology and metabolism 2015 Jul 22Change in adiponectin explains most of the change in HDL particles induced by lifestyle intervention but not metformin treatment in the Diabetes Prevention Program.
Goldberg RB; Temprosa M; Mele L; Orchard T; Mather K; Bray G; Horton E; Kitabchi A; Krakoff J; Marcovina S; Perreault L; White N; Diabetes Prevention Program Research Group.; Metabolism: clinical and experimental 2015 Dec 2Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion in the Diabetes Prevention Program Cohort.
Mather KJ; Pan Q; Knowler WC; Funahashi T; Bray GA; Arakaki R; Falkner B; Sharma K; Goldstein BJ; DPP Research Group; PloS one 2015 Aug 27Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting.
Thosar SS; Bielko SL; Wiggins CC; Klaunig JE; Mather KJ; Wallace JP; Medical science monitor : international medical journal of experimental and clinical research 2015 Apr 7Cardiovascular and hemodynamic effects of glucagon-like peptide-1.
Goodwill AG; Mather KJ; Conteh AM; Sassoon DJ; Noblet JN; Tune JD; Reviews in endocrine & metabolic disorders 2014 SepExtrapancreatic effects of GLP-1 and other incretins.
Mather K; Reviews in endocrine & metabolic disorders 2014 SepFailure of hyperglycemia and hyperinsulinemia to compensate for impaired metabolic response to an oral glucose load.
Hussain M; Janghorbani M; Schuette S; Considine RV; Chisholm RL; Mather KJ; Journal of diabetes and its complications 2014 Nov 24Profound defects in ß-cell function in screen-detected type 2 diabetes are not improved with glucose-lowering treatment in the Early Diabetes Intervention Program (EDIP).
Hannon TS; Kirkman MS; Patel YR; Considine RV; Mather KJ; Diabetes/metabolism research and reviews 2014 Novß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Halban PA; Polonsky KS; Bowden DW; Hawkins MA; Ling C; Mather KJ; Powers AC; Rhodes CJ; Sussel L; Weir GC; Diabetes care 2014 May 8Lifestyle and metformin interventions have a durable effect to lower CRP and tPA levels in the diabetes prevention program except in those who develop diabetes.
Goldberg RB; Temprosa MG; Mather KJ; Orchard TJ; Kitabchi AE; Watson KE; Diabetes Prevention Program Research Group; Diabetes care 2014 May 13Does hormone therapy affect blood pressure changes in the Diabetes Prevention Program?
Kim C; Golden SH; Kong S; Nan B; Mather KJ; Barrett-Connor E; Diabetes Prevention Program Research Group; Menopause (New York, N.Y.) 2014 MayRegression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes study.
Perreault L; Temprosa M; Mather KJ; Horton E; Kitabchi A; Larkin M; Montez MG; Thayer D; Orchard TJ; Hamman RF; Goldberg RB; Diabetes Prevention Program Research Group; Diabetes care 2014 Jun 26Glucagon-like peptide-1 (7-36) but not (9-36) augments cardiac output during myocardial ischemia via a Frank-Starling mechanism.
Goodwill AG; Tune JD; Noblet JN; Conteh AM; Sassoon D; Casalini ED; Mather KJ; Basic research in cardiology 2014 Jul 9Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program.
Walford GA; Ma Y; Christophi CA; Goldberg RB; Jarolim P; Horton E; Mather KJ; Barrett-Connor E; Davis J; Florez JC; Wang TJ; Diabetes Prevention Program Research Group.; Diabetologia 2014 Feb 20Short and long-term lifestyle coaching approaches used to address diverse participant barriers to weight loss and physical activity adherence.
Venditti EM; Wylie-Rosett J; Delahanty LM; Mele L; Hoskin MA; Edelstein SL; Diabetes Prevention Program Research Group.; The international journal of behavioral nutrition and physical activity 2014 Feb 12Effect of Prolonged Sitting and Breaks in Sitting Time on Endothelial Function.
Thosar SS; Bielko SL; Mather KJ; Johnston JD; Wallace JP; Medicine and science in sports and exercise 2014 Aug 18ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Halban PA; Polonsky KS; Bowden DW; Hawkins MA; Ling C; Mather KJ; Powers AC; Rhodes CJ; Sussel L; Weir GC; The Journal of clinical endocrinology and metabolism 2014 Apr 8Metabolic syndrome components and their response to lifestyle and metformin interventions are associated with differences in diabetes risk in persons with impaired glucose tolerance.
Florez H; Temprosa MG; Orchard TJ; Mather KJ; Marcovina SM; Barrett-Connor E; Horton E; Saudek C; Pi-Sunyer XF; Ratner RE; Goldberg RB; Diabetes Prevention Program Research Group.; Diabetes, obesity & metabolism 2013 Oct 29Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD).
Goldfine AB; Buck JS; Desouza C; Fonseca V; Chen YD; Shoelson SE; Jablonski KA; Creager MA; TINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team.; Diabetes care 2013 Oct 15[13C]glucose breath testing provides a noninvasive measure of insulin resistance: calibration analyses against clamp studies.
Hussain M; Jangorbhani M; Schuette S; Considine RV; Chisholm RL; Mather KJ; Diabetes technology & therapeutics 2013 Oct 11Effect of acarbose to delay progression of carotid intima-media thickness in early diabetes.
Patel YR; Kirkman MS; Considine RV; Hannon TS; Mather KJ; Diabetes/metabolism research and reviews 2013 OctRestoring Insulin Secretion (RISE): design of studies of ß-cell preservation in prediabetes and early type 2 diabetes across the life span.
RISE Consortium.; Diabetes care 2013 Nov 5Impact of diagnosis of diabetes on health-related quality of life among high risk individuals: the Diabetes Prevention Program outcomes study.
Marrero D; Pan Q; Barrett-Connor E; de Groot M; Zhang P; Percy C; Florez H; Ackermann R; Montez M; Rubin RR; DPPOS Research Group; Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 2013 May 26Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE).
Nathan DM; Buse JB; Kahn SE; Krause-Steinrauf H; Larkin ME; Staten M; Wexler D; Lachin JM; GRADE Study Research Group.; Diabetes care 2013 May 20Insulin resistance in the vasculature.
Mather KJ; Steinberg HO; Baron AD; The Journal of clinical investigation 2013 Mar 1The vascular endothelium in diabetes--a therapeutic target?
Mather KJ; Reviews in endocrine & metabolic disorders 2013 MarImpaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus.
Moberly SP; Mather KJ; Berwick ZC; Owen MK; Goodwill AG; Casalini ED; Hutchins GD; Green MA; Ng Y; Considine RV; Perry KM; Chisholm RL; Tune JD; Basic research in cardiology 2013 Jun 14Detection of islet ß-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.
Fisher MM; Perez Chumbiauca CN; Mather KJ; Mirmira RG; Tersey SA; Endocrinology 2013 Jul 3Clinical use of adiponectin as a marker of metabolic dysregulation.
Mather KJ; Goldberg RB; Best practice & research. Clinical endocrinology & metabolism 2013 Jul 22Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial.
Goldfine AB; Fonseca V; Jablonski KA; Chen YD; Tipton L; Staten MA; Shoelson SE; Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team.; Annals of internal medicine 2013 Jul 2Equivalence of arterial and venous blood for [11C]CO2-metabolite analysis following intravenous administration of 1-[11C]acetate and 1-[11C]palmitate.
Ng Y; Moberly SP; Mather KJ; Brown-Proctor C; Hutchins GD; Green MA; Nuclear medicine and biology 2013 Jan 8Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program.
Goldberg R; Temprosa M; Otvos J; Brunzell J; Marcovina S; Mather K; Arakaki R; Watson K; Horton E; Barrett-Connor E; The Journal of clinical endocrinology and metabolism 2013 Aug 26Sex steroid levels and response to weight loss interventions among postmenopausal women in the diabetes prevention program.
Kim C; Barrett-Connor E; Randolph JF; Kong S; Nan B; Mather KJ; Golden SH; Diabetes Prevention Program Research Group.; Obesity (Silver Spring, Md.) 2013 Aug 23Pentoxifylline, inflammation, and endothelial function in HIV-infected persons: a randomized, placebo-controlled trial.
Gupta SK; Mi D; Dubé MP; Saha CK; Johnson RM; Stein JH; Clauss MA; Mather KJ; Desta Z; Liu Z; PloS one 2013 Apr 9Reductions in glucose among postmenopausal women who use and do not use estrogen therapy.
Kim C; Kong S; Laughlin GA; Golden SH; Mather KJ; Nan B; Randolph JF Jr; Edelstein SL; Labrie F; Buschur E; Barrett-Connor E; Diabetes Prevention Program Research Group.; Menopause (New York, N.Y.) 2013 AprTargeting the consequences of the metabolic syndrome in the Diabetes Prevention Program.
Goldberg RB; Mather K; Arteriosclerosis, thrombosis, and vascular biology 2012 SepConfirming glycemic status in the Diabetes Prevention Program: implications for diagnosing diabetes in high risk adults.
Christophi CA; Resnick HE; Ratner RE; Temprosa M; Fowler S; Knowler WC; Shamoon H; Barrett-Connor E; Kahn SE; Diabetes Prevention Program Research Group.; Journal of diabetes and its complications 2012 Nov 7Vitamin C prevents the acute decline of flow-mediated dilation after altered shear rate patterns.
Johnson BD; Mather KJ; Newcomer SC; Mickleborough TD; Wallace JP; Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2012 Nov 21Measuring the transition to diabetes.
Hannon TS; Mather KJ; Journal of diabetes and its complications 2012 Nov 17Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study.
Perreault L; Pan Q; Mather KJ; Watson KE; Hamman RF; Kahn SE; Diabetes Prevention Program Research Group.; Lancet (London, England) 2012 Jun 9The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program.
Florez JC; Jablonski KA; Taylor A; Mather K; Horton E; White NH; Barrett-Connor E; Knowler WC; Shuldiner AR; Pollin TI; Diabetes Prevention Program Research Group.; Diabetes care 2012 Jun 29Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program.
Kim C; Kong S; Laughlin GA; Golden SH; Mather KJ; Nan B; Edelstein SL; Randolph JF Jr; Labrie F; Buschur E; Barrett-Connor E; The Journal of clinical endocrinology and metabolism 2012 Jun 11Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow.
Moberly SP; Berwick ZC; Kohr M; Svendsen M; Mather KJ; Tune JD; Experimental biology and medicine (Maywood, N.J.) 2012 Feb 16Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.
Mather KJ; Christophi CA; Jablonski KA; Knowler WC; Goldberg RB; Kahn SE; Spector T; Dastani Z; Waterworth D; Richards JB; Funahashi T; Pi-Sunyer FX; Pollin TI; Florez JC; Franks PW; Diabetes Prevention Program Research Group; Diabetic medicine : a journal of the British Diabetic Association 2012 DecRacial/ethnic differences in sex hormone levels among postmenopausal women in the diabetes prevention program.
Kim C; Golden SH; Mather KJ; Laughlin GA; Kong S; Nan B; Barrett-Connor E; Randolph JF Jr; Diabetes Prevention Program Research Group.; The Journal of clinical endocrinology and metabolism 2012 Aug 9Brachial artery flow-mediated dilation following exercise with augmented oscillatory and retrograde shear rate.
Johnson BD; Mather KJ; Newcomer SC; Mickleborough TD; Wallace JP; Cardiovascular ultrasound 2012 Aug 11Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Gupta SK; Shen C; Mather KJ; Agarwal R; Dubé MP; The Journal of infectious diseases 2011 Oct 19Mechanotransduction of shear in the endothelium: basic studies and clinical implications.
Johnson BD; Mather KJ; Wallace JP; Vascular medicine (London, England) 2011 OctEffects of losartan on whole body, skeletal muscle and vascular insulin responses in obesity/insulin resistance without hypertension.
Lteif AA; Chisholm RL; Gilbert K; Considine RV; Mather KJ; Diabetes, obesity & metabolism 2011 Nov 24Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans.
Han KA; Patel Y; Lteif AA; Chisholm R; Mather KJ; Diabetes/metabolism research and reviews 2011 MayA cross-sectional evaluation of seasonality as a determinant of endothelial function.
Patel YR; Han KA; Lteif AA; Wallace JP; Mather KJ; Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2011 Jul 3TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program.
McCaffery JM; Jablonski KA; Franks PW; Dagogo-Jack S; Wing RR; Knowler WC; Delahanty L; Dabelea D; Hamman R; Shuldiner AR; Florez JC; Diabetes Prevention Program Research Group.; PloS one 2011 Jul 26Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
Delahanty LM; Pan Q; Jablonski KA; Watson KE; McCaffery JM; Shuldiner A; Kahn SE; Knowler WC; Florez JC; Franks PW; Diabetes Prevention Program Research Group.; Diabetes care 2011 Dec 16Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes.
Garber A; Henry RR; Ratner R; Hale P; Chang CT; Bode B; LEAD-3 (Mono) Study Group.; Diabetes, obesity & metabolism 2011 AprInfluence of motor complete spinal cord injury on visceral and subcutaneous adipose tissue measured by multi-axial magnetic resonance imaging.
Gorgey AS; Mather KJ; Poarch HJ; Gater DR; The journal of spinal cord medicine 2011Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study.
Gupta SK; Johnson RM; Mather KJ; Clauss M; Rehman J; Saha C; Desta Z; Dubé MP; AIDS (London, England) 2010 Jun 1Intra-individual variability of CO2 breath isotope enrichment compared to blood glucose in the oral glucose tolerance test.
Singal P; Janghorbani M; Schuette SA; Chisholm R; Mather KJ; Diabetes technology & therapeutics 2010 DecAntidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
Rubin RR; Ma Y; Peyrot M; Marrero DG; Price DW; Barrett-Connor E; Knowler WC; Diabetes Prevention Program Research Group.; Diabetes care 2010 Aug 30Relationship of body composition, metabolic status, antiretroviral use, and HIV disease factors to endothelial dysfunction in HIV-infected subjects.
Dubé MP; Shen C; Mather KJ; Waltz J; Greenwald M; Gupta SK; AIDS research and human retroviruses 2010 Aug10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study.
Diabetes Prevention Program Research Group.; Knowler WC; Fowler SE; Hamman RF; Christophi CA; Hoffman HJ; Brenneman AT; Brown-Friday JO; Goldberg R; Venditti E; Nathan DM; Lancet (London, England) 2009 Oct 29Simple modeling allows prediction of steady-state glucose disposal rate from early data in hyperinsulinemic glucose clamps.
Singal P; Muniyappa R; Chisholm R; Hall G; Chen H; Quon MJ; Mather KJ; American journal of physiology. Endocrinology and metabolism 2009 Nov 17Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk.
Padilla J; Johnson BD; Newcomer SC; Wilhite DP; Mickleborough TD; Fly AD; Mather KJ; Wallace JP; Journal of vascular research 2009 Jun 30Role of endogenous ET-1 in the regulation of myocardial blood flow in lean and obese humans.
Mather KJ; Lteif AA; Veeneman E; Fain R; Giger S; Perry K; Hutchins GD; Obesity (Silver Spring, Md.) 2009 Jun 18Effect of progression from impaired glucose tolerance to diabetes on cardiovascular risk factors and its amelioration by lifestyle and metformin intervention: the Diabetes Prevention Program randomized trial by the Diabetes Prevention Program Research Group.
Goldberg RB; Temprosa M; Haffner S; Orchard TJ; Ratner RE; Fowler SE; Mather K; Marcovina S; Saudek C; Matulik MJ; Price D; Diabetes Prevention Program Research Group.; Diabetes care 2009 Jan 26Surrogate measures of insulin resistance: of rats, mice, and men.
Mather K; American journal of physiology. Endocrinology and metabolism 2009 FebNormalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus.
Padilla J; Johnson BD; Newcomer SC; Wilhite DP; Mickleborough TD; Fly AD; Mather KJ; Wallace JP; Cardiovascular ultrasound 2008 Sep 4Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans.
Lteif AA; Fulford AD; Considine RV; Gelfand I; Baron AD; Mather KJ; American journal of physiology. Endocrinology and metabolism 2008 Oct 28Relationship between brachial artery flow-mediated dilatation, hyperemic shear stress, and the metabolic syndrome.
Title LM; Lonn E; Charbonneau F; Fung M; Mather KJ; Verma S; Anderson TJ; Vascular medicine (London, England) 2008 NovEndothelin contributes differently to peripheral vascular tone and blood pressure in human obesity and diabetes.
Yoon N; Lteif AA; Han K; Mather KJ; Journal of the American Society of Hypertension : JASH 2008 MayImprovement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study.
Gupta SK; Johnson RM; Saha C; Mather KJ; Greenwald ML; Waltz JS; Rehman J; Dubé MP; AIDS (London, England) 2008 Mar 12Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
Moore AF; Jablonski KA; McAteer JB; Saxena R; Pollin TI; Franks PW; Hanson RL; Shuldiner AR; Knowler WC; Altshuler D; Florez JC; Diabetes Prevention Program Research Group.; Diabetes 2008 Jun 10Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program.
Mather KJ; Funahashi T; Matsuzawa Y; Edelstein S; Bray GA; Kahn SE; Crandall J; Marcovina S; Goldstein B; Goldberg R; Diabetes Prevention Program; Diabetes 2008 Jan 11First versus repeat treatment with a lifestyle intervention program: attendance and weight loss outcomes.
Venditti EM; Bray GA; Carrion-Petersen ML; Delahanty LM; Edelstein SL; Hamman RF; Hoskin MA; Knowler WC; Ma Y; Diabetes Prevention Program Research Group.; International journal of obesity (2005) 2008 Aug 19No impairment of endothelial function or insulin sensitivity with 4 weeks of the HIV protease inhibitors atazanavir or lopinavir-ritonavir in healthy subjects without HIV infection: a placebo-controlled trial.
Dubé MP; Shen C; Greenwald M; Mather KJ; Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008 Aug 15Endothelin limits insulin action in obese/insulin-resistant humans.
Lteif A; Vaishnava P; Baron AD; Mather KJ; Diabetes 2007 MarProteinuria and endothelial dysfunction in stable HIV-infected patients. A pilot study.
Gupta SK; Mather KJ; Agarwal R; Saha CK; Considine RV; Dubé MP; Journal of acquired immune deficiency syndromes (1999) 2007 Aug 15Blood pressure response to type A endothelin receptor antagonism in human obesity and diabetes mellitus.
Han KA; Lteif AA; Mather KJ; Journal of human hypertension 2006 Jul 20Interactions of endothelin and insulin: expanding parameters of insulin resistance.
Strawbridge AB; Elmendorf JS; Mather KJ; Current diabetes reviews 2006 AugIntensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance.
Haffner S; Temprosa M; Crandall J; Fowler S; Goldberg R; Horton E; Marcovina S; Mather K; Orchard T; Ratner R; Barrett-Connor E; Diabetes Prevention Program Research Group.; Diabetes 2005 MayInsulin and endothelin in the acute regulation of adiponectin in vivo in humans.
Brame LA; Considine RV; Yamauchi M; Baron AD; Mather KJ; Obesity research 2005 MarObesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks.
Lteif AA; Han K; Mather KJ; Circulation 2005 Jun 27Function determines structure in the vasculature: lessons from insulin resistance.
Mather K; Verma S; American journal of physiology. Regulatory, integrative and comparative physiology 2005 AugMeasurement of arterial stiffness in diabetes: a cautionary tale.
Mather K; Lewanczuk R; Diabetes care 2004 MarInsulin resistance as a therapeutic target for improved endothelial function: metformin.
Brame L; Verma S; Anderson T; Lteif A; Mather K; Current drug targets. Cardiovascular & haematological disorders 2004 MarInteractions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes.
Mather KJ; Lteif A; Steinberg HO; Baron AD; Diabetes 2004 AugWeight loss and endothelial function in obesity.
Mather KJ; Steinberg HO; Baron AD; Diabetes care 2003 JunEndothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes.
Mather KJ; Mirzamohammadi B; Lteif A; Steinberg HO; Baron AD; Diabetes 2002 DecRepeatability characteristics of simple indices of insulin resistance: implications for research applications.
Mather KJ; Hunt AE; Steinberg HO; Paradisi G; Hook G; Katz A; Quon MJ; Baron AD; The Journal of clinical endocrinology and metabolism 2001 NovPrevalence of IgA-antiendomysial antibody in asymptomatic low bone mineral density.
Mather KJ; Meddings JB; Beck PL; Scott RB; Hanley DA; The American journal of gastroenterology 2001 JanEndothelin receptor blockade improves endothelial function in human internal mammary arteries.
Verma S; Lovren F; Dumont AS; Mather KJ; Maitland A; Kieser TM; Kidd W; McNeill JH; Stewart DJ; Triggle CR; Anderson TJ; Cardiovascular research 2001 JanCyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers: randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation.
Verma S; Raj SR; Shewchuk L; Mather KJ; Anderson TJ; Circulation 2001 Dec 11Improved endothelial function with metformin in type 2 diabetes mellitus.
Mather KJ; Verma S; Anderson TJ; Journal of the American College of Cardiology 2001 AprTetrahydrobiopterin improves endothelial function in human saphenous veins.
Verma S; Lovren F; Dumont AS; Mather KJ; Maitland A; Kieser TM; Triggle CR; Anderson TJ; The Journal of thoracic and cardiovascular surgery 2000 OctNormal endothelial function despite insulin resistance in healthy women with the polycystic ovary syndrome.
Mather KJ; Verma S; Corenblum B; Anderson TJ; The Journal of clinical endocrinology and metabolism 2000 MayQuantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.
Katz A; Nambi SS; Mather K; Baron AD; Follmann DA; Sullivan G; Quon MJ; The Journal of clinical endocrinology and metabolism 2000 JulHyperinsulinemia in polycystic ovary syndrome correlates with increased cardiovascular risk independent of obesity.
Mather KJ; Kwan F; Corenblum B; Fertility and sterility 2000 JanPreserved forearm endothelial responses with acute exposure to progesterone: A randomized cross-over trial of 17-beta estradiol, progesterone, and 17-beta estradiol with progesterone in healthy menopausal women.
Mather KJ; Norman EG; Prior JC; Elliott TG; The Journal of clinical endocrinology and metabolism 2000 DecEvidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow.
Mather K; Laakso M; Edelman S; Hook G; Baron A; American journal of physiology. Endocrinology and metabolism 2000 DecMaintenance of serum calcium by parathyroid hormone-related peptide during lactation in a hypoparathyroid patient.
Mather KJ; Chik CL; Corenblum B; The Journal of clinical endocrinology and metabolism 1999 FebOffice hypertension in type 2 (non-insulin-dependent) diabetic patients.
Burgess E; Mather K; Ross S; Josefsberg Z; Diabetologia 1991 Sep -
Professional OrganizationsAmerican Diabetes Association
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Board CertificationsEndocrinologyAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
Diabetes and metabolism
Cardiac disease in diabetes
Diabetes medicine effects on cardiac disease
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