Robert L. Bacallao, MD
Professor Emeritus of Medicine
- Phone
- (317) 278-0471
- Address
-
Research II, Suite E202
950 W Walnut St
R2 E202
Indianapolis, IN 46202-5188 - PubMed:
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| Year | Degree | Institution |
|---|---|---|
| 1980 | MD | University of Illinois |
| 1976 | BS | Northwestern University |
My scientific focus has centered on the question as to how epithelial cells organize toform a functioning epithelium. Epithelial cells perform the absorptive and secretoryfunctions of an organism and these activities frequently require the generation oftremendous ionic, electrical and pressure gradients. These gradients are achieved bythe unique structural and functional organization of epithelial plasma membranes. Wehave studied how this organization is achieved by examining processes that disrupt thepolarized features of epithelial. Ischemic injury has been shown to cause profoundderangements in epithelial organization and this is an area of intensive investigation inmy laboratory.A second disease process that has been shown to disrupt the polarized phenotype ofepithelial cells is autosomal dominant polycystic kidney disease (ADPKD). Proteinsorting defects and Golgi complex dysfunction have been described in epithelial cellsderived from ADPKD kidneys. A gene responsible for this disease has recently beenidentified and has been called PKD1. Computer analysis of the PKD1 gene sequencesuggests that the gene product is a transmembrane protein which interacts with theextracellular matrix. However, a definitive function for the PKD1 gene product has notbeen discovered. This is the second area of research activity in my laboratory. Weemploy a variety of biochemical, molecular and cell biology methods to address thesescientific questions.
Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability
Danielle Janosevic, Josephine Axis, Robert L. Bacallao, Kurt Amsler Journal of Cellular Biochemistry September 8, 2015
Danielle Janosevic, Josephine Axis, Robert L. Bacallao, Kurt Amsler Journal of Cellular Biochemistry September 8, 2015
Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells.
Jamal MH; Nunes ACF; Vaziri ND; Ramchandran R; Bacallao RL; Nauli AM; Nauli SM; Biochemical pharmacology 2020 May 26
Jamal MH; Nunes ACF; Vaziri ND; Ramchandran R; Bacallao RL; Nauli AM; Nauli SM; Biochemical pharmacology 2020 May 26
Lowe syndrome patient cells display mTOR- and RhoGTPase-dependent phenotypes alleviated by rapamycin and statins.
Madhivanan K; Ramadesikan S; Hsieh WC; Aguilar MC; Hanna CB; Bacallao RL; Aguilar RC; Human molecular genetics 2020 Jun 27
Madhivanan K; Ramadesikan S; Hsieh WC; Aguilar MC; Hanna CB; Bacallao RL; Aguilar RC; Human molecular genetics 2020 Jun 27
Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.
Kolb AL; Corridon PR; Zhang S; Xu W; Witzmann FA; Collett JA; Rhodes GJ; Winfree S; Bready D; Pfeffenberger ZJ; Pomerantz JM; Hato T; Nagami GT; Molitoris BA; Basile DP; Atkinson SJ; Bacallao RL; 2018 Jan 25
Kolb AL; Corridon PR; Zhang S; Xu W; Witzmann FA; Collett JA; Rhodes GJ; Winfree S; Bready D; Pfeffenberger ZJ; Pomerantz JM; Hato T; Nagami GT; Molitoris BA; Basile DP; Atkinson SJ; Bacallao RL; 2018 Jan 25
Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
Eadon MT; Hause RJ; Stark AL; Cheng YH; Wheeler HE; Burgess KS; Benson EA; Cunningham PN; Bacallao RL; Dagher PC; Skaar TC; Dolan ME; International journal of molecular sciences 2017 Mar 18
Eadon MT; Hause RJ; Stark AL; Cheng YH; Wheeler HE; Burgess KS; Benson EA; Cunningham PN; Bacallao RL; Dagher PC; Skaar TC; Dolan ME; International journal of molecular sciences 2017 Mar 18
Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys.
Collett JA; Corridon PR; Mehrotra P; Kolb AL; Rhodes GJ; Miller CA; Molitoris BA; Pennington JG; Sandoval RM; Atkinson SJ; Campos-Bilderback SB; Basile DP; Bacallao RL; Journal of the American Society of Nephrology : JASN 2017 Jan 25
Collett JA; Corridon PR; Mehrotra P; Kolb AL; Rhodes GJ; Miller CA; Molitoris BA; Pennington JG; Sandoval RM; Atkinson SJ; Campos-Bilderback SB; Basile DP; Bacallao RL; Journal of the American Society of Nephrology : JASN 2017 Jan 25
<i>In Vivo</i> siRNA Delivery and Rebound of Renal <i>LRP2</i> in Mice.
Eadon MT; Cheng YH; Hato T; Benson EA; Ipe J; Collins KS; De Luca T; El-Achkar TM; Bacallao RL; Skaar TC; Dagher PC; Journal of drug delivery 2017 Dec 20
Eadon MT; Cheng YH; Hato T; Benson EA; Ipe J; Collins KS; De Luca T; El-Achkar TM; Bacallao RL; Skaar TC; Dagher PC; Journal of drug delivery 2017 Dec 20
Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD.
de Almeida RM; Clendenon SG; Richards WG; Boedigheimer M; Damore M; Rossetti S; Harris PC; Herbert BS; Xu WM; Wandinger-Ness A; Ward HH; Glazier JA; Bacallao RL; Human genomics 2016 Nov 21
de Almeida RM; Clendenon SG; Richards WG; Boedigheimer M; Damore M; Rossetti S; Harris PC; Herbert BS; Xu WM; Wandinger-Ness A; Ward HH; Glazier JA; Bacallao RL; Human genomics 2016 Nov 21
Virtual-Tissue Computer Simulations Define the Roles of Cell Adhesion and Proliferation in the Onset of Kidney Cystic Disease.
Belmonte JM; Clendenon SG; Oliveira GM; Swat MH; Greene EV; Jeyaraman S; Glazier JA; Bacallao RL; Molecular biology of the cell 2016 May 18
Belmonte JM; Clendenon SG; Oliveira GM; Swat MH; Greene EV; Jeyaraman S; Glazier JA; Bacallao RL; Molecular biology of the cell 2016 May 18
Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.
Avin KG; Chen NX; Organ JM; Zarse C; O'Neill K; Conway RG; Konrad RJ; Bacallao RL; Allen MR; Moe SM; PloS one 2016 Aug 3
Avin KG; Chen NX; Organ JM; Zarse C; O'Neill K; Conway RG; Konrad RJ; Bacallao RL; Allen MR; Moe SM; PloS one 2016 Aug 3
Occludin Content Modulates Hydrogen Peroxide-Induced Increase in Renal Epithelial Paracellular Permeability.
Janosevic D; Axis J; Bacallao RL; Amsler K; Journal of cellular biochemistry 2015 Sep 17
Janosevic D; Axis J; Bacallao RL; Amsler K; Journal of cellular biochemistry 2015 Sep 17
Dichloroacetate treatment accelerates the development of pathology in rodent autosomal recessive polycystic kidney disease.
Gattone VH 2nd; Bacallao RL; American journal of physiology. Renal physiology 2014 Sep 18
Gattone VH 2nd; Bacallao RL; American journal of physiology. Renal physiology 2014 Sep 18
Management of Pain in Autosomal Dominant Polycystic Kidney Disease and Anatomy of Renal Innervation.
Tellman MW; Bahler CD; Shumate AM; Bacallao RL; Sundaram CP; The Journal of urology 2014 Dec 19
Tellman MW; Bahler CD; Shumate AM; Bacallao RL; Sundaram CP; The Journal of urology 2014 Dec 19
Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.
Aboualaiwi WA; Muntean BS; Ratnam S; Joe B; Liu L; Booth RL; Rodriguez I; Herbert BS; Bacallao RL; Fruttiger M; Mak TW; Zhou J; Nauli SM; Circulation 2013 Nov 14
Aboualaiwi WA; Muntean BS; Ratnam S; Joe B; Liu L; Booth RL; Rodriguez I; Herbert BS; Bacallao RL; Fruttiger M; Mak TW; Zhou J; Nauli SM; Circulation 2013 Nov 14
A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors.
Corridon PR; Rhodes GJ; Leonard EC; Basile DP; Gattone VH 2nd; Bacallao RL; Atkinson SJ; American journal of physiology. Renal physiology 2013 Mar 6
Corridon PR; Rhodes GJ; Leonard EC; Basile DP; Gattone VH 2nd; Bacallao RL; Atkinson SJ; American journal of physiology. Renal physiology 2013 Mar 6
Inversin modulates the cortical actin network during mitosis.
Werner ME; Ward HH; Phillips CL; Miller C; Gattone VH; Bacallao RL; American journal of physiology. Cell physiology 2013 Mar 20
Werner ME; Ward HH; Phillips CL; Miller C; Gattone VH; Bacallao RL; American journal of physiology. Cell physiology 2013 Mar 20
A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1.
Herbert BS; Grimes BR; Xu WM; Werner M; Ward C; Rossetti S; Harris P; Bello-Reuss E; Ward HH; Miller C; Gattone VH 2nd; Phillips CL; Wandinger-Ness A; Bacallao RL; PloS one 2013 Jan 28
Herbert BS; Grimes BR; Xu WM; Werner M; Ward C; Rossetti S; Harris P; Bello-Reuss E; Ward HH; Miller C; Gattone VH 2nd; Phillips CL; Wandinger-Ness A; Bacallao RL; PloS one 2013 Jan 28
Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture.
Kher R; Sha EC; Escobar MR; Andreoli EM; Wang P; Xu WM; Wandinger-Ness A; Bacallao RL; American journal of physiology. Cell physiology 2011 Mar 9
Kher R; Sha EC; Escobar MR; Andreoli EM; Wang P; Xu WM; Wandinger-Ness A; Bacallao RL; American journal of physiology. Cell physiology 2011 Mar 9
MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury.
Lee SY; Hörbelt M; Mang HE; Knipe NL; Bacallao RL; Sado Y; Sutton TA; American journal of physiology. Renal physiology 2011 Mar 30
Lee SY; Hörbelt M; Mang HE; Knipe NL; Bacallao RL; Sado Y; Sutton TA; American journal of physiology. Renal physiology 2011 Mar 30
Calcimimetics inhibit renal pathology in rodent nephronophthisis.
Chen NX; Moe SM; Eggleston-Gulyas T; Chen X; Hoffmeyer WD; Bacallao RL; Herbert BS; Gattone VH 2nd; Kidney international 2011 Jun 1
Chen NX; Moe SM; Eggleston-Gulyas T; Chen X; Hoffmeyer WD; Bacallao RL; Herbert BS; Gattone VH 2nd; Kidney international 2011 Jun 1
Lysophosphatidic acid is a modulator of cyst growth in autosomal dominant polycystic kidney disease.
Blazer-Yost BL; Blacklock BJ; Flaig S; Bacallao RL; Gattone VH; Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011 Dec 16
Blazer-Yost BL; Blacklock BJ; Flaig S; Bacallao RL; Gattone VH; Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011 Dec 16
Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells.
Babbey CM; Bacallao RL; Dunn KW; American journal of physiology. Renal physiology 2010 Jun 24
Babbey CM; Bacallao RL; Dunn KW; American journal of physiology. Renal physiology 2010 Jun 24
Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.
Basile DP; Friedrich JL; Spahic J; Knipe N; Mang H; Leonard EC; Changizi-Ashtiyani S; Bacallao RL; Molitoris BA; Sutton TA; American journal of physiology. Renal physiology 2010 Dec 1
Basile DP; Friedrich JL; Spahic J; Knipe N; Mang H; Leonard EC; Changizi-Ashtiyani S; Bacallao RL; Molitoris BA; Sutton TA; American journal of physiology. Renal physiology 2010 Dec 1
Differential expression of renal proteins in a rodent model of Meckel syndrome.
Mason SB; Lai X; Ringham HN; Bacallao RL; Harris PC; Witzmann FA; Gattone VH 2nd; Nephron. Experimental nephrology 2010 Aug 6
Mason SB; Lai X; Ringham HN; Bacallao RL; Harris PC; Witzmann FA; Gattone VH 2nd; Nephron. Experimental nephrology 2010 Aug 6
The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.
Mason SB; Lai X; Bacallao RL; Blazer-Yost BL; Gattone VH; Wang KC; Witzmann FA; Proteomics. Clinical applications 2009 Jun 24
Mason SB; Lai X; Bacallao RL; Blazer-Yost BL; Gattone VH; Wang KC; Witzmann FA; Proteomics. Clinical applications 2009 Jun 24
Cystic kidney diseases and planar cell polarity signaling.
Bacallao RL; McNeill H; Clinical genetics 2009 Feb
Bacallao RL; McNeill H; Clinical genetics 2009 Feb
Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients.
Lai X; Bacallao RL; Blazer-Yost BL; Hong D; Mason SB; Witzmann FA; Proteomics. Clinical applications 2008 Jul 1
Lai X; Bacallao RL; Blazer-Yost BL; Hong D; Mason SB; Witzmann FA; Proteomics. Clinical applications 2008 Jul 1
Imaging gene expression.
Kher R; Bacallao RL; Nephron. Experimental nephrology 2006 Mar 10
Kher R; Bacallao RL; Nephron. Experimental nephrology 2006 Mar 10
Pulmonary immunity to viral infection: adenovirus infection of lung dendritic cells renders T cells nonresponsive to interleukin-2.
Thiele AT; Sumpter TL; Walker JA; Xu Q; Chang CH; Bacallao RL; Kher R; Wilkes DS; Journal of virology 2006 Feb
Thiele AT; Sumpter TL; Walker JA; Xu Q; Chang CH; Bacallao RL; Kher R; Wilkes DS; Journal of virology 2006 Feb
Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na(+) channels.
Blazer-Yost BL; Vahle JC; Byars JM; Bacallao RL; American journal of physiology. Cell physiology 2004 Jul 28
Blazer-Yost BL; Vahle JC; Byars JM; Bacallao RL; American journal of physiology. Cell physiology 2004 Jul 28
Renal cysts of inv/inv mice resemble early infantile nephronophthisis.
Phillips CL; Miller KJ; Filson AJ; Nürnberger J; Clendenon JL; Cook GW; Dunn KW; Overbeek PA; Gattone VH 2nd; Bacallao RL; Journal of the American Society of Nephrology : JASN 2004 Jul
Phillips CL; Miller KJ; Filson AJ; Nürnberger J; Clendenon JL; Cook GW; Dunn KW; Overbeek PA; Gattone VH 2nd; Bacallao RL; Journal of the American Society of Nephrology : JASN 2004 Jul
Novel light microscopy imaging techniques in nephrology.
Bacallao RL; Yu W; Dunn KW; Phillips CL; Current opinion in nephrology and hypertension 2003 Jul
Bacallao RL; Yu W; Dunn KW; Phillips CL; Current opinion in nephrology and hypertension 2003 Jul
Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells.
Nürnberger J; Bacallao RL; Phillips CL; Molecular biology of the cell 2002 Sep
Nürnberger J; Bacallao RL; Phillips CL; Molecular biology of the cell 2002 Sep
Functional studies of the kidney of living animals using multicolor two-photon microscopy.
Dunn KW; Sandoval RM; Kelly KJ; Dagher PC; Tanner GA; Atkinson SJ; Bacallao RL; Molitoris BA; American journal of physiology. Cell physiology 2002 Sep
Dunn KW; Sandoval RM; Kelly KJ; Dagher PC; Tanner GA; Atkinson SJ; Bacallao RL; Molitoris BA; American journal of physiology. Cell physiology 2002 Sep
Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells.
Sandoval RM; Bacallao RL; Dunn KW; Leiser JD; Molitoris BA; American journal of physiology. Renal physiology 2002 Aug 21
Sandoval RM; Bacallao RL; Dunn KW; Leiser JD; Molitoris BA; American journal of physiology. Renal physiology 2002 Aug 21
Recent advances in the understanding of polycystic kidney disease.
Bacallao RL; Carone FA; Current opinion in nephrology and hypertension 1997 Jul
Bacallao RL; Carone FA; Current opinion in nephrology and hypertension 1997 Jul
American Association for the Advancement of Science
American Physiology Society
American Society for Cell Biology
American Society of Nephrology
American Board of Internal Medicine - Nephrology
American Board of Internal Medicine - Nephrology
American Board of Internal Medicine - Internal Medicine
PKD
Org:
Desc: Trustee Teaching Award
Scope: University
Date: 2010-05-01
Desc: Trustee Teaching Award
Scope: University
Date: 2010-05-01
Org: Tau Beta Pi
Desc: Scholarship award
Scope: National
Date:
Desc: Scholarship award
Scope: National
Date:
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