Research II, Suite E202
950 W Walnut St
Titles & Appointments
Bruce A. Molitoris Professor of Nephrology
Professor of Medicine
Adjunct Professor of Anatomy, Cell Biology & Physiology
1985MDAmerican University of Beirut
1980BSAmerican University of Beirut
My lab investigates the mechanisms of acute kidney injury (AKI) in animal models of renal ischemia- reperfusion and sepsis. In particular, we study the interplay between tubular apoptosis, inflammation, metabolism and innate immunity in shaping the renal response to injury and therapy. We have identified guanine nucleotides, p53, macrophage subsets and Toll-like receptors as major modulators of the injury process, metabolism and tubular cross-talk as well as the post injury outcome and response to therapy. In addition to various biochemical, genetic and molecular approaches, we pioneered novel 2-photon intra vital microscopy techniques to study these processes in the live animal.
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