Pierre C. Dagher, MD
Bruce A. Molitoris Professor of Nephrology
Phone
(317) 278-2867
Address
Research II, Suite E202
950 W Walnut St
R2 E202
Indianapolis, IN 46202-5188
950 W Walnut St
R2 E202
Indianapolis, IN 46202-5188
Titles & Appointments
- Bruce A. Molitoris Professor of Nephrology
- Professor of Medicine
- Adjunct Professor of Anatomy, Cell Biology & Physiology
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Education1985 MD American University of Beirut1980 BS American University of Beirut
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Research
My lab investigates the mechanisms of acute kidney injury (AKI) in animal models of renal ischemia- reperfusion and sepsis. In particular, we study the interplay between tubular apoptosis, inflammation, metabolism and innate immunity in shaping the renal response to injury and therapy. We have identified guanine nucleotides, p53, macrophage subsets and Toll-like receptors as major modulators of the injury process, metabolism and tubular cross-talk as well as the post injury outcome and response to therapy. In addition to various biochemical, genetic and molecular approaches, we pioneered novel 2-photon intra vital microscopy techniques to study these processes in the live animal.
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PublicationsCirculating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.
LaFavers KA; Macedo E; Garimella PS; Lima C; Khan S; Myslinski J; McClintick J; Witzmann FA; Winfree S; Phillips CL; Hato T; Dagher PC; Wu XR; El-Achkar TM; Micanovic R; Science translational medicine 2019 Oct 2Automatic segmentation of intravital fluorescence microscopy images by K-means clustering of FLIM phasors.
Zhang Y; Hato T; Dagher PC; Nichols EL; Smith CJ; Dunn KW; Howard SS; Optics letters 2019 Aug 15Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.
Winfree S; Dagher PC; Dunn KW; Eadon MT; Ferkowicz M; Barwinska D; Kelly KJ; Sutton TA; El-Achkar TM; Nephron 2018 Jun 5Bacterial sepsis triggers an antiviral response that causes translation shutdown.
Hato T; Maier B; Syed F; Myslinski J; Zollman A; Plotkin Z; Eadon MT; Dagher PC; The Journal of clinical investigation 2018 Dec 3Kidney Imaging: Intravital Microscopy.
Hato T; Winfree S; Dagher PC; Methods in molecular biology (Clifton, N.J.) 2018Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury.
Dube S; Matam T; Yen J; Mang HE; Dagher PC; Hato T; Sutton TA; Journal of immunology research 2017 Oct 17Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney.
Hato T; Zollman A; Plotkin Z; El-Achkar TM; Maier BF; Pay SL; Dube S; Cabral P; Yoshimoto M; McClintick J; Dagher PC; Journal of the American Society of Nephrology : JASN 2017 Oct 10Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Micanovic R; Khan S; Janosevic D; Lee ME; Hato T; Srour EF; Winfree S; Ghosh J; Tong Y; Rice SE; Dagher PC; Wu XR; El-Achkar TM; Journal of the American Society of Nephrology : JASN 2017 Nov 27Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.
Eadon MT; Hause RJ; Stark AL; Cheng YH; Wheeler HE; Burgess KS; Benson EA; Cunningham PN; Bacallao RL; Dagher PC; Skaar TC; Dolan ME; International journal of molecular sciences 2017 Mar 18Two-Photon Intravital Fluorescence Lifetime Imaging of the Kidney Reveals Cell-Type Specific Metabolic Signatures.
Hato T; Winfree S; Day R; Sandoval RM; Molitoris BA; Yoder MC; Wiggins RC; Zheng Y; Dunn KW; Dagher PC; Journal of the American Society of Nephrology : JASN 2017 Mar 1Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.
Winfree S; Ferkowicz MJ; Dagher PC; Kelly KJ; Eadon MT; Sutton TA; Markel TA; Yoder MC; Dunn KW; El-Achkar TM; Translational research : the journal of laboratory and clinical medicine 2017 Jul 22Intravital imaging of the kidney.
Hato T; Winfree S; Dagher PC; Methods (San Diego, Calif.) 2017 Apr 12Novel application of complimentary imaging techniques to examine in vivo glucose metabolism in the kidney.
Hato T; Friedman AN; Mang HE; Plotkin Z; Dube S; Hutchins GD; Territo PR; McCarthy BP; Riley AA; Pichumani K; Malloy CR; Harris RA; Dagher PC; Sutton TA; American journal of physiology. Renal physiology 2016 Jan 13Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury.
Dagher PC; Hato T; Mang HE; Plotkin Z; Richardson QV; Massad M; Mai E; Kuehl SE; Graham P; Kumar R; Sutton TA; International journal of molecular sciences 2016 Apr 29A two-week regimen of high-dose integrase inhibitors does not cause nephrotoxicity in mice.
Eadon MT; Zhang H; Skaar TC; Hato T; Dagher PC; Gupta SK; Desta Z; Antiviral chemistry & chemotherapy 2015 Jul 30Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.
Micanovic R; Chitteti BR; Dagher PC; Srour EF; Khan S; Hato T; Lyle A; Tong Y; Wu XR; El-Achkar TM; Journal of the American Society of Nephrology : JASN 2015 Jan 2The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules.
Hato T; Sandoval R; Dagher PC; Intravital 2015 Aug 28Tubular Cross-Talk in Acute Kidney Injury: a Story of Sense and Sensibility.
El-Achkar TM; Dagher PC; American journal of physiology. Renal physiology 2015 Apr 15The caspase 3 sensor Phiphilux G2D2 is activated non-specifically in S1 renal proximal tubules
Takashi Hatoa, Ruben Sandovala & Pierre C Daghera* Intravital 2015How the Innate Immune System Senses Trouble and Causes Trouble.
Hato T; Dagher PC; Clinical journal of the American Society of Nephrology : CJASN 2014 Nov 20The Macrophage Mediates the Renoprotective Effects of Endotoxin Preconditioning.
Hato T; Winfree S; Kalakeche R; Dube S; Kumar R; Yoshimoto M; Plotkin Z; Dagher PC; Journal of the American Society of Nephrology : JASN 2014 Nov 14Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.
Lakhter AJ; Hamilton J; Dagher PC; Mukkamala S; Hato T; Dong XC; Mayo LD; Harris RA; Shekhar A; Ivan M; Brustovetsky N; Naidu SR; Oncotarget 2014 Dec 30Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.
Hato T; El-Achkar TM; Dagher PC; American journal of physiology. Renal physiology 2013 Mar 20p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Sutton TA; Hato T; Mai E; Yoshimoto M; Kuehl S; Anderson M; Mang H; Plotkin Z; Chan RJ; Dagher PC; Journal of the American Society of Nephrology : JASN 2012 Dec 6The p53 inhibitor pifithrin-a can stimulate fibrosis in a rat model of ischemic acute kidney injury.
Dagher PC; Mai EM; Hato T; Lee SY; Anderson MD; Karozos SC; Mang HE; Knipe NL; Plotkin Z; Sutton TA; American journal of physiology. Renal physiology 2011 Nov 2Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment.
Kalakeche R; Hato T; Rhodes G; Dunn KW; El-Achkar TM; Plotkin Z; Sandoval RM; Dagher PC; Journal of the American Society of Nephrology : JASN 2011 Jul 22Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism.
El-Achkar TM; McCracken R; Rauchman M; Heitmeier MR; Al-Aly Z; Dagher PC; Wu XR; American journal of physiology. Renal physiology 2011 Jan 12Fueling the fire in acute kidney injury: endothelial cells collect their Toll.
Sutton TA; Dagher PC; Kidney international 2011 FebsiRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury.
Molitoris BA; Dagher PC; Sandoval RM; Campos SB; Ashush H; Fridman E; Brafman A; Faerman A; Atkinson SJ; Thompson JD; Kalinski H; Skaliter R; Erlich S; Feinstein E; Journal of the American Society of Nephrology : JASN 2009 May 21p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
Sutton TA; Wilkinson J; Mang HE; Knipe NL; Plotkin Z; Hosein M; Zak K; Wittenborn J; Dagher PC; American journal of physiology. Renal physiology 2008 Sep 24Tumor necrosis factor-alpha induces intrinsic apoptotic signaling during renal obstruction through truncated bid activation.
Campbell MT; Dagher P; Hile KL; Zhang H; Meldrum DR; Rink RC; Meldrum KK; The Journal of urology 2008 Oct 31Pathways of renal injury in systemic gram-negative sepsis.
El-Achkar TM; Hosein M; Dagher PC; European journal of clinical investigation 2008 OctTamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression.
El-Achkar TM; Wu XR; Rauchman M; McCracken R; Kiefer S; Dagher PC; American journal of physiology. Renal physiology 2008 May 21An expanding role of Toll-like receptors in sepsis-induced acute kidney injury.
Dagher PC; Basile DP; American journal of physiology. Renal physiology 2008 Mar 19Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent.
El-Achkar TM; Plotkin Z; Marcic B; Dagher PC; American journal of physiology. Renal physiology 2007 Jul 18Renal Toll-like receptors: recent advances and implications for disease.
El-Achkar TM; Dagher PC; Nature clinical practice. Nephrology 2006 OctSepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney.
El-Achkar TM; Huang X; Plotkin Z; Sandoval RM; Rhodes GJ; Dagher PC; American journal of physiology. Renal physiology 2005 Dec 6Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation.
Hallows KR; Fitch AC; Richardson CA; Reynolds PR; Clancy JP; Dagher PC; Witters LA; Kolls JK; Pilewski JM; The Journal of biological chemistry 2005 Dec 18Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury.
Sutton TA; Kelly KJ; Mang HE; Plotkin Z; Sandoval RM; Dagher PC; American journal of physiology. Renal physiology 2004 Sep 7TNF-alpha mediates obstruction-induced renal tubular cell apoptosis and proapoptotic signaling.
Misseri R; Meldrum DR; Dinarello CA; Dagher P; Hile KL; Rink RC; Meldrum KK; American journal of physiology. Renal physiology 2004 Oct 26Unilateral ureteral obstruction induces renal tubular cell production of tumor necrosis factor-alpha independent of inflammatory cell infiltration.
Misseri R; Meldrum DR; Dagher P; Hile K; Rink RC; Meldrum KK; The Journal of urology 2004 OctMinocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury.
Kelly KJ; Sutton TA; Weathered N; Ray N; Caldwell EJ; Plotkin Z; Dagher PC; American journal of physiology. Renal physiology 2004 Jun 1Apoptosis in ischemic renal injury: roles of GTP depletion and p53.
Dagher PC; Kidney international 2004 AugRho GTPases show differential sensitivity to nucleotide triphosphate depletion in a model of ischemic cell injury.
Hallett MA; Dagher PC; Atkinson SJ; American journal of physiology. Cell physiology 2003 Mar 5P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor.
Kelly KJ; Plotkin Z; Vulgamott SL; Dagher PC; Journal of the American Society of Nephrology : JASN 2003 JanNewly developed techniques to study and diagnose acute renal failure.
Dagher PC; Herget-Rosenthal S; Ruehm SG; Jo SK; Star RA; Agarwal R; Molitoris BA; Journal of the American Society of Nephrology : JASN 2003 AugFunctional studies of the kidney of living animals using multicolor two-photon microscopy.
Dunn KW; Sandoval RM; Kelly KJ; Dagher PC; Tanner GA; Atkinson SJ; Bacallao RL; Molitoris BA; American journal of physiology. Cell physiology 2002 SepA novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis.
Kelly KJ; Sandoval RM; Dunn KW; Molitoris BA; Dagher PC; American journal of physiology. Cell physiology 2002 Dec 21Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury.
Kelly KJ; Plotkin Z; Dagher PC; The Journal of clinical investigation 2001 NovGuanine nucleosides and Jurkat cell death: roles of ATP depletion and accumulation of deoxyribonucleotides.
Batiuk TD; Schnizlein-Bick C; Plotkin Z; Dagher PC; American journal of physiology. Cell physiology 2001 DecModeling ischemia in vitro: selective depletion of adenine and guanine nucleotide pools.
Dagher PC; American journal of physiology. Cell physiology 2000 OctModulation of chloride secretion in the rat ileum by intracellular bicarbonate.
Dagher PC; Chawla H; Michael J; Egnor RW; Charney AN; Comparative biochemistry and physiology. Part A, Physiology 1997 MayAcid-base effects on colonic electrolyte transport revisited.
Charney AN; Dagher PC; Gastroenterology 1996 NovDissociation of colonic apical Na/H exchange activity from bulk cytoplasmic pH.
Dagher PC; Behm T; Taglietta-Kohlbrecher A; Egnor RW; Charney AN; The American journal of physiology 1996 JunShort-chain fatty acids inhibit cAMP-mediated chloride secretion in rat colon.
Dagher PC; Egnor RW; Taglietta-Kohlbrecher A; Charney AN; The American journal of physiology 1996 DecModulation of secretagogue-induced chloride secretion by intracellular bicarbonate.
Dagher PC; Morton TZ; Joo CS; Taglietta-Kohlbrecher A; Egnor RW; Charney AN; The American journal of physiology 1994 MayMechanism of bicarbonate secretion in rat (Rattus rattus) colon.
Dagher PC; Rho JI; Charney AN; Comparative biochemistry and physiology. Comparative physiology 1993 MayEffect of intracellular acidification on colonic NaCl absorption.
Dagher PC; Egnor RW; Charney AN; The American journal of physiology 1993 MarModulation of chloride secretion in the rat colon by intracellular bicarbonate.
Dagher PC; Balsam L; Weber JT; Egnor RW; Charney AN; Gastroenterology 1992 Jul -
Professional OrganizationsAlpha Omega Alpha Honor Medical Society
Research Labs
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