
Michael J. Econs, MD
Distinguished Professor
Bio
Dr. Econs is Distinguished Professor of Medicine and Medical and Molecular Genetics and is the director of the division of Endocrinology and Metabolism. He enjoys mentoring fellows and young faculty. He is particularly proud of the outstanding faculty and fellows that he has recruited and/or mentored over the years.Â
His own area of interest is metabolic bone disease. In this regard, he sees patients with a variety of bone and mineral disorders and his lab does clinical, translational and basic studies of metabolic bone disease. He teaches fellows, residents and students in his metabolic bone clinic as well as on the general endocrine consult service. Work in the Econs lab led to the discovery of FGF23, which eventually led to the first new therapy in over 30 years for X-linked hypophosphatemic rickets (XLH) and tumor induced osteomalacia (burosumab, Crysvita®). His past work described novel clinical features of autosomal dominant hypophosphatemic rickets (ADHR), which eventually led to an understanding of the relationship between iron deficiency and increases in FGF23. The IU group recently published a paper demonstrating successful treatment of ADHR with low dose oral iron (Imel et al, JBMR 2020). His lab is currently performing translational studies in autosomal dominant osteopetrosis (ADO2) using a mouse model of this disease, which was developed in his lab, and he and Dr. Imel have initiated a natural history study in ADO2 patients. His lab continues to do research in the genetics of osteoporosis and is performing translational studies of a novel gene.Â
Titles & Appointments
- Distinguished Professor
- Glenn W. Irwin, Jr. Professor of Endocrinology and Metabolism
- Professor of Medicine
- Professor of Medical & Molecular Genetics
- Division Chief
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Education1989 FEL Endocrinology Fellowship, Duke University Medical Center1986 RES Internal Medicine Residency, University of Maryland1983 MD University of California, San Francisco1979 BA Johns Hopkins University
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Research
His general area of interest is the genetic aspects of metabolic bone disease. In this regard, He performs clinical, translational and basic studies of metabolic bone disorders. He played critical roles in the discovery of the genes responsible for X-linked hypophosphatemic rickets (PHEX), autosomal dominant hypophosphatemic rickets (FGF23), autosomal dominant osteopetrosis (CLCN7), and osteoglophonic dysplasia (FGFR1). As noted above, his lab’s work in FGF23 led to the first new therapy for XLH and tumor induced osteomalacia in 30+ years and the use of oral iron supplements for the treatment of ADHR. His work also provided proof of concept that unglycosylated FGF23 can be used to treat familial tumoral calcinosis.
Dr. Econs was recruited to Indiana University to bring his program in phosphate homeostasis and lead the genetics of osteoporosis program. Upon arrival, he was asked to see patients having ADO2. Recognizing that there was a high concentration of families with ADO2 locally, he began to study the disorder. His studies eventually led to identification of missense mutations in CLCN7 as the cause of ADO2. Subsequently, his lab found through cell culture studies that the difference between ADO2 carriers and affected individuals was due to differences in the osteoclasts instead of the bone microenvironment (Chu et al JBMR 2006). To study the pathophysiology of the disease further, they made an animal model of ADO2. This model has already allowed them to test multiple therapies and he and Dr. Imel performed a clinical trial using one of these. Along with Dr. Imel, he has initiated an ADO2 natural history study. Once again, his lab used a combination of human studies, mouse models, and cell culture to test clinically and translationally important hypotheses about a human disease.
In addition to the work above, his lab has a major interest in the genetics of osteoporosis. In collaboration with a large international group of investigators, they performed genome-wide association studies for several complex traits. This work led to a landmark publication identifying 56 loci that affect bone mineral density (Estrada et al Nat Genetics 2012), plus several other publications on the genetic determinants of vitamin D status (Wang et al Lancet, 2010) and age of menarche (Perry et al Nature, 2014). His laboratory has taken this work directly into animal models, resulting in creation of the WNT16-overexpressing transgenic mouse (Alam et al, Endocrinology 2015), which has a high bone mass phenotype. Moreover, his unpublished work using allele-specific expression in human bone has identified 4 genes for which expression differences likely play critical roles in the determination of bone density. Cell culture studies have guided them to focus on one of these genes. The KO mouse model has a severe bone phenotype and his lab is exploring mechanisms by which the protein affects bone strength.
Dr. Econs states that he has not limited himself to a particular type of investigation, but instead sought out new approaches and collaborators, because he understands that staying in one’s “comfort zone” limits the significance of the science. Therefore, he uses a wide variety of tools (human studies, mouse models and cell culture) to answer practical questions about a variety of diseases and physiologies.
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PublicationsDiagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group.
Wu CC; Econs MJ; DiMeglio LA; Insogna KL; Levine MA; Orchard PJ; Miller WP; Petryk A; Rush ET; Shoback DM; Ward LM; Polgreen LE; 2017 Sep 1Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC; Demissie S; Hsu YH; Yerges-Armstrong LM; Chou WC; Stolk L; Livshits G; Broer L; Johnson T; Koller DL; Kutalik Z; Luan J; Malkin I; Ried JS; Smith AV; Thorleifsson G; Vandenput L; Hua Zhao J; Zhang W; Aghdassi A; Åkesson K; Amin N; Baier LJ; Barroso I; Bennett DA; Bertram L; Biffar R; Bochud M; Boehnke M; Borecki IB; Buchman AS; Byberg L; Campbell H; Campos Obanda N; Cauley JA; Cawthon PM; Cederberg H; Chen Z; Cho NH; Jin Choi H; Claussnitzer M; Collins F; Cummings SR; De Jager PL; Demuth I; Dhonukshe-Rutten RAM; Diatchenko L; Eiriksdottir G; Enneman AW; Erdos M; Eriksson JG; Eriksson J; Estrada K; Evans DS; Feitosa MF; Fu M; Garcia M; Gieger C; Girke T; Glazer NL; Grallert H; Grewal J; Han BG; Hanson RL; Hayward C; Hofman A; Hoffman EP; Homuth G; Hsueh WC; Hubal MJ; Hubbard A; Huffman KM; Husted LB; Illig T; Ingelsson E; Ittermann T; Jansson JO; Jordan JM; Jula A; Karlsson M; Khaw KT; Kilpeläinen TO; Klopp N; Kloth JSL; Koistinen HA; Kraus WE; Kritchevsky S; Kuulasmaa T; Kuusisto J; Laakso M; Lahti J; Lang T; Langdahl BL; Launer LJ; Lee JY; Lerch MM; Lewis JR; Lind L; Lindgren C; Liu Y; Liu T; Liu Y; Ljunggren Ö; Lorentzon M; Luben RN; Maixner W; McGuigan FE; Medina-Gomez C; Meitinger T; Melhus H; Mellström D; Melov S; Michaëlsson K; Mitchell BD; Morris AP; Mosekilde L; Newman A; Nielson CM; O'Connell JR; Oostra BA; Orwoll ES; Palotie A; Parker SCJ; Peacock M; Perola M; Peters A; Polasek O; Prince RL; Räikkönen K; Ralston SH; Ripatti S; Robbins JA; Rotter JI; Rudan I; Salomaa V; Satterfield S; Schadt EE; Schipf S; Scott L; Sehmi J; Shen J; Soo Shin C; Sigurdsson G; Smith S; Soranzo N; Stancáková A; Steinhagen-Thiessen E; Streeten EA; Styrkarsdottir U; Swart KMA; Tan ST; Tarnopolsky MA; Thompson P; Thomson CA; Thorsteinsdottir U; Tikkanen E; Tranah GJ; Tuomilehto J; van Schoor NM; Verma A; Vollenweider P; Völzke H; Wactawski-Wende J; Walker M; Weedon MN; Welch R; Wichmann HE; Widen E; Williams FMK; Wilson JF; Wright NC; Xie W; Yu L; Zhou Y; Chambers JC; 2017 Nov 7A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.
Ichikawa S; Gerard-O'Riley RL; Acton D; McQueen AK; Strobel IE; Witcher PC; Feng JQ; Econs MJ; 2017 Mar 1Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens MC; Demissie S; Hsu YH; Yerges-Armstrong LM; Chou WC; Stolk L; Livshits G; Broer L; Johnson T; Koller DL; Kutalik Z; Luan J; Malkin I; Ried JS; Smith AV; Thorleifsson G; Vandenput L; Hua Zhao J; Zhang W; Aghdassi A; Åkesson K; Amin N; Baier LJ; Barroso I; Bennett DA; Bertram L; Biffar R; Bochud M; Boehnke M; Borecki IB; Buchman AS; Byberg L; Campbell H; Campos Obanda N; Cauley JA; Cawthon PM; Cederberg H; Chen Z; Cho NH; Jin Choi H; Claussnitzer M; Collins F; Cummings SR; De Jager PL; Demuth I; Dhonukshe-Rutten RAM; Diatchenko L; Eiriksdottir G; Enneman AW; Erdos M; Eriksson JG; Eriksson J; Estrada K; Evans DS; Feitosa MF; Fu M; Garcia M; Gieger C; Girke T; Glazer NL; Grallert H; Grewal J; Han BG; Hanson RL; Hayward C; Hofman A; Hoffman EP; Homuth G; Hsueh WC; Hubal MJ; Hubbard A; Huffman KM; Husted LB; Illig T; Ingelsson E; Ittermann T; Jansson JO; Jordan JM; Jula A; Karlsson M; Khaw KT; Kilpeläinen TO; Klopp N; Kloth JSL; Koistinen HA; Kraus WE; Kritchevsky S; Kuulasmaa T; Kuusisto J; Laakso M; Lahti J; Lang T; Langdahl BL; Launer LJ; Lee JY; Lerch MM; Lewis JR; Lind L; Lindgren C; Liu Y; Liu T; Liu Y; Ljunggren Ö; Lorentzon M; Luben RN; Maixner W; McGuigan FE; Medina-Gomez C; Meitinger T; Melhus H; Mellström D; Melov S; Michaëlsson K; Mitchell BD; Morris AP; Mosekilde L; Newman A; Nielson CM; O'Connell JR; Oostra BA; Orwoll ES; Palotie A; Parker SCJ; Peacock M; Perola M; Peters A; Polasek O; Prince RL; Räikkönen K; Ralston SH; Ripatti S; Robbins JA; Rotter JI; Rudan I; Salomaa V; Satterfield S; Schadt EE; Schipf S; Scott L; Sehmi J; Shen J; Soo Shin C; Sigurdsson G; Smith S; Soranzo N; Stancáková A; Steinhagen-Thiessen E; Streeten EA; Styrkarsdottir U; Swart KMA; Tan ST; Tarnopolsky MA; Thompson P; Thomson CA; Thorsteinsdottir U; Tikkanen E; Tranah GJ; Tuomilehto J; van Schoor NM; Verma A; Vollenweider P; Völzke H; Wactawski-Wende J; Walker M; Weedon MN; Welch R; Wichmann HE; Widen E; Williams FMK; Wilson JF; Wright NC; Xie W; Yu L; Zhou Y; Chambers JC; 2017 Jul 19Osteopetroses, emphasizing potential approaches to treatment.
Teti A; Econs MJ; 2017 Feb 4Phenotypic and Genotypic Characterization and Treatment of a Cohort With Familial Tumoral Calcinosis/Hyperostosis-Hyperphosphatemia Syndrome.
Ramnitz MS; Gourh P; Goldbach-Mansky R; Wodajo F; Ichikawa S; Econs MJ; White KE; Molinolo A; Chen MY; Heller T; Del Rivero J; Seo-Mayer P; Arabshahi B; Jackson MB; Hatab S; McCarthy E; Guthrie LC; Brillante BA; Gafni RI; Collins MT; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016 Sep 20Phenotypic severity of autosomal dominant osteopetrosis type II (ADO2) mice on different genetic backgrounds recapitulates the features of human disease.
Alam I; McQueen AK; Acton D; Reilly AM; Gerard-O'Riley RL; Oakes DK; Kasipathi C; Huffer A; Wright WB; Econs MJ; Bone 2016 Oct 14Serum fibroblast growth factor 23, serum iron and bone mineral density in premenopausal women.
Imel EA; Liu Z; McQueen AK; Acton D; Acton A; Padgett LR; Peacock M; Econs MJ; Bone 2016 Mar 8Genetic Variants Associated with Circulating Parathyroid Hormone.
Robinson-Cohen C; Lutsey PL; Kleber ME; Nielson CM; Mitchell BD; Bis JC; Eny KM; Portas L; Eriksson J; Lorentzon M; Koller DL; Milaneschi Y; Teumer A; Pilz S; Nethander M; Selvin E; Tang W; Weng LC; Wong HS; Lai D; Peacock M; Hannemann A; Völker U; Homuth G; Nauk M; Murgia F; Pattee JW; Orwoll E; Zmuda JM; Riancho JA; Wolf M; Williams F; Penninx B; Econs MJ; Ryan KA; Ohlsson C; Paterson AD; Psaty BM; Siscovick DS; Rotter JI; Pirastu M; Streeten E; März W; Fox C; Coresh J; Wallaschofski H; Pankow JS; de Boer IH; Kestenbaum B; 2016 Dec 7Bone Mass and Strength are Significantly Improved in Mice Overexpressing Human WNT16 in Osteocytes.
Alam I; Reilly AM; Alkhouli M; Gerard-O'Riley RL; Kasipathi C; Oakes DK; Wright WB; Acton D; McQueen AK; Patel B; Lim KE; Robling AG; Econs MJ; Calcified tissue international 2016 Dec 24Conventional Therapy in Adults With XLH Improves Dental Manifestations, But Not Enthesopathy.
Econs MJ; The Journal of clinical endocrinology and metabolism 2015 OctOsteoblast-Specific Overexpression of Human WNT16 Increases Both Cortical and Trabecular Bone Mass and Structure in Mice.
Alam I; Alkhouli M; Gerard-O'Riley RL; Wright WB; Acton D; Gray AK; Patel B; Reilly AM; Lim KE; Robling AG; Econs MJ; Endocrinology 2015 Nov 19Interferon Gamma, but not Calcitriol Improves the Osteopetrotic Phenotypes in ADO2 Mice.
Alam I; Gray AK; Acton D; Gerard-O'Riley RL; Reilly AM; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 May 5The Case | Ectopic calcifications in a child.
Keskar VS; Imel EA; Kulkarni M; Mane S; Jamale TE; Econs MJ; Hase NK; Kidney international 2015 MayGenome-wide association study of serum iron phenotypes in premenopausal women of European descent.
Koller DL; Imel EA; Lai D; Padgett LR; Acton D; Gray A; Peacock M; Econs MJ; Foroud T; Blood cells, molecules & diseases 2015 Dec 3Fine mapping of bone structure and strength QTLs in heterogeneous stock rat.
Alam I; Koller DL; Cañete T; Blázquez G; Mont-Cardona C; López-Aumatell R; Martínez-Membrives E; Díaz-Morán S; Tobeña A; Fernández-Teruel A; Stridh P; Diez M; Olsson T; Johannesson M; Baud A; Econs MJ; Foroud T; Bone 2015 Aug 19Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.
White KE; Hum JM; Econs MJ; Current osteoporosis reports 2014 SepPhenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Kemp JP; Medina-Gomez C; Estrada K; St Pourcain B; Heppe DH; Warrington NM; Oei L; Ring SM; Kruithof CJ; Timpson NJ; Wolber LE; Reppe S; Gautvik K; Grundberg E; Ge B; van der Eerden B; van de Peppel J; Hibbs MA; Ackert-Bicknell CL; Choi K; Koller DL; Econs MJ; Williams FM; Foroud T; Zillikens MC; Ohlsson C; Hofman A; Uitterlinden AG; Davey Smith G; Jaddoe VW; Tobias JH; Rivadeneira F; Evans DM; PLoS genetics 2014 Jun 19Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Perry JR; Day F; Elks CE; Sulem P; Thompson DJ; Ferreira T; He C; Chasman DI; Esko T; Thorleifsson G; Albrecht E; Ang WQ; Corre T; Cousminer DL; Feenstra B; Franceschini N; Ganna A; Johnson AD; Kjellqvist S; Lunetta KL; McMahon G; Nolte IM; Paternoster L; Porcu E; Smith AV; Stolk L; Teumer A; TÅ¡ernikova N; Tikkanen E; Ulivi S; Wagner EK; Amin N; Bierut LJ; Byrne EM; Hottenga JJ; Koller DL; Mangino M; Pers TH; Yerges-Armstrong LM; Hua Zhao J; Andrulis IL; Anton-Culver H; Atsma F; Bandinelli S; Beckmann MW; Benitez J; Blomqvist C; Bojesen SE; Bolla MK; Bonanni B; Brauch H; Brenner H; Buring JE; Chang-Claude J; Chanock S; Chen J; Chenevix-Trench G; Collée JM; Couch FJ; Couper D; Coviello AD; Cox A; Czene K; D'adamo AP; Davey Smith G; De Vivo I; Demerath EW; Dennis J; Devilee P; Dieffenbach AK; Dunning AM; Eiriksdottir G; Eriksson JG; Fasching PA; Ferrucci L; Flesch-Janys D; Flyger H; Foroud T; Franke L; Garcia ME; García-Closas M; Geller F; de Geus EE; Giles GG; Gudbjartsson DF; Gudnason V; Guénel P; Guo S; Hall P; Hamann U; Haring R; Hartman CA; Heath AC; Hofman A; Hooning MJ; Hopper JL; Hu FB; Hunter DJ; Karasik D; Kiel DP; Knight JA; Kosma VM; Kutalik Z; Lai S; Lambrechts D; Lindblom A; Mägi R; Magnusson PK; Mannermaa A; Martin NG; Masson G; McArdle PF; McArdle WL; Melbye M; Michailidou K; Mihailov E; Milani L; Milne RL; Nevanlinna H; Neven P; Nohr EA; Oldehinkel AJ; Oostra BA; Palotie A; Peacock M; Pedersen NL; Peterlongo P; Peto J; Pharoah PD; Postma DS; Pouta A; Pylkäs K; Radice P; Ring S; Rivadeneira F; Robino A; Rose LM; Rudolph A; Salomaa V; Sanna S; Schlessinger D; Schmidt MK; Southey MC; Sovio U; Stampfer MJ; Stöckl D; Storniolo AM; Timpson NJ; Tyrer J; Visser JA; Vollenweider P; Völzke H; Waeber G; Waldenberger M; Wallaschofski H; Wang Q; Willemsen G; Winqvist R; Wolffenbuttel BH; Wright MJ; Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines Cohort Study; InterAct Consortium; Early Growth Genetics (EGG) Consortium; Boomsma DI; Econs MJ; Kha Nature 2014 Jul 23Genetic rescue of glycosylation-deficient Fgf23 in the Galnt3 knockout mouse.
Ichikawa S; Gray AK; Padgett LR; Allen MR; Clinkenbeard EL; Sarpa NM; White KE; Econs MJ; Endocrinology 2014 Jul 22High-resolution genome screen for bone mineral density in heterogeneous stock rat.
Alam I; Koller DL; Cañete T; Blázquez G; López-Aumatell R; Martínez-Membrives E; Díaz-Morán S; Tobeña A; Fernández-Teruel A; Stridh P; Diez M; Olsson T; Johannesson M; Baud A; Econs MJ; Foroud T; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014 JulSIBLING family genes and bone mineral density: association and allele-specific expression in humans.
Alam I; Padgett LR; Ichikawa S; Alkhouli M; Koller DL; Lai D; Peacock M; Xuei X; Foroud T; Edenberg HJ; Econs MJ; Bone 2014 Apr 18Intronic deletions in the SLC34A3 gene: a cautionary tale for mutation analysis of hereditary hypophosphatemic rickets with hypercalciuria.
Ichikawa S; Tuchman S; Padgett LR; Gray AK; Baluarte HJ; Econs MJ; Bone 2013 Oct 29Generation of the first autosomal dominant osteopetrosis type II (ADO2) disease models.
Alam I; Gray AK; Chu K; Ichikawa S; Mohammad KS; Capannolo M; Capulli M; Maurizi A; Muraca M; Teti A; Econs MJ; Del Fattore A; Bone 2013 Nov 1Dosage effect of a Phex mutation in a murine model of X-linked hypophosphatemia.
Ichikawa S; Gray AK; Bikorimana E; Econs MJ; Calcified tissue international 2013 May 23Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.
Koller DL; Zheng HF; Karasik D; Yerges-Armstrong L; Liu CT; McGuigan F; Kemp JP; Giroux S; Lai D; Edenberg HJ; Peacock M; Czerwinski SA; Choh AC; McMahon G; St Pourcain B; Timpson NJ; Lawlor DA; Evans DM; Towne B; Blangero J; Carless MA; Kammerer C; Goltzman D; Kovacs CS; Prior JC; Spector TD; Rousseau F; Tobias JH; Akesson K; Econs MJ; Mitchell BD; Richards JB; Kiel DP; Foroud T; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 MarIron and fibroblast growth factor 23 in X-linked hypophosphatemia.
Imel EA; Gray AK; Padgett LR; Econs MJ; Bone 2013 Dec 8regSNPs: a strategy for prioritizing regulatory single nucleotide substitutions.
Teng M; Ichikawa S; Padgett LR; Wang Y; Mort M; Cooper DN; Koller DL; Foroud T; Edenberg HJ; Econs MJ; Liu Y; Bioinformatics (Oxford, England) 2012 May 18Approach to the hypophosphatemic patient.
Imel EA; Econs MJ; The Journal of clinical endocrinology and metabolism 2012 MarA Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells.
Ichikawa S; Austin AM; Gray AK; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012 FebGenome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
Estrada K; Styrkarsdottir U; Evangelou E; Hsu YH; Duncan EL; Ntzani EE; Oei L; Albagha OM; Amin N; Kemp JP; Koller DL; Li G; Liu CT; Minster RL; Moayyeri A; Vandenput L; Willner D; Xiao SM; Yerges-Armstrong LM; Zheng HF; Alonso N; Eriksson J; Kammerer CM; Kaptoge SK; Leo PJ; Thorleifsson G; Wilson SG; Wilson JF; Aalto V; Alen M; Aragaki AK; Aspelund T; Center JR; Dailiana Z; Duggan DJ; Garcia M; Garcia-Giralt N; Giroux S; Hallmans G; Hocking LJ; Husted LB; Jameson KA; Khusainova R; Kim GS; Kooperberg C; Koromila T; Kruk M; Laaksonen M; Lacroix AZ; Lee SH; Leung PC; Lewis JR; Masi L; Mencej-Bedrac S; Nguyen TV; Nogues X; Patel MS; Prezelj J; Rose LM; Scollen S; Siggeirsdottir K; Smith AV; Svensson O; Trompet S; Trummer O; van Schoor NM; Woo J; Zhu K; Balcells S; Brandi ML; Buckley BM; Cheng S; Christiansen C; Cooper C; Dedoussis G; Ford I; Frost M; Goltzman D; González-Macías J; Kähönen M; Karlsson M; Khusnutdinova E; Koh JM; Kollia P; Langdahl BL; Leslie WD; Lips P; Ljunggren Ö; Lorenc RS; Marc J; Mellström D; Obermayer-Pietsch B; Olmos JM; Pettersson-Kymmer U; Reid DM; Riancho JA; Ridker PM; Rousseau F; Slagboom PE; Tang NL; Urreizti R; Van Hul W; Viikari J; Zarrabeitia MT; Aulchenko YS; Castano-Betancourt M; Grundberg E; Herrera L; Ingvarsson T; Johannsdottir H; Kwan T; Li R; Luben R; Medina-Gómez C; Palsson ST; Reppe S; Rotter JI; Sigurdsson G; van Meurs JB; Verlaan D; Williams FM; Wood AR; Zhou Y; Gautvik KM; Pastinen T; Raychaudhuri S; Cauley JA; Chasman DI; Clark GR; Cummings SR; Danoy P; Dennison EM; Eastell R; Eisman JA; Gudnason V; Hofman A; Jackson RD; Jones G; Jukema JW; Khaw KT; Lehtimäki T; Liu Y; Lorentzon M; McCloskey E; Mitchell BD; Nandakumar K; Nicholson GC; Oostra BA; Peacock M; Pols HA; Prince RL; Raitakari O; Reid IR; Robbins J; Sambrook PN; Sham PC; Shuldiner AR; Tylavsky FA; van Duijn CM; Wareham NJ; Cupples LA; Econs MJ; Evans DM; Harris TB; Kung AW; Psaty BM; Reeve J; Spector TD; Streeten EA; Zillikens MC; Thorsteinsdottir U; Ohlsson C; Kara Nature genetics 2012 Apr 15Dietary phosphate restriction normalizes biochemical and skeletal abnormalities in a murine model of tumoral calcinosis.
Ichikawa S; Austin AM; Gray AK; Allen MR; Econs MJ; Endocrinology 2011 Oct 18Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility.
Alam I; Koller DL; Sun Q; Roeder RK; Cañete T; Blázquez G; López-Aumatell R; Martínez-Membrives E; Vicens-Costa E; Mont C; Díaz S; Tobeña A; Fernández-Teruel A; Whitley A; Strid P; Diez M; Johannesson M; Flint J; Econs MJ; Turner CH; Foroud T; Bone 2011 Feb 18Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans.
Imel EA; Peacock M; Gray AK; Padgett LR; Hui SL; Econs MJ; The Journal of clinical endocrinology and metabolism 2011 Aug 31Identification of genes influencing skeletal phenotypes in congenic P/NP rats.
Alam I; Carr LG; Liang T; Liu Y; Edenberg HJ; Econs MJ; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 JunGenome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women.
Koller DL; Ichikawa S; Lai D; Padgett LR; Doheny KF; Pugh E; Paschall J; Hui SL; Edenberg HJ; Xuei X; Peacock M; Econs MJ; Foroud T; The Journal of clinical endocrinology and metabolism 2010 Feb 17Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations.
Imel EA; DiMeglio LA; Hui SL; Carpenter TO; Econs MJ; The Journal of clinical endocrinology and metabolism 2010 Feb 15Mosaicism in osteopathia striata with cranial sclerosis.
Joseph DJ; Ichikawa S; Econs MJ; The Journal of clinical endocrinology and metabolism 2010 Feb 11Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
Ichikawa S; Koller DL; Padgett LR; Lai D; Hui SL; Peacock M; Foroud T; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010 AugClinical variability of familial tumoral calcinosis caused by novel GALNT3 mutations.
Ichikawa S; Baujat G; Seyahi A; Garoufali AG; Imel EA; Padgett LR; Austin AM; Sorenson AH; Pejin Z; Topouchian V; Quartier P; Cormier-Daire V; Dechaux M; Malandrinou FCh; Singhellakis PN; Le Merrer M; Econs MJ; American journal of medical genetics. Part A 2010 AprBone mineral density variation in men is influenced by sex-specific and non sex-specific quantitative trait loci.
Peacock M; Koller DL; Lai D; Hui S; Foroud T; Econs MJ; Bone 2009 May 8Epistasis between QTLs for bone density variation in Copenhagen x dark agouti F2 rats.
Koller DL; Liu L; Alam I; Sun Q; Econs MJ; Foroud T; Turner CH; Mammalian genome : official journal of the International Mammalian Genome Society 2009 Jan 20Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression.
Ichikawa S; Sorenson AH; Austin AM; Mackenzie DS; Fritz TA; Moh A; Hui SL; Econs MJ; Endocrinology 2009 Feb 12Race and sex differences in bone mineral density and geometry at the femur.
Peacock M; Buckwalter KA; Persohn S; Hangartner TN; Econs MJ; Hui S; Bone 2009 Apr 24Linkage screen for BMD phenotypes in male and female COP and DA rat strains.
Koller DL; Liu L; Alam I; Sun Q; Econs MJ; Foroud T; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 SepIntroduction to skeletal genetics.
Econs MJ; Journal of musculoskeletal & neuronal interactions 2008 OctIdentification of a linkage disequilibrium block in chromosome 1q associated with BMD in premenopausal white women.
Ichikawa S; Koller DL; Curry LR; Lai D; Xuei X; Pugh EW; Tsai YY; Doheny KF; Edenberg HJ; Hui SL; Foroud T; Peacock M; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 OctMutational survey of the PHEX gene in patients with X-linked hypophosphatemic rickets.
Ichikawa S; Traxler EA; Estwick SA; Curry LR; Johnson ML; Sorenson AH; Imel EA; Econs MJ; Bone 2008 Jun 18Efficient and stable gene expression into human osteoclasts using an HIV-1-based lentiviral vector.
Chu K; Cornetta KG; Econs MJ; DNA and cell biology 2008 JunSex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA rats.
Alam I; Sun Q; Liu L; Koller DL; Carr LG; Econs MJ; Foroud T; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 JunEpistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats.
Koller DL; Liu L; Alam I; Sun Q; Econs MJ; Foroud T; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008 JanAssociation of adenylate cyclase 10 (ADCY10) polymorphisms and bone mineral density in healthy adults.
Ichikawa S; Koller DL; Curry LR; Lai D; Xuei X; Edenberg HJ; Hui SL; Peacock M; Foroud T; Econs MJ; Calcified tissue international 2008 Dec 18CLCN7 polymorphisms and bone mineral density in healthy premenopausal white women and in white men.
Chu K; Koller DL; Ichikawa S; Snyder R; Curry L; Lai D; Austin A; Xuei X; Edenberg HJ; Hui SL; Foroud TM; Peacock M; Econs MJ; Bone 2008 Aug 8Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.
Alam I; Sun Q; Liu L; Koller DL; Liu Y; Edenberg HJ; Econs MJ; Foroud T; Turner CH; Physiological genomics 2008 Aug 26A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis.
Ichikawa S; Imel EA; Kreiter ML; Yu X; Mackenzie DS; Sorenson AH; Goetz R; Mohammadi M; White KE; Econs MJ; The Journal of clinical investigation 2007 SepAssociation studies of ALOX5 and bone mineral density in healthy adults.
Foroud T; Ichikawa S; Koller D; Lai D; Curry L; Xuei X; Edenberg HJ; Hui S; Peacock M; Econs MJ; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 Oct 2A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis.
Ichikawa S; Imel EA; Kreiter ML; Yu X; Mackenzie DS; Sorenson AH; Goetz R; Mohammadi M; White KE; Econs MJ; Journal of musculoskeletal & neuronal interactions 2007 OctGenetic loci affecting bone structure and strength in inbred COP and DA rats.
Sun Q; Alam I; Liu L; Koller DL; Carr LG; Econs MJ; Foroud T; Turner CH; Bone 2007 Nov 28Novel GALNT3 mutations causing hyperostosis-hyperphosphatemia syndrome result in low intact fibroblast growth factor 23 concentrations.
Ichikawa S; Guigonis V; Imel EA; Courouble M; Heissat S; Henley JD; Sorenson AH; Petit B; Lienhardt A; Econs MJ; The Journal of clinical endocrinology and metabolism 2007 Feb 20Fibrous dysplasia, phosphate wasting and fibroblast growth factor 23.
Imel EA; Econs MJ; Pediatric endocrinology reviews : PER 2007 AugFGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets.
Imel EA; Hui SL; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007 AprSensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia.
Imel EA; Peacock M; Pitukcheewanont P; Heller HJ; Ward LM; Shulman D; Kassem M; Rackoff P; Zimering M; Dalkin A; Drobny E; Colussi G; Shaker JL; Hoogendoorn EH; Hui SL; Econs MJ; The Journal of clinical endocrinology and metabolism 2006 Mar 21Intronic deletions in the SLC34A3 gene cause hereditary hypophosphatemic rickets with hypercalciuria.
Ichikawa S; Sorenson AH; Imel EA; Friedman NE; Gertner JM; Econs MJ; The Journal of clinical endocrinology and metabolism 2006 Jul 18Heritability of changes in bone size and bone mass with age in premenopausal white sisters.
Hui SL; Koller DL; Foroud TM; Econs MJ; Johnston CC; Peacock M; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 JulDisease status in autosomal dominant osteopetrosis type 2 is determined by osteoclastic properties.
Chu K; Snyder R; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 JulPolymorphisms in the bone morphogenetic protein 2 (BMP2) gene do not affect bone mineral density in white men or women.
Ichikawa S; Johnson ML; Koller DL; Lai D; Xuei X; Edenberg HJ; Hui SL; Foroud TM; Peacock M; Econs MJ; Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006 Jan 24The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23.
White KE; Larsson TE; Econs MJ; Endocrine reviews 2006 Feb 7Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength.
Alam I; Sun Q; Liu L; Koller DL; Fishburn T; Carr LG; Econs MJ; Foroud T; Turner CH; Bone 2006 Feb 3Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene.
Ichikawa S; Imel EA; Sorenson AH; Severe R; Knudson P; Harris GJ; Shaker JL; Econs MJ; The Journal of clinical endocrinology and metabolism 2006 Aug 29Human ALOX12, but not ALOX15, is associated with BMD in white men and women.
Ichikawa S; Koller DL; Johnson ML; Lai D; Xuei X; Edenberg HJ; Klein RF; Orwoll ES; Hui SL; Foroud TM; Peacock M; Econs MJ; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Apr 5Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strains.
Koller DL; Alam I; Sun Q; Liu L; Fishburn T; Carr LG; Econs MJ; Foroud T; Turner CH; Mammalian genome : official journal of the International Mammalian Genome Society 2005 Sep 14Sex-specific quantitative trait loci contribute to normal variation in bone structure at the proximal femur in men.
Peacock M; Koller DL; Lai D; Hui S; Foroud T; Econs MJ; Bone 2005 OctWhole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats.
Alam I; Sun Q; Liu L; Koller DL; Fishburn T; Carr LG; Econs MJ; Foroud T; Turner CH; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005 May 23Fibroblast growth factor 23: roles in health and disease.
Imel EA; Econs MJ; Journal of the American Society of Nephrology : JASN 2005 Jul 20Analysis of variation in expression of autosomal dominant osteopetrosis type 2: searching for modifier genes.
Chu K; Koller DL; Snyder R; Fishburn T; Lai D; Waguespack SG; Foroud T; Econs MJ; Bone 2005 Aug 24Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women.
Ichikawa S; Koller DL; Peacock M; Johnson ML; Lai D; Hui SL; Johnston CC; Foroud TM; Econs MJ; The Journal of clinical endocrinology and metabolism 2005 Aug 23 -
Professional OrganizationsAmerican Federation for Clinical ResearchAmerican Society for Bone and Mineral ResearchAmerican Society for Clinical InvestigationAssociation of American PhysiciansEndocrine Society
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Board CertificationsAmerican Board of Internal Medicine - Endocrinology, Diabetes and MetabolismAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
Metabolic Bone disease including: osteomalacias, osteoporosis, Paget's disease of the bone, hyperparathyroidism, hypoparathyroidism, etc. I am particularly interested in taking care of individuals who have inherited metabolic bone disorders.
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AwardsOrg: Indiana University
Desc: Bicentennial Medal
Scope: University
Date: 1905-07-14
Org: Indiana University
Desc: Distinguished Professor
Scope: University
Date: 1905-07-13
Org: The American Society for Clinical Investigation
Desc: Elected Member
Scope: National
Date: 1905-06-25