4844-Chen, Neal

Neal X. Chen, MD, PhD

Associate Research Professor of Medicine

Phone
(317) 274-3724
Address
Research Institute, Room 219
950 W. Walnut St.
Indianapolis , IN 46202-5181
PubMed:
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Key Publications


  1. Regulation of reactive oxygen species in the pathogenesis of matrix vesicles induced calcification of recipient vascular smooth muscle cells.

Chen NX, O'Neill KD, Dominguez JM 2nd, Moe SM.Vasc Med. 2021 Dec;26(6):585-594. doi: 10.1177/1358863X211024721. Epub 2021 Aug 2.PMID: 34338093

 

  1. Effect of Advanced Glycation End-Products (AGE) Lowering Drug ALT-711 on Biochemical, Vascular, and Bone Parameters in a Rat Model of CKD-MBD.

Chen NX, Srinivasan S, O'Neill K, Nickolas TL, Wallace JM, Allen MR, Metzger CE, Creecy A, Avin KG, Moe SM.J Bone Miner Res. 2020 Mar;35(3):608-617. doi: 10.1002/jbmr.3925. Epub 2019 Dec 30.PMID: 31743501

 

  1. Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions.

Avin KG, Dominguez JM 2nd, Chen NX, Hato T, Myslinski JJ, Gao H, Liu Y, McKinley TO, Brown KM, Moe SM, Natoli RM.J Orthop Res. 2022 Oct 6. doi: 10.1002/jor.25452. Online ahead of print.PMID: 36200412

 

  1. Non-Additive Effects of Combined NOX1/4 Inhibition and Calcimimetic Treatment on a Rat Model of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).

Damrath JG, Chen NX, Metzger CE, Srinivasan S, O'Neill K, Biruete A, Avin KG, Wallace JM, Allen MR, Moe SM.JBMR Plus. 2022 Feb 11;6(3):e10600. doi: 10.1002/jbm4.10600. eCollection 2022 Mar.PMID: 35309859 

 

  1. Voluntary Wheel Running Has Beneficial Effects in a Rat Model of CKD-Mineral Bone Disorder (CKD-MBD).

Avin KG, Allen MR, Chen NX, Srinivasan S, O'Neill KD, Troutman AD, Mast G, Swallow EA, Brown MB, Wallace JM, Zimmers TA, Warden SJ, Moe SM.J Am Soc Nephrol. 2019 Oct;30(10):1898-1909. doi: 10.1681/ASN.2019040349. Epub 2019 Sep 9.PMID: 31501355 

 

  1. Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD.

Biruete A, Metzger CE, Chen NX, Swallow EA, Vrabec C, Clinkenbeard EL, Stacy AJ, Srinivasan S, O'Neill K, Avin KG, Allen MR, Moe SM.Nephrol Dial Transplant. 2022 Sep 22;37(10):1857-1867. doi: 10.1093/ndt/gfac162.PMID: 35482713

 

  1. Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.

Chen NX, O'Neill KD, Moe SM.Kidney Int. 2018 Feb;93(2):343-354. doi: 10.1016/j.kint.2017.07.019. Epub 2017 Oct 9.PMID: 29032812 

  1. Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model.

Rodenbeck SD, Zarse CA, McKenney-Drake ML, Bruning RS, Sturek M, Chen NX, Moe SM.Nephrol Dial Transplant. 2017 Mar 1;32(3):450-458. doi: 10.1093/ndt/gfw274.PMID: 27510531

 

  1. Low Bone Turnover in Chronic Kidney Disease Is Associated with Decreased VEGF-A Expression and Osteoblast Differentiation.

Chen NX, O'Neill KD, Allen MR, Newman CL, Moe SM.Am J Nephrol. 2015;41(6):464-73. doi: 10.1159/000438461. Epub 2015 Jul 25.PMID: 26228644

 

  1. Differential miRNA Expression in Cells and Matrix Vesicles in Vascular Smooth Muscle Cells from Rats with Kidney Disease.

Chaturvedi P, Chen NX, O'Neill K, McClintick JN, Moe SM, Janga SC.PLoS One. 2015 Jun 26;10(6):e0131589. doi: 10.1371/journal.pone.0131589. eCollection 2015.PMID: 26115487 

 

  1. Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy.

Moe SM, Chen NX, Newman CL, Organ JM, Kneissel M, Kramer I, Gattone VH 2nd, Allen MR.J Bone Miner Res. 2015 Mar;30(3):499-509. doi: 10.1002/jbmr.2372.PMID: 25407607 

 

  1. Pathogenesis of arrhythmias in a model of CKD.

Hsueh CH, Chen NX, Lin SF, Chen PS, Gattone VH 2nd, Allen MR, Fishbein MC, Moe SM.J Am Soc Nephrol. 2014 Dec;25(12):2812-21. doi: 10.1681/ASN.2013121343. Epub 2014 May 22.PMID: 24854269 

 

  1. The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat.

Moe SM, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX.J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.PMID: 21826734 

 

  1. Calcimimetics inhibit renal pathology in rodent nephronophthisis.

Chen NX, Moe SM, Eggleston-Gulyas T, Chen X, Hoffmeyer WD, Bacallao RL, Herbert BS, Gattone VH 2nd.Kidney Int. 2011 Sep;80(6):612-9. doi: 10.1038/ki.2011.139. Epub 2011 Jun 1.PMID: 21633408 

 

  1. A rat model of chronic kidney disease-mineral bone disorder.

Moe SM, Chen NX, Seifert MF, Sinders RM, Duan D, Chen X, Liang Y, Radcliff JS, White KE, Gattone VH 2nd.Kidney Int. 2009 Jan;75(2):176-84. doi: 10.1038/ki.2008.456. Epub 2008 Sep 17.PMID: 18800026

 

  1. Mechanisms of vascular calcification in chronic kidney disease.

Moe SM, Chen NX.J Am Soc Nephrol. 2008 Feb;19(2):213-6. doi: 10.1681/ASN.2007080854. Epub 2007 Dec 19.PMID: 18094365 Review.

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