
David Crabb, MD
Professor Emeritus of Medicine
Bio
I have been involved in alcoholism and liver research since the early 1980’s. This has included the study of effects of ethanol on intermediary metabolism in the liver and adipocytes, using cultured cells, and in vivo animal and human models. In addition, I have been closely involved in studies on the genetics of alcoholism, the epidemiology of alcohol use disorders,  and human and animal studies of responses to alcohol, through my role as Director of the Indiana Alcohol Research Center.  The Center has been funded for three decades.
We discovered that ethanol inhibits the activity of PPARα, activates SREBP1c, and inhibits AMP-dependent protein kinase (AMPK) in liver. The changes in the transcription factors and AMPK make the liver less capable of oxidizing fatty acids and induce fatty acid synthesizing enzymes. The inhibition of AMPK results in increased acetyl-CoA carboxylase activity and malonyl-CoA levels, blocking the ability of fatty acyl-CoA to enter the mitochondrion. More recently we have uncovered effects of alcohol use on ChREBP, which is relevant to the development of fatty liver from both alcohol and diet, and ceramide and protein phosphatase 2 (PP2A) that have implications for activation of stress kinases, and inhibition of anti-apoptotic pathways. These actions of alcohol on nuclear receptor signaling and stress kinases are directly relevant to the pathogenesis of alcoholic steatosis, alcoholic hepatitis, and likely to other forms of fatty liver, such as those related to obesity and diabetes (NAFLD and NASH) and to drug toxicity.  Â
My involvement in the care of patients with alcoholism, research on pathogenesis of alcoholic liver injury, and my hepatology training led to involvement in organizing a multi-center consortium funded by the NIAAA to study the natural history and treatments for alcoholic hepatitis (TREAT: Translational Research and Evolving Alcoholic hepatitis Treatment) as well as performing mechanistic studies on the pathways leading to severe liver injury in human subjects.  In addition, I have been involved in implementing screening for hazardous alcohol use (screening, brief intervention and referral to treatment) across the Eskenazi Health system.
Web Address:Â http://medicine.iupui.edu/IARC
Key Publications
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Titles & Appointments
- Professor Emeritus of Medicine
- Professor Emeritus of Biochemistry & Molecular Biology
- CMO, Eskenazi Health
- Chief of Internal Medicine at Eskenazi Health Hospital
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Education2002 FEL Fellowship, Indiana University Medical Center2001 RES Residency, Indiana University Medical Center1978 MD Indiana University1974 BS Purdue University
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Research
Alcohol metabolism, Liver Gene Expression.
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PublicationsIn Memoriam-Lawrence Lumeng, MD: Researcher, Clinician, Leader, Mentor, Family Man, and Friend.
Chalasani NP; Crabb DW; Rex DK; Gastroenterology 2017 Sep 5Challenges in patient enrollment and retention in clinical studies for alcoholic hepatitis: Experience of the TREAT Consortium.
Comerford M; Lourens S; Liangpunsakul S; Chalasani NP; Sanyal AJ; Shah VH; Kamath PS; Puri P; Katz BP; Radaeva S; Crabb DW; Alcoholism, clinical and experimental research 2017 Oct 5Alcohol abstinence ameliorates the dysregulated immune profiles in patients with alcoholic hepatitis: A prospective observational study.
Li W; Amet T; Xing Y; Yang D; Liangpunsakul S; Puri P; Kamath PS; Sanyal AJ; Shah VH; Katz BP; Radaeva S; Crabb DW; Chalasani N; Yu Q; Hepatology (Baltimore, Md.) 2017 Jun 30An exploratory genome-wide analysis of genetic risk for alcoholic hepatitis.
Beaudoin JJ; Long N; Liangpunsakul S; Puri P; Kamath PS; Shah V; Sanyal AJ; Crabb DW; Chalasani NP; Urban TJ; TREAT Consortium.; Scandinavian journal of gastroenterology 2017 Aug 4Lawrence Lumeng, MD: Researcher, Clinician, Leader, Mentor - In Memoriam.
Crabb DW; McBride WJ; Grahame NJ; Bell RL; Kareken DA; Alcoholism, clinical and experimental research 2017 Aug 21Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis.
Liangpunsakul S; Puri P; Shah V; Kamath P; Sanyal A; Urban T; Ren X; Katz B; Radaeva S; Chalasani N; Crabb DW; Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Jun 15Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.
Crabb DW; Bataller R; Chalasani NP; Kamath PS; Lucey M; Mathurin P; McClain C; McCullough A; Mitchell MC; Morgan TR; Nagy L; Radaeva S; Sanyal A; Shah V; Szabo G; NIAAA Alcoholic Hepatitis Consortia; Gastroenterology 2016 Feb 24An Assessment of SBIRT Prescreening and Screening Outcomes by Medical Setting and Administration Methodology.
Agley J; Crabb DW; Harris LE; Gassman RA; Gerke SP; Health services research and managerial epidemiology 2015 Oct 26Early Detection of Alcoholic Liver Disease: Are We a Step Closer?
Liangpunsakul S; Crabb DW; Gastroenterology 2015 Nov 22The Utility of Commonly Used Laboratory Tests to Screen for Excessive Alcohol Use in Clinical Practice.
Gough G; Heathers L; Puckett D; Westerhold C; Ren X; Yu Z; Crabb DW; Liangpunsakul S; Alcoholism, clinical and experimental research 2015 Jun 25Novel serum biomarkers for detection of excessive alcohol use.
Liangpunsakul S; Lai X; Ross RA; Yu Z; Modlik E; Westerhold C; Heathers L; Paul R; O'Connor S; Crabb DW; Witzmann F; Alcoholism, clinical and experimental research 2015 Feb 19Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers.
Liangpunsakul S; Bennett R; Westerhold C; Ross RA; Crabb DW; Lai X; Witzmann FA; Alcohol (Fayetteville, N.Y.) 2014 Sep 28Metabolism.
Plawecki MH; Crabb DW; Handbook of clinical neurology 2014Activation of carbohydrate response element-binding protein by ethanol.
Liangpunsakul S; Ross RA; Crabb DW; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2013 FebEthanol impairs differentiation of human adipocyte stromal cells in culture.
Crabb DW; Zeng Y; Liangpunsakul S; Jones R; Considine R; Alcoholism, clinical and experimental research 2011 May 20Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration.
Matsumoto M; Cyganek I; Sanghani PC; Cho WK; Liangpunsakul S; Crabb DW; Alcoholism, clinical and experimental research 2011 JanImipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice.
Liangpunsakul S; Rahmini Y; Ross RA; Zhao Z; Xu Y; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2011 Dec 22Relationship among alcohol intake, body fat, and physical activity: a population-based study.
Liangpunsakul S; Crabb DW; Qi R; Annals of epidemiology 2010 SepInhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.
Liangpunsakul S; Sozio MS; Shin E; Zhao Z; Xu Y; Ross RA; Zeng Y; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2010 Mar 11Relationship between alcohol drinking and aspartate aminotransferase:alanine aminotransferase (AST:ALT) ratio, mean corpuscular volume (MCV), gamma-glutamyl transpeptidase (GGT), and apolipoprotein A1 and B in the U.S. population.
Liangpunsakul S; Qi R; Crabb DW; Witzmann F; Journal of studies on alcohol and drugs 2010 MarSerum Proteomic Profiles In Subjects with Heavy Alcohol Abuse.
Liangpunsakul S; Lai X; Ringham HN; Crabb DW; Witzmann FA; Journal of proteomics & bioinformatics 2009 May 20A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS.
Lai X; Liangpunsakul S; Crabb DW; Ringham HN; Witzmann FA; Electrophoresis 2009 JunEffects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.
Liangpunsakul S; Wou SE; Wineinger KD; Zeng Y; Cyganek I; Jayaram HN; Crabb DW; Archives of biochemistry and biophysics 2009 Feb 21Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.
Liangpunsakul S; Wou SE; Zeng Y; Ross RA; Jayaram HN; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2008 Oct 2Alcohol and lipid metabolism.
Sozio M; Crabb DW; American journal of physiology. Endocrinology and metabolism 2008 Mar 18Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population.
Fischer M; Wetherill LF; Carr LG; You M; Crabb DW; Alcoholism, clinical and experimental research 2007 OctAcetaldehyde generating enzyme systems: roles of alcohol dehydrogenase, CYP2E1 and catalase, and speculations on the role of other enzymes and processes.
Crabb DW; Liangpunsakul S; Novartis Foundation symposium 2007Alcohol and lipid metabolism.
Crabb DW; Liangpunsakul S; Journal of gastroenterology and hepatology 2006 OctProtein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol.
Bell RL; Kimpel MW; Rodd ZA; Strother WN; Bai F; Peper CL; Mayfield RD; Lumeng L; Crabb DW; McBride WJ; Witzmann FA; Alcohol (Fayetteville, N.Y.) 2006 AugGlobal effects of vitamin A deficiency on gene expression in rat liver: evidence for hypoandrogenism.
McClintick JN; Crabb DW; Tian H; Pinaire J; Smith JR; Jerome RE; Edenberg HJ; The Journal of nutritional biochemistry 2005 Sep 19Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
You M; Considine RV; Leone TC; Kelly DP; Crabb DW; Hepatology (Baltimore, Md.) 2005 SepRecent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
You M; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2004 JulOverview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology.
Crabb DW; Matsumoto M; Chang D; You M; The Proceedings of the Nutrition Society 2004 FebThe role of AMP-activated protein kinase in the action of ethanol in the liver.
You M; Matsumoto M; Pacold CM; Cho WK; Crabb DW; Gastroenterology 2004 DecMolecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins.
You M; Crabb DW; Alcohol (Fayetteville, N.Y.) 2004 AugMolecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha.
Crabb DW; Galli A; Fischer M; You M; Alcohol (Fayetteville, N.Y.) 2004 AugSystemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis.
Chalasani N; Deeg MA; Crabb DW; The American journal of gastroenterology 2004 AugAlcohol deranges hepatic lipid metabolism via altered transcriptional regulation.
Crabb DW; Transactions of the American Clinical and Climatological Association 2004Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.
Chalasani N; Gorski JC; Asghar MS; Asghar A; Foresman B; Hall SD; Crabb DW; Hepatology (Baltimore, Md.) 2003 MarPeroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice.
Fischer M; You M; Matsumoto M; Crabb DW; The Journal of biological chemistry 2003 Jun 5Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol-preferring and -nonpreferring rats.
Witzmann FA; Li J; Strother WN; McBride WJ; Hunter L; Crabb DW; Lumeng L; Li TK; Proteomics 2003 JulReproducibility of oligonucleotide arrays using small samples.
McClintick JN; Jerome RE; Nicholson CR; Crabb DW; Edenberg HJ; BMC genomics 2003 Jan 30Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis?
Chalasani N; Crabb DW; Cummings OW; Kwo PY; Asghar A; Pandya PK; Considine RV; The American journal of gastroenterology 2003 DecMetabolic and anthropometric evaluation of insulin resistance in nondiabetic patients with nonalcoholic steatohepatitis.
Chalasani N; Deeg MA; Persohn S; Crabb DW; The American journal of gastroenterology 2003 AugEthanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).
You M; Fischer M; Deeg MA; Crabb DW; The Journal of biological chemistry 2002 May 29Alcohol and retinoids.
Crabb DW; Pinairs J; Hasanadka R; Fang M; Leo MA; Lieber CS; Tsukamoto H; Motomura K; Miyahara T; Ohata M; Bosron W; Sanghani S; Kedishvili N; Shiraishi H; Yokoyama H; Miyagi M; Ishii H; Bergheim I; Menzl I; Parlesak A; Bode C; Alcoholism, clinical and experimental research 2001 MayAlcoholic liver disease.
Lumeng L; Crabb DW; Current opinion in gastroenterology 2001 MayPeroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo.
Crabb DW; Pinaire J; Chou WY; Sissom S; Peters JM; Harris RA; Stewart M; Alcoholism, clinical and experimental research 2001 JulThe transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.
Galli A; Pinaire J; Fischer M; Dorris R; Crabb DW; The Journal of biological chemistry 2001 Jan 5Genetic and environmental influences on alcohol metabolism in humans.
Li TK; Yin SJ; Crabb DW; O'Connor S; Ramchandani VA; Alcoholism, clinical and experimental research 2001 JanAlcoholic liver disease.
Lumeng L; Crabb DW; Current opinion in gastroenterology 2000 MayEffects of vitamin A deficiency on rat liver alcohol dehydrogenase expression and alcohol elimination rate in rats.
Pinaire J; Smith JR; Cho WK; Crabb DW; Alcoholism, clinical and experimental research 2000 DecMammalian 3-hydroxyisobutyrate dehydrogenase.
Hawes JW; Crabb DW; Chan RJ; Rougraff PM; Paxton R; Harris RA; Methods in enzymology 2000Sensitivity of virally-driven luciferase reporter plasmids to members of the steroid/thyroid/retinoid family of nuclear receptors.
Everett LM; Crabb DW; The Journal of steroid biochemistry and molecular biology 1999 SepAn A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength.
Chou WY; Stewart MJ; Carr LG; Zheng D; Stewart TR; Williams A; Pinaire J; Crabb DW; Alcoholism, clinical and experimental research 1999 JunPathogenesis of alcoholic liver disease: newer mechanisms of injury.
Crabb DW; The Keio journal of medicine 1999 DecAlcohol and medication interactions.
Weathermon R; Crabb DW; Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4.
Stewart MJ; Dipple KM; Estonius M; Nakshatri H; Everett LM; Crabb DW; Biochimica et biophysica acta 1998 Aug 20First pass metabolism of ethanol: gastric or hepatic, mountain or molehill?
Crabb DW; Hepatology (Baltimore, Md.) 1997 MayA direct repeat (DR-1) element in the first exon modulates transcription of the preproenkephalin A gene.
Chan RM; Stewart MJ; Crabb DW; Brain research. Molecular brain research 1997 AprStructural and mechanistic aspects of a new family of dehydrogenases, the beta-hydroxyacid dehydrogenases.
Hawes JW; Harper ET; Crabb DW; Harris RA; Advances in experimental medicine and biology 1997The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene.
Stewart MJ; Dipple KM; Stewart TR; Crabb DW; Gene 1996 Sep 16The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion.
Xiao Q; Weiner H; Crabb DW; The Journal of clinical investigation 1996 Nov 1Gene regulation of alcohol metabolizing enzymes.
Crabb DW; Edenberg HJ; Alcoholism, clinical and experimental research 1996 NovDexamethasone represses phorbol ester-, forskolin-, and calcium-stimulated expression of a preproenkephalin A promoter-chloramphenicol acetyltransferase gene via a receptor-mediated mechanism.
Crabb DW; Stewart MJ; Chan RJ; Brain research. Molecular brain research 1996 NovCatabolism of isobutyrate by colonocytes.
Jaskiewicz J; Zhao Y; Hawes JW; Shimomura Y; Crabb DW; Harris RA; Archives of biochemistry and biophysics 1996 Mar 15Structural and mechanistic similarities of 6-phosphogluconate and 3-hydroxyisobutyrate dehydrogenases reveal a new enzyme family, the 3-hydroxyacid dehydrogenases.
Hawes JW; Harper ET; Crabb DW; Harris RA; FEBS letters 1996 Jul 8Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues.
Stewart MJ; Malek K; Crabb DW; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1996 FebThe aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells.
Xiao Q; Weiner H; Johnston T; Crabb DW; The Journal of clinical investigation 1995 NovThe novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.
Stewart MJ; Malek K; Xiao Q; Dipple KM; Crabb DW; Biochemical and biophysical research communications 1995 Jun 6Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells.
Crabb DW; Stewart MJ; Xiao Q; Alcoholism, clinical and experimental research 1995 DecChemical modification and site-directed mutagenesis studies of rat 3-hydroxyisobutyrate dehydrogenase.
Hawes JW; Crabb DW; Chan RM; Rougraff PM; Harris RA; Biochemistry 1995 Apr 4Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease.
Crabb DW; Progress in liver diseases 1995A new family of protein kinases--the mitochondrial protein kinases.
Harris RA; Popov KM; Zhao Y; Kedishvili NY; Shimomura Y; Crabb DW; Advances in enzyme regulation 1995Tissue-specific expression and preliminary functional analysis of the 5' flanking regions of the human mitochondrial aldehyde dehydrogenase (ALDH2) gene.
Dipple KM; Stewart MJ; Crabb DW; Advances in experimental medicine and biology 1995Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders.
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Hwu HG; Chen CC; Yeh EK; Yin SJ; Alcoholism, clinical and experimental research 1994 JunAllele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics.
Chan RJ; McBride AW; Thomasson HR; Ykenney A; Crabb DW; Alcoholism, clinical and experimental research 1994 JunSite-directed mutagenesis of phosphorylation sites of the branched chain alpha-ketoacid dehydrogenase complex.
Zhao Y; Hawes J; Popov KM; Jaskiewicz J; Shimomura Y; Crabb DW; Harris RA; The Journal of biological chemistry 1994 Jul 15Seven transmembrane domain receptor subtypes identified in NG108-15 cells by reverse transcription-polymerase chain reaction.
Chan RJ; McBride AW; Crabb DW; Biochemical and biophysical research communications 1994 Dec 15Genetic aspects and risk factors in alcoholism and alcoholic liver disease.
Lumeng L; Crabb DW; Gastroenterology 1994 AugIntrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression.
Chen L; Davis GJ; Crabb DW; Lumeng L; Hepatology (Baltimore, Md.) 1994 AprAlcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes.
Crabb DW; Dipple KM; Thomasson HR; The Journal of laboratory and clinical medicine 1993 SepEffects of ethanol on urinary acidification and on gluconeogenesis by isolated renal tubules.
Crabb DW; Sidhu R; Metabolism: clinical and experimental 1993 OctThe mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner.
Dipple KM; Crabb DW; Biochemical and biophysical research communications 1993 May 28Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism.
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Behavior genetics 1993 MarDetection of a CA repeat polymorphism in the rat class I alcohol dehydrogenase gene.
Carr LG; Koivisto T; Eriksson CJ; Crabb DW; Alcoholism, clinical and experimental research 1993 FebPrimary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases.
Popov KM; Kedishvili NY; Zhao Y; Shimomura Y; Crabb DW; Harris RA; The Journal of biological chemistry 1993 Dec 15Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney.
Dipple KM; Qulali M; Ross RA; Crabb DW; Hepatology (Baltimore, Md.) 1993 AprModulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo.
Qulali M; Dipple KM; Crabb DW; Advances in experimental medicine and biology 1993Evolutionary relationships of branched chain and nonspecific alcohol and aldehyde dehydrogenases.
Crabb DW; Kedishvili NY; Popov KM; Rougraff P; Zhao Y; Harris RA; Advances in experimental medicine and biology 1993Molecular cloning of the branched-chain alpha-keto acid dehydrogenase kinase and the CoA-dependent methylmalonate semialdehyde dehydrogenase.
Harris RA; Popov KM; Kedishvili NY; Zhao Y; Shimomura Y; Robbins B; Crabb DW; Advances in enzyme regulation 1993Recent developments in alcoholism:the liver.
Crabb DW; Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1993CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily. cDNA cloning, evolutionary relationships, and tissue distribution.
Kedishvili NY; Popov KM; Rougraff PM; Zhao Y; Crabb DW; Harris RA; The Journal of biological chemistry 1992 Sep 25Molecular cloning of the E1 beta subunit of the rat branched chain alpha-ketoacid dehydrogenase.
Zhao Y; Kuntz MJ; Harris RA; Crabb DW; Biochimica et biophysica acta 1992 Sep 24Estradiol regulates class I alcohol dehydrogenase gene expression in renal medulla of male rats by a post-transcriptional mechanism.
Qulali M; Crabb DW; Archives of biochemistry and biophysics 1992 SepHighlights of the RSA symposium on enzymes of alcohol metabolism.
Crabb DW; Lands W; Alcoholism, clinical and experimental research 1992 OctCorticosterone induces rat liver alcohol dehydrogenase mRNA but not enzyme protein or activity.
Qulali M; Crabb DW; Alcoholism, clinical and experimental research 1992 JunADH1, 2 and 3: genes whose times have come.
Crabb DW; Hepatology (Baltimore, Md.) 1992 DecPolymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA.
Carr LG; Mellencamp RJ; Crabb DW; Weiner H; Lumeng L; Li TK; Alcoholism, clinical and experimental research 1991 OctMolecular defects in the E1 alpha subunit of the branched-chain alpha-ketoacid dehydrogenase complex that cause maple syrup urine disease.
Zhang B; Zhao Y; Harris RA; Crabb DW; Molecular biology & medicine 1991 FebEstradiol induces class I alcohol dehydrogenase activity and mRNA in kidney of female rats.
Qulali M; Ross RA; Crabb DW; Archives of biochemistry and biophysics 1991 Aug 1Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Thomasson HR; Edenberg HJ; Crabb DW; Mai XL; Jerome RE; Li TK; Wang SP; Lin YT; Lu RB; Yin SJ; American journal of human genetics 1991 AprMethylmalonic aciduria presenting in an adult.
Gerhardt M; Burke EM; Brandt IK; Crabb DW; Journal of inherited metabolic disease 1991Endocrine regulation and methylation patterns of rat class I alcohol dehydrogenase in liver and kidney.
Crabb DW; Qulali M; Dipple KM; Advances in experimental medicine and biology 1991Premature translation termination of the pre-E1 alpha subunit of the branched chain alpha-ketoacid dehydrogenase as a cause of maple syrup urine disease in Polled Hereford calves.
Zhang B; Healy PJ; Zhao Y; Crabb DW; Harris RA; The Journal of biological chemistry 1990 Feb 15Biological markers for increased risk of alcoholism and for quantitation of alcohol consumption.
Crabb DW; The Journal of clinical investigation 1990 FebSequence of the E1 alpha subunit of branched-chain alpha-ketoacid dehydrogenase in two patients with thiamine-responsive maple syrup urine disease.
Zhang B; Wappner RS; Brandt IK; Harris RA; Crabb DW; American journal of human genetics 1990 AprRegulation of the branched-chain alpha-ketoacid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease.
Harris RA; Zhang B; Goodwin GW; Kuntz MJ; Shimomura Y; Rougraff P; Dexter P; Zhao Y; Gibson R; Crabb DW; Advances in enzyme regulation 1990Structure and expression of the rat class I alcohol dehydrogenase gene.
Crabb DW; Stein PM; Dipple KM; Hittle JB; Sidhu R; Qulali M; Zhang K; Edenberg HJ; Genomics 1989 NovThe heat-shock response in cultured cells exposed to ethanol and its metabolites.
Walsh KH; Crabb DW; The Journal of laboratory and clinical medicine 1989 NovGenotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
Crabb DW; Edenberg HJ; Bosron WF; Li TK; The Journal of clinical investigation 1989 JanCloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.
Rougraff PM; Zhang B; Kuntz MJ; Harris RA; Crabb DW; The Journal of biological chemistry 1989 Apr 5Evidence for both a regulatory mutation and a structural mutation in a family with maple syrup urine disease.
Zhang B; Edenberg HJ; Crabb DW; Harris RA; The Journal of clinical investigation 1989 AprLocalization of the human gene for the El alpha subunit of branched chain keto acid dehydrogenase (BCKDHA) to chromosome 19q13.1----q13.2.
Fekete G; Plattner R; Crabb DW; Zhang B; Harris RA; Heerema N; Palmer CG; Cytogenetics and cell genetics 1989Assignment of the gene for the E1 alpha subunit of branched chain alpha-ketoacid dehydrogenase to chromosome 19.
Crabb DW; Deaven LL; Luedemann M; Zhang B; Harris RA; Cytogenetics and cell genetics 1989cDNA cloning of the E1 alpha subunit of the branched-chain alpha-keto acid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease.
Zhang B; Kuntz MJ; Goodwin GW; Edenberg HJ; Crabb DW; Harris RA; Annals of the New York Academy of Sciences 1989Regulation of the expression of the rat alcohol dehydrogenase gene by glucocorticoids.
Qulali M; Wolfla CE; Ross RA; Crabb DW; Progress in clinical and biological research 1989Nucleotide and deduced amino acid sequence of the E1 alpha subunit of human liver branched-chain alpha-ketoacid dehydrogenase.
Zhang B; Crabb DW; Harris RA; Gene 1988 Sep 15Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone.
Wolfla CE; Ross RA; Crabb DW; Archives of biochemistry and biophysics 1988 May 15The molecular biology of alcohol dehydrogenase: implications for the control of alcohol metabolism.
Hittle JB; Crabb DW; The Journal of laboratory and clinical medicine 1988 JulPurification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver.
Rougraff PM; Paxton R; Kuntz MJ; Crabb DW; Harris RA; The Journal of biological chemistry 1988 Jan 5Molecular cloning of a cDNA for the E1 alpha subunit of rat liver branched chain alpha-ketoacid dehydrogenase.
Zhang B; Kuntz MJ; Goodwin GW; Harris RA; Crabb DW; The Journal of biological chemistry 1987 Nov 5Loss of sexual differentiation of rat hepatocytes in short-term culture.
Roepke JE; Crabb DW; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987Cloning and sequencing of a cDNA encoding rat liver alcohol dehydrogenase.
Crabb DW; Edenberg HJ; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987Ethanol metabolism.
Crabb DW; Bosron WF; Li TK; Pharmacology & therapeutics 1987 -
Professional OrganizationsAmerican Society for Clinical InvestigationAssociation of American Physicians
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Board CertificationsAmerican Board of Internal Medicine - GastroenterologyAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
Hepatobiliary diseases with particular emphasis on chronic hepatitis, cirrhosis, alcoholic liver disease.
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AwardsOrg: The American Society for Clinical Investigation
Desc: Elected Member
Scope: National
Date: 1905-06-14