David Crabb, MD
Professor Emeritus of Medicine
Professor Emeritus of Biochemistry & Molecular Biology
CMO, Eskenazi Health
Chief of Internal Medicine at Eskenazi Health Hospital
Bio
I have been involved in alcoholism and liver research since the early 1980’s. This has included the study of effects of ethanol on intermediary metabolism in the liver and adipocytes, using cultured cells, and in vivo animal and human models. In addition, I have been closely involved in studies on the genetics of alcoholism, the epidemiology of alcohol use disorders, and human and animal studies of responses to alcohol, through my role as Director of the Indiana Alcohol Research Center. The Center has been funded for three decades.
We discovered that ethanol inhibits the activity of PPARα, activates SREBP1c, and inhibits AMP-dependent protein kinase (AMPK) in liver. The changes in the transcription factors and AMPK make the liver less capable of oxidizing fatty acids and induce fatty acid synthesizing enzymes. The inhibition of AMPK results in increased acetyl-CoA carboxylase activity and malonyl-CoA levels, blocking the ability of fatty acyl-CoA to enter the mitochondrion. More recently we have uncovered effects of alcohol use on ChREBP, which is relevant to the development of fatty liver from both alcohol and diet, and ceramide and protein phosphatase 2 (PP2A) that have implications for activation of stress kinases, and inhibition of anti-apoptotic pathways. These actions of alcohol on nuclear receptor signaling and stress kinases are directly relevant to the pathogenesis of alcoholic steatosis, alcoholic hepatitis, and likely to other forms of fatty liver, such as those related to obesity and diabetes (NAFLD and NASH) and to drug toxicity.
My involvement in the care of patients with alcoholism, research on pathogenesis of alcoholic liver injury, and my hepatology training led to involvement in organizing a multi-center consortium funded by the NIAAA to study the natural history and treatments for alcoholic hepatitis (TREAT: Translational Research and Evolving Alcoholic hepatitis Treatment) as well as performing mechanistic studies on the pathways leading to severe liver injury in human subjects. In addition, I have been involved in implementing screening for hazardous alcohol use (screening, brief intervention and referral to treatment) across the Eskenazi Health system.
Year | Degree | Institution |
---|---|---|
2002 | Fellowship | Indiana University Medical Center |
2001 | Residency | Indiana University Medical Center |
1978 | MD | Indiana University |
1974 | BS | Purdue University |
Alcohol metabolism, Liver Gene Expression.
Chalasani NP; Crabb DW; Rex DK; Gastroenterology 2017 Sep 5
Comerford M; Lourens S; Liangpunsakul S; Chalasani NP; Sanyal AJ; Shah VH; Kamath PS; Puri P; Katz BP; Radaeva S; Crabb DW; Alcoholism, clinical and experimental research 2017 Oct 5
Li W; Amet T; Xing Y; Yang D; Liangpunsakul S; Puri P; Kamath PS; Sanyal AJ; Shah VH; Katz BP; Radaeva S; Crabb DW; Chalasani N; Yu Q; Hepatology (Baltimore, Md.) 2017 Jun 30
Beaudoin JJ; Long N; Liangpunsakul S; Puri P; Kamath PS; Shah V; Sanyal AJ; Crabb DW; Chalasani NP; Urban TJ; TREAT Consortium.; Scandinavian journal of gastroenterology 2017 Aug 4
Crabb DW; McBride WJ; Grahame NJ; Bell RL; Kareken DA; Alcoholism, clinical and experimental research 2017 Aug 21
Liangpunsakul S; Puri P; Shah V; Kamath P; Sanyal A; Urban T; Ren X; Katz B; Radaeva S; Chalasani N; Crabb DW; Translational Research and Evolving Alcoholic Hepatitis Treatment Consortium; Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2016 Jun 15
Crabb DW; Bataller R; Chalasani NP; Kamath PS; Lucey M; Mathurin P; McClain C; McCullough A; Mitchell MC; Morgan TR; Nagy L; Radaeva S; Sanyal A; Shah V; Szabo G; NIAAA Alcoholic Hepatitis Consortia; Gastroenterology 2016 Feb 24
Agley J; Crabb DW; Harris LE; Gassman RA; Gerke SP; Health services research and managerial epidemiology 2015 Oct 26
Liangpunsakul S; Crabb DW; Gastroenterology 2015 Nov 22
Gough G; Heathers L; Puckett D; Westerhold C; Ren X; Yu Z; Crabb DW; Liangpunsakul S; Alcoholism, clinical and experimental research 2015 Jun 25
Liangpunsakul S; Lai X; Ross RA; Yu Z; Modlik E; Westerhold C; Heathers L; Paul R; O'Connor S; Crabb DW; Witzmann F; Alcoholism, clinical and experimental research 2015 Feb 19
Liangpunsakul S; Bennett R; Westerhold C; Ross RA; Crabb DW; Lai X; Witzmann FA; Alcohol (Fayetteville, N.Y.) 2014 Sep 28
Plawecki MH; Crabb DW; Handbook of clinical neurology 2014
Liangpunsakul S; Ross RA; Crabb DW; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2013 Feb
Crabb DW; Zeng Y; Liangpunsakul S; Jones R; Considine R; Alcoholism, clinical and experimental research 2011 May 20
Matsumoto M; Cyganek I; Sanghani PC; Cho WK; Liangpunsakul S; Crabb DW; Alcoholism, clinical and experimental research 2011 Jan
Liangpunsakul S; Rahmini Y; Ross RA; Zhao Z; Xu Y; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2011 Dec 22
Liangpunsakul S; Crabb DW; Qi R; Annals of epidemiology 2010 Sep
Liangpunsakul S; Sozio MS; Shin E; Zhao Z; Xu Y; Ross RA; Zeng Y; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2010 Mar 11
Liangpunsakul S; Qi R; Crabb DW; Witzmann F; Journal of studies on alcohol and drugs 2010 Mar
Liangpunsakul S; Lai X; Ringham HN; Crabb DW; Witzmann FA; Journal of proteomics & bioinformatics 2009 May 20
Lai X; Liangpunsakul S; Crabb DW; Ringham HN; Witzmann FA; Electrophoresis 2009 Jun
Liangpunsakul S; Wou SE; Wineinger KD; Zeng Y; Cyganek I; Jayaram HN; Crabb DW; Archives of biochemistry and biophysics 2009 Feb 21
Liangpunsakul S; Wou SE; Zeng Y; Ross RA; Jayaram HN; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2008 Oct 2
Sozio M; Crabb DW; American journal of physiology. Endocrinology and metabolism 2008 Mar 18
Fischer M; Wetherill LF; Carr LG; You M; Crabb DW; Alcoholism, clinical and experimental research 2007 Oct
Crabb DW; Liangpunsakul S; Novartis Foundation symposium 2007
Crabb DW; Liangpunsakul S; Journal of gastroenterology and hepatology 2006 Oct
Bell RL; Kimpel MW; Rodd ZA; Strother WN; Bai F; Peper CL; Mayfield RD; Lumeng L; Crabb DW; McBride WJ; Witzmann FA; Alcohol (Fayetteville, N.Y.) 2006 Aug
McClintick JN; Crabb DW; Tian H; Pinaire J; Smith JR; Jerome RE; Edenberg HJ; The Journal of nutritional biochemistry 2005 Sep 19
You M; Considine RV; Leone TC; Kelly DP; Crabb DW; Hepatology (Baltimore, Md.) 2005 Sep
You M; Crabb DW; American journal of physiology. Gastrointestinal and liver physiology 2004 Jul
Crabb DW; Matsumoto M; Chang D; You M; The Proceedings of the Nutrition Society 2004 Feb
You M; Matsumoto M; Pacold CM; Cho WK; Crabb DW; Gastroenterology 2004 Dec
You M; Crabb DW; Alcohol (Fayetteville, N.Y.) 2004 Aug
Crabb DW; Galli A; Fischer M; You M; Alcohol (Fayetteville, N.Y.) 2004 Aug
Chalasani N; Deeg MA; Crabb DW; The American journal of gastroenterology 2004 Aug
Crabb DW; Transactions of the American Clinical and Climatological Association 2004
Chalasani N; Gorski JC; Asghar MS; Asghar A; Foresman B; Hall SD; Crabb DW; Hepatology (Baltimore, Md.) 2003 Mar
Fischer M; You M; Matsumoto M; Crabb DW; The Journal of biological chemistry 2003 Jun 5
Witzmann FA; Li J; Strother WN; McBride WJ; Hunter L; Crabb DW; Lumeng L; Li TK; Proteomics 2003 Jul
McClintick JN; Jerome RE; Nicholson CR; Crabb DW; Edenberg HJ; BMC genomics 2003 Jan 30
Chalasani N; Crabb DW; Cummings OW; Kwo PY; Asghar A; Pandya PK; Considine RV; The American journal of gastroenterology 2003 Dec
Chalasani N; Deeg MA; Persohn S; Crabb DW; The American journal of gastroenterology 2003 Aug
You M; Fischer M; Deeg MA; Crabb DW; The Journal of biological chemistry 2002 May 29
Crabb DW; Pinairs J; Hasanadka R; Fang M; Leo MA; Lieber CS; Tsukamoto H; Motomura K; Miyahara T; Ohata M; Bosron W; Sanghani S; Kedishvili N; Shiraishi H; Yokoyama H; Miyagi M; Ishii H; Bergheim I; Menzl I; Parlesak A; Bode C; Alcoholism, clinical and experimental research 2001 May
Lumeng L; Crabb DW; Current opinion in gastroenterology 2001 May
Crabb DW; Pinaire J; Chou WY; Sissom S; Peters JM; Harris RA; Stewart M; Alcoholism, clinical and experimental research 2001 Jul
Galli A; Pinaire J; Fischer M; Dorris R; Crabb DW; The Journal of biological chemistry 2001 Jan 5
Li TK; Yin SJ; Crabb DW; O'Connor S; Ramchandani VA; Alcoholism, clinical and experimental research 2001 Jan
Lumeng L; Crabb DW; Current opinion in gastroenterology 2000 May
Pinaire J; Smith JR; Cho WK; Crabb DW; Alcoholism, clinical and experimental research 2000 Dec
Hawes JW; Crabb DW; Chan RJ; Rougraff PM; Paxton R; Harris RA; Methods in enzymology 2000
Everett LM; Crabb DW; The Journal of steroid biochemistry and molecular biology 1999 Sep
Chou WY; Stewart MJ; Carr LG; Zheng D; Stewart TR; Williams A; Pinaire J; Crabb DW; Alcoholism, clinical and experimental research 1999 Jun
Crabb DW; The Keio journal of medicine 1999 Dec
Weathermon R; Crabb DW; Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 1999
Stewart MJ; Dipple KM; Estonius M; Nakshatri H; Everett LM; Crabb DW; Biochimica et biophysica acta 1998 Aug 20
Crabb DW; Hepatology (Baltimore, Md.) 1997 May
Chan RM; Stewart MJ; Crabb DW; Brain research. Molecular brain research 1997 Apr
Hawes JW; Harper ET; Crabb DW; Harris RA; Advances in experimental medicine and biology 1997
Stewart MJ; Dipple KM; Stewart TR; Crabb DW; Gene 1996 Sep 16
Xiao Q; Weiner H; Crabb DW; The Journal of clinical investigation 1996 Nov 1
Crabb DW; Edenberg HJ; Alcoholism, clinical and experimental research 1996 Nov
Crabb DW; Stewart MJ; Chan RJ; Brain research. Molecular brain research 1996 Nov
Jaskiewicz J; Zhao Y; Hawes JW; Shimomura Y; Crabb DW; Harris RA; Archives of biochemistry and biophysics 1996 Mar 15
Hawes JW; Harper ET; Crabb DW; Harris RA; FEBS letters 1996 Jul 8
Stewart MJ; Malek K; Crabb DW; Journal of investigative medicine : the official publication of the American Federation for Clinical Research 1996 Feb
Xiao Q; Weiner H; Johnston T; Crabb DW; The Journal of clinical investigation 1995 Nov
Stewart MJ; Malek K; Xiao Q; Dipple KM; Crabb DW; Biochemical and biophysical research communications 1995 Jun 6
Crabb DW; Stewart MJ; Xiao Q; Alcoholism, clinical and experimental research 1995 Dec
Hawes JW; Crabb DW; Chan RM; Rougraff PM; Harris RA; Biochemistry 1995 Apr 4
Crabb DW; Progress in liver diseases 1995
Harris RA; Popov KM; Zhao Y; Kedishvili NY; Shimomura Y; Crabb DW; Advances in enzyme regulation 1995
Dipple KM; Stewart MJ; Crabb DW; Advances in experimental medicine and biology 1995
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Hwu HG; Chen CC; Yeh EK; Yin SJ; Alcoholism, clinical and experimental research 1994 Jun
Chan RJ; McBride AW; Thomasson HR; Ykenney A; Crabb DW; Alcoholism, clinical and experimental research 1994 Jun
Zhao Y; Hawes J; Popov KM; Jaskiewicz J; Shimomura Y; Crabb DW; Harris RA; The Journal of biological chemistry 1994 Jul 15
Chan RJ; McBride AW; Crabb DW; Biochemical and biophysical research communications 1994 Dec 15
Lumeng L; Crabb DW; Gastroenterology 1994 Aug
Chen L; Davis GJ; Crabb DW; Lumeng L; Hepatology (Baltimore, Md.) 1994 Apr
Crabb DW; Dipple KM; Thomasson HR; The Journal of laboratory and clinical medicine 1993 Sep
Crabb DW; Sidhu R; Metabolism: clinical and experimental 1993 Oct
Dipple KM; Crabb DW; Biochemical and biophysical research communications 1993 May 28
Thomasson HR; Crabb DW; Edenberg HJ; Li TK; Behavior genetics 1993 Mar
Carr LG; Koivisto T; Eriksson CJ; Crabb DW; Alcoholism, clinical and experimental research 1993 Feb
Popov KM; Kedishvili NY; Zhao Y; Shimomura Y; Crabb DW; Harris RA; The Journal of biological chemistry 1993 Dec 15
Dipple KM; Qulali M; Ross RA; Crabb DW; Hepatology (Baltimore, Md.) 1993 Apr
Qulali M; Dipple KM; Crabb DW; Advances in experimental medicine and biology 1993
Crabb DW; Kedishvili NY; Popov KM; Rougraff P; Zhao Y; Harris RA; Advances in experimental medicine and biology 1993
Harris RA; Popov KM; Kedishvili NY; Zhao Y; Shimomura Y; Robbins B; Crabb DW; Advances in enzyme regulation 1993
Crabb DW; Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism 1993
Kedishvili NY; Popov KM; Rougraff PM; Zhao Y; Crabb DW; Harris RA; The Journal of biological chemistry 1992 Sep 25
Zhao Y; Kuntz MJ; Harris RA; Crabb DW; Biochimica et biophysica acta 1992 Sep 24
Qulali M; Crabb DW; Archives of biochemistry and biophysics 1992 Sep
Crabb DW; Lands W; Alcoholism, clinical and experimental research 1992 Oct
Qulali M; Crabb DW; Alcoholism, clinical and experimental research 1992 Jun
Crabb DW; Hepatology (Baltimore, Md.) 1992 Dec
Carr LG; Mellencamp RJ; Crabb DW; Weiner H; Lumeng L; Li TK; Alcoholism, clinical and experimental research 1991 Oct
Zhang B; Zhao Y; Harris RA; Crabb DW; Molecular biology & medicine 1991 Feb
Qulali M; Ross RA; Crabb DW; Archives of biochemistry and biophysics 1991 Aug 1
Thomasson HR; Edenberg HJ; Crabb DW; Mai XL; Jerome RE; Li TK; Wang SP; Lin YT; Lu RB; Yin SJ; American journal of human genetics 1991 Apr
Gerhardt M; Burke EM; Brandt IK; Crabb DW; Journal of inherited metabolic disease 1991
Crabb DW; Qulali M; Dipple KM; Advances in experimental medicine and biology 1991
Zhang B; Healy PJ; Zhao Y; Crabb DW; Harris RA; The Journal of biological chemistry 1990 Feb 15
Crabb DW; The Journal of clinical investigation 1990 Feb
Zhang B; Wappner RS; Brandt IK; Harris RA; Crabb DW; American journal of human genetics 1990 Apr
Harris RA; Zhang B; Goodwin GW; Kuntz MJ; Shimomura Y; Rougraff P; Dexter P; Zhao Y; Gibson R; Crabb DW; Advances in enzyme regulation 1990
Crabb DW; Stein PM; Dipple KM; Hittle JB; Sidhu R; Qulali M; Zhang K; Edenberg HJ; Genomics 1989 Nov
Walsh KH; Crabb DW; The Journal of laboratory and clinical medicine 1989 Nov
Crabb DW; Edenberg HJ; Bosron WF; Li TK; The Journal of clinical investigation 1989 Jan
Rougraff PM; Zhang B; Kuntz MJ; Harris RA; Crabb DW; The Journal of biological chemistry 1989 Apr 5
Zhang B; Edenberg HJ; Crabb DW; Harris RA; The Journal of clinical investigation 1989 Apr
Fekete G; Plattner R; Crabb DW; Zhang B; Harris RA; Heerema N; Palmer CG; Cytogenetics and cell genetics 1989
Crabb DW; Deaven LL; Luedemann M; Zhang B; Harris RA; Cytogenetics and cell genetics 1989
Zhang B; Kuntz MJ; Goodwin GW; Edenberg HJ; Crabb DW; Harris RA; Annals of the New York Academy of Sciences 1989
Qulali M; Wolfla CE; Ross RA; Crabb DW; Progress in clinical and biological research 1989
Zhang B; Crabb DW; Harris RA; Gene 1988 Sep 15
Wolfla CE; Ross RA; Crabb DW; Archives of biochemistry and biophysics 1988 May 15
Hittle JB; Crabb DW; The Journal of laboratory and clinical medicine 1988 Jul
Rougraff PM; Paxton R; Kuntz MJ; Crabb DW; Harris RA; The Journal of biological chemistry 1988 Jan 5
Zhang B; Kuntz MJ; Goodwin GW; Harris RA; Crabb DW; The Journal of biological chemistry 1987 Nov 5
Roepke JE; Crabb DW; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987
Crabb DW; Edenberg HJ; Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987
Crabb DW; Bosron WF; Li TK; Pharmacology & therapeutics 1987
Hepatobiliary diseases with particular emphasis on chronic hepatitis, cirrhosis, alcoholic liver disease.
Desc: Trustee Teaching Award
Scope: University
Date: 2014-05-01
Desc: Elected Member
Scope: National
Date: 1905-06-14