Paris Roach, MD
Associate Professor of Clinical Medicine
Address
Gatch Hall, Suite 365
1120 W. Michigan St.
Indianapolis, IN 46202-5111
1120 W. Michigan St.
Indianapolis, IN 46202-5111
Bio
Paris Roach, MD, is board certified in internal medicine, endocrinonology, diabetes and metabolism. He is the fellowship program director for the division of endocrinology and metabolism. Dr. Roach's primary clinical interest is the care of people with diabetes, with a focus on Type 1 diabetes and insulin pump therapy.
Dr. Roach received his doctor of medicine degree from Indiana University School of Medicine, where he also completed his internship and residency in internal medicine. He completed his fellowship in endocrinology at the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. He is currently editor in chief of the Diabetes Forecast, which is a patient-focused publication of the American Diabetes Association.
Titles & Appointments
- Associate Professor of Clinical Medicine
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Education1994 FEL Staff Fellow, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases1990 RES Internal Medicine Residency, Indiana University1987 MD Indiana University1983 BS Butler University
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Research
Diabetes Health Care Delivery
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PublicationsListening to patients' voices: linguistic indicators related to diabetes self-management.
Connor U; Anton M; Goering E; Lauten K; Hayat A; Roach P; Balunda S; Communication & medicine 2012AMPK -> ULK1 -> autophagy.
Roach PJ; Molecular and cellular biology 2011 May 31Phosphate incorporation during glycogen synthesis and Lafora disease.
Tagliabracci VS; Heiss C; Karthik C; Contreras CJ; Glushka J; Ishihara M; Azadi P; Hurley TD; DePaoli-Roach AA; Roach PJ; Cell metabolism 2011 Mar 2Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
DePaoli-Roach AA; Segvich DM; Meyer CM; Rahimi Y; Worby CA; Gentry MS; Roach PJ; Human molecular genetics 2011 Dec 20Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1.
Jiang S; Wells CD; Roach PJ; Biochemical and biophysical research communications 2011 Aug 27Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen.
Baskaran S; Chikwana VM; Contreras CJ; Davis KD; Wilson WA; DePaoli-Roach AA; Roach PJ; Hurley TD; The Journal of biological chemistry 2011 Aug 11Structural basis for glucose-6-phosphate activation of glycogen synthase.
Baskaran S; Roach PJ; DePaoli-Roach AA; Hurley TD; Proceedings of the National Academy of Sciences of the United States of America 2010 Sep 27Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism.
Jiang S; Heller B; Tagliabracci VS; Zhai L; Irimia JM; DePaoli-Roach AA; Wells CD; Skurat AV; Roach PJ; The Journal of biological chemistry 2010 Sep 1Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.
DePaoli-Roach AA; Tagliabracci VS; Segvich DM; Meyer CM; Irimia JM; Roach PJ; The Journal of biological chemistry 2010 Jun 10Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice.
Irimia JM; Meyer CM; Peper CL; Zhai L; Bock CB; Previs SF; McGuinness OP; DePaoli-Roach A; Roach PJ; The Journal of biological chemistry 2010 Feb 23Insights into the mechanism of polysaccharide dephosphorylation by a glucan phosphatase.
Tagliabracci VS; Roach PJ; Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 19Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene.
Heyen CA; Tagliabracci VS; Zhai L; Roach PJ; Biochemical and biophysical research communications 2009 Nov 5Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting.
Yoon NM; Cavaghan MK; Brunelle RL; Roach P; Clinical therapeutics 2009 JulAbnormal metabolism of glycogen phosphate as a cause for Lafora disease.
Tagliabracci VS; Girard JM; Segvich D; Meyer C; Turnbull J; Zhao X; Minassian BA; Depaoli-Roach AA; Roach PJ; The Journal of biological chemistry 2008 Oct 13New insulin analogues and routes of delivery: pharmacodynamic and clinical considerations.
Roach P; Clinical pharmacokinetics 2008Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.
Tagliabracci VS; Turnbull J; Wang W; Girard JM; Zhao X; Skurat AV; Delgado-Escueta AV; Minassian BA; Depaoli-Roach AA; Roach PJ; Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 26Relationship between glycogen accumulation and the laforin dual specificity phosphatase.
Wang W; Parker GE; Skurat AV; Raben N; DePaoli-Roach AA; Roach PJ; Biochemical and biophysical research communications 2006 Sep 26Interaction between glycogenin and glycogen synthase.
Skurat AV; Dietrich AD; Roach PJ; Archives of biochemistry and biophysics 2006 Oct 10Glycogen metabolism in tissues from a mouse model of Lafora disease.
Wang W; Lohi H; Skurat AV; DePaoli-Roach AA; Minassian BA; Roach PJ; Archives of biochemistry and biophysics 2006 Nov 3Direct detection of glycogenin reaction products during glycogen initiation.
Hurley TD; Walls C; Bennett JR; Roach PJ; Wang M; Biochemical and biophysical research communications 2006 Jul 28Comparison of insulin lispro mixture 25/75 with insulin glargine during a 24-h standardized test-meal period in patients with Type 2 diabetes.
Roach P; Malone JK; Diabetic medicine : a journal of the British Diabetic Association 2006 JulGene expression profiling of mice with genetically modified muscle glycogen content.
Parker GE; Pederson BA; Obayashi M; Schroeder JM; Harris RA; Roach PJ; The Biochemical journal 2006 Apr 1Mice with elevated muscle glycogen stores do not have improved exercise performance.
Pederson BA; Cope CR; Irimia JM; Schroeder JM; Thurberg BL; Depaoli-Roach AA; Roach PJ; Biochemical and biophysical research communications 2005 Jun 3Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise.
Pederson BA; Cope CR; Schroeder JM; Smith MW; Irimia JM; Thurberg BL; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 2005 Feb 11Glucose metabolism in mice lacking muscle glycogen synthase.
Pederson BA; Schroeder JM; Parker GE; Smith MW; DePaoli-Roach AA; Roach PJ; Diabetes 2005 DecRequirements for catalysis in mammalian glycogenin.
Hurley TD; Stout S; Miner E; Zhou J; Roach PJ; The Journal of biological chemistry 2005 Apr 22Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p.
Wilson WA; Wang Z; Roach PJ; Biochemical and biophysical research communications 2005 Apr 1A critical dialogue: communicating with type 2 diabetes patients about cardiovascular risk.
Roach P; Marrero D; Vascular health and risk management 2005Increased glycogen storage in yeast results in less branched glycogen.
Wilson WA; Hughes WE; Tomamichel W; Roach PJ; Biochemical and biophysical research communications 2004 Jul 23Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae.
Pederson BA; Wilson WA; Roach PJ; The Journal of biological chemistry 2004 Jan 23Structure-function analysis of GNIP, the glycogenin-interacting protein.
Zhai L; Dietrich A; Skurat AV; Roach PJ; Archives of biochemistry and biophysics 2004 Jan 15Glycogen and related polysaccharides inhibit the laforin dual-specificity protein phosphatase.
Wang W; Roach PJ; Biochemical and biophysical research communications 2004 Dec 17Better systems, not guidelines, for glucose monitoring.
Roach P; BMJ (Clinical research ed.) 2004 Dec 11Abnormal cardiac development in the absence of heart glycogen.
Pederson BA; Chen H; Schroeder JM; Shou W; DePaoli-Roach AA; Roach PJ; Molecular and cellular biology 2004 AugEffects of multiple daily injection therapy with Humalog mixtures versus separately injected insulin lispro and NPH insulin in adults with type I diabetes mellitus.
Roach P; Bai S; Charbonnel B; Consoli A; Taboga C; Tiengo A; Bolli G; High Mix Study Group; Clinical therapeutics 2004 AprHumalog Mix50 before carbohydrate-rich meals in type 2 diabetes mellitus.
Roach P; Arora V; Campaigne BN; Mattoo V; Rangwala S; India Mix25/Mix50 Study Group; Diabetes, obesity & metabolism 2003 SepA 75% insulin lispro/25% NPL mixture provides a longer duration of insulin activity compared with insulin lispro alone in patients with Type 1 diabetes.
Roach P; Woodworth J; Gudat U; Cerimele B; Diebler F; Pein M; Dreyer M; Diabetic medicine : a journal of the British Diabetic Association 2003 NovOverexpression of glycogen synthase in mouse muscle results in less branched glycogen.
Pederson BA; Csitkovits AG; Simon R; Schroeder JM; Wang W; Skurat AV; Roach PJ; Biochemical and biophysical research communications 2003 Jun 13Saccharomyces gene deletion project: applications and use in the study of protein kinases and phosphatases.
Wilson WA; Roach PJ; Methods in enzymology 2003Determination of mammalian glycogen synthase phosphatase activity.
DePaoli-Roach AA; Vilardo PG; Kim JH; Mavila N; Vemuri B; Roach PJ; Methods in enzymology 2003Nutrient-regulated protein kinases in budding yeast.
Wilson WA; Roach PJ; Cell 2002 Oct 18Crystal structure of the autocatalytic initiator of glycogen biosynthesis, glycogenin.
Gibbons BJ; Roach PJ; Hurley TD; Journal of molecular biology 2002 May 31Analysis of respiratory mutants reveals new aspects of the control of glycogen accumulation by the cyclin-dependent protein kinase Pho85p.
Wilson WA; Wang Z; Roach PJ; FEBS letters 2002 Mar 27GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis.
Skurat AV; Dietrich AD; Zhai L; Roach PJ; The Journal of biological chemistry 2002 Mar 26Systematic identification of the genes affecting glycogen storage in the yeast Saccharomyces cerevisiae: implication of the vacuole as a determinant of glycogen level.
Wilson WA; Wang Z; Roach PJ; Molecular & cellular proteomics : MCP 2002 MarGlycogen and its metabolism.
Roach PJ; Current molecular medicine 2002 MarMutations of muscle glycogen synthase that disable activation by glucose 6-phosphate.
Hanashiro I; Roach PJ; Archives of biochemistry and biophysics 2002 Jan 15Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures.
Roach P; Woodworth JR; Clinical pharmacokinetics 2002Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p.
Wang Z; Wilson WA; Fujino MA; Roach PJ; Molecular and cellular biology 2001 SepThe yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p.
Wang Z; Wilson WA; Fujino MA; Roach PJ; FEBS letters 2001 Oct 12Do rodents have a gene encoding glycogenin-2, the liver isoform of the self-glucosylating initiator of glycogen synthesis?
Zhai L; Schroeder J; Skurat AV; Roach PJ; IUBMB life 2001 FebRegulation of glycogen synthase. Identification of residues involved in regulation by the allosteric ligand glucose-6-P and by phosphorylation.
Pederson BA; Cheng C; Wilson WA; Roach PJ; The Journal of biological chemistry 2000 Sep 8Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.
Skurat AV; Dietrich AD; Roach PJ; Diabetes 2000 JulStructure and chromosomal localization of the human glycogenin-2 gene GYG2.
Zhai L; Mu J; Zong H; DePaoli-Roach AA; Roach PJ; Gene 2000 Jan 25Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p.
Wilson WA; Mahrenholz AM; Roach PJ; Molecular and cellular biology 1999 OctSelf-glucosylation of glycogenin, the initiator of glycogen biosynthesis, involves an inter-subunit reaction.
Lin A; Mu J; Yang J; Roach PJ; Archives of biochemistry and biophysics 1999 Mar 1Improved postprandial blood glucose control and reduced nocturnal hypoglycemia during treatment with two novel insulin lispro-protamine formulations, insulin lispro mix25 and insulin lispro mix50. Mix50 Study Group.
Roach P; Trautmann M; Arora V; Sun B; Anderson JH Jr; Clinical therapeutics 1999 MarImproved postprandial glycemic control during treatment with Humalog Mix25, a novel protamine-based insulin lispro formulation. Humalog Mix25 Study Group.
Roach P; Yue L; Arora V; Diabetes care 1999 AugA note on the sample size determination in two-period repeated measurements crossover design with application to clinical trials.
Yue LQ; Roach P; Journal of biopharmaceutical statistics 1998 NovCrystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition.
Longenecker KL; Roach PJ; Hurley TD; Acta crystallographica. Section D, Biological crystallography 1998 May 1Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10.
Huang D; Moffat J; Wilson WA; Moore L; Cheng C; Roach PJ; Andrews B; Molecular and cellular biology 1998 JunCharacterization of human glycogenin-2, a self-glucosylating initiator of liver glycogen metabolism.
Mu J; Roach PJ; The Journal of biological chemistry 1998 Dec 25Novel aspects of the regulation of glycogen storage.
Roach PJ; Cheng C; Huang D; Lin A; Mu J; Skurat AV; Wilson W; Zhai L; Journal of basic and clinical physiology and pharmacology 1998Glucose-6-P control of glycogen synthase phosphorylation in yeast.
Huang D; Wilson WA; Roach PJ; The Journal of biological chemistry 1997 Sep 5Glycogenin-2, a novel self-glucosylating protein involved in liver glycogen biosynthesis.
Mu J; Skurat AV; Roach PJ; The Journal of biological chemistry 1997 Oct 31Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p.
Cheng C; Huang D; Roach PJ; Yeast (Chichester, England) 1997 JanGlycogen biogenesis in rat 1 fibroblasts expressing rabbit muscle glycogenin.
Skurat AV; Lim SS; Roach PJ; European journal of biochemistry / FEBS 1997 Apr 1Self-glucosylating initiator proteins and their role in glycogen biosynthesis.
Roach PJ; Skurat AV; Progress in nucleic acid research and molecular biology 1997Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo.
Mu J; Cheng C; Roach PJ; The Journal of biological chemistry 1996 Oct 25Genetic interactions between REG1/HEX2 and GLC7, the gene encoding the protein phosphatase type 1 catalytic subunit in Saccharomyces cerevisiae.
Huang D; Chun KT; Goebl MG; Roach PJ; Genetics 1996 MayMultiple mechanisms for the phosphorylation of C-terminal regulatory sites in rabbit muscle glycogen synthase expressed in COS cells.
Skurat AV; Roach PJ; The Biochemical journal 1996 Jan 1Pho85p, a cyclin-dependent protein kinase, and the Snf1p protein kinase act antagonistically to control glycogen accumulation in Saccharomyces cerevisiae.
Huang D; Farkas I; Roach PJ; Molecular and cellular biology 1996 AugThree-dimensional structure of mammalian casein kinase I: molecular basis for phosphate recognition.
Longenecker KL; Roach PJ; Hurley TD; Journal of molecular biology 1996 Apr 5Rate-determining steps in the biosynthesis of glycogen in COS cells.
Skurat AV; Peng HL; Chang HY; Cannon JF; Roach PJ; Archives of biochemistry and biophysics 1996 Apr 15Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta.
Graves PR; Roach PJ; The Journal of biological chemistry 1995 Sep 15Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.
Zhai L; Graves PR; Robinson LC; Italiano M; Culbertson MR; Rowles J; Cobb MH; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1995 May 26Phosphorylation of sites 3a and 3b (Ser640 and Ser644) in the control of rabbit muscle glycogen synthase.
Skurat AV; Roach PJ; The Journal of biological chemistry 1995 May 26Mechanism of glycogenin self-glucosylation.
Cao Y; Steinrauf LK; Roach PJ; Archives of biochemistry and biophysics 1995 May 10Phosphorylation and activation of p90rsk by glycogen synthase kinase-3.
Wang QM; Vik TA; Ryder JW; Roach PJ; Biochemical and biophysical research communications 1995 Mar 17Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy.
Hardy TA; Wu D; Roach PJ; Biochemical and biophysical research communications 1995 Mar 17Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae.
Cheng C; Mu J; Farkas I; Huang D; Goebl MG; Roach PJ; Molecular and cellular biology 1995 DecPhosphorylation and activation of the ATP-Mg-dependent protein phosphatase by the mitogen-activated protein kinase.
Wang QM; Guan KL; Roach PJ; DePaoli-Roach AA; The Journal of biological chemistry 1995 Aug 4Rabbit skeletal muscle glycogen synthase expressed in COS cells. Identification of regulatory phosphorylation sites.
Skurat AV; Wang Y; Roach PJ; The Journal of biological chemistry 1994 Oct 14Interactions between cAMP-dependent and SNF1 protein kinases in the control of glycogen accumulation in Saccharomyces cerevisiae.
Hardy TA; Huang D; Roach PJ; The Journal of biological chemistry 1994 Nov 11Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.
Wang QM; Fiol CJ; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1994 May 20Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2.
Park IK; Roach P; Bondor J; Fox SP; DePaoli-Roach AA; The Journal of biological chemistry 1994 Jan 14Isoform differences in substrate recognition by glycogen synthase kinases 3 alpha and 3 beta in the phosphorylation of phosphatase inhibitor 2.
Wang QM; Park IK; Fiol CJ; Roach PJ; DePaoli-Roach AA; Biochemistry 1994 Jan 11A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.
Fiol CJ; Williams JS; Chou CH; Wang QM; Roach PJ; Andrisani OM; The Journal of biological chemistry 1994 Dec 23Use of a synthetic peptide as a selective substrate for glycogen synthase kinase 3.
Wang QM; Roach PJ; Fiol CJ; Analytical biochemistry 1994 Aug 1Initiation of glycogen synthesis. Control of glycogenin by glycogen phosphorylase.
Cao Y; Skurat AV; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1993 Oct 15Inactivation of rabbit muscle glycogen synthase by glycogen synthase kinase-3. Dominant role of the phosphorylation of Ser-640 (site-3a).
Wang Y; Roach PJ; The Journal of biological chemistry 1993 Nov 15Control of yeast glycogen synthase-2 by COOH-terminal phosphorylation.
Hardy TA; Roach PJ; The Journal of biological chemistry 1993 Nov 15Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.
Graves PR; Haas DW; Hagedorn CH; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1993 Mar 25Glucose control of rabbit skeletal muscle glycogenin expressed in COS cells.
Skurat AV; Cao Y; Roach PJ; The Journal of biological chemistry 1993 Jul 15Characterization of rabbit skeletal muscle glycogenin. Tyrosine 194 is essential for function.
Cao Y; Mahrenholz AM; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1993 Jul 15Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase.
Zhang W; DePaoli-Roach AA; Roach PJ; Archives of biochemistry and biophysics 1993 JulRabbit skeletal muscle glycogenin. Molecular cloning and production of fully functional protein in Escherichia coli.
Viskupic E; Cao Y; Zhang W; Cheng C; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1992 Dec 25Recombinant rabbit muscle casein kinase I alpha is inhibited by heparin and activated by polylysine.
Zhai L; Graves PR; Longenecker KL; DePaoli-Roach AA; Roach PJ; Biochemical and biophysical research communications 1992 Dec 15Role of acidic residues as substrate determinants for casein kinase I.
Flotow H; Roach PJ; The Journal of biological chemistry 1991 Feb 25Multisite and hierarchal protein phosphorylation.
Roach PJ; The Journal of biological chemistry 1991 Aug 5Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled.
Farkas I; Hardy TA; Goebl MG; Roach PJ; The Journal of biological chemistry 1991 Aug 25Glycogen metabolism and signal transduction in mammals and yeast.
Roach PJ; Cao Y; Corbett CA; DePaoli-Roach AA; Farkas I; Fiol CJ; Flotow H; Graves PR; Hardy TA; Hrubey TW; Advances in enzyme regulation 1991Control of glycogen synthase by hierarchal protein phosphorylation.
Roach PJ; FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990 SepPhosphoserine in peptide substrates can specify casein kinase II action.
Hrubey TW; Roach PJ; Biochemical and biophysical research communications 1990 Oct 15Isolation of the GSY1 gene encoding yeast glycogen synthase and evidence for the existence of a second gene.
Farkas I; Hardy TA; DePaoli-Roach AA; Roach PJ; The Journal of biological chemistry 1990 Dec 5Phosphate groups as substrate determinants for casein kinase I action.
Flotow H; Graves PR; Wang AQ; Fiol CJ; Roeske RW; Roach PJ; The Journal of biological chemistry 1990 Aug 25Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates.
Fiol CJ; Wang A; Roeske RW; Roach PJ; The Journal of biological chemistry 1990 Apr 15Stabilization of glycogen stores and stimulation of glycogen synthesis in hepatocytes by phenacyl imidazolium compounds.
Harris RA; Yamanouchi K; Roach PJ; Yen TT; Dominianni SJ; Stephens TW; The Journal of biological chemistry 1989 Sep 5Glycogen synthase turnover and phosphorylation in rat H4IIE hepatoma cells.
Armstrong DJ; Roach PJ; Archives of biochemistry and biophysics 1989 Nov 15Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones.
Zhang WM; Browner MF; Fletterick RJ; DePaoli-Roach AA; Roach PJ; FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989 NovSynergistic phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. Implications for hormonal regulation of glycogen synthase.
Flotow H; Roach PJ; The Journal of biological chemistry 1989 Jun 5Identification of phosphorylation sites in peptides using a gas-phase sequencer.
Wang YH; Fiol CJ; DePaoli-Roach AA; Bell AW; Hermodson MA; Roach PJ; Analytical biochemistry 1988 Nov 1Phosphoserine as a recognition determinant for glycogen synthase kinase-3: phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1.
Fiol CJ; Haseman JH; Wang YH; Roach PJ; Roeske RW; Kowalczuk M; DePaoli-Roach AA; Archives of biochemistry and biophysics 1988 DecCatalytic site of rabbit glycogen synthase isozymes. Identification of an active site lysine close to the amino terminus of the subunit.
Mahrenholz AM; Wang YH; Roach PJ; The Journal of biological chemistry 1988 Aug 5Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40.
Mahrenholz AM; Votaw P; Roach PJ; Depaoli-Roach AA; Zioncheck TF; Harrison ML; Geahlen RL; Biochemical and biophysical research communications 1988 Aug 30Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3.
Fiol CJ; Mahrenholz AM; Wang Y; Roeske RW; Roach PJ; The Journal of biological chemistry 1987 Oct 15Multiple phosphorylation of mouse muscle glycogen synthase.
Lee FT; Ahmad Z; DePaoli-Roach AA; Roach PJ; Archives of biochemistry and biophysics 1987 Nov 1 -
Board CertificationsAmerican Board of Internal Medicine - Endocrinology, Diabetes and MetabolismAmerican Board of Internal Medicine - Internal Medicine
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Clinical Interests
Diabetes, Insulin Therapy
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AwardsOrg:
Desc: Trustee Teaching Award
Scope: University
Date: 2023-05-01
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