Timothy A. Sutton, MD, PhD

Faculty

Timothy A. Sutton, MD, PhD

Associate Professor of Medicine

Phone (317) 274-5300

Address

Research II, Suite E202
950 W Walnut St
R2 E202
Indianapolis, IN 46202-5188

Bio

Mechanisms of renal microvascular endothelial cell dysfunction following injury with an emphasis on ischemia-reperfusion injury.

Titles & Appointments

Associate Professor of Medicine
Key Clinical Educator
KCE - NEPH

Education

1992 MD Indiana University

1990 PhD Indiana University

1985 BS Indiana University
Research

Mechanisms of renal microvascular endothelial cell dysfunction following injury with an emphasis on ischemia-reperfusion injury.
Publications

Integrated Cytometry With Machine Learning Applied to High-Content Imaging of Human Kidney Tissue for In Situ Cell Classification and Neighborhood Analysis.
Winfree S; McNutt AT; Khochare S; Borgard TJ; Barwinska D; Sabo AR; Ferkowicz MJ; Williams JC Jr; Lingeman JE; Gulbronson CJ; Kelly KJ; Sutton TA; Dagher PC; Eadon MT; Dunn KW; El-Achkar TM; Laboratory investigation; a journal of technical methods and pathology 2023 Feb 4

Alterations in Protein Translation and Carboxylic Acid Catabolic Processes in Diabetic Kidney Disease.
Collins KS; Eadon MT; Cheng YH; Barwinska D; Melo Ferreira R; McCarthy TW; Janosevic D; Syed F; Maier B; El-Achkar TM; Kelly KJ; Phillips CL; Hato T; Sutton TA; Dagher PC; Cells 2022 Mar 30

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation.
Menon R; Bomback AS; Lake BB; Stutzke C; Grewenow SM; Menez S; D'Agati VD; Jain S; Kidney Precision Medicine Project; Kidney international 2022 Mar 23

Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease.
Liu J; Nair V; Zhao YY; Chang DY; Limonte C; Bansal N; Fermin D; Eichinger F; Tanner EC; Bellovich KA; Steigerwalt S; Bhat Z; Hawkins JJ; Subramanian L; Rosas SE; Sedor JR; Vasquez MA; Waikar SS; Bitzer M; Pennathur S; Brosius FC; De Boer I; Chen M; Kretzler M; Ju W; Kidney Precision Medicine Project and Michigan Translational Core C-PROBE Investigator Group; Kidney Precision Medicine Project and Michigan Translational Core C-PROBE Investigator Group; Diabetes 2022 Dec 1

A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology.
Lutnick B; Manthey D; Becker JU; Ginley B; Moos K; Zuckerman JE; Rodrigues L; Gallan AJ; Barisoni L; Alpers CE; Wang XX; Myakala K; Jones BA; Levi M; Kopp JB; Yoshida T; Zee J; Han SS; Jain S; Rosenberg AZ; Jen KY; Sarder P; Kidney Precision Medicine Project; Communications medicine 2022 Aug 19

Serving on a Graduate Medical Education Diversity, Equity, Inclusion, and Justice Committee: Lessons Learned From a Journey of Growth and Healing.
Kara A; Wright C; Funches L; Williamson F; Hicks RA; Sutton TA; Nabhan Z; Frontiers in public health 2022 Apr 27

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis.
Schmidt IM; Colona MR; Kestenbaum BR; Alexopoulos LG; Palsson R; Srivastava A; Liu J; Stillman IE; Rennke HG; Vaidya VS; Wu H; Humphreys BD; Waikar SS; Kidney Precision Medicine Project (KPMP); Kidney international 2021 May 27

Rationale and design of the Kidney Precision Medicine Project.
de Boer IH; Alpers CE; Azeloglu EU; Balis UGJ; Barasch JM; Barisoni L; Blank KN; Bomback AS; Brown K; Dagher PC; Dighe AL; Eadon MT; El-Achkar TM; Gaut JP; Hacohen N; He Y; Hodgin JB; Jain S; Kellum JA; Kiryluk K; Knight R; Laszik ZG; Lienczewski C; Mariani LH; McClelland RL; Menez S; Moledina DG; Mooney SD; O'Toole JF; Palevsky PM; Parikh CR; Poggio ED; Rosas SE; Rosengart MR; Sarwal MM; Schaub JA; Sedor JR; Sharma K; Steck B; Toto RD; Troyanskaya OG; Tuttle KR; Vazquez MA; Waikar SS; Williams K; Wilson FP; Zhang K; Iyengar R; Kretzler M; Himmelfarb J; Kidney Precision Medicine Project; Kidney international 2021 Mar

Patient perspectives and involvement in precision medicine research.
Tuttle KR; Bebiak J; Brown K; Campbell C; Dighe A; Hyashi L; Jefferson N; Roberts GV; Stutzke C; Knight R; Kidney Precision Medicine Project; Kidney international 2021 Mar

Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury.
Melo Ferreira R; Sabo AR; Winfree S; Collins KS; Janosevic D; Gulbronson CJ; Cheng YH; Casbon L; Barwinska D; Ferkowicz MJ; Xuei X; Zhang C; Dunn KW; Kelly KJ; Sutton TA; Hato T; Dagher PC; El-Achkar TM; Eadon MT; JCI insight 2021 Jun 22

Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.
Ferkowicz MJ; Winfree S; Sabo AR; Kamocka MM; Khochare S; Barwinska D; Eadon MT; Cheng YH; Phillips CL; Sutton TA; Kelly KJ; Dagher PC; El-Achkar TM; Dunn KW; Kidney Precision Medicine Project.; Laboratory investigation; a journal of technical methods and pathology 2021 Jan 6

Clinical, histopathologic and molecular features of idiopathic and diabetic nodular mesangial sclerosis in humans.
Eadon MT; Lampe S; Baig MM; Collins KS; Melo Ferreira R; Mang H; Cheng YH; Barwinska D; El-Achkar TM; Schwantes-An TH; Winfree S; Temm CJ; Ferkowicz MJ; Dunn KW; Kelly KJ; Sutton TA; Moe SM; Moorthi RN; Phillips CL; Dagher PC; Kidney Precision Medicine Project.; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2021 Feb 4

Molecular characterization of the human kidney interstitium in health and disease.
Barwinska D; El-Achkar TM; Ferreira RM; Syed F; Cheng YH; Winfree S; Ferkowicz MJ; Hato T; Collins KS; Dunn KW; Kelly KJ; Sutton TA; Rovin BH; Parikh SV; Phillips CL; Dagher PC; Eadon MT; Kidney Precision Medicine Project.; Science advances 2021 Feb 10

A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project.
Butler CR; Appelbaum PS; Ascani H; Aulisio M; Campbell CE; de Boer IH; Dighe AL; Hall DE; Himmelfarb J; Knight R; Mehl K; Murugan R; Rosas SE; Sedor JR; O'Toole JF; Tuttle KR; Waikar SS; Freeman M; Kidney Precision Medicine Project; American journal of kidney diseases : the official journal of the National Kidney Foundation 2021 Dec 4

Integrating Patient Priorities with Science by Community Engagement in the Kidney Precision Medicine Project.
Tuttle KR; Knight R; Appelbaum PS; Arora T; Bansal S; Bebiak J; Brown K; Campbell C; Cooperman L; Corona-Villalobos CP; Dighe A; de Boer IH; Hall DE; Jefferson N; Jolly S; Kermani A; Lee SC; Mehl K; Murugan R; Roberts GV; Rosas SE; Himmelfarb J; Miller RT; Kidney Precision Medicine Project; Clinical journal of the American Society of Nephrology : CJASN 2020 Nov 30

Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue.
Barwinska D; Ferkowicz MJ; Cheng YH; Winfree S; Dunn KW; Kelly KJ; Sutton TA; Rovin BH; Parikh SV; Phillips CL; Dagher PC; El-Achkar TM; Eadon MT; Kidney Precision Medicine Project.; Journal of visualized experiments : JoVE 2020 Jun 9

Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.
Winfree S; Dagher PC; Dunn KW; Eadon MT; Ferkowicz M; Barwinska D; Kelly KJ; Sutton TA; El-Achkar TM; Nephron 2018 Jun 5

Live-Animal Imaging of Renal Function by Multiphoton Microscopy.
Dunn KW; Sutton TA; Sandoval RM; Current protocols in cytometry 2018 Jan 18

Novel roles for mucin 1 in the kidney.
Al-Bataineh MM; Sutton TA; Hughey RP; Current opinion in nephrology and hypertension 2017 Sep

Endothelial STAT3 Modulates Protective Mechanisms in a Mouse Ischemia-Reperfusion Model of Acute Kidney Injury.
Dube S; Matam T; Yen J; Mang HE; Dagher PC; Hato T; Sutton TA; Journal of immunology research 2017 Oct 17

Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications.
Winfree S; Ferkowicz MJ; Dagher PC; Kelly KJ; Eadon MT; Sutton TA; Markel TA; Yoder MC; Dunn KW; El-Achkar TM; Translational research : the journal of laboratory and clinical medicine 2017 Jul 22

Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells.
Winfree S; Khan S; Micanovic R; Eadon MT; Kelly KJ; Sutton TA; Phillips CL; Dunn KW; El-Achkar TM; Journal of the American Society of Nephrology : JASN 2017 Feb 2

Muc1 enhances the beta-catenin protective pathway during ischemia-reperfusion injury.
Al-Bataineh MM; Kinlough CL; Poland PA; Pastor-Soler NM; Sutton TA; Mang HE; Bastacky SI; Gendler SJ; Madsen CS; Singh S; Monga SP; Hughey RP; American journal of physiology. Renal physiology 2016 Jan 6

Novel application of complimentary imaging techniques to examine in vivo glucose metabolism in the kidney.
Hato T; Friedman AN; Mang HE; Plotkin Z; Dube S; Hutchins GD; Territo PR; McCarthy BP; Riley AA; Pichumani K; Malloy CR; Harris RA; Dagher PC; Sutton TA; American journal of physiology. Renal physiology 2016 Jan 13

Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury.
Dagher PC; Hato T; Mang HE; Plotkin Z; Richardson QV; Massad M; Mai E; Kuehl SE; Graham P; Kumar R; Sutton TA; International journal of molecular sciences 2016 Apr 29

Muc1 is Protective during Kidney Ischemia-Reperfusion Injury.
Pastor-Soler NM; Sutton TA; Mang HE; Kinlough CL; Gendler SJ; Madsen CS; Bastacky SI; Ho J; Al-Bataineh MM; Hallows KR; Singh S; Monga SP; Kobayashi H; Haase VH; Hughey RP; American journal of physiology. Renal physiology 2015 Apr 29

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.
Kapitsinou PP; Sano H; Michael M; Kobayashi H; Davidoff O; Bian A; Yao B; Zhang MZ; Harris RC; Duffy KJ; Erickson-Miller CL; Sutton TA; Haase VH; The Journal of clinical investigation 2014 May 1

Live-animal imaging of renal function by multiphoton microscopy.
Dunn KW; Sutton TA; Sandoval RM; Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2012 Oct

p53 is renoprotective after ischemic kidney injury by reducing inflammation.
Sutton TA; Hato T; Mai E; Yoshimoto M; Kuehl S; Anderson M; Mang H; Plotkin Z; Chan RJ; Dagher PC; Journal of the American Society of Nephrology : JASN 2012 Dec 6

Activated pericytes and the inhibition of renal vascular stability: obstacles for kidney repair.
Basile DP; Sutton TA; Journal of the American Society of Nephrology : JASN 2012 Apr 12

Pathophysiology of acute kidney injury.
Basile DP; Anderson MD; Sutton TA; Comprehensive Physiology 2012 Apr

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice.
Rajashekhar G; Gupta A; Marin A; Friedrich J; Willuweit A; Berg DT; Cramer MS; Sandusky GE; Sutton TA; Basile DP; Grinnell BW; Clauss M; American journal of physiology. Renal physiology 2011 Nov 30

The p53 inhibitor pifithrin-a can stimulate fibrosis in a rat model of ischemic acute kidney injury.
Dagher PC; Mai EM; Hato T; Lee SY; Anderson MD; Karozos SC; Mang HE; Knipe NL; Plotkin Z; Sutton TA; American journal of physiology. Renal physiology 2011 Nov 2

MMP-9 gene deletion mitigates microvascular loss in a model of ischemic acute kidney injury.
Lee SY; Hörbelt M; Mang HE; Knipe NL; Bacallao RL; Sado Y; Sutton TA; American journal of physiology. Renal physiology 2011 Mar 30

Fueling the fire in acute kidney injury: endothelial cells collect their Toll.
Sutton TA; Dagher PC; Kidney international 2011 Feb

Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.
Basile DP; Friedrich JL; Spahic J; Knipe N; Mang H; Leonard EC; Changizi-Ashtiyani S; Bacallao RL; Molitoris BA; Sutton TA; American journal of physiology. Renal physiology 2010 Dec 1

Alteration of microvascular permeability in acute kidney injury.
Sutton TA; Microvascular research 2008 Sep 25

p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.
Sutton TA; Wilkinson J; Mang HE; Knipe NL; Plotkin Z; Hosein M; Zak K; Wittenborn J; Dagher PC; American journal of physiology. Renal physiology 2008 Sep 24

Preservation of peritubular capillary endothelial integrity and increasing pericytes may be critical to recovery from postischemic acute kidney injury.
Kwon O; Hong SM; Sutton TA; Temm CJ; American journal of physiology. Renal physiology 2008 Jun 18

Functional studies in living animals using multiphoton microscopy.
Dunn KW; Sutton TA; ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2008

Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy.
Hörbelt M; Wotzlaw C; Sutton TA; Molitoris BA; Philipp T; Kribben A; Fandrey J; Pietruck F; Kidney international 2007 May 2

Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury.
Hörbelt M; Lee SY; Mang HE; Knipe NL; Sado Y; Kribben A; Sutton TA; American journal of physiology. Renal physiology 2007 Jul 11

Live-animal imaging of renal function by multiphoton microscopy.
Dunn KW; Sutton TA; Sandoval RM; Current protocols in cytometry / editorial board, J. Paul Robinson, managing editor ... [et al.] 2007 Jul

Imaging vascular pathology.
Sutton TA; Horbelt M; Sandoval RM; Nephron. Physiology 2006 Mar 10

Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury.
Sutton TA; Kelly KJ; Mang HE; Plotkin Z; Sandoval RM; Dagher PC; American journal of physiology. Renal physiology 2004 Sep 7

Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury.
Kelly KJ; Sutton TA; Weathered N; Ray N; Caldwell EJ; Plotkin Z; Dagher PC; American journal of physiology. Renal physiology 2004 Jun 1

Endothelial injury and dysfunction: role in the extension phase of acute renal failure.
Molitoris BA; Sutton TA; Kidney international 2004 Aug

Injury of the renal microvascular endothelium alters barrier function after ischemia.
Sutton TA; Mang HE; Campos SB; Sandoval RM; Yoder MC; Molitoris BA; American journal of physiology. Renal physiology 2003 Apr 8

Microvascular endothelial injury and dysfunction during ischemic acute renal failure.
Sutton TA; Fisher CJ; Molitoris BA; Kidney international 2002 Nov

Endothelial injury and dysfunction in ischemic acute renal failure.
Molitoris BA; Sandoval R; Sutton TA; Critical care medicine 2002 May

Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion.
Sutton TA; Mang HE; Atkinson SJ; American journal of physiology. Renal physiology 2001 Nov

Mechanisms of cellular injury in ischemic acute renal failure.
Sutton TA; Molitoris BA; Seminars in nephrology 1998 Sep

Phosphorylation by protein kinase C of the 20,000-dalton light chain of myosin in intact and chemically skinned vascular smooth muscle.
Sutton TA; Haeberle JR; The Journal of biological chemistry 1990 Feb 15

Phosphorylation of two sites on smooth muscle myosin. Effects on contraction of glycerinated vascular smooth muscle.
Haeberle JR; Sutton TA; Trockman BA; The Journal of biological chemistry 1988 Mar 25
Professional Organizations

Alpha Omega Alpha Honor Medical Society
Board Certifications

American Board of Internal Medicine - Nephrology

American Board of Internal Medicine - Internal Medicine
Clinical Interests

Acute renal failure.

Looking for patient care?

To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.

Find a doctor