Brian Walker, PhD

Faculty

Brian Walker, PhD

Daniel and Lori Efroymson Professor of Oncology

Email bw75@iu.edu

Phone (317) 274-0843

Address

IB 544B
HEMO
IN
Indianapolis, IN

Titles & Appointments

Daniel and Lori Efroymson Professor of Oncology
Professor of Medicine

Education

2000 PhD University of London

1996 BSC University of Edinburgh
Research

Genomics and epigenetics of multiple myeloma (MM) and related plasma cell dyscrasias.
Publications

The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma.
Boyle EM; Deshpande S; Tytarenko R; Ashby C; Wang Y; Bauer MA; Johnson SK; Wardell CP; Thanendrarajan S; Zangari M; Facon T; Dumontet C; Barlogie B; Arbini A; Rustad EH; Maura F; Landgren O; Zhan F; van Rhee F; Schinke C; Davies FE; Morgan GJ; Walker BA; Nature communications 2021 Jan 12

Monitoring treatment response and disease progression in myeloma with circulating cell-free DNA.
Deshpande S; Tytarenko RG; Wang Y; Boyle EM; Ashby C; Schinke CD; Thanendrarajan S; Zangari M; Zhan F; Davies FE; Morgan GJ; van Rhee F; Walker BA; European journal of haematology 2020 Oct 26

Bone marrow microenvironments that contribute to patient outcomes in newly diagnosed multiple myeloma: A cohort study of patients in the Total Therapy clinical trials.
Danziger SA; McConnell M; Gockley J; Young MH; Rosenthal A; Schmitz F; Reiss DJ; Farmer P; Alapat DV; Singh A; Ashby C; Bauer M; Ren Y; Smith K; Couto SS; van Rhee F; Davies F; Zangari M; Petty N; Orlowski RZ; Dhodapkar MV; Copeland WB; Fox B; Hoering A; Fitch A; Newhall K; Barlogie B; Trotter MWB; Hershberg RM; Walker BA; Dervan AP; Ratushny AV; Morgan GJ; PLoS medicine 2020 Nov 4

Two Cases of Vancomycin-Resistant Enterococcus faecium Bacteremia With Development of Daptomycin-Resistant Phenotype and its Detection Using Oxford Nanopore Sequencing.
Udaondo Z; Jenjaroenpun P; Wongsurawat T; Meyers E; Anderson C; Lopez J; Mohan M; Tytarenko R; Walker B; Ussery D; Kothari A; Jun SR; Open forum infectious diseases 2020 May 23

Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns.
Schinke C; Boyle EM; Ashby C; Wang Y; Lyzogubov V; Wardell C; Qu P; Hoering A; Deshpande S; Ryan K; Thanendrarajan S; Mohan M; Yarlagadda N; Khan M; Choudhury SR; Zangari M; van Rhee F; Davies F; Barlogie B; Morgan G; Walker BA; Blood cancer journal 2020 Jun 19

Long-term outcomes after autologous stem cell transplantation for multiple myeloma.
Nishimura KK; Barlogie B; van Rhee F; Zangari M; Walker BA; Rosenthal A; Schinke C; Thanendrarajan S; Davies FE; Hoering A; Morgan GJ; Blood advances 2020 Jan 28

BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma.
Boyle EM; Ashby C; Tytarenko RG; Deshpande S; Wang H; Wang Y; Rosenthal A; Sawyer J; Tian E; Flynt E; Hoering A; Johnson SK; Rutherford MW; Wardell CP; Bauer MA; Dumontet C; Facon T; Thanendrarajan S; Schinke CD; Zangari M; van Rhee F; Barlogie B; Cairns D; Jackson G; Thakurta A; Davies FE; Morgan GJ; Walker BA; Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Jan 27

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma.
Bauer MA; Ashby C; Wardell C; Boyle EM; Ortiz M; Flynt E; Thakurta A; Morgan G; Walker BA; Haematologica 2020 Feb 20

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease.
Mason MJ; Schinke C; Eng CLP; Towfic F; Gruber F; Dervan A; White BS; Pratapa A; Guan Y; Chen H; Cui Y; Li B; Yu T; Chaibub Neto E; Mavrommatis K; Ortiz M; Lyzogubov V; Bisht K; Dai HY; Schmitz F; Flynt E; Dan Rozelle; Danziger SA; Ratushny A; Multiple Myeloma DREAM Consortium.; Dalton WS; Goldschmidt H; Avet-Loiseau H; Samur M; Hayete B; Sonneveld P; Shain KH; Munshi N; Auclair D; Hose D; Morgan G; Trotter M; Bassett D; Goke J; Walker BA; Thakurta A; Guinney J; Leukemia 2020 Feb 14

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma.
Choudhury SR; Ashby C; Tytarenko R; Bauer M; Wang Y; Deshpande S; Den J; Schinke C; Zangari M; Thanendrarajan S; Davies FE; van Rhee F; Morgan GJ; Walker BA; Journal of hematology & oncology 2020 Aug 6

TarPan: an easily adaptable targeted sequencing panel viewer for research and clinical use.
Ashby C; Rutherford M; Bauer MA; Peterson EA; Wang Y; Boyle EM; Wardell CP; Walker BA; BMC bioinformatics 2020 Apr 15

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations.
George SL; Izquierdo E; Campbell J; Koutroumanidou E; Proszek P; Jamal S; Hughes D; Yuan L; Marshall LV; Carceller F; Chisholm JC; Vaidya S; Mandeville H; Angelini P; Wasti A; Bexelius T; Thway K; Gatz SA; Clarke M; Al-Lazikani B; Barone G; Anderson J; Tweddle DA; Gonzalez D; Walker BA; Barton J; Depani S; Eze J; Ahmed SW; Moreno L; Pearson A; Shipley J; Jones C; Hargrave D; Jacques TS; Hubank M; Chesler L; European journal of cancer (Oxford, England : 1990) 2019 Sep 19

Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance.
Pearson A; Proszek P; Pascual J; Fribbens C; Shamsher MK; Kingston B; O'Leary B; Herrera-Abreu MT; Cutts RJ; Garcia-Murillas I; Bye H; Walker BA; Gonzalez De Castro D; Yuan L; Jamal S; Hubank M; Lopez-Knowles E; Schuster EF; Dowsett M; Osin P; Nerurkar A; Parton M; Okines AFC; Johnston SRD; Ring A; Turner NC; Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Oct 7

Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma.
Mikulasova A; Ashby C; Tytarenko RG; Qu P; Rosenthal A; Dent JA; Ryan KR; Bauer MA; Wardell CP; Hoering A; Mavrommatis K; Trotter M; Deshpande S; Yaccoby S; Tian E; Keats J; Auclair D; Jackson GH; Davies FE; Thakurta A; Morgan GJ; Walker BA; Haematologica 2019 Jun 20

Daratumumab and dexamethasone is safe and effective for triple refractory myeloma patients: final results of the IFM 2014-04 (Etoile du Nord) trial.
Boyle EM; Leleu X; Petillon MO; Karlin L; Doyen C; Demarquette H; Royer B; Macro M; Moreau P; Fostier K; Marie-Lorraine C; Zarnitsky C; Perrot A; Herbaux C; Poulain S; Manier S; Beauvais D; Walker BA; Wardell CP; Vincent L; Frenzel L; Caillon H; Susanna S; Dejoie T; Avet-Loiseau H; Mohty M; Facon T; IFM2014-04 investigators.; British journal of haematology 2019 Jun 19

Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53.
Ashby C; Tytarenko RG; Wang Y; Weinhold N; Johnson SK; Bauer M; Wardell CP; Schinke C; Thanendrarajan S; Zangari M; van Rhee F; Davies FE; Sawyer JR; Morgan GJ; Walker BA; Oncotarget 2019 Jan 22

Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.
Jones JR; Weinhold N; Ashby C; Walker BA; Wardell C; Pawlyn C; Rasche L; Melchor L; Cairns DA; Gregory WM; Johnson D; Begum DB; Ellis S; Sherborne AL; Cook G; Kaiser MF; Drayson MT; Owen RG; Jackson GH; Davies FE; Greaves M; Morgan GJ; NCRI Haemato-Oncology CSG.; Haematologica 2019 Feb 7

An acquired high-risk chromosome instability phenotype in multiple myeloma: Jumping 1q Syndrome.
Sawyer JR; Tian E; Walker BA; Wardell C; Lukacs JL; Sammartino G; Bailey C; Schinke CD; Thanendrarajan S; Davies FE; Morgan GJ; Barlogie B; Zangari M; van Rhee F; Blood cancer journal 2019 Aug 9

Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Went M; Kinnersley B; Sud A; Johnson DC; Weinhold N; Försti A; van Duin M; Orlando G; Mitchell JS; Kuiper R; Walker BA; Gregory WM; Hoffmann P; Jackson GH; Nöthen MM; da Silva Filho MI; Thomsen H; Broyl A; Davies FE; Thorsteinsdottir U; Hansson M; Kaiser M; Sonneveld P; Goldschmidt H; Stefansson K; Hemminki K; Nilsson B; Morgan GJ; Houlston RS; Human genomics 2019 Aug 20

Draft Genome Sequences of 48 Vancomycin-Resistant Enterococcus faecium Strains Isolated from Inpatients with Bacteremia and Urinary Tract Infection.
Udaondo Z; Wongsurawat T; Jenjaroenpun P; Anderson C; Lopez J; Mohan M; Tytarenko R; Walker B; Nookaew I; Ussery D; Kothari A; Jun SR; Microbiology resource announcements 2019 Apr 11

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Walker BA; Mavrommatis K; Wardell CP; Ashby TC; Bauer M; Davies F; Rosenthal A; Wang H; Qu P; Hoering A; Samur M; Towfic F; Ortiz M; Flynt E; Yu Z; Yang Z; Rozelle D; Obenauer J; Trotter M; Auclair D; Keats J; Bolli N; Fulciniti M; Szalat R; Moreau P; Durie B; Stewart AK; Goldschmidt H; Raab MS; Einsele H; Sonneveld P; San Miguel J; Lonial S; Jackson GH; Anderson KC; Avet-Loiseau H; Munshi N; Thakurta A; Morgan G; Leukemia 2018 Jul 2

Combination of flow cytometry and functional imaging for monitoring of residual disease in myeloma.
Rasche L; Alapat D; Kumar M; Gershner G; McDonald J; Wardell CP; Samant R; Van Hemert R; Epstein J; Williams AF; Thanendrarajan S; Schinke C; Bauer M; Ashby C; Tytarenko RG; van Rhee F; Walker BA; Zangari M; Barlogie B; Davies FE; Morgan GJ; Weinhold N; Leukemia 2018 Dec 20
Professional Organizations

Royal College of Pathologists, UK

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