Dr. Greenfield earned his undergraduate degree in biology from New College of Florida and master’s and doctoral degrees in marine biology and biomineralization, respectively, from the University of the North Carolina at Chapel Hill. He completed post-doctoral studies in bone cell biology at Washington University in St. Louis before joining the faculty at Case Western Reserve University in Cleveland in 1990, where he remained before moving to Indianapolis in 2019 to join the IUSM Department of Orthopaedic Surgey, the Indiana Center for Musculoskeletal Health, and the Indiana University Simon Cancer Center.
Dr. Greenfield's long-standing research interests focus on basic and translational aspects of bone biology, and on osteosarcoma metastasis.
The osteosarcoma project aims to repurpose FDA-approved drugs to block growth of lung metastases - the primary cause of lethality in osteosarcoma patients. Current studies utilize 3D sarcosphere cultures and mouse models.
The bone biology projects aim to understand how aging, inflammation, infection, and PKA signaling regulate bone turnover, fracture healing, and implant integration/loosening. Current studies utilize cell cultures (osteoblasts, osteoclasts, and macrophages) and murine models (transgenic and surgical).