Robert E. Stratford, PhD
Adjunct Clinical Associate Professor of Medicine
- Phone
- (317) 274-2822
- Address
-
R2 480
CPHR
IN
Indianapolis, IN - PubMed:
Bio
Robert Stratford, Ph.D., is an Adjunct Associate Professor in the Division of Clinical Pharmacology at the Indiana University School of Medicine. He currently serves as Director of Early Development and Translational Sciences at Otsuka Product Development and Commercialization. Prior to joining Ostuka Dr. Stratford held several key positions in academia and industry. Dr. Stratford served as Associate Professor of Medicine and Director of the Disease and Therapeutic Response Modeling and Simulation program at Indiana University, Associate Professor at the Duquesne University School of Pharmacy, and an Assistant Professor in the College of Pharmacy at Xavier University of Louisiana, an Historical Black College and University. Prior to entering the academic world, Dr. Stratford worked for over 23 years at Eli Lilly and Company in both the Product Development and Drug Disposition organizations. The overarching objective of Dr. Stratford’s research is to employ modeling approaches to describe and predict the disposition of drugs and their effects in humans. To achieve this objective, state-of-the-art modeling approaches are used to create in vitro cell-based models, as well as in vivo PK/PD and physiologically-based PK/PD models. The desire is to describe and integrate the complexities of drug action at the molecular, cell, tissue/organ, and organismal levels, the latter encompassing the individual to patient population continuum.Year | Degree | Institution |
---|---|---|
1987 | PhD | University of Southern California |
1979 | BS | University of California, Irvine |
The goal of my research is to use pharmacokinetic and pharmacodynamic (PK/PD) modeling approaches to describe the processes of drug absorption, distribution, metabolism and excretion (PK), and ensuing drug actions (PD) based on pre-clinical experimentation to confirm, and ultimately predict drug exposure and ensuing effects in humans. To support this goal, in vitro techniques are employed alongside in vivo non-clinical experiments. This integrated approach informs model design, and is subsequently used to 1) translate drug exposure and effects from animals to humans, and 2) develop hypotheses that broaden and/or deepen our understanding of the pharmacokinetic and pharmacodynamic elements of a patient's response to pharmacotherapy.
Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine.
van Gaalen MM; Schlumbohm C; Folgering JH; Adhikari S; Bhattacharya C; Steinbach D; Stratford RE Jr; The Journal of pharmacology and experimental therapeutics 2019 Feb 7
van Gaalen MM; Schlumbohm C; Folgering JH; Adhikari S; Bhattacharya C; Steinbach D; Stratford RE Jr; The Journal of pharmacology and experimental therapeutics 2019 Feb 7
Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response.
Folgering JH; Choi M; Schlumbohm C; van Gaalen MM; Stratford RE Jr; Journal of neuroscience methods 2019 Feb 12
Folgering JH; Choi M; Schlumbohm C; van Gaalen MM; Stratford RE Jr; Journal of neuroscience methods 2019 Feb 12
Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2',7'-Dichloroflourescein Disposition in Caco-2 Cells.
Drennen C; Gorse E; Stratford RE Jr; Journal of pharmaceutical sciences 2017 Dec 14
Drennen C; Gorse E; Stratford RE Jr; Journal of pharmaceutical sciences 2017 Dec 14
Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions.
Chimezie C; Ewing A; Schexnayder C; Bratton M; Glotser E; Skripnikova E; Sá P; Boué S; Stratford RE Jr; Journal of pharmaceutical sciences 2016 Jan 11
Chimezie C; Ewing A; Schexnayder C; Bratton M; Glotser E; Skripnikova E; Sá P; Boué S; Stratford RE Jr; Journal of pharmaceutical sciences 2016 Jan 11
Development of a Rat Plasma and Brain Extracellular Fluid Pharmacokinetic Model for Bupropion and Hydroxybupropion Based on Microdialysis Sampling, and Application to Predict Human Brain Concentrations.
Cremers TI; Flik G; Folgering JH; Rollema H; Stratford RE Jr; Drug metabolism and disposition: the biological fate of chemicals 2016 Feb 25
Cremers TI; Flik G; Folgering JH; Rollema H; Stratford RE Jr; Drug metabolism and disposition: the biological fate of chemicals 2016 Feb 25
Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics.
Li CH; Stratford RE Jr; Velez de Mendizabal N; Cremers TI; Pollock BG; Mulsant BH; Remington G; Bies RR; Journal of translational medicine 2014 Aug 20
Li CH; Stratford RE Jr; Velez de Mendizabal N; Cremers TI; Pollock BG; Mulsant BH; Remington G; Bies RR; Journal of translational medicine 2014 Aug 20
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
Filla SA; Winter MA; Johnson KW; Bleakman D; Bell MG; Bleisch TJ; Castaño AM; Clemens-Smith A; del Prado M; Dieckman DK; Dominguez E; Escribano A; Ho KH; Hudziak KJ; Katofiasc MA; Martinez-Perez JA; Mateo A; Mathes BM; Mattiuz EL; Ogden AM; Phebus LA; Stack DR; Stratford RE; Ornstein PL; Journal of medicinal chemistry 2002 Sep 26
Filla SA; Winter MA; Johnson KW; Bleakman D; Bell MG; Bleisch TJ; Castaño AM; Clemens-Smith A; del Prado M; Dieckman DK; Dominguez E; Escribano A; Ho KH; Hudziak KJ; Katofiasc MA; Martinez-Perez JA; Mateo A; Mathes BM; Mattiuz EL; Ogden AM; Phebus LA; Stack DR; Stratford RE; Ornstein PL; Journal of medicinal chemistry 2002 Sep 26
Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication.
Stratford RE Jr; Clay MP; Heinz BA; Kuhfeld MT; Osborne SJ; Phillips DL; Sweetana SA; Tebbe MJ; Vasudevan V; Zornes LL; Lindstrom TD; Journal of pharmaceutical sciences 1999 Aug
Stratford RE Jr; Clay MP; Heinz BA; Kuhfeld MT; Osborne SJ; Phillips DL; Sweetana SA; Tebbe MJ; Vasudevan V; Zornes LL; Lindstrom TD; Journal of pharmaceutical sciences 1999 Aug
Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria.
Nicas TI; Mullen DL; Flokowitsch JE; Preston DA; Snyder NJ; Stratford RE; Cooper RD; Antimicrobial agents and chemotherapy 1995 Nov
Nicas TI; Mullen DL; Flokowitsch JE; Preston DA; Snyder NJ; Stratford RE; Cooper RD; Antimicrobial agents and chemotherapy 1995 Nov
American Society for Clinical Pharmacology and Therapeutics
Looking for patient care?
To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.