Subramanyam Dasari, PhD
Postdoctoral Fellow in Medical & Molecular Genetics
- Address
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Myers Hall 200
MSCI
BL
Bloomington, IN - PubMed:
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Bio
Dr. Subramanyam Dasari completed his Ph.D. (2014) in Cancer Biology (Biotechnology) at the School of Herbal Studies and Natural Sciences, Department of Biotechnology from Dravidian University, Andhra Pradesh, India. During his doctoral training, he studied the use of potential serum protein biomarkers used to evaluate the diagnosis and prognosis of gynecological cancers (cervical cancer, ovarian and endometrial) and Breast Cancers. Dr.Dasari also focused on the role of the microbiome and their role in the development of gynecological cancers (cervical cancer). Then Dr.Dasari joined as a Postdoctoral research fellow at UIC, College of Medicine at Rockford, USA (2015-2017) to study the anticancer effects and their mechanism of biotherapeutic compounds (Vitamin K2, Neferine and DRP-27) against prostate cancer and cervical cancers. Then he pursued a postdoctoral fellowship in the department of Medical & Molecular Genetics, IU School of medicine, Bloomington, Indiana. Dr. Dasari is seeking to understand the reciprocal interactions between ovarian cancer cells and their tumor microenvironment for the regulation of metastatic colonization in ovarian cancer. Dr.Dasari used in vitro organotypic 3D culture models, and mouse xenograft models of metastasis along with cell and molecular biological approaches to study the reciprocal interactions between the metastasizing cancer cells with their microenvironment at the site of metastasis through microRNAs (miR-4454 and miR-193b) and transcription factors (ETS1).
Key Publications
https://pubmed.ncbi.nlm.nih.gov/34654724/https://pubmed.ncbi.nlm.nih.gov/32350057/
https://pubmed.ncbi.nlm.nih.gov/31640297/
https://pubmed.ncbi.nlm.nih.gov/30222146/
https://pubmed.ncbi.nlm.nih.gov/29174800/
| Year | Degree | Institution |
|---|---|---|
| 2014 | PhD | Dravidian University |
| 2005 | MSC | Sri Venkateswara University |
| 2003 | BSC | Sri Krishnadevaraya University |
My long-term research interests involve the development of a comprehensive understanding of the interactions of microenvironment with ovarian cancer cells during the establishment of ovarian cancer metastasis and devise new therapies targeting metastatic disease. Currently, we are seeking to understand the reciprocal interactions between ovarian cancer cells and the tumor microenvironment for the regulation of metastatic colonization in ovarian cancer. We are specifically interested in the regulation of key microRNAs (miR-4454 and miR-193b) and transcription factors (ETS1) by these paracrine/juxtacrine interactions and the mechanism by which they drive metastatic colonization in ovarian cancer. We have developed novel assays like a proximal culture and a 3D organoid culture to study the interaction between cancer cells and their tumor microenvironment.