Faculty

Scott G. Canfield, PhD

Assistant Professor of Anatomy, Cell Biology & Physiology

Address

620 Chestnut St.
HH 135

Terre Haute, IN 47809

Key Publications

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells. Canfield SG, Stebbins MJ, Morales BS, Asai SW, Vatine GD, Svendsen CN, Palecek SP, Shusta EV. J Neurochem. 2017 Mar;140(6):874-888. doi: 10.1111/jnc.13923. Epub 2017 Feb 14.

High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission. Canfield SG, Zaja I, Godshaw B, Twaroski D, Bai X, Bosnjak ZJ. Anesth Analg. 2016 May;122(5):1269-79. doi: 10.1213/ANE.0000000000001254.

Marked hyperglycemia attenuates anesthetic preconditioning in human-induced pluripotent stem cell-derived cardiomyocytes. Canfield SG, Sepac A, Sedlic F, Muravyeva MY, Bai X, Bosnjak ZJ. Anesthesiology. 2012 Oct;117(4):735-44.

Titles & Appointments

Assistant Professor of Anatomy, Cell Biology & Physiology

Education

2013 PhD Medical College of Wisconsin

2006 BS Northland College
Research

Dr. Canfield’s research program is centered on the development of a human stem cell-derived blood-brain barrier model consisting of brain microvascular endothelial cells, astrocytes, neurons, and pericytes. The stem cell-derived brain microvascular endothelial cells are responsive to inductive neuronal cues, expresses functional and active efflux transporters, tight junction proteins and nutrient transporters all contributing to a physiological barrier. His laboratory investigates how varying pathological conditions and environmental toxins can negatively affect the blood-brain barrier in an attempt to unveil novel therapeutic strategies.

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