38384-Miller, Marcus

Marcus J. Miller, PhD

Assistant Professor of Clinical Medical & Molecular Genetics

IB 344C
Indianapolis, IN


Marcus J. Miller, PhD FACMG, is an ABMGG certified clinical biochemical geneticist that oversees the Biochemical Genetics Laboratory at Indiana University School of Medicine.  Prior to this position, Dr. Miller was an assistant professor at Baylor College of Medicine and an assistant director within the Baylor Genetics Laboratories.  Dr. Miller’s research interests focus on improving the diagnosis and management of patients with inborn errors of metabolism. 


Key Publications

Miller, M.J., Luu, S.M, Graham, B. H. (2021) “Acute Hyperammonemia, Lactic Acidosis, and Ketoacidosis in a Developmentally Normal Child” Clin Chm: 67-11.

Miller M.J.
, Cusmano-Ozog K, Oglesbee D, & Young S (2020) “Laboratory analysis of acylcarnitines, 2020 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG).” Genet Med:1-10.

Griffin, C., Z. Ammous, G. H. Vance, B. H. Graham and M. J. Miller (2019). "Rapid quantification of underivatized alloisoleucine and argininosuccinate using mixed-mode chromatography with tandem mass spectrometry." J Chromatogr B Analyt Technol Biomed Life Sci 1128: 121786, PMID31518899

Jain, M., Kennedy, A.D., Elsea S.H., Miller, M.J., (2017) “Analytes Related to Erythrocyte Metabolism are Reliable Biomarkers for Preanalytical Error Due to Delayed Plasma Processing in Metabolomics Studies” Clinica Chimica Acta, PMID28069401.   

Miller, M.J., Bostwick, B.L., Kennedy, A.D., Taraka, D., Sun, Q., Sutton, V.R., Elsea, S.H., (2016) “Chronic oral L-carnitine supplementation drives marked plasma TMAO elevations in patients with organic acidemias despite dietary meat restrictions” Journal of Inherited Metabolic Disease Reports, PMID26936850 

Miller, M.J., Burrage L.C., Gibson, J.B., Strenk, M.E., Lose, J.E, Bick, D.P., Elsea, S.H., Sutton, V.R., Sun, Q., Graham, B.H., Craigen, W.J., Zhang, W., Wong, L.C. (2015) “Recurrent ACADVL molecular findings in individuals with a positive newborn screen for very long chain acyl-coA dehydrogenase (VLCAD) deficiency in the United States­­” Molecular Genetics and Metabolism, 116(3): 139-145. PMID26385305 

Burrage, L.C, Miller, M.J., Wong, L.J., Kennedy, A.D., Sutton, V.R., Sun, Q., Elsea, S.H., Graham, B.H. (2015) “Elevations of C14:1 and C14:2 Plasma Acylcarnitines in Fasted Children: A Diagnostic Dilemma” Journal of Pediatrics,  PMID26602010 

Miller, M.J, Kennedy, A.D., Eckhart, A.D., Burrage, L.C., Wulff, J.E., Miller, L.A.D., Milburn, M.V., Ryals, J.A., Beaudet, A.L., Sun, Q., Sutton, V.R., Elsea, S.H. (2015) “Untargeted metabolomic analysis for the clinical screening of inborn errors of metabolism.”  Journal of Inherited Metabolic Disease, 38(6): 1029-1039. PMID25875217  

Miller, M.J., Soler-Alfonso, C.R., Grund, J.E., Fang, P., Sun, Q., Elsea, S.H., Sutton, V.R. (2014).  Improved standards for prenatal diagnosis of citrullinemia.  Molecular Genetics and Metabolism, 112, 205-209.


Titles & Appointments

  • Assistant Professor of Clinical Medical & Molecular Genetics
  • Director, IU Biochemical Genetics Laboratory
  • Education
    2011 PhD University of Wisconsin
    2005 BS Purdue University
  • Professional Organizations
    American Board of Medical Genetics and Genomics (ABMGG)
    American College of Medical Genetics and Genomics
    American Society of Human Genetics
  • Board Certifications
    American Board of Medical Genetics and Genomics - Clinical Molecular Genetics and Genomics*
    American Board of Medical Genetics and Genomics - Clinical Biochemical Genetics*

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