Associate Professsor, School of Engineering & Technology
Adjunct Professor of Orthopaedic Surgery
2007PhDUniversity of Michigan
2004MSUniversity of Michigan
2002BSGeorgia Institute of Technology
Dr. Wallace's laboratory (Bone Biology and Mechanics Laboratory, BBML) is focused on understand how exogenous mechanical stimulation models impact cellular output, tissue quality, bone mass and fracture resistance as a function of age and disease state. They study how bone changes under different matrix-based disease states (e.g. osteogenesis imperfecta, osteoporosis, osteolathyrism), and use mechanical stimulation as a means to compensate for these changes. Trainees in the BBML will take a materials science approach towards studying the mechanical properties of bone at multiple hierarchical length scales, from the nanoscale structure of collagen and mineral to the whole bone at the macroscale.In vitrostudies (fluid flow, substrate bending) complimentin vivomodels of mechanical loading (treadmill running, tibial loading). Techniques including cell culture, qPCR, atomic force microscopy, microCT, Raman spectroscopy nanoindentation whole bone mechanical testing are routinely used.
Looking for patient care?
To schedule an appointment with a faculty member physician of IU School of Medicine, contact Indiana University Health at 888-484-3258 or use the physician finder by clicking the button below.