25560-Wallace, Joseph

Joseph Wallace, PhD

Chair, Biomedical Engineering

SL 220
Indianapolis, IN
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Titles & Appointments

  • Chair, Biomedical Engineering
  • Professor of Biomedical Engineering
  • Adjunct Professor of Orthopaedic Surgery
  • Education
    2007 PhD University of Michigan
    2004 MS University of Michigan
    2002 BS Georgia Institute of Technology
  • Research

    Dr. Wallace's laboratory (Bone Biology and Mechanics Laboratory, BBML) is focused on understand how exogenous mechanical stimulation models impact cellular output, tissue quality, bone mass and fracture resistance as a function of age and disease state. They study how bone changes under different matrix-based disease states (e.g. osteogenesis imperfecta, osteoporosis, osteolathyrism), and use mechanical stimulation as a means to compensate for these changes. Trainees in the BBML will take a materials science approach towards studying the mechanical properties of bone at multiple hierarchical length scales, from the nanoscale structure of collagen and mineral to the whole bone at the macroscale.In vitro studies (fluid flow, substrate bending) compliment in vivo models of mechanical loading (treadmill running, tibial loading). Techniques including cell culture, qPCR, atomic force microscopy, microCT, Raman spectroscopy   nanoindentation whole bone mechanical testing are routinely used. 

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