Dr. Yamamoto was an Assistant and Associate Professor with tenure in the Department of Pharmacology at the Northeastern Ohio Universities College of Medicine. Subsequently, he was Professor and Director of the Program in Basic and Clinical Neurosciences in the Department of Psychiatry at Case Western Reserve University School of Medicine before moving to Boston University School of Medicine as Professor and Director of the Laboratory of Neurochemistry in the Department of Pharmacology. In 2008, he joined the Department of Neurosciences at the University of Toledo College of Medicine as Chair and Professor.In 2015, he was appointed the Chair of the Department of Pharmacology and Toxicology and the Robert B. Forney Professor of Toxicology at the Indiana University School of Medicine. Dr. Yamamoto has served and continues to serve as a regular and ad hoc member of NIH Study Sections and is a member of several advisory boards of NIH-sponsored research centers and programs. He also is on the editorial boards of several journals.