I-Chen Ivorine Yu, PhD
Assistant Professor of Anatomy, Cell Biology & Physiology
Adjunct Assistant Professor of Pathology & Laboratory Medicine
- Address
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IPFW Med Ed 111
MEDF
FW
Fort Wayne, IN - PubMed:
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Bio
Dr. I-Chen Ivorine Yu is a neuroscientist specializing in glial biology and neuroinflammation, with a focus on aging-related cognitive decline, vascular contributions to dementia, and Alzheimer’s disease (AD). She is an Assistant Professor in the Department of Anatomy, Cell Biology, and Physiology at Indiana University School of Medicine and joined the Stark Neurosciences Research Institute in 2023. Previously, Dr. Yu completed postdoctoral research at Pfizer Research and Development (R&D) in Cambridge, Massachusetts, where she investigated neural circuit regulation in the context of metabolic disorders and further honed her expertise in translational neuroscience and pharmaceutical drug discovery.
Dr. Yu's research is deeply committed to understanding the immune and vascular mechanisms underlying cognitive decline. She has led numerous studies on microglial plasticity, immune-vascular interactions, and the effects of metabolic and environmental factors on neurodegeneration. Her work bridges gaps between basic science and therapeutic development, contributing to new strategies for addressing Alzheimer's and related dementias.
| Year | Degree | Institution |
|---|---|---|
| 2010 | PhD | University of Rochester |
| 2005 | MS | University of Rochester |
| 2001 | MS | National Taiwan University |
| 1999 | BS | National Taiwan University |
My research focuses on the intricate relationships between neuroinflammation, vascular dysfunction, and cognitive impairment, with an emphasis on Alzheimer’s disease (AD) and vascular contributions to dementia (VCID). Specifically, we investigate how environmental and metabolic risk factors—such as the ApoE4 genotype and systemic inflammation—affect microglial immunometabolism and the integrity of the blood-brain barrier. Our work is particularly concentrated on understanding the immune-vascular interactions that drive cognitive decline in mixed forms of vascular and Alzheimer's dementias. Through this research, we aim to bridge the gap between cerebrovascular dysfunction and neuroinflammation, ultimately identifying novel therapeutic targets for neurodegenerative diseases.
Paraiso HC; Kuo PC; Curfman ET; Moon HJ; Sweazey RD; Yen JH; Chang FL; Yu IC; Journal of neuroinflammation 2018 Mar 29
Kuo PC; Brown DA; Scofield BA; Paraiso HC; Wang PY; Yu IC; Yen JH; Brain, behavior, and immunity 2018 Mar 28
Yu IC; Kuo PC; Yen JH; Paraiso HC; Curfman ET; Hong-Goka BC; Sweazey RD; Chang FL; Translational stroke research 2017 Jun 17
Kuo PC; Yu IC; Scofield BA; Brown DA; Curfman ET; Paraiso HC; Chang FL; Yen JH; Brain, behavior, and immunity 2017 Jan 26
Kuo PC; Brown DA; Scofield BA; Yu IC; Chang FL; Wang PY; Yen JH; Brain, behavior, and immunity 2016 Mar 21
Kuo PC; Scofield BA; Yu IC; Chang FL; Ganea D; Yen JH; Journal of the American Heart Association 2016 Jan 8
Yu IC; Lin HY; Sparks JD; Yeh S; Chang C; Diabetes 2014 Oct
Yu IC; Lin HY; Liu NC; Sparks JD; Yeh S; Fang LY; Chen L; Chang C; Diabetes 2012 Nov 8
Kim E; Liu NC; Yu IC; Lin HY; Lee YF; Sparks JD; Chen LM; Chang C; Diabetes 2011 Apr 8
Lai JJ; Lai KP; Chuang KH; Chang P; Yu IC; Lin WJ; Chang C; The Journal of clinical investigation 2009 Nov 9
Liu NC; Lin WJ; Yu IC; Lin HY; Liu S; Lee YF; Chang C; Endocrine 2009 Jul 18
Lin HY; Yu IC; Wang RS; Chen YT; Liu NC; Altuwaijri S; Hsu CL; Ma WL; Jokinen J; Sparks JD; Yeh S; Chang C; Hepatology (Baltimore, Md.) 2008 Jun
Yu IC; Lin HY; Liu NC; Wang RS; Sparks JD; Yeh S; Chang C; Endocrinology 2008 Feb 14
Liu NC; Lin WJ; Kim E; Collins LL; Lin HY; Yu IC; Sparks JD; Chen LM; Lee YF; Chang C; Diabetes 2007 Sep 7
Xu Q; Lin HY; Yeh SD; Yu IC; Wang RS; Chen YT; Zhang C; Altuwaijri S; Chen LM; Chuang KH; Chiang HS; Yeh S; Chang C; Endocrine 2007 Oct 23
Yang Z; Chang YJ; Yu IC; Yeh S; Wu CC; Miyamoto H; Merry DE; Sobue G; Chen LM; Chang SS; Chang C; Nature medicine 2007 Mar 4
Huang C; Chang SC; Yu IC; Tsay YG; Chang MF; Journal of virology 2007 Mar 21