21706-O'Neil, Kathleen

Kathleen M. O'Neil, MD

Professor Emeritus of Clinical Pediatrics

RR 307
Indianapolis, IN


Dr. O'Neil is a Professor of Pediatrics at Indiana University School of Medicine in the Division of Pediatric Rheumatology. She studied at Tufts University School of Medicine in Boston, the Yale-New Haven Hospital in New Haven, CT and the Johns Hopkins School of Medicine in Baltimore. She has taught at the University of Maryland, SUNY at Buffalo, and University of Oklahoma before moving to IU in 2012. Clinical interests include all pediatric rheumatic conditions, especially severe multisystem disorders (SLE, juvenile dermatomyositis, vasculitis, sclerodermas and autoinflammatory diseases). She participates in multi-center research including the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Childhood Arthritis and Rheumatology Research Alliance (CARRA). She was a founding member of CARRA. She coordinates a multi-center study of hormone effects during puberty on disease activity and autoimmunity in childhood SLE. Her work strives to understand why autoimmune diseases are more frequent in girls, and why many begin or worsen near puberty. She participates in multi-center trials of novel medications in childhood rheumatic diseases and is a leader in national and international research organizations.

Key Publications

1.     Brunner HI, Bennett MR, Abulaban K, Klein-Gitelman MS, O’Neil KM, Tucker L, Ardoin SP, Rouster-Stevens KA, Onel KB, Singer NG, Eberhard AB, Jung JK, Imundo L, Wright TB, Witte D, Rovin BH, Ying J, Devarajan P.  Development of a novel renal activity index of lupus nephritis in children and young adults.  Arthritis Care & Research 68:1003-1011.  2016.  UI: 26473509

2.     Westwell-Roper C, Lubieniecka JM, Brown KL, Morishita KA, Mammen C, Wagner-Weiner L, Yen E, Li SC, O'Neil KM, Lapidus SK, Brogan P, Cimaz R, Cabral DA; for ARChiVe Investigators Network within the PedVas initiative. Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey.  Pediatr Rheumatol Online J. 2017. 15:61. doi: 10.1186/s12969-017-0191-z.

3.     Bernatsky S, Clarke AE, Niaki OZ, Labrecque J, Schanberg LE, Silverman ED, Hayward K, Imundo L, Brunner HI, Haines KA, Cron RQ, Oen K, Wagner-Weiner L, Rosenberg AM, O'Neil KM, Duffy CM, von Scheven E, Joseph L, Lee JL, Ramsey-Goldman R.  J Rheumatol. 2017. pii: jrheum.170179. doi: 10.3899/jrheum.170179. PMID:  28765255

4.     Go EJL, O'Neil KM.  Curr Opin Rheumatol. The catastrophic antiphospholipid syndrome in children.2017 Sep;29(5):516-522. doi: 10.1097/BOR.0000000000000426.  PMID:  28632503.


5.     Moncrieffe H, Bennett MF, Tsoras M, Luyrink LK, Johnson AL, Xu H, Dare J, Becker ML, Prahalad S, Rosenkranz M, O'Neil KM, Nigrovic PA, Griffin TA, Lovell DJ, Grom AA, Medvedovic M, Thompson SD.  Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate.  Rheumatology (Oxford). 2017 1;56:1542-1551. doi: 10.1093/rheumatology/kex206.  PMID:  28582527

Titles & Appointments

  • Professor Emeritus of Clinical Pediatrics
  • Education
    1986 FEL John Hopkins University
    1982 RES Yale University School of Medicine
    1978 MD Tufts University
    1974 BA Wellesley College
  • Research

    Dr. O'Neil is interested in mechanisms of action of inflammation and autoimmunity in systemic lupus erythematosus, including the sex dichotomy that makes SLE more common in females.  Having trained as an immunologist in a complement lab, she is interested in the role of serine protease systems like complement and the clotting system in pathology in lupus and the antiphospholipid syndrome.  She works with clinical research groups to help test safety and efficacy of novel therapeutic agents in rheumatic diseases of childhood, and comparative efficacy studies of treatments in current use.

  • Professional Organizations
    American Academy of Pediatrics
    American College of Rheumatology
    American Pediatric Society
    Childhood Arthritis & Rheumatology Research Alliance
    Pediatric Rheumatology Collaborative Study Group
  • Board Certifications
    American Board of Pediatrics - Pediatric Rheumatology
    American Board of Pediatrics - Pediatrics
  • Clinical Interests

    Dr. O'Neil specializes in diagnosis and treatment of rheumatic diseases of childhood, including systemic lupus erythematosus, juvenile idiopathic arthritis, juvenile inflammatory myositis, localized and systemic scleroderma, mixed connective tissue disease, vasculitis and autoinflammatory disorders of systemic inflammation.


    Riley Hospital for Children at IU Health
    Riley Outpatient Center (ROC), MSA3
    705 Riley Hospital Drive, 3rd floor
    Indianapolis, IN 46202

    IU North Medical Center
    11725 N Illinois Street, Suite 450
    Carmel, IN 46032

  • Awards
    Org: American College of Rheumatology - PRSYM Meeting organizers
    Desc: Top Clinical and Therapeutic Research Abstract
    Scope: International
    Date: 2017-05-17
    Org: Alpha Omega Alpha Medical Honor Society
    Desc: Alpha Omega Alpha
    Scope: National
    Date: 1978-01-01

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