15263-Sheets, Patrick

Patrick L. Sheets, PhD

Associate Professor of Pharmacology & Toxicology


I have an extensive background in pharmacology, biophysics, and neurobiology with specific expertise in ion channel physiology, electrophysiology, retrograde labeling in the brain, cortical circuit mapping, high resolution imaging, and optogenetics. Outside of the lab I enjoy cooking, biking, golfing, weightlifting, and spending time with my family. I am also an avid fan of the Chicago Cubs, Chicago Bears, and Purdue Boilermakers. 

Honors and Awards



 Distinguished Student Award Academic Excellence

Purdue University



Best Poster Award

Indianapolis Society for Neuroscience



 Paul and Carole Stark Research Fellowship

IU School of Medicine



Society for Neuroscience Travel Award



Travel Award for Outstanding Abstract

Indiana University



KK Chen Fellowship

IU School of Medicine

Department of Pharmacology & Toxicology



Institutional National Research Award

T32 Trainee




National Research Award

F32 Postdoctoral




Leadership in Academic Medicine Program


IU School of Medicine 


Titles & Appointments

  • Associate Professor of Pharmacology & Toxicology
  • Education
    2012 FEL Northwestern University
    2007 PhD Indiana University
    2003 MS Purdue University
    2001 BS Purdue University
  • Research

    The main objectives of my laboratory are to elucidate the functional organization of circuit pathways involved in pain modulation and to understand how these same pathways are altered by different modalities of pain.  Our lab uses a multifaceted approach (pain models in mice, retrograde labeling, slice electrophysiology, laser scanning photostimulation, high resolution imaging, optogenetics, behavior) to resolve these critical unknowns. The rationale for ourwork is that identifying the neural mechanisms through which pain alters circuit function in defined brain pathwayswill produce critical knowledge regarding the affective and emotional dimensions of pain. Such an understanding can lead to novel strategies for therapeutic intervention and improvement of clinical guidelines.

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